CN116270291A - Odor-removing skin care composition and application thereof - Google Patents
Odor-removing skin care composition and application thereof Download PDFInfo
- Publication number
- CN116270291A CN116270291A CN202310168819.8A CN202310168819A CN116270291A CN 116270291 A CN116270291 A CN 116270291A CN 202310168819 A CN202310168819 A CN 202310168819A CN 116270291 A CN116270291 A CN 116270291A
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- odor
- skin care
- care composition
- carnosine
- pentanediol
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Classifications
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A—HUMAN NECESSITIES
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q15/00—Anti-perspirants or body deodorants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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Abstract
The invention provides a smell-removing skin care composition and application thereof, wherein the smell-removing skin care composition comprises the following components: polypeptides and alcohols, wherein the polypeptides include acetyl tetrapeptide-2 and carnosine; the alcohols include pentanediol and ethanol. The odor-removing skin care composition comprises four components of acetyl tetrapeptide-2, carnosine, pentanediol and ethanol, the four components complement each other, the odor-removing skin care composition has a synergistic effect in removing body odor from isovaleric acid, 2-nonenal and the like, and the odor-removing skin care composition is different from the traditional method for treating body odor in a sealing way, does not damage tissues such as hair follicles, glands and the like, and has extremely high safety; the invention is also different from traditional perfume products, is a tasteless product, and does not remove body odor through a fragrance-giving covering way.
Description
Technical Field
The invention belongs to the field of daily chemicals, and particularly relates to a deodorizing skin care composition and application thereof, a deodorizing skin care spray and a preparation method thereof.
Background
Each individual's smell is unique as the fingerprint, each individual has its unique body odor imprint; body odor footprint is a combination of body odor of different parts of the body (e.g., skin, head, armpit, foot). Sex, eating habits, age, living environment and the like can have different degrees of influence on body taste.
When the body is off-flavor, most of which is generated by metabolism and oxidation of various gland secretions and skin cuticle wastes of the body through skin flora, volatile organic compounds mainly comprise low molecular weight fatty acids, aldehydes, ketones, nitrogen-containing or sulfur compounds, wherein the typical compounds are isovaleric acid and 2-nonenal, and the isovaleric acid is more common in young people; 2-nonenal is more common in older populations.
Perfumes and personal care products can enhance, mask or alter our body odor, traditional perfume products achieve odor masking by perfuming primarily, but the perfume fragrance may combine with body odor to produce more unpleasant gases.
CN114760997a discloses a pharmaceutical formulation comprising an anticholinergic and a ternary solvent comprising 5% to 15% v/v glycol, 60% to 70% v/v alcohol and 5% to 20% v/v water. Also provided are methods of pharmaceutical formulation comprising the step of mixing an anticholinergic with a mixture comprising an alcohol, a glycol, water, a humectant, and a pH buffering agent at room temperature. Also provided is a method of inhibiting a non-pathological body odor in a mammal. Also provided is a method of treating odor-causing acrosecretion and reducing microbial overgrowth in a mammalian subject, and the use of a pharmaceutical formulation.
CN112237618A discloses a buccal tablet for removing halitosis and body odor, which is prepared from the following raw materials by weight: the buccal tablet for removing halitosis and body odor can invigorate spleen and stomach, and condition viscera metabolism function, improves internal and external circulation, so as to remove mouth and body foul gas, has no side effect, and has simple preparation method and easy implementation and popularization.
Therefore, it is very significant to develop an odor removal product which effectively removes body odor, is self-odorless, and has high application safety.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide an odor-removing skin care composition and application thereof, an odor-removing skin care spray and a preparation method thereof.
To achieve the purpose, the invention adopts the following technical scheme:
in a first aspect, the present invention provides a deodorant skin care composition comprising:
polypeptides and alcohols, wherein the polypeptides include acetyl tetrapeptide-2 and carnosine; the alcohols include pentanediol and ethanol.
The invention creatively uses the polypeptide and the alcohol substances in preparing the odor-free skin care product, wherein the polypeptide comprises acetyl tetrapeptide-2 and carnosine; alcohols include pentanediol and ethanol, wherein acetyl tetrapeptide-2 and carnosine can be combined with isovaleric acid of an odor source to biodegrade odor substances, and polypeptide substances can promote the synthesis of proteins such as elastin, collagen and the like, so that good skin care effect can be achieved; the pentanediol has remarkable antibacterial effect, can effectively inhibit the growth and metabolism of skin flora, reduce volatile organic compounds generated by the metabolism of the pentanediol, such as isovaleric acid, 2-nonenoic acid and the like, and has the effect of promoting permeation, so that the effect of removing peculiar smell of polypeptide substances can be improved; the ethanol has cooling and astringing effects, and can reduce generation of odor substances and bring cool and comfortable use feeling.
Typical human body odorous gases are mainly isovaleric acid and 2-nonenal, isovaleric acid is common in young people, and 2-nonenal is common in old people. The odor-removing skin care composition comprises four components of acetyl tetrapeptide-2, carnosine, pentanediol and ethanol, the four components complement each other, the odor-removing skin care composition has a synergistic effect in removing body odor from isovaleric acid, 2-nonenal and the like, and the odor-removing skin care composition is different from the traditional method for treating body odor in a sealing way, does not damage tissues such as hair follicles, glands and the like, and has extremely high safety; the invention is also different from traditional perfume products, is a tasteless product, and does not remove body odor through a fragrance-giving covering way. In addition, the carnosine and the acetyl tetrapeptide-2 in the odor-removing skin care composition have unexpected synergistic effect in terms of antioxidation.
Preferably, the polypeptide further comprises: any one or a combination of at least two of acetyl hexapeptide-1, acetyl hexapeptide-8, palmitoyl tripeptide-1, tripeptide-1 copper, oligopeptide-1, oligopeptide-2 or hexapeptide-2, wherein the combination of at least two of the acetyl hexapeptide-1 and the acetyl hexapeptide-8, the combination of the acetyl hexapeptide-8 and the palmitoyl tripeptide-8, or the combination of palmitoyl tripeptide-1 and tripeptide-1 copper, etc. can be selected, and any other combination modes are not described herein.
Preferably, the alcohol further comprises: any one or a combination of at least two of propylene glycol, butylene glycol, 1, 2-hexanediol or glycerin, wherein the combination of at least two of the propylene glycol and butylene glycol, the combination of butylene glycol and 1, 2-hexanediol or the combination of propylene glycol and 1, 2-hexanediol is optional, and any other combination mode is not described herein.
Preferably, the odor-free skin care composition further comprises: any one or a combination of at least two of the humectant, the antioxidant or the solubilizer, wherein the combination of at least two comprises a combination of the humectant and the antioxidant, a combination of the humectant and the solubilizer or a combination of the antioxidant and the solubilizer, and other arbitrary combination modes can be selected, and are not repeated here.
Preferably, the humectant includes any one or a combination of at least two of lactic acid, arginine, betaine, dendrobium polysaccharide or sodium hyaluronate, and the combination of at least two of them includes a combination of sodium hyaluronate and lactic acid, a combination of lactic acid and arginine or a combination of arginine and betaine, etc., and any other combination modes may be selected, and will not be described herein.
Preferably, the antioxidant includes any one or a combination of at least two of nicotinamide, panthenol or palmitoyl pentapeptide, and the combination of at least two of nicotinamide and panthenol, panthenol and palmitoyl pentapeptide or palmitoyl pentapeptide and nicotinamide are selected, and any other combination mode is not described herein.
Preferably, the mass ratio of the polypeptide to the alcohol is (1-10): 1-30.
The specific values in (1-10) can be 1,2, 3, 4, 5, 6, 7, 8, 9 or 10, etc.;
the specific values in (1-30) may be 1, 5, 9, 13, 17, 21, 26, 29 or 30, etc.;
other specific point values in the numerical ranges are selectable, and will not be described in detail herein.
When the mass ratio of the polypeptide to the alcohol in the odor-removing skin care composition is in the range of (1-10): 1-30, the odor-removing skin care composition has more remarkable effect of removing body odor.
Preferably, the mass ratio of the acetyl tetrapeptide-2 to the carnosine is (1-10): 1-10;
the specific values in (1-10) can be 1,2, 3, 4, 5, 6, 7, 8, 9 or 10, etc.; other specific point values in the numerical ranges are selectable, and will not be described in detail herein.
When the mass ratio of the two polypeptide components is (1-10) to (1-10), the two polypeptide components have more remarkable synergistic effect in the aspect of odor elimination.
Preferably, the mass ratio of the pentanediol to the ethanol is (1-10): 5-20.
The specific values in (1-10) can be 1,2, 3, 4, 5, 6, 7, 8, 9 or 10, etc.;
the specific values in (5-20) may be selected from 5, 7, 9, 11, 13, 15, 17, 19 or 20, etc.;
other specific point values in the numerical ranges are selectable, and will not be described in detail herein.
In a second aspect, the present invention provides the use of a odour-combating skin care composition as described in the first aspect for the preparation of a skin odour-combating care product.
The odor removal skin care compositions of the present invention can be used to prepare odor removal care products such as body washes, body milks, body deodorant sprays, and the like, as are well known to those skilled in the art.
Preferably, the dosage form of the skin odor removal care product comprises a spray, cream, liniment, cream or gel.
The skin odor-removing nursing product can be selected into different dosage forms according to actual requirements, such as a spray can be used for armpits, necks and other parts, and cream, cream and gel can be used for parts with serious symptoms and long-term retention and treatment of active ingredients.
In a third aspect, the present invention provides a odour-reducing skin care spray, the starting materials for the preparation of which comprise a odour-reducing skin care composition as described in the first aspect and water.
In a fourth aspect, the present invention provides a method of preparing a odour-reducing skin care spray according to the third aspect, the method comprising the steps of:
(1) Heating water to 60-90deg.C, maintaining for 5-40min, and cooling to 30-50deg.C;
(2) Sequentially adding pentanediol, acetyl tetrapeptide-2, carnosine and ethanol into the water prepared in the step (1), stirring for 5-30min, and packaging into spray bottles to obtain the odor-removing skin care spray
The specific value of 60-90deg.C can be 60 deg.C, 65 deg.C, 70 deg.C, 75 deg.C, 80 deg.C, 85 deg.C or 90 deg.C, etc.;
the specific value of the 5-40min can be selected from 5min, 9min, 13min, 17min, 21min, 25min, 29min, 33min, 37min or 40min, etc.;
the specific value of 30-50deg.C can be 30deg.C, 35deg.C, 40deg.C, 45deg.C or 50deg.C;
the specific value of the 5-30min can be selected from 5min, 9min, 13min, 17min, 21min, 25min, 29min or 30min, etc.;
other specific point values in the numerical ranges are selectable, and will not be described in detail herein.
The odor-removing skin care spray is prepared by only sequentially adding pentanediol, acetyl tetrapeptide-2, carnosine and ethanol after heating, heat preservation and cooling treatment of water.
Compared with the prior art, the invention has the following beneficial effects:
1. the invention creatively uses the polypeptide and the alcohol substances in preparing the odor-free skin care product, wherein the polypeptide comprises acetyl tetrapeptide-2 and carnosine; alcohols include pentanediol and ethanol, wherein acetyl tetrapeptide-2 and carnosine can be combined with isovaleric acid of an odor source to biodegrade odor substances, and polypeptide substances can promote the synthesis of proteins such as elastin, collagen and the like, so that good skin care effect can be achieved; the pentanediol has remarkable antibacterial effect, can effectively inhibit the growth and metabolism of skin flora, reduce volatile organic compounds generated by the metabolism of the pentanediol, such as isovaleric acid, 2-nonenoic acid and the like, and has the effect of promoting permeation, so that the effect of removing peculiar smell of polypeptide substances can be improved; the ethanol has cooling and astringing effects, and can reduce generation of odor substances and bring cool and comfortable use feeling.
Typical human body odorous gases are mainly isovaleric acid and 2-nonenal, isovaleric acid is common in young people, and 2-nonenal is common in old people. The odor-removing skin care composition comprises four components of acetyl tetrapeptide-2, carnosine, pentanediol and ethanol, the four components complement each other, the odor-removing skin care composition has a synergistic effect in removing body odor from isovaleric acid, 2-nonenal and the like, and the odor-removing skin care composition is different from the traditional method for treating body odor in a sealing way, does not damage tissues such as hair follicles, glands and the like, and has extremely high safety; the invention is also different from traditional perfume products, is a tasteless product, and does not remove body odor through a fragrance-giving covering way. In addition, the carnosine and the acetyl tetrapeptide-2 in the odor-removing skin care composition have unexpected synergistic effect in the aspects of antioxidation and the like.
2. The odor removal skin care compositions of the present invention can be used to prepare odor removal care products such as body washes, body milks, body deodorant sprays, and the like, as are well known to those skilled in the art.
3. The odor-removing skin care spray provided by the invention is prepared by only adding pentanediol, acetyl tetrapeptide-2, carnosine and ethanol after heating, heat preservation and cooling treatment of water.
Detailed Description
The technical scheme of the invention is further described by the following specific embodiments. It will be apparent to those skilled in the art that the examples are merely to aid in understanding the invention and are not to be construed as a specific limitation thereof.
The procedures, conditions, reagents, experimental methods, etc. for carrying out the present invention are common knowledge and common knowledge in the art, except for those specifically mentioned below, and the present invention is not particularly limited. The experimental methods in each example, in which specific conditions are not noted, are generally performed under conventional conditions or under conditions recommended by the manufacturer.
Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. However, in case of conflict, the present specification, including definitions, will control.
Example 1
The present embodiment provides a deodorant skin care composition comprising: 3 parts of acetyl tetrapeptide-2, 3 parts of carnosine, 5 parts of pentanediol and 10 parts of ethanol (polypeptide: alcohol is 6:15, acetyl tetrapeptide-2: carnosine is 1:1, pentanediol: ethanol is 5:10), and adding pure water to supplement 100 parts to prepare the odor-free skin care composition.
Example 2
The present embodiment provides a deodorant skin care composition comprising: 0.5 part of acetyl tetrapeptide-2, 5 parts of carnosine, 10 parts of pentanediol and 20 parts of ethanol (the ratio of polypeptide to alcohol is 5.5:30, the ratio of acetyl tetrapeptide-2 to carnosine is 1:10, the ratio of pentanediol to ethanol is 10:20), and adding pure water to supplement 100 parts of the mixture to prepare the odor-removing skin care composition.
Example 3
The present embodiment provides a deodorant skin care composition comprising: 10 parts of acetyl tetrapeptide-2, 10 parts of carnosine, 1 part of pentanediol and 5 parts of ethanol (polypeptide: alcohol is 10:3, acetyl tetrapeptide-2: carnosine is 10:10, pentanediol: ethanol is 1:5), and adding pure water to supplement 100 parts to prepare the odor-free skin care composition.
Example 4
This example provides an odor-free skin care composition, which is prepared by a method differing from example 1 only in that 3 parts of acetyl tetrapeptide-2, 3 parts of carnosine, 5 parts of pentanediol, 10 parts of ethanol (the mass ratio of polypeptide to alcohol is 6:15) are replaced with 0.5 parts of acetyl tetrapeptide-2, 0.5 parts of carnosine, 11 parts of pentanediol, 22 parts of ethanol (the mass ratio of polypeptide to alcohol is 1:33), and the rest is the same as example 1.
Example 5
This example provides an odor-free skin care composition, which is prepared by a method differing from example 1 only in that 3 parts of acetyl tetrapeptide-2, 3 parts of carnosine, 5 parts of pentanediol, 10 parts of ethanol (the mass ratio of polypeptide to alcohol is 6:15) are replaced with 6 parts of acetyl tetrapeptide-2, 6 parts of carnosine, 0.3 part of pentanediol, 0.7 part of ethanol (the mass ratio of polypeptide to alcohol is 12:1), and the rest is the same as example 1.
Comparative example 1
This comparative example provides an odor-free skin care composition which is prepared by a process differing from example 1 only in that it does not contain acetyl tetrapeptide-2 and the parts by mass of acetyl tetrapeptide-2 are distributed to carnosine, the remainder being the same as example 1.
Comparative example 2
This comparative example provides an odor-free skin care composition that is prepared by a process that differs from example 1 only in that it does not contain carnosine and that the mass fraction of carnosine is distributed to acetyl tetrapeptide-2, the remainder being the same as example 1.
Comparative example 3
This comparative example provides an odor-free skin care composition which is prepared by a process differing from example 1 only in that it does not contain acetyl tetrapeptide-2, and the parts by mass of acetyl tetrapeptide-2 are proportionally distributed to carnosine, pentanediol and ethanol, and the remainder is the same as example 1.
Comparative example 4
This comparative example provides an odor-free skin care composition that is prepared by a process that differs from example 1 only in that it does not contain carnosine and that the mass fraction of carnosine is apportioned to acetyl tetrapeptide-2, pentanediol, and ethanol, the remainder being the same as example 1.
Comparative example 5
This comparative example provides an odor-free skin care composition that is prepared by a process that differs from example 1 only in that no pentanediol is present and that is divided into acetyl tetrapeptide-2, carnosine and ethanol in parts by weight, the remainder being the same as example 1.
Comparative example 6
This comparative example provides an odor-free skin care composition that is prepared by a process that differs from example 1 only in that it does not contain ethanol and that the parts by weight of ethanol are proportioned to acetyl tetrapeptide-2, pentanediol and carnosine, the remainder being the same as example 1.
Application example 1
The application example provides an odor-removing skin care spray, the preparation raw materials of which comprise the odor-removing skin care composition prepared in the example 1 and water, and the preparation method of the odor-removing skin care spray comprises the following steps:
heating pure water to 80 ℃, preserving heat for 20min, then cooling to 40 ℃, sequentially adding pentanediol, acetyl tetrapeptide-2 water solution (20 mass percent) and carnosine water solution (20 mass percent) into the mixture while stirring, stirring for 15min, and packaging into spray bottles to obtain the odor-removing skin care spray.
Application examples 2 to 5
Application examples 2-5 provided 4 odor-free skin care sprays, which were prepared by the same method as application example 1 except that the odor-free skin care composition prepared in example 1 was replaced with the odor-free skin care composition prepared in examples 2-5, and the remainder was the same as application example 1.
Comparative examples 1 to 6 were used
Application comparative examples 1-6 provided 6 odor-free skin care sprays, which were prepared by the same method as application example 1 except that the odor-free skin care composition prepared in example 1 was replaced with the odor-free skin care composition prepared in comparative examples 1-6, and the remainder was the same as application example 1.
Test example 1
The antibacterial effect evaluation was performed on the odor-free skin care compositions prepared in examples 1 to 3 or comparative example 5,
the specific evaluation method comprises the following steps:
(1) Preparation of 5X 10 concentration using sterile PBS buffer 4 CFU/mL (100. Mu.L drop in 5mL sample solution, recovery colony count 5X 10) 4 CFU) escherichia coli (ATCC 25922) and staphylococcus aureus (ATCC 6538);
(2) Mixing 100 μl of the bacterial suspension with 5mL of the odor-free skin care composition prepared in the example or comparative example, and allowing the mixture to act for 20min, wherein the blank group contains 5mL of sterile water mixed with the bacterial suspension;
(3) After 20min of action, 200 mu L of each group of evenly mixed sample liquid in the step (2) is respectively sucked and evenly coated on the surface of a solid culture medium, a flat plate is turned over for culturing for 48h at 37 ℃ to count colonies, and at least double parallel counting is carried out on each dilution.
(4) Plate counts were performed and the bacteriostasis rate was calculated, bacteriostasis rate= (blank colony count-experimental colony count)/blank colony count x 100%.
TABLE 1
As can be seen from the data in table 1, the odor-free skin care compositions of examples 1 to 3 have good inhibitory effects on common gram-negative bacteria such as escherichia coli or gram-positive bacteria such as staphylococcus aureus, and the comparative example 5 lacks pentanediol compared with example 1, and the antibacterial rate is significantly lower than that of example 1, which indicates that the composition including pentanediol can exert excellent antibacterial effect, thereby improving the odor-free effect of the composition.
Test example 2
This test example evaluates the antioxidant properties of the odor-free skin care compositions prepared in examples 1-5 or comparative examples 1-2.
ABTS free radical scavenging ability (Trolox equivalent antioxidant capacity, TEAC) test is one of the most common methods for evaluating the oxidation resistance of compounds. Its main principle is that potassium persulfate (K) 2 S 2 O 8 ) Direct generation of stable cationic free radical ABTS with ABTS + Antioxidant substances and ABTS + The reaction occurs to fade the reaction system.
The specific evaluation steps are as follows:
(1) Formulation of ABTS + And (3) storing liquid: 5mL of ABTS solution (7.4 mmol/L) and 5mL of potassium persulfate (2.6 mmol/L) are uniformly mixed and placed at 25 ℃ for 12h;
(2) Before use, ABTS was buffered with PBS at pH 7.4 + Diluting the stock solution, and adjusting absorbance at 734nm to 0.70+ -0.02 to obtain ABTS + A working fluid;
(3) Taking 0.2mL of ABTS + Working fluid was mixed with 10 μl of sample of the odor-free skin care composition, the composition was replaced with pure water in a blank, and the absorbance was measured every 6min in a 96-well plate at 30deg.C for 30 min. ABTS radical clearance after 30min treatment was calculated from the following formula:
ABTS radical clearance (%) = (a) 0 -A i /A 0 ) X 100%, where A 0 Absorbance values for the blank group, A i Absorbance values for each experimental group.
TABLE 2
| Group of | ABTS radical clearance (%) |
| Example 1 | 63.4 |
| Example 2 | 72.5 |
| Example 3 | 59.1 |
| Example 4 | 43.2 |
| Example 5 | 40.2 |
| Comparative example 1 | 18.9 |
| Comparative example 2 | 29.1 |
As can be seen from the data in table 2, the odor-free skin care composition of the present invention can exert a remarkable antioxidant effect and has an effect of reducing the generation of oxidative malodor substances generated by the skin flora.
Compared with example 1, example 4 and example 5 have lower ABTS free radical clearance than example 1, which shows that the odor-free skin care composition has stronger antioxidation when the mass ratio of polypeptide to alcohol is in the range of (1-10): the ratio of (1-30);
the absence of one of the acetyl tetrapeptide-2 and carnosine in comparative example 1 and comparative example 2, which is lower than example 1, shows that both components of acetyl tetrapeptide-2 and carnosine have a synergistic effect in improving the antioxidant effect of the odor-free skin care composition.
Test example 3
The odor removal effect of the odor removal skin care spray prepared in the application example and the application comparative example is evaluated in the test example, and the specific evaluation method is as follows:
(1) 120 volunteers 18-60 years old were selected, 10 people per group, and each group was half-divided into 12 groups.
(2) The spray (about 1 mL) prepared in each application example or application comparative example was sprayed on the neck, armpit and abdomen of the volunteer 10 times daily, 3 times daily, and the spray was continuously used for 28 days, and the components of the spray used by the volunteer in the blank group were replaced with pure water.
(3) After 28 days of use, volunteers self-evaluate according to the reduction of symptoms of body odor, with the following evaluation criteria: obvious effect (4 minutes): the symptoms of body odor are reduced by more than 70 percent and are effective (3 points): the symptoms of body odor are reduced by 30-70%, slightly effective (2 points): physical odor symptoms were reduced by 30% or less, ineffective (1 point): no obvious change of body odor. Based on volunteer self-evaluation results, an average value was calculated.
TABLE 3 Table 3
| Group of | Self-evaluation score for relieving peculiar smell effect |
| Application example 1 | 3.7 |
| Application example 2 | 3.2 |
| Application example 3 | 3.4 |
| Application example 4 | 2.8 |
| Application example 5 | 2.9 |
| Comparative example 1 was used | 1.6 |
| Comparative example 2 was used | 1.8 |
| Comparative example 3 was used | 1.3 |
| Comparative example 4 was used | 1.7 |
| Comparative example 5 was used | 2.3 |
| Comparative example 6 was used | 2.0 |
As can be seen from the data in Table 3, compared with application example 1, application example 4 and application example 5 have lower self-evaluation scores of the effect of relieving the peculiar smell than application example 1, which indicates that the odor-removing skin care composition has stronger effect of removing the peculiar smell of the body when the mass ratio of the polypeptide to the alcohol is in the range of (1-10): the ratio of (1-30);
compared with application example 1, application comparative example 2 lacks one of acetyl tetrapeptide-2 and carnosine, the self-evaluation scores of the peculiar smell effect alleviation are lower than those of the application example 1, which shows that the acetyl tetrapeptide-2 and carnosine have synergistic effect in improving the antioxidation effect of the odor-removing skin care composition, enhancing the biodegradation of peculiar smell substances and further improving the odor removal.
Compared with application example 1, application comparative examples 3-6 lack one of acetyl tetrapeptide-2, carnosine, pentanediol and ethanol respectively, and the self-evaluation score for relieving the peculiar smell effect is lower than that of application example 1, which shows that the acetyl tetrapeptide-2, carnosine, pentanediol and ethanol have unexpected synergistic effect in improving the body peculiar smell.
Test example 4
The safety of the spray obtained in the application example was evaluated. The specific evaluation method comprises the following steps: the test is carried out according to the human skin patch test method in the human body safety test method of the seventh chapter in the cosmetic safety technical Specification 2015 edition. (1) Female volunteers 18-60 years old meeting the experimental requirements were selected, excluding criteria: (a) Antihistamines used in the last week or immunosuppressants used in the last month; (b) Any anti-inflammatory agent is applied to the tested part in the last two months; (c) a subject suffering from a clinically unhealed inflammatory skin condition; (d) insulin dependent diabetes mellitus; (e) Asthma or other chronic respiratory disease patients undergoing treatment; (f) receiving an anti-cancer chemotherapeutic within approximately 6 months; (g) patients with immunodeficiency or autoimmune disease; (h) lactating or pregnant women; (i) Bilateral mastectomy and bilateral axillary lymphadenectomy; (n) affecting the determination of the test result at the skin site due to scars, pigments, atrophy, port-marks or other imperfections; (o) participate in other clinical trial researchers; (p) highly sensitive body constitution; (q) non-volunteer participants or those who were unable to complete the prescribed content as required by the trial. (2) one group for each application example, 10 volunteers per group; the selected area is not more than 50mm 2 A plaque test apparatus of about 1mm depth. The spray prepared by each application example is sprayed into the small chamber of the spot tester, and the dosage is about 01g. The control wells were empty of any material. The patch test with the test object is applied to the back or forearm of the subject by hypoallergenic tape, and is applied to the skin with palm light pressure for 24 hr. (3) Skin reactions were observed according to the criteria of Table 4 for 30min (after disappearance of the indentations), 24h and 48h, respectively, after removal of the subject plaque tester. And evaluated according to the criteria of table 4.
TABLE 4 Table 4
The results show that the odor-removing skin-care spray prepared by the invention is safe and non-irritating for human body application.
The applicant states that the present invention is illustrated by the above examples of the preparation process of the present invention, but the present invention is not limited to the above examples, i.e. it does not mean that the present invention must be practiced by relying on the above examples. It should be apparent to those skilled in the art that any modification of the present invention, equivalent substitution of raw materials for the product of the present invention, addition of auxiliary components, selection of specific modes, etc., falls within the scope of the present invention and the scope of disclosure.
The preferred embodiments of the present invention have been described in detail above, but the present invention is not limited to the specific details of the above embodiments, and various simple modifications can be made to the technical solution of the present invention within the scope of the technical concept of the present invention, and all the simple modifications belong to the protection scope of the present invention.
In addition, the specific features described in the above embodiments may be combined in any suitable manner, and in order to avoid unnecessary repetition, various possible combinations are not described further.
Claims (10)
1. An odor-free skin care composition, characterized in that said odor-free skin care composition comprises:
polypeptides and alcohols, wherein the polypeptides include acetyl tetrapeptide-2 and carnosine; the alcohols include pentanediol and ethanol.
2. The odor-free skin care composition of claim 1, wherein said polypeptide further comprises:
any one or a combination of at least two of acetyl hexapeptide-1, acetyl hexapeptide-8, palmitoyl tripeptide-1, tripeptide-1 copper, oligopeptide-1, oligopeptide-2 or hexapeptide-2.
3. The odor-free skin care composition of claim 1 or 2, wherein said alcohol further comprises:
any one or a combination of at least two of propylene glycol, butylene glycol, 1, 2-hexanediol or glycerin.
4. A odor-free skin care composition according to any one of claims 1-3, wherein said odor-free skin care composition further comprises:
any one or a combination of at least two of a humectant, an antioxidant or a solubilizing agent;
preferably, the humectant comprises any one or a combination of at least two of lactic acid, arginine, betaine, dendrobe polysaccharide or sodium hyaluronate;
preferably, the antioxidant comprises any one or a combination of at least two of nicotinamide, panthenol or palmitoyl pentapeptide.
5. A deodorant skin care composition according to any one of claims 1 to 4, wherein the mass ratio of said polypeptide to alcohol is (1 to 10): 1 to 30.
6. A deodorant skin care composition according to any one of claims 1 to 5, wherein the mass ratio of acetyl tetrapeptide-2 to carnosine is (1 to 10): 1 to 10;
preferably, the mass ratio of the pentanediol to the ethanol is (1-10): 5-20.
7. Use of a deodorant skin care composition according to any one of claims 1-6 for the preparation of a skin deodorant care product.
8. The use according to claim 7, wherein the formulation of the skin-cleansing care product comprises a spray, cream, liniment, cream or gel.
9. An odor-free skin care spray, characterized in that the odor-free skin care spray is prepared from the odor-free skin care composition as claimed in any one of claims 1 to 6 and water.
10. A method of preparing a deodorant skin care spray as claimed in claim 9, wherein the method comprises the steps of:
(1) Heating water to 60-90deg.C, maintaining for 5-40min, and cooling to 30-50deg.C;
(2) Sequentially adding pentanediol, acetyl tetrapeptide-2, carnosine and ethanol into the water prepared in the step (1), stirring for 5-30min, and packaging into spray bottles to prepare the odor-removing skin care spray.
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| CN202310168819.8A CN116270291B (en) | 2023-02-24 | 2023-02-24 | Odor-removing skin care composition and application thereof |
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| CN202310168819.8A CN116270291B (en) | 2023-02-24 | 2023-02-24 | Odor-removing skin care composition and application thereof |
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| CN116270291B CN116270291B (en) | 2023-12-08 |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10237458A1 (en) * | 2002-08-16 | 2004-02-26 | Beiersdorf Ag | Use of carnosine in e.g. cosmetic or dermatological formulations with deodorant to condense 2-nonenal and similar aldehydes to difficultly volatile and olfactorally inconspicuous compounds |
| CN1620248A (en) * | 2002-02-19 | 2005-05-25 | 西姆莱斯有限责任两合公司 | Synergistic mixtures of 1,2-alkane diols |
| CN102203115A (en) * | 2008-10-03 | 2011-09-28 | 利普泰股份公司 | Peptides useful in the treatment and/or care of skin, mucous membranes, scalp and/or hair and their use in cosmetic or pharmaceutical compositions |
| CN116685300A (en) * | 2020-12-09 | 2023-09-01 | 西姆莱斯股份公司 | Composition comprising one or more (bio) -alkanediols with an antioxidant |
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2023
- 2023-02-24 CN CN202310168819.8A patent/CN116270291B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1620248A (en) * | 2002-02-19 | 2005-05-25 | 西姆莱斯有限责任两合公司 | Synergistic mixtures of 1,2-alkane diols |
| DE10237458A1 (en) * | 2002-08-16 | 2004-02-26 | Beiersdorf Ag | Use of carnosine in e.g. cosmetic or dermatological formulations with deodorant to condense 2-nonenal and similar aldehydes to difficultly volatile and olfactorally inconspicuous compounds |
| CN102203115A (en) * | 2008-10-03 | 2011-09-28 | 利普泰股份公司 | Peptides useful in the treatment and/or care of skin, mucous membranes, scalp and/or hair and their use in cosmetic or pharmaceutical compositions |
| CN116685300A (en) * | 2020-12-09 | 2023-09-01 | 西姆莱斯股份公司 | Composition comprising one or more (bio) -alkanediols with an antioxidant |
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| "Labope Penepagen Capture Cream", pages 3 - 4 * |
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| CN116270291B (en) | 2023-12-08 |
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