CN1175408A - Double coptis root spray and nasal liniment and preparing process thereof - Google Patents
Double coptis root spray and nasal liniment and preparing process thereof Download PDFInfo
- Publication number
- CN1175408A CN1175408A CN 97101390 CN97101390A CN1175408A CN 1175408 A CN1175408 A CN 1175408A CN 97101390 CN97101390 CN 97101390 CN 97101390 A CN97101390 A CN 97101390A CN 1175408 A CN1175408 A CN 1175408A
- Authority
- CN
- China
- Prior art keywords
- spray
- shuanghuanlian
- clear key
- extract
- liniment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
A spray or liniment of nose for curing cold features that said medicine is directly applied to the focus in upper respiratory tract other than to whole body, so developing a new approach to cure cold. Its advantages are convenience and no need of injection or taking medicine. It can also to cut off the infection way of cold effectively.
Description
The invention belongs to pharmaceutical preparation and preparation method thereof
Flu is a kind of mondial commonly encountered diseases, frequently-occurring disease, has 85% people to catch a cold 2-6 time within 1 year approximately.Therefore the control of flu has become worldwide research topic, flu is the actute infection of the upper respiratory tract mucosa that caused by virus etc., its primary lesion is at nasal mucosa, the virus and the antibacterial of general flu only are present in the upper respiratory tract top layer, seldom enter blood or body deep tissues, belong to the top layer and infect, therefore to say objectively, the whole body administration carried out of conventional dosage forms treatment flu in the past and the blood drug level of being emphasized thereof are limited by form of administration real the genus, the mistaken ideas that can not the direct administration of focus be entered.
The objective of the invention is to use the means of new formulation technology, provide to society and can effectively cut off the flu route of transmission, interrupt the flu pathological process rapidly, make its healing (clear key) SHUANGHUANLIAN spray, nose liniment in the direct administration of cacorhinia kitchen range of starting stage.
The present invention includes key SHUANGHUANLIAN spray clearly, existing division such as nose liniment is as follows:
Clear key SHUANGHUANLIAN spray (or nose liniment) is by medicine, solvent, and formations such as additives, wherein drug main will be made of Flos Lonicerae extract, Fructus Forsythiae extract, Radix Scutellariae extract etc., and its consumption should account for the 1-15% of objective thing total amount in the spray (nose liniment); At least a among the optional water of solvent, the ethanol, its consumption should account for the 70-99% of spray (nose liniment) content total amount; Additives (osmotic pressure regulator, correctives, cosolvent etc.) can be selected sodium chloride, glucose, stevioside, cyclamate, protein sugar, Mentholum (oil), Tweens, spans, phospholipid etc. for use, and its consumption accounts for the 0-5% of spray (nose liniment) content total amount.Its preparation method be by feed intake, extract, several procedures the such as refining dry powder of gained after the extraction of three kinds of medical materials, refining, the spray drying (or directly throw) adjustment, packing finish, wherein extract, the main points of refining step are that (1) Radix Scutellariae puies forward the acid precipitation method with water and extract refining baicalin, (2) Flos Lonicerae, the optional water of Fructus Forsythiae are carried, the mode of precipitate with ethanol or the water water lift is heavy and the filterable mode of ultra micro is extracted refining Flos Lonicerae, Fructus Forsythiae extract; The control of fluid temperature when the main points of adjustment operation are the control of pH value and add the correctives Mentholum.
The present invention is the method by form improvement, virus at general flu only forms local actute infection focus on the upper respiratory tract mucosa top layer, seldom enter the fact of blood, change traditional whole body administering mode into upper respiratory tract focus position direct spray delivery, therefore can create other dosage form administration incomparable high focus drug level, can cut off the course of disease of flu, curative effect height rapidly, instant effect, the toxic agent effect is little.
Provide following embodiment for the present invention is further illustrated:
Embodiment: clear key SHUANGHUANLIAN spray
Getting 10.5g baicalin (Radix Scutellariae extract) stirring adds in the 1300ml distilled water down, transfer PH to 7.0 to make it dissolving with 40% sodium hydroxide solution, continue to stir, slowly add the 67.5g Flos Lonicerae, Fructus Forsythiae extracts refining dry powder, 1.25g stevioside, 5g cyclamate, 6.5g tween 80 make it dissolving, and it is 1500ml that adding distil water makes the medicinal liquid cumulative volume in right amount, transfer PH to 7.0 with 40% sodium hydroxide, heating when fluid temperature rises to 45-50 and spends, adds the 0.5g Mentholum, fully stir and make the Mentholum dissolving, mix homogeneously cools, and filters, filtrate is sub-packed in that gland seals promptly in 100 aerosol containers.
Nose liniment and spray prescription constitutes, and preparation method is identical, just its medicinal liquid is sub-packed in the nose liniment bottle promptly.
Annotate: " clear key " two words on application title one hurdle are drawn together with parantheses in this specification, its Reason is now to have ratified the nomenclature of drug produced for " the two coptis sprays of clear key " but is in fear of To have " the clear key " of function character when country rectifies nomenclature of drug in the future when two words remove, The patent application name does not conform to nomenclature of drug, so draw together with parantheses.
Claims (8)
1, (clear key) SHUANGHUANLIAN spray is characterized in that this spray is to be made of medicine, solvent, additives etc.
2, (clear key) as claimed in claim 1 SHUANGHUANLIAN spray, the medicine that it is characterized in that this spray is by Flos Lonicerae extract, formations such as Fructus Forsythiae extract, Radix Scutellariae extract, its consumption should account for the 1-15% of spray content total amount;
3, (clear key) as claimed in claim 1 SHUANGHUANLIAN spray, its domestic animal is that the optional water of the solvent of this spray, ethanol etc. are wherein at least a, its consumption accounts for the 70-99% of spray content total amount.
4, (clear key) as claimed in claim 1 SHUANGHUANLIAN spray, additives (the osmotic pressure regulator that it is characterized in that spray, correctives, cosolvent) can select sodium chloride, glucose, stevioside, cyclamate, protein sugar, Mentholum, Oleum menthae, Tweens, spans, phospholipid etc. for use, its consumption accounts for the 0-5% of spraying mist agent content total amount.
5, (clear key) as claimed in claim 1 SHUANGHUANLIAN spray, it is characterized in that this spray preparing process by feed intake, extract, make with extra care, several procedures such as adjustment, packing finish, or by feed intake (directly throwing three kinds of medicinal material extract, refining, dry back gained dry powder), operations such as adjustment, packing are finished.
6, (clear key) as claimed in claim 5 SHUANGHUANLIAN spray preparing process is characterized in that the extraction of different pharmaceutical, process for purification have nothing in common with each other, and wherein Radix Scutellariae is to carry with water, and the acid precipitation method is extracted refining baicalin; Flos Lonicerae, the optional water of Fructus Forsythiae are carried, the mode or the water of precipitate with ethanol are carried, water precipitating and the filterable mode of ultra micro are extracted refining Flos Lonicerae, Fructus Forsythiae extract;
7, (clear key) as claimed in claim 5 SHUANGHUANLIAN spray preparing process is characterized in that adjusting the operation liquid PH value and should be controlled at 5.0-7.0; Fluid temperature should be controlled at 30-60 degree Celsius when adding the correctives Mentholum.
8, to it is characterized in that the prescription of this nose liniment constitutes and preparation method thereof identical with spray for (clear key) SHUANGHUANLIAN nose liniment, just medicinal liquid is sub-packed in the nose liniment bottle during packing to get final product.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 97101390 CN1175408A (en) | 1997-03-06 | 1997-03-06 | Double coptis root spray and nasal liniment and preparing process thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 97101390 CN1175408A (en) | 1997-03-06 | 1997-03-06 | Double coptis root spray and nasal liniment and preparing process thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CN1175408A true CN1175408A (en) | 1998-03-11 |
Family
ID=5165704
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 97101390 Pending CN1175408A (en) | 1997-03-06 | 1997-03-06 | Double coptis root spray and nasal liniment and preparing process thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN1175408A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009151300A3 (en) * | 2008-06-13 | 2010-02-04 | Ahn-Gook Pharmaceutical Co., Ltd. | Extract of coptidis rhizoma and use thereof in treating respiratory disease |
CN105664017A (en) * | 2016-01-21 | 2016-06-15 | 刘德玉 | Preparation method of qiuma wuqiao spray series |
-
1997
- 1997-03-06 CN CN 97101390 patent/CN1175408A/en active Pending
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009151300A3 (en) * | 2008-06-13 | 2010-02-04 | Ahn-Gook Pharmaceutical Co., Ltd. | Extract of coptidis rhizoma and use thereof in treating respiratory disease |
RU2461388C1 (en) * | 2008-06-13 | 2012-09-20 | Ахн-Гоок Фармасьютикал Ко., Лтд. | Extract coptidis rhizoma and its use in treating respiratory disease |
US8425953B2 (en) | 2008-06-13 | 2013-04-23 | Ahn-Gook Pharmaceutical Co., Ltd. | Extract of Coptidis rhizoma and novel use thereof in treating respiratory disease |
USRE45524E1 (en) | 2008-06-13 | 2015-05-19 | Ahngook Pharmaceutical Co., Ltd. | Extract of Coptidis rhizoma and novel use thereof in treating respiratory disease |
CN105664017A (en) * | 2016-01-21 | 2016-06-15 | 刘德玉 | Preparation method of qiuma wuqiao spray series |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN100339120C (en) | External applied medicine for treating prickly heat | |
CN102406698B (en) | External medicinal liquid for treating vitiligo | |
CN111558031A (en) | Pure plant multifunctional eye special nutrient solution and preparation method thereof | |
CN103721138B (en) | A kind of traditional Chinese medicine for external application and its preparation method treating rosacea | |
CN1175408A (en) | Double coptis root spray and nasal liniment and preparing process thereof | |
CN114767824B (en) | Preparation for treating laryngeal cough and preparation method thereof | |
CN110179843A (en) | External-use pharmaceutical composition for treating non-allergic rhinitis | |
CN1025478C (en) | Nose liniment and preparing process | |
CN109464517A (en) | Clearing heat and detoxicating paediatrics external application massage ointment formula, the method and application for preparing ointment | |
CN102139051A (en) | Application of soft capsule capable of clearing heat and eliminating toxin in preparation of medicament for treating viral pneumonia | |
CN101648015A (en) | Chinese medicinal composition for treating glaucoma and application thereof | |
CN1163133A (en) | Spray and nose liniment for preventing and curing common cold and its preparing method | |
CN1966051B (en) | Antivirus medicament for resisting virus | |
CN105497291A (en) | Medicine composition for treating schizophrenia | |
CN104815063B (en) | A kind of relaxing bowel and preparation method | |
CN115869352B (en) | Traditional Chinese medicine compound preparation for treating androgenetic alopecia and preparation method and application thereof | |
CN1085095A (en) | A kind of inhalation and production method thereof | |
CN107375384A (en) | A kind of gynaecological gel containing P-Cymene and preparation method thereof | |
CN105535065A (en) | Medicine composition for treating schizophrenia | |
CN106109927A (en) | A kind of pharmaceutical composition treating chloasma and preparation method thereof | |
CN106729631A (en) | Treat the externally applied spray of intractable skin ulcer | |
CN101530472A (en) | Preparation method and application of preparation for different extraction parts of biond magnolia flower | |
CN101129997A (en) | Oral liquid of curcuma aromatica for relieving exterior syndrome | |
CN103028004B (en) | Traditional Chinese medicine preparation for treating human body demodicidosis | |
CN1047092C (en) | External use medicine and clothes for preventing and curing asthma and/or chronic bronchitis |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
WD01 | Invention patent application deemed withdrawn after publication |