CN116270917A - 一种降尿酸保健茶 - Google Patents
一种降尿酸保健茶 Download PDFInfo
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Abstract
本发明涉及一种降尿酸保健茶，本发明有效解决了针对患有高尿酸血症的青少年患者由于其身体发育因素导致用药受限进而无法在早期进行干预并治疗的问题；解决的技术方案包括：本发明基于肺主气司呼吸，有通调水道作用，肾主水，有调节水液的作用，并根据肺肾母子关系的理论组方而成，其副作用小、口感好、适合青少年患者，可在早期针对患有高尿酸血症的青少年患者进行及时的干预并治疗，实现良好的预后效果。
Description
技术领域
本发明涉及茶饮技术领域，尤其涉及一种降尿酸保健茶。
背景技术
随着生活水平和饮食结构的改变，青少年儿童高尿酸血症发生率有非常明显的上升，随着患病率的提高，如果不加干预，长期高尿酸血症除了引起急性通风性关节炎、痛风性肾病和反复发作所致的关节损毁、肾功能不全外，还与代谢综合征和成年后心脑血管疾病的发生密切相关，严重影响患者的生活质量；
针对上述情况，目前采取西医治疗方式虽然可抑制尿酸的形成，但是此类药物副作用比较大，会损害肾功能，若长期使用严重的会导致肾衰竭，加之青少年个体及脏器发育情况致使多种药物使用受限，致使多种药物使用受限，进而不能实现早期干预并且进行治疗，而高尿酸血症的早期干预治疗对治疗高尿酸血症极为重要；
鉴于此，我们提供一种降尿酸保健茶用于解决以上问题。
发明内容
本发明提供的一种降尿酸保健茶，基于肺主气司呼吸，有通调水道作用，肾主水，有调节水液的作用，并根据肺肾母子关系的理论组方而成，其副作用小、口感好、适合青少年患者。
本发明提供一种降尿酸保健茶，由以下组分的颗粒剂组成，分别为：百合、车前草、玉米须、山慈菇、生山楂，其中百合10g、车前草10g、玉米须10g、山慈菇10g、生山楂10g。
方解：
百合：养阴润肺，主入肺心，长于清肺润燥止咳，能治肺阴虚的燥热咳嗽，肺虚久咳，痰中带血，劳咳嗽咯血，清热解毒，临床观察具有明显的降尿酸效果；
车前草：主小便不利、淋浊带下、水肿胀满、暑湿泻痢、目赤障翳、痰热咳喘，有显著的利尿作用，并且具有祛痰、抗菌、降压效果，作用于呼吸中枢，有很强的止咳力，能增进气管、支气管黏液的分泌，而有祛痰作用；
玉米须：降血脂、利尿、降压、利胆、降血糖；
山慈菇：具有清热解毒，消痈散结等功效，常用于痈肿疔毒，瘰疬痰核，蛇虫咬伤，瘸瘕痞块；
生山楂：消食健胃、袪瘀活血且有助于消化，降血脂、降血糖、治疗食积。
上述技术方案有益效果在于：
(1)本方案基于肺主气司呼吸，有通调水道作用，肾主水，有调节水液的作用，并根据肺肾母子关系的理论组方而成，其副作用小，尤其针对患有高尿酸血症的青少年早期患者可及时进行干预并治疗，可实现较好的预后治疗效果；
(2)本方案中的降尿酸保健茶为茶饮制剂，服用方便且口感较好，易被青少年所接受，适合青少年患者进行高尿酸血症的治疗。
附图说明
图1为本发明不同组血尿酸浓度柱状示意图；
图2为本发明不同组血尿酸浓度表格示意图。
具体实施方式
一种降尿酸保健茶，由以下组分的颗粒剂组成，分别为：百合、车前草、玉米须、山慈菇、生山楂，其中百合10g、车前草10g、玉米须10g、山慈菇10g、生山楂10g；
将上述各种原料按照要求的剂量混合并且用热水冲泡，其冲泡的浓度大小根据不同人群的口感进行相应的调配，患者在服用时，可添加适量的水调配成饮剂(根据不同人口味的不同，可调配成具有相应浓度的降尿酸保健茶)，每日服用2-3次，用药时间不限，每次引用量＞200ml，尤其适用于患有高尿酸血症的青少年患者，口感好且副作用小，没有任何添加，不含化学成分和抗生素，长期服用对患者机体无损害。
实验报告
实验动物：清洁级Wistar大鼠(雄性)，鼠龄3周(约100g)
分组：70只并且进行适应性喂养3天，正常(Control)组常规饲养，其余大鼠统一造模，造模后随机分为6组：模型(生理盐水)组、苯溴马隆组、别嘌呤组、治疗组(中药高、中、低剂量)组，每组10只；
造模方法：复制高尿酸血症(HUA)模型：除正常(Control)组外，其他6组给予酵母膏10g/kg联合腺嘌呤100g/kg上、下午各灌胃1次，每次2mL，两次灌胃间隔大于66/14h，持续灌胃7d，同时分别于实验第1、5、10天腹腔注射300mg/kg氧嗪酸钾1次，模型(生理盐水)组灌胃和注射等体积生理盐水；
干预方法：
(1)正常(Control)组：每组10只，灌胃等量生理盐水；
(2)模型(生理盐水)组：每组10只，灌胃等量生理盐水；
(3)苯溴马隆组：每组10只，建立高尿酸血症模型，灌胃苯溴马隆；
(4)别嘌醇组：每组10只，建立高尿酸血症模型，灌胃别嘌醇；
(5)高剂量组：每组10只，建立高尿酸血症模型，灌胃高剂量降尿酸茶(每毫升含生药0.5g)；
(6)中剂量组：每组10只，建立高尿酸血症模型，灌胃中剂量降尿酸茶(每毫升含生药1g)；
(7)低剂量组：每组10只，建立高尿酸血症模型，灌胃低剂量降尿酸茶(每毫升含生药2g)；
实验药品：
(1)降尿酸茶：根据临床经验总结，方药(颗粒剂)组成百合10g、车前草10g、玉米须10g、山慈菇10g、生山楂10g；
(2)苯溴马隆片(昆山龙灯瑞迪制药有限公司，H20010790，50*10片)使用研磨器充分研磨，使用分析天平准确称重0.065g后，加入100毫升蒸馏水充分溶解，配成6.5mg/kg溶液；
(3)别嘌醇片(广州康和药业有限公司，H44021695，0.1g*100片)使用研磨器充分研磨，使用分析天平准确称重0.12g后，加入100毫升蒸馏水充分溶解，配成12mg/kg溶液；
(4)酵母膏与腺嘌呤混合物：酵母膏与蒸馏水按照5：1(w：v)的比例进行7/14混匀，混匀后置于4℃保存，使用前需先经温水浴至30～35℃再行灌胃；
(5)氧嗪酸钾混悬液：准确称取氧嗪酸钾后，用灭菌生理盐水配置成3％浓度的混悬液，使用前摇匀并经温水浴至30～35℃后再行注射。
血尿酸水平检测：
造模后及药物干预后，每组取10只大鼠，大鼠眼内眦取血，检测大鼠血尿酸水平。
血尿酸结果：
各组小鼠进行血尿酸检验，并且分别得出模型组、苯溴马隆组、别嘌醇组、高剂量组、中剂量组、低剂量组小鼠的血尿酸水平，并且将上述各组小鼠的血尿酸水平进行对比，结果如附图1、2中所示：
其中；
正常(Control)组血清尿酸含量分别为：281.2938μmol/L、272.0899μmol/L；
模型(生理盐水)组血清尿酸含量分别为：357.2258μmol/L、339.9685μmol/L；
苯溴马隆组血清尿酸含量分别为：295.0996μmol/L、274.9661μmol/L、320.4103μmol/L；
别嘌醇组血清尿酸含量分别为：257.7088μmol/L、278.9928μmol/L；
低剂量组血清尿酸含量分别为：310.0559μmol/L、335.9418μmol/L；
中剂量组血清尿酸含量分别为：307.7549μmol/L、315.9418μmol/L、308.3302μmol/L；
高剂量组血清尿酸含量分别为：288.1967μmol/L、292.7986μmol/L、304.8787μmol/L；
在实验条件下，本方案中降尿酸保健茶的降尿酸效果，与实验中的其他药物相近且无显著性差异，表明降尿酸茶具有良好的降尿酸作用。
典型病例：
病例1.
尚某，13岁，患有强直性脊柱炎，于2022年8月23日复诊时发现血尿酸升高，UA：507μmol/L，期间给予降尿酸茶，组分：百合10g，车前草10g，玉米须10g，山慈菇10g，山楂10g，将上述原料混合并且加水冲泡口服引用，口服引用本方案中的降尿酸茶近20日，于9月12日在当地医院复查血尿酸UA：341.2μmol/L，相对于初次检测时其血尿酸水平明显降低。
病例2.
胡某，19岁，2022年8月12日首诊，既往体检时发现血尿酸升高，要求复查，其UA：613μmol/L，随后给予其降尿酸茶，组分：百合10g，车前草10g，玉米须10g，山慈菇10g，山楂10g，将上述原料混合并且加水冲泡口服引用，口服引用本方案中的降尿酸茶近一个礼拜，于8与19日来院进行复查，其血尿酸UA：330μmol/L，相对于首诊检测时的血尿酸水平明显降低。
上面只是为了说明本发明，应该理解为本发明并不局限于以上实施例，符合本发明思想的各种变通形式均在本发明的保护范围之内。
Claims (2)
1.一种降尿酸保健茶，其特征在于，由以下组分组成，分别为：百合、车前草、玉米须、山慈菇、生山楂，其中百合10g、车前草10g、玉米须10g、山慈菇10g、生山楂10g。
2.根据权利要求1所述的一种降尿酸保健茶，其特征在于，所述百合、车前草、玉米须、山慈菇、生山楂均为颗粒剂。
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