CN1163133A - Spray and nose liniment for preventing and curing common cold and its preparing method - Google Patents
Spray and nose liniment for preventing and curing common cold and its preparing method Download PDFInfo
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- CN1163133A CN1163133A CN 96122296 CN96122296A CN1163133A CN 1163133 A CN1163133 A CN 1163133A CN 96122296 CN96122296 CN 96122296 CN 96122296 A CN96122296 A CN 96122296A CN 1163133 A CN1163133 A CN 1163133A
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Abstract
The present invention belongs to medicinal preparation and its preparation process, and it features that based on the aetiologic, pathologic, immunologic and clinic characteristics of common cold, the present invention changes traditional whole-body medicine supply into the direct spray medicine supply to focus of infected upper respiratory tract to cure common cold in the initial stage. The present invention makes it possible to change people's medicine supplying habit of curing common cold and to cure common cold lightly without taking medicine and injection.
Description
The invention belongs to pharmaceutical preparation and preparation method thereof
Flu is a kind of mondial commonly encountered diseases, frequently-occurring disease.Have 85% people can catch a cold 2-6 time within 1 year approximately, therefore the control of flu has become worldwide research topic.Yet, what is flu actually? flu is the actute infection of the upper respiratory tract mucosa that caused by virus etc., its primary lesion is at nasal mucosa, the virus of general flu, antibacterial is only on the upper respiratory tract top layer, seldom enter blood or body deep tissues, therefore unkind saying: the real mistaken ideas that entered by the form of administration restriction that belong to of whole body administration that the flu of conventional dosage forms treatment is in the past carried out and the blood drug level of being emphasized thereof, and the suspicion that suppresses the human immunologic function is arranged, so the article of " sense stomach should not medication " is delivered and be entitled as to Tongji Hospital, Tongji Medical Univ contagious department professor Gao Mei pod on " Popular Medicine " 1996 (11) 44-45.
The objective of the invention is characteristics such as nosetiology, pathology, immunology and clinical manifestation at flu, use the means of new formulation technology, to society provide can effectively cut off the flu route of transmission, interrupt the flu pathological process rapidly, make the control spray for cold of its healing, nose liniment in the direct administration of cacorhinia kitchen range of starting stage.
Control spray for cold of the present invention, nose liniment can divide PH adjustable type and Chinese medicine heat clearing away detoxifcation class spray, nose liniment etc. according to its composition and the mechanism of action, and now divisions are as follows:
PH adjustable type control spray for cold (nose liniment) is to be made of PH regulator, additives, solvent etc.Wherein the acid that can select for use any (or several) of meeting medicinal requirements pH value can be transferred to 2-6 of PH regulator maybe can transfer to pH value the alkali of 9-13, as; Hydrochloric acid, acetic acid, citric acid, lactic acid, fruit acid, ascorbic acid, sodium hydroxide, sodium carbonate, sodium bicarbonate etc., its consumption is the 0.001-10% of spray (or nose liniment) total amount; Or acid water or the alkaline water directly selecting ion water generator for use and produced together with solvent.Additives (osmotic pressure regulator, cosolvent, correctives etc.) can be selected sodium chloride, stevioside, cyclamate, Mentholum, Oleum menthae, Tweens, spans, phospholipid etc. for use, and its consumption accounts for the 0-5% of spray (or nose liniment) total amount.The optional water of solvent, ethanol, propylene glycol etc. are wherein at least a, and its consumption accounts for the 90-99.99% of spray (or nose liniment) total amount, its preparation method be by feed intake, several procedures such as adjustment, packing finish.The operation main points of operation wherein adjusted are the PH of medicinal liquid, and PH should be in 2-6 or 9-13 scope.
Chinese medicine antipyretic and antidotal type control spray for cold (or nose liniment) is to be made of medicine, additives, solvent etc., wherein the representativeness of antipyretic and antidotal type medicine medicine commonly used is: Flos Lonicerae, Radix Scutellariae, Fructus Forsythiae, Radix Isatidis, Folium Isatidis, the public pod of Pu etc., and its side of representative is; 1, antitoxic bolus of honeysuckle flower and forsythia (1) (Flos Lonicerae, Fructus Forsythiae, Radix Platycodonis, Herba Menthae, tasteless preserved soybean, Herba Lophatheri, Fructus Arctii, Herba Schizonepetae, Radix Glycyrrhizae etc.; If add Rhizoma Phragmitis in the side then is that Lonicerae and Forsythiae Powder side (2) then is Saigae Tataricae detoxifying pills side (3) if add Cornu Saigae Tataricae in the side); 2, QINGKAILING (4) (cholic acid, Hyodeoxycholic Acid, Concha Margaritifera powder, Cornu Bubali, baicalin, plank, Flos Lonicerae, Radix Isatidis etc.; If add some fragrant diaphoretic medicine Borneolum Syntheticums, Mentholum, Radix Curcumae, Herba Pogostemonis, Rhizoma Acori Graminei etc. on this basis, then be analgesic antiphlogistic capsule side (5)); 3, FUFANG YUXINGCAO PIAN (6) (Herba Houttuyniae, Radix Scutellariae, Radix Isatidis, Fructus Forsythiae, Flos Lonicerae); 4, Pu ground blue Pianomide (7) (Radix Scutellariae, the public pod of Pu, Herba Corydalis Bungeanae, Radix Isatidis), 5, children's antipyretic oral liquid (8) (Folium Isatidis, Fructus Forsythiae, Radix Scutellariae, Rhizoma Paridis, Radix Isatidis, Fructus Gardeniae, Folium Bambusae, Radix Bupleuri, Flos Lonicerae, Cortex Moutan, Pheretima, Radix Cynanchi Atrati); 6, anti inflammation and heat resolution ball (9) heat-clearing and toxic substances removing sides such as (the public pod of Pu, Radix Saposhnikoviae, Radix Glycyrrhizae, Fructus Forsythiae, Flos Loniceraes), its extract accounts for the 1.0-30% of spray total amount; The optional water of solvent, ethanol, propylene glycol etc. of usefulness wherein adjusted is wherein at least a, and its consumption accounts for the 70-99% of spray (nose liniment) total amount; Additives (osmotic pressure regulator, correctives, cosolvent etc.) can select for use its consumptions such as sodium chloride, stevioside, cyclamate, Mentholum (oil), Tweens, spans, phospholipid to account for the 0-5% of spray total amount, its preparation method by feed intake, extract, make with extra care, several procedures such as adjustment, packing finish.Wherein the main points of extraction, refining step are: (1) at first should select for use steam distillation to extract volatile oil for the plant amedica that contains volatile oil, and residue medicinal residues and medicinal liquid processing method are with not containing the volatile oil plant amedica; (2) the volatile oil plant amedica selects that water is carried for use for not containing, precipitate with ethanol extracts, refining mode gets final product.(3) for shell, angle class animal drugs select acid, alkali hydrolysis method or enzymatic hydrolysis for use, precipitate with ethanol is refining then gets final product.
The present invention is the method by form improvement, virus at general flu only forms local actute infection focus on the upper respiratory tract mucosa top layer, seldom enter the fact of blood, change traditional whole body administering mode into upper respiratory tract focus position direct spray delivery, therefore can create other dosage form administration incomparable high focus drug level, can cut off the course of disease of flu rapidly, curative effect height, instant effect, toxic and side effects are little.
Provide following embodiment for the present invention is further illustrated;
Embodiment 1, PH adjustable type control spray for cold
Get the 1300ml distilled water and add tween 80,4.5g, cyclamate 6g, Mentholum 0.45g is heated to 50 ℃, fully stirs to make the Mentholum dissolving, other gets distilled water 200ml adding glacial acetic acid 10g (or oxygen sodium oxide 5g) and makes it dissolving, under agitation add slowly in the above-mentioned 1300ml solution, transfer pH value to 3.5 (12), add water to 1500ml, the an amount of sodium chloride of reuse transfers to medicinal liquid etc. and oozes, and is sub-packed in 100 aerosol containers to get final product.
Embodiment 2, Yinqiao detoxification spray
Prescription nine flavors; get Herba Menthae; Herba Schizonepetae; it is standby that Fructus Forsythiae extracts volatile oil; medicinal residues and medicinal liquid add Flos Lonicerae; Herba Lophatheri; tasteless preserved soybean; Fructus Arctii; Radix Glycyrrhizae; Radix Platycodonis etc. add suitable quantity of water and decoct secondary; each 1.5 hours; collecting decoction; filter; be concentrated into relative density and be about 117 (90 degree are surveyed); add ethanol and make this 65-70% of pure content; cold preservation; left standstill 48 hours; filter; filtrate recycling ethanol; add 0.% (w/v) activated carbon; heat 15 minutes; filter, add above-mentioned standby volatile oil; solubilizing agent; correctives etc. (when Flos Lonicerae is write out a prescription consumption when being 360g) add water move to 1500ml; add an amount of sodium chloride and transfer to etc. and to ooze are sub-packed in 100 aerosol containers and get final product.
Embodiment 3, QINGKAILING spray
Prescription 8 flavors, get Radix Isatidis, Fructus Gardeniae decocts with water twice, filter, merging filtrate, being concentrated into relative density is 1.12-1.16 (80 degree are surveyed) fluid extract, and the adding Flos Lonicerae extract makes it dissolving, stir and to add ethanol down and make and contain the alcohol amount and reach 65-70%, cold preservation, left standstill 48 hours, filter, the standby water intaking horn powder barium hydroxide hydrolysis of filtrate recycling ethanol, hydrolyzed solution is standby, get the Concha Margaritifera powder sulphuric acid hydrolysis, hydrolyzed solution under agitation slowly adds transfers PH to 4 in the above-mentioned standby Cornu Bubali hydrolysate, placement makes precipitation fully, filter, concentrate, adding ethanol, to make pure content be 65-70%, left standstill after stirring evenly 48 hours, filters, reclaim ethanol to there not being the alcohol flavor, transfer PH to 7, leave standstill, filter, it is standby that filtrate is concentrated into relative density 1.1.Get and make it dissolving in the sodium hydrate aqueous solution that Hyodeoxycholic Acid under agitation adds PH11, getting taurine under agitation adds in the above-mentioned solution, transfer PH to 9 to make it to dissolve fully with 20% sodium hydroxide, getting the baicalin stirring adds in the above-mentioned solution down, transfer PH to 7 with 20% sodium hydroxide, make its whole dissolvings, with above-mentioned standby extraction clear paste, the hydrolysis clear paste mixes in proper order, transfer pH value to 7,0.5% activated carbon heating 15 minutes, filter, filtrate adds solubilizing agent, correctives (when Concha Margaritifera powder is 200g in the prescription) adds water to 1500ml, is sub-packed in 100 aerosol containers to get final product.
Embodiment 4, compound houttuynin spray
The prescription five tastes, getting the Radix Scutellariae water puies forward the acid precipitation method to extract baicalin standby, getting Herba Houttuyniae, Radix Isatidis, Fructus Forsythiae, Flos Lonicerae decocts with water 2 times, each 1.5 hours, collecting decoction, filtration, filtrate are concentrated into relative density 1.15 (90 degree survey), put coldly, add ethanol to determining alcohol 65% under stirring, left standstill 24 hours, and filtered.Filtrate recycling ethanol, add standby baicalin, transfer pH value to 7 to make it dissolving with 20% sodium hydroxide, add 0.5% (w/v) activated carbon, additives such as correctives (when the Herba Houttuyniae amount is 580g in the prescription) are left standstill, filter, added to little boiling 15 minutes, adds water to 1500ml, mix homogeneously is sub-packed in 100 aerosol containers and gets final product.
Embodiment 5, children's antipyretic spray
12 flavors of writing out a prescription, with Cortex Moutan, Radix Bupleuri, the Fructus Forsythiae steam distillation, collect distillate, medicinal residues and Folium Isatidis, Radix Scutellariae, Rhizoma Paridis, Radix Isatidis, plank, Herba Lophatheri, Radix Bupleuri, Flos Lonicerae, Pheretima, ten flavors such as Radix Cynanchi Atrati, decoct with water secondary, each one hour, collecting decoction, filter, be concentrated into relative density 1.15 (90 degree are surveyed), add ethanol, make that to contain alcohol amount be 70%, leave standstill, get supernatant, reclaim ethanol, add 0.5% (w/v) activated carbon, heat little boiling 15 minutes, leave standstill, filter, filtrate and above-mentioned distillate merge, and (when the Folium Isatidis consumption is 300mg in the prescription) adds water and adjust total amount to 1500ml, adds mix homogeneously such as correctives, be sub-packed in 100 aerosol containers and get final product.
Nose liniment and spray prescription constitute, preparation method is identical, just it are sub-packed in the nose liniment bottle to get final product.Annotate: 1,502 page 2 of Chinese Pharmacopoeia nineteen ninety version, Drug Standard of Ministry of Public Health of the Peoples Republic of China WS3-B-0409-903, Drug Standard of Ministry of Public Health of the Peoples Republic of China WS3-B-0146-894, Drug Standard of Ministry of Public Health of the Peoples Republic of China (93) is defended the accurate word 2-36 of medicine numbers 5, Drug Standard of Ministry of Public Health of the Peoples Republic of China WS3-B-1259-926, Drug Standard of Ministry of Public Health of the Peoples Republic of China WS3-B-1388-937, Drug Standard of Ministry of Public Health of the Peoples Republic of China WS3-B-0649-918, Drug Standard of Ministry of Public Health of the Peoples Republic of China WS3-B-1089-929, Drug Standard of Ministry of Public Health of the Peoples Republic of China WS3-B-1615-93
Claims (8)
1, a kind of control spray for cold is characterized in that this spray is to be made of medicine, solvent, additives etc.
2, control spray for cold as claimed in claim 1, the medicine that it is characterized in that this spray can be made of PH regulator or antipyretic and antidotal type Chinese medicine, wherein the acid that can select for use any (or several) of meeting medicinal requirements pH value can be transferred to 2-6 of PH regulator maybe can transfer to pH value the alkali of 9-13, its consumptions such as example hydrochloric acid, acetic acid, citric acid, lactic acid, fruit acid, ascorbic acid, sodium hydroxide, sodium carbonate, sodium bicarbonate are the 0.001-10% of spray total amount, or acid water or the saltiness water directly selecting ion water generator for use and produced together with solvent; Wherein the antipyretic and antidotal type prescriptions of Chinese medicine is optional is active ingredient prescription (as: antitoxic bolus of honeysuckle flower and forsythia (1), Yinqiao detoxification loose (2), Saigae Tataricae detoxifying pills (3), QINGKAILING (4), analgesic antiphlogistic capsule (5), FUFANG YUXINGCAO PIAN (6), Pu ground blue Pianomide (7), children's antipyretic oral liquid (8), anti inflammation and heat resolution ball (9) etc.) in order at least a among Flos Lonicerae, Radix Scutellariae, Fructus Forsythiae, Radix Isatidis, Folium Isatidis, the Herba Taraxaci etc., and its extract should account for the 1.0-30% of spray total amount.
3, control spray for cold as claimed in claim 1, the optional water of solvent that it is characterized in that this spray, ethanol, propylene glycol etc. are wherein at least a, and its consumption accounts for the 70-99% of spray total amount.
4, control spray for cold as claimed in claim 1, the additives (osmotic pressure regulator, correctives, cosolvent etc.) that it is characterized in that spray can be selected sodium chloride, Folium Stevlae Rebaudianae formula, cyclamate, Mentholum, Oleum menthae, Tweens, spans, phospholipid etc. for use, and its consumption accounts for the 0-5% of spray total amount.
5, control spray for cold as claimed in claim 1, it is characterized in that this spray preparing process by feed intake, extract, make with extra care, several procedures such as adjustment, packing finish.
6, the preparation method of control spray for cold as claimed in claim 5, it is characterized in that its extraction of different classes of medicine, process for purification have nothing in common with each other, the plant amedica that wherein contains volatile oil should select for use steam distillation to extract volatile oil, and residue medicinal liquid and medicinal residues processing method are with not containing the volatile oil plant amedica; Wherein do not contain the volatile oil plant amedica and select that water is carried, the extraction process for purification of precipitate with ethanol is finished for use; After wherein can selecting for use acid, alkali hydrolysis method or enzymatic hydrolysis process to be hydrolyzed for shell, angle class animal drugs, the refining grade of precipitate with ethanol finished.
7, the preparation method of control spray for cold as claimed in claim 5 is characterized in that when the effective ingredient that feeds intake is selected the PH regulator for use, and the operation main points of adjustment operation are the PH of medicinal liquid, and PH should be in 2-6 or 9-13 scope.
8, a kind of anti-curing cold use nose liniment, and it is identical with spray that the prescription that it is characterized in that this nose liniment constitutes and preparation method thereof, when being packing medicinal liquid is loaded in the nose liniment bottle to get final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 96122296 CN1163133A (en) | 1996-12-20 | 1996-12-20 | Spray and nose liniment for preventing and curing common cold and its preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 96122296 CN1163133A (en) | 1996-12-20 | 1996-12-20 | Spray and nose liniment for preventing and curing common cold and its preparing method |
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| Publication Number | Publication Date |
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| CN1163133A true CN1163133A (en) | 1997-10-29 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 96122296 Pending CN1163133A (en) | 1996-12-20 | 1996-12-20 | Spray and nose liniment for preventing and curing common cold and its preparing method |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102697941A (en) * | 2011-03-28 | 2012-10-03 | 胡维民 | Chinese patent drug for preventing influenza by direct nasal irrigation |
| CN102727625A (en) * | 2011-03-30 | 2012-10-17 | 赵文志 | Improved preparation of compound Ganmaoling tablet |
| CN103040883A (en) * | 2013-01-21 | 2013-04-17 | 广东岭南职业技术学院 | Compound radix isatidis spray and preparation method thereof |
| CN105434905A (en) * | 2014-09-24 | 2016-03-30 | 河南亚卫动物药业有限公司 | Lonicera and forsythia powder micro-pill preparation and preparing method thereof |
| CN106214751A (en) * | 2016-08-31 | 2016-12-14 | 天津中新药业研究中心 | A kind of compositions treating headache and preparation method thereof |
| CN107441179A (en) * | 2017-09-04 | 2017-12-08 | 杜冰 | The medicine spray and preparation method and application of a kind of preventing cold |
-
1996
- 1996-12-20 CN CN 96122296 patent/CN1163133A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102697941A (en) * | 2011-03-28 | 2012-10-03 | 胡维民 | Chinese patent drug for preventing influenza by direct nasal irrigation |
| CN102727625A (en) * | 2011-03-30 | 2012-10-17 | 赵文志 | Improved preparation of compound Ganmaoling tablet |
| CN103040883A (en) * | 2013-01-21 | 2013-04-17 | 广东岭南职业技术学院 | Compound radix isatidis spray and preparation method thereof |
| CN105434905A (en) * | 2014-09-24 | 2016-03-30 | 河南亚卫动物药业有限公司 | Lonicera and forsythia powder micro-pill preparation and preparing method thereof |
| CN106214751A (en) * | 2016-08-31 | 2016-12-14 | 天津中新药业研究中心 | A kind of compositions treating headache and preparation method thereof |
| CN107441179A (en) * | 2017-09-04 | 2017-12-08 | 杜冰 | The medicine spray and preparation method and application of a kind of preventing cold |
| CN107441179B (en) * | 2017-09-04 | 2021-02-12 | 杜冰 | Medicinal spray for preventing cold and preparation method and application thereof |
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