CN111374998A - Sleep spray composition aerosol and preparation method thereof - Google Patents
Sleep spray composition aerosol and preparation method thereof Download PDFInfo
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- CN111374998A CN111374998A CN202010182946.XA CN202010182946A CN111374998A CN 111374998 A CN111374998 A CN 111374998A CN 202010182946 A CN202010182946 A CN 202010182946A CN 111374998 A CN111374998 A CN 111374998A
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- 239000000203 mixture Substances 0.000 title claims abstract description 72
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- 238000002360 preparation method Methods 0.000 title abstract description 16
- 238000001856 aerosol method Methods 0.000 title description 2
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- ANZUDYZHSVGBRF-UHFFFAOYSA-N 3-ethylnonane-1,2,3-triol Chemical compound CCCCCCC(O)(CC)C(O)CO ANZUDYZHSVGBRF-UHFFFAOYSA-N 0.000 description 1
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- 235000010254 Jasminum officinale Nutrition 0.000 description 1
- 240000005385 Jasminum sambac Species 0.000 description 1
- 244000178870 Lavandula angustifolia Species 0.000 description 1
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- 102000015636 Oligopeptides Human genes 0.000 description 1
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- WXAYTPABEADAAB-UHFFFAOYSA-N Oxyphencyclimine hydrochloride Chemical compound Cl.CN1CCCN=C1COC(=O)C(O)(C=1C=CC=CC=1)C1CCCCC1 WXAYTPABEADAAB-UHFFFAOYSA-N 0.000 description 1
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- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 1
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- 239000001102 lavandula vera Substances 0.000 description 1
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- JCCNYMKQOSZNPW-UHFFFAOYSA-N loratadine Chemical group C1CN(C(=O)OCC)CCC1=C1C2=NC=CC=C2CCC2=CC(Cl)=CC=C21 JCCNYMKQOSZNPW-UHFFFAOYSA-N 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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Abstract
The invention belongs to the technical field of cosmetics, and particularly relates to a sleep-aiding spray composition and a preparation method thereof, wherein the sleep-aiding spray composition comprises the following components in parts by mass: propellant 0.1-2.0%, water 43.8-99.229%, hemp leaf extract 0.01-2.0%, octopamine 0.01-5.0%, aminobutyric acid 0.1-5.0%, polyalcohol 0.5-40%, antiseptic 0.05-2%, and aromatic 0.001-0.2%. The sleep spray composition aerosol provided by the invention adopts a binary bag valve package aerosol technical form, is uniform and fine in spray state, has plant aromatic smell, is quiet and tranquillizing, and can promote the secretion of melatonin, thereby achieving the effect of sleep aiding.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to a sleep spray composition aerosol and a preparation method thereof.
Background
With the acceleration of the pace of modern life, the pressure of people's life is increasing, and the influence of the popularization of electronic products on the penetration of living aspects, the sleep problem is a ubiquitous problem of young generations. According to data of CBNData '2018 Chinese Internet user sleep white paper' (data research time: 2018, 1-2 months, N is 2000), 56% of Internet users think that the users have problems in sleep, and the main sleep problems include dreaminess, continuous light sleep, heavy head and head in the morning, insomnia, early sleepiness and the like. Aiming at the ubiquitous sleep problem, sleep improving products in the cosmetic market are mostly aromatherapy products, and the effects of the aromatherapy products are different from person to person and are different.
Chinese patent CN104800774B discloses a composition for improving sleep quality and its use, comprising: lavender essential oil: 2-8 parts of curcuma aromatica essential oil: 2-8 parts of rosemary essential oil, 1-5 parts of rosemary essential oil and 1-5 parts of jasmine essential oil. Although the product has a certain curative effect on promoting sleep, the essential oil formula is required to be used for nasal clip inhalation administration during use, which is inconvenient and cannot fundamentally solve the problem of sleep quality.
Therefore, a sleep product which is effective for most people, really has theoretical data to prove helpful for sleep and is simple and convenient to use is urgently needed. There is no product reported to improve the quality of sleep by combining a composition for improving the quality of sleep with a spray form.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides a sleep spray composition aerosol and a preparation method thereof.
In order to achieve the above purpose, the technical scheme of the invention is as follows:
a sleep spray composition aerosol comprises the following components in parts by mass: propellant 0.1-2.0%, water 43.8-99.229%, hemp leaf extract 0.01-2.0%, octopamine 0.01-5.0%, aminobutyric acid 0.1-5.0%, polyalcohol 0.5-40%, antiseptic 0.05-2%, and aromatic 0.001-0.2%.
Further, the sleep spray composition aerosol consists of the following components in parts by mass: propellant 0.1%, water 86.2%, hemp leaf extract 0.5%, octopamine 0.5%, aminobutyric acid 2.0%, polyalcohol 10.0%, antiseptic 0.6%, and aromatic 0.1%.
Further, the propellant is nitrogen.
Further, the polyhydric alcohol is dipropylene glycol.
Further, the preservative is phenoxyethanol and ethylhexyl glycerol in a weight ratio of 0.5: 0.1.
Further, the aromatic is lavender oil.
In addition, the invention also provides a preparation method of the sleep spray composition aerosol, which comprises the following steps:
s1, mixing, stirring and dispersing the polyhydric alcohol, the preservative and the aromatic uniformly to obtain a mixed solution A;
s2, adding water with the formula ratio into a reaction kettle, heating to 80-85 ℃ while stirring, preserving heat for half an hour, and then cooling;
s3, cooling the water in the step S2 to 40-45 ℃, adding the hemp leaf extract, the mantine and the aminobutyric acid, and stirring for 10-15min until the raw materials are completely dissolved to obtain a mixed solution B;
s4, adding the mixed liquid A obtained in the step S1 into the mixed liquid B obtained in the step S3, stirring for 5-10min, uniformly mixing, canning, sealing, and filling nitrogen to obtain the product.
In the sleep spray composition aerosol provided by the invention, the added hemp leaf extract is extracted from industrial hemp. The industrial hemp contains mental active components: tetrahydrocannabinol (THC) is less than 0.3%, the folium Cannabis extract obtained from industrial Cannabis can be used in cosmetic product, and its main active ingredient is Cannabidiol (CBD), and has effects of relieving inflammation, keeping moisture, inhibiting bacteria, and promoting wound healing; meanwhile, the plant aroma of the plant also has a tranquilizing effect.
In the sleep spray composition aerosol provided by the invention, the oximantine is composed of water, lactobacillus/soybean milk fermentation product filtrate, butanediol and 1, 2-pentanediol, and mainly has the effects of resisting allergy, maintaining diversity of beneficial bacterial groups of skin, promoting synthesis of collagen, promoting synthesis of hyaluronic acid and keeping moisture for a long time.
In the sleep spray composition aerosol provided by the invention, the main effect of the aminobutyric acid is a nerve-inhibiting amino acid, and the sleep spray composition aerosol has the effects of removing wrinkles by removing wrinkles, smoothing skin and repairing damaged skin. Aminobutyric acid acts on GABA receptors in animal cells, the GABA receptors are chloride ion channels, the inhibition or excitability of GABA depends on the concentration of chloride ions inside and outside cell membranes, after the GABA receptors are activated, the chloride ion channels are opened, the permeability of the cell membranes to chloride ions can be increased, the chloride ions flow into nerve cells, the hyperpolarization of the cell membranes is caused, the excitation of nerve cell units is inhibited, and therefore the exercise amount of animals is reduced, and the physiological effects of calming, hypnosis, anticonvulsion and blood pressure reduction are achieved.
The applicant of the invention unexpectedly finds that when the cannabis leaf extract, the oxitenmin and the aminobutyric acid are used in combination, the melatonin secretion can be effectively promoted, so that the effect of improving sleep is achieved.
In addition, in the sleep spray composition aerosol provided by the invention, the adopted propellant is nitrogen, is a colorless and tasteless gas and is one of the main components of air. In addition, nitrogen is chemically inert and hardly reacts with other substances at normal temperature, and therefore, nitrogen is often used for preparing preservatives. The product can be used as a propellant, and can reduce the corrosion prevention system of the product and improve the mildness of the product. And the non-flammable property improves the safety of the product. Finally, nitrogen is a difficult-to-liquefy gas, which is a compressed gas, filled in the product without mixing with the material, and can make the product spray out according to a predetermined shape.
Compared with the prior art, the sleep spray composition aerosol provided by the invention has the following advantages:
(1) the sleep spray composition aerosol provided by the invention can promote melatonin secretion when the cannabis leaf extract, the oxitenmin and the aminobutyric acid are combined for use, and meanwhile, the odor of the plant aromatherapy essential oil is effectively matched, so that the sleep improvement effect is achieved.
(2) The sleep spray composition aerosol provided by the invention combines the sleep-aiding component with the spray form for the first time, can spray out a fine water mist form, and is convenient and simple to use.
(3) Compared with the traditional sleep-assisting aromatherapy or other health-care products, the sleep spray composition aerosol provided by the invention has a wider application range, has better effects on symptoms such as insomnia, dreaminess, waking up, easy waking up in the middle of the night and the like caused by various people's body discomfort, and is safe and free of side effects.
Drawings
FIG. 1 shows the concentration of 6-hydroxysulfate-based melatonin in test example one;
wherein A represents the mean melatonin concentration (pg/ml) in example 1,
b represents the mean concentration of melatonin (pg/ml) in example 2,
c represents the mean concentration of melatonin (pg/ml) in example 3,
d represents the mean concentration of melatonin (pg/ml) in example 4,
e represents the mean concentration of melatonin (pg/ml) in example 5,
f represents the mean concentration of melatonin (pg/ml) in example 6,
g represents the average concentration (pg/ml) of melatonin in comparative example 1,
h represents the mean concentration of melatonin (pg/ml) in comparative example 2,
i represents the mean concentration of melatonin (pg/ml) of comparative example 3,
j represents the mean concentration of melatonin (pg/ml) of comparative example 4,
k represents the mean melatonin concentration (pg/ml) of the blank control group.
Detailed Description
The present invention is further illustrated by the following description of specific embodiments, which are not intended to limit the invention, and various modifications and improvements can be made by those skilled in the art based on the basic idea of the invention, but the invention is within the protection scope of the invention.
The cannabis leaf extract was obtained from Hengya Biochemical Co., Ltd, Guangzhou,
ormin was purchased from guangzhou yujin trading limited,
the lavender oil is purchased from Guangzhou Chengjiya Biotech limited,
lactobacillus/soy extract fermentation filtrate was purchased from guangzhou yujin trade ltd,
oligopeptide-1 was purchased from shenzhen, aeqi biotechnology limited.
The other reagents used in the invention are common reagents and can be purchased from conventional reagent production and sale companies.
Example 1 an Aerosol spray formulation of a sleep spray composition
The sleep spray composition aerosol is composed of the following components in parts by mass: 0.1% of nitrogen, 99.229% of water, 0.01% of hemp leaf extract, 0.01% of octopamine, 0.1% of aminobutyric acid, 0.5% of dipropylene glycol, 0.05% of preservative and 0.001% of lavender oil.
The preservative is composed of phenoxyethanol and ethylhexyl glycerin according to a weight ratio of 0.5: 0.1.
The preparation method of the sleep spray composition aerosol comprises the following steps:
s1, mixing dipropylene glycol, preservative and lavender oil, stirring and dispersing uniformly to obtain a mixed solution A;
s2, adding water with the formula ratio into a reaction kettle, heating to 80 ℃ while stirring, preserving heat for half an hour, and then cooling;
s3, cooling the water in the step S2 to 40 ℃, adding the hemp leaf extract, the octopamine and the aminobutyric acid, and stirring for 10min until the raw materials are completely dissolved to obtain a mixed solution B;
s4, adding the mixed liquid A obtained in the step S1 into the mixed liquid B obtained in the step S3, stirring for 5min, uniformly mixing, canning, sealing, and filling nitrogen to obtain the product.
Example 2 an Aerosol spray formulation of a sleep spray composition
The sleep spray composition aerosol is composed of the following components in parts by mass: 0.1% of nitrogen, 86.2% of water, 0.5% of hemp leaf extract, 0.5% of octopamine, 2.0% of aminobutyric acid, 10.0% of dipropylene glycol, 0.6% of preservative and 0.1% of lavender oil.
The preservative is composed of phenoxyethanol and ethylhexyl glycerin according to a weight ratio of 0.5: 0.1.
The preparation method of the sleep spray composition aerosol comprises the following steps:
s1, mixing dipropylene glycol, preservative and lavender oil, stirring and dispersing uniformly to obtain a mixed solution A;
s2, adding water with the formula ratio into a reaction kettle, heating to 83 ℃ while stirring, preserving heat for half an hour, and then cooling;
s3, cooling the water in the step S2 to 43 ℃, adding the hemp leaf extract, the octopamine and the aminobutyric acid, and stirring for 12min until the raw materials are completely dissolved to obtain a mixed solution B;
s4, adding the mixed liquid A obtained in the step S1 into the mixed liquid B obtained in the step S3, stirring for 8min, uniformly mixing, canning, sealing, and filling nitrogen to obtain the product.
Example 3 an Aerosol of a sleep spray composition
The sleep spray composition aerosol is composed of the following components in parts by mass: 0.1% of nitrogen, 86.5% of water, 0.2% of hemp leaf extract, 0.5% of octopamine, 2.0% of aminobutyric acid, 10.0% of dipropylene glycol, 0.6% of preservative and 0.1% of lavender oil.
The preservative is composed of phenoxyethanol and ethylhexyl glycerin according to a weight ratio of 0.5: 0.1.
The preparation method of the sleep spray composition aerosol comprises the following steps:
s1, mixing dipropylene glycol, preservative and lavender oil, stirring and dispersing uniformly to obtain a mixed solution A;
s2, adding water with the formula ratio into a reaction kettle, heating to 83 ℃ while stirring, preserving heat for half an hour, and then cooling;
s3, cooling the water in the step S2 to 43 ℃, adding the hemp leaf extract, the octopamine and the aminobutyric acid, and stirring for 12min until the raw materials are completely dissolved to obtain a mixed solution B;
s4, adding the mixed liquid A obtained in the step S1 into the mixed liquid B obtained in the step S3, stirring for 8min, uniformly mixing, canning, sealing, and filling nitrogen to obtain the product.
Example 4 an Aerosol spray composition for sleep
The sleep spray composition aerosol is composed of the following components in parts by mass: 0.1% of nitrogen, 84.7% of water, 1% of hemp leaf extract, 0.5% of octopamine, 3.0% of aminobutyric acid, 10.0% of dipropylene glycol, 0.6% of preservative and 0.1% of lavender oil.
The preservative is composed of phenoxyethanol and ethylhexyl glycerin according to a weight ratio of 0.5: 0.1.
The preparation method of the sleep spray composition aerosol comprises the following steps:
s1, mixing dipropylene glycol, preservative and lavender oil, stirring and dispersing uniformly to obtain a mixed solution A;
s2, adding water with the formula ratio into a reaction kettle, heating to 83 ℃ while stirring, preserving heat for half an hour, and then cooling;
s3, cooling the water in the step S2 to 43 ℃, adding the hemp leaf extract, the octopamine and the aminobutyric acid, and stirring for 12min until the raw materials are completely dissolved to obtain a mixed solution B;
s4, adding the mixed liquid A obtained in the step S1 into the mixed liquid B obtained in the step S3, stirring for 8min, uniformly mixing, canning, sealing, and filling nitrogen to obtain the product.
Example 5 an Aerosol sleep spray composition
The sleep spray composition aerosol is composed of the following components in parts by mass: 0.1% of nitrogen, 86.2% of water, 1% of hemp leaf extract, 1% of octopamine, 1% of aminobutyric acid, 10.0% of dipropylene glycol, 0.6% of preservative and 0.1% of lavender oil.
The preservative is composed of phenoxyethanol and ethylhexyl glycerin according to a weight ratio of 0.5: 0.1.
The preparation method of the sleep spray composition aerosol comprises the following steps:
s1, mixing dipropylene glycol, preservative and lavender oil, stirring and dispersing uniformly to obtain a mixed solution A;
s2, adding water with the formula ratio into a reaction kettle, heating to 83 ℃ while stirring, preserving heat for half an hour, and then cooling;
s3, cooling the water in the step S2 to 43 ℃, adding the hemp leaf extract, the octopamine and the aminobutyric acid, and stirring for 12min until the raw materials are completely dissolved to obtain a mixed solution B;
s4, adding the mixed liquid A obtained in the step S1 into the mixed liquid B obtained in the step S3, stirring for 8min, uniformly mixing, canning, sealing, and filling nitrogen to obtain the product.
Example 6 an Aerosol spray composition for sleep
The sleep spray composition aerosol comprises the following components in parts by mass: 2.0% of nitrogen, 43.8% of water, 2.0% of hemp leaf extract, 5.0% of octopamine, 5.0% of aminobutyric acid, 40% of dipropylene glycol, 2% of preservative and 0.2% of lavender oil.
The preservative is composed of phenoxyethanol and ethylhexyl glycerin according to a weight ratio of 0.5: 0.1.
The preparation method of the sleep spray composition aerosol comprises the following steps:
s1, mixing dipropylene glycol, preservative and lavender oil, stirring and dispersing uniformly to obtain a mixed solution A;
s2, adding water with the formula ratio into a reaction kettle, heating to 85 ℃ while stirring, preserving heat for half an hour, and then cooling;
s3, cooling the water in the step S2 to 45 ℃, adding the hemp leaf extract, the octopamine and the aminobutyric acid, and stirring for 15min until the raw materials are completely dissolved to obtain a mixed solution B;
s4, adding the mixed liquid A obtained in the step S1 into the mixed liquid B obtained in the step S3, stirring for 10min, uniformly mixing, canning, sealing, and filling nitrogen to obtain the product.
Comparative example 1 aerosol spray composition for sleep
The sleep spray composition aerosol is composed of the following components in parts by mass: 0.1% of nitrogen, 86.2% of water, 0.5% of dipotassium glycyrrhizinate, 0.5% of octopamine, 2.0% of aminobutyric acid, 10.0% of dipropylene glycol, 0.6% of preservative and 0.1% of lavender oil.
The preservative is composed of phenoxyethanol and ethylhexyl glycerin according to a weight ratio of 0.5: 0.1.
The preparation method of the sleep spray composition aerosol is similar to that of example 2.
The difference from example 2 is that the cannabis leaf extract was replaced with dipotassium glycyrrhizinate.
Comparative example 2 aerosol spray composition for sleep
The sleep spray composition aerosol is composed of the following components in parts by mass: 0.1% of nitrogen, 86.2% of water, 0.5% of dipotassium glycyrrhizinate, 0.5% of lactobacillus/soybean extract fermentation product filtrate, 2.0% of aminobutyric acid, 10.0% of dipropylene glycol, 0.6% of preservative and 0.1% of lavender oil.
The preservative is composed of phenoxyethanol and ethylhexyl glycerin according to a weight ratio of 0.5: 0.1.
The preparation method of the sleep spray composition aerosol is similar to that of example 2.
The difference from example 2 is that the loratidine was replaced by lactobacillus/soy extract fermentation filtrate. Comparative example 3 aerosol spray composition for sleep
The sleep spray composition aerosol is composed of the following components in parts by mass: 0.1% of nitrogen, 86.2% of water, 0.5% of dipotassium glycyrrhizinate, 0.5% of octoting amine, 12.0% of oligopeptide, 10.0% of dipropylene glycol, 0.6% of preservative and 0.1% of lavender oil.
The preservative is composed of phenoxyethanol and ethylhexyl glycerin according to a weight ratio of 0.5: 0.1.
The preparation method of the sleep spray composition aerosol is similar to that of example 2.
The difference from example 2 is that the aminobutyric acid is replaced with oligopeptide-1.
Comparative example 4A spray composition aerosol for sleep
The sleep spray composition aerosol is composed of the following components in parts by mass: 0.1% of nitrogen, 81.2% of water, 0.5% of dipotassium glycyrrhizinate, 5.5% of octopamine, 2.0% of aminobutyric acid, 10.0% of dipropylene glycol, 0.6% of preservative and 0.1% of lavender oil.
The preservative is composed of phenoxyethanol and ethylhexyl glycerin according to a weight ratio of 0.5: 0.1.
The preparation method of the sleep spray composition aerosol is similar to that of example 2.
The difference from the example 2 is that the addition ratio of the baitamine is changed to 5.5 percent, the water is reduced to 81.2 percent, and the rest components are not changed.
Test example I test of melatonin concentration in urine
1. Test subjects: aerosols of sleep spray compositions prepared in examples 1-6 and comparative examples 1-4.
2. Test subjects: 50 insomnia subjects with age 29-35 years.
3. Test methods ① subjects sprayed whole body with an aerosol product containing no combination of cannabis leaf extract, octopamine, and aminobutyric acid 19:00 after bathing for the first day, then urine samples were collected at intervals of two hours to test the urine for the average concentration of 6-hydroxysul atomelatonin, which is a blank group, subjects ② sprayed whole body with one of the aerosol products of sleep spray compositions prepared in examples 1-6 and comparative examples 1-4, respectively, 19:00 after bathing for each day thereafter, urine samples were collected at intervals of two hours to test the urine for the average concentration of 6-hydroxysul atomelatonin.
4. Test results
The test results are shown in table 1.
TABLE 16 mean concentration of sulfato-hydroxy melatonin (pg/ml)
As can be seen from table 1, the aerosol formulations of the sleep spray compositions prepared in examples 1 to 6 significantly increased the melatonin secretion amount after use, and rapidly increased during the period of 23:00 to 3:00, facilitating deep sleep, as compared to the blank group. Meanwhile, in the embodiment 2, the melatonin reaches a maximum value at 3:00, then starts to decrease, and gradually enters light sleep, so that the melatonin is favorable for waking in the morning. Compared with the blank group, the sleep spray composition aerosol prepared in the comparative examples 1 to 4 has very small effect of promoting melatonin secretion, and the combination of the cannabis leaf extract, the oximin and the aminobutyric acid in the invention can promote melatonin secretion, thereby achieving the effect of improving sleep.
It can also be seen from fig. 1 that, after the use of the sleep spray composition aerosols prepared in examples 1 to 6, the melatonin secretion amount was significantly higher than that of the sleep spray composition aerosols prepared in comparative examples 1 to 4 and the blank control group.
Test example two, sleep quality test after aerosol spray formulation for sleep
1. Test materials: aerosols of sleep spray compositions prepared in examples 1-6 and comparative examples 1-4.
2. Test materials: 100 insomnia subjects, age 29-35 years;
3. the test method comprises the following steps: after bathing, the subjects used the aerosol product of the sleep spray composition of examples 1-6 and comparative examples 1-4, which was used continuously for 7 days, and evaluated the quality of sleep.
4. Trial results
The test results are shown in table 2.
TABLE 2 sleep quality test
As can be seen from Table 2: the aerosol products of the sleep spray compositions prepared in examples 1-6 and comparative example 4 had short onset of sleep, less dreaming, less light sleep, and the use of examples 1-6 also resulted in good morning wake up and a more wakeful condition, whereas the use of comparative example 4 had a feeling of morning wakefulness and a more vague condition; meanwhile, the aerosol products of the sleep spray compositions prepared in comparative examples 1 to 3 showed little improvement in the time to sleep, long time to sleep, more dreams, and long light sleep, and had a more sleepy feeling after waking in the morning.
The foregoing embodiments are merely illustrative of the principles and utilities of the present invention and are not intended to limit the invention. Any person skilled in the art can modify or change the above-mentioned embodiments without departing from the spirit and scope of the present invention. Accordingly, it is intended that all equivalent modifications or changes which can be made by those skilled in the art without departing from the spirit and technical spirit of the present invention be covered by the claims of the present invention.
Claims (7)
1. The sleep spray composition aerosol is characterized by comprising the following components in parts by mass: propellant 0.1-2.0%, water 43.8-99.229%, hemp leaf extract 0.01-2.0%, octopamine 0.01-5.0%, aminobutyric acid 0.1-5.0%, polyalcohol 0.5-40%, antiseptic 0.05-2%, and aromatic 0.001-0.2%.
2. The sleep spray composition aerosol as claimed in claim 1, which is characterized by comprising the following components in parts by mass: propellant 0.1%, water 86.2%, hemp leaf extract 0.5%, octopamine 0.5%, aminobutyric acid 2.0%, polyalcohol 10.0%, antiseptic 0.6%, and aromatic 0.1%.
3. The aerosol sleep spray composition of claim 1 or 2, wherein the propellant is nitrogen.
4. The aerosol sleep spray composition of claim 1 or 2, wherein the polyol is dipropylene glycol.
5. The aerosol sleep spray composition of claim 1 or 2, wherein the preservative is phenoxyethanol, ethylhexylglycerin, in a weight ratio of 0.5: 0.1.
6. The aerosol sleep spray composition of claim 1 or 2, wherein the fragrance is lavender oil.
7. A method of preparing an aerosol of a sleep spray composition as claimed in any one of claims 1 to 6, comprising the steps of:
s1, mixing, stirring and dispersing the polyhydric alcohol, the preservative and the aromatic uniformly to obtain a mixed solution A;
s2, adding water with the formula ratio into a reaction kettle, heating to 80-85 ℃ while stirring, preserving heat for half an hour, and then cooling;
s3, cooling the water in the step S2 to 40-45 ℃, adding the hemp leaf extract, the mantine and the aminobutyric acid, and stirring for 10-15min until the raw materials are completely dissolved to obtain a mixed solution B;
s4, adding the mixed liquid A obtained in the step S1 into the mixed liquid B obtained in the step S3, stirring for 5-10min, uniformly mixing, canning, sealing, and filling nitrogen to obtain the product.
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