CN111617013A - Composition with sleep-aiding effect, spray and preparation method thereof - Google Patents

Abstract

The invention discloses a composition with sleep-aiding efficacy, a spray and a preparation method thereof. The composition with the sleep-aiding efficacy comprises the following components in percentage by mass: sandalwood oil: butter oil: bitter orange flower oil: the rosewood oil is 2-4: 1-2: 1-2: 1 to 2. Meanwhile, the invention also provides a sleep-aiding spray containing the composition. According to the invention, by strictly selecting the matching and adding proportion of the perfume components, the perfume components are matched with the hemp leaf extract to cooperatively play a sleep-aiding effect, the smell is relaxed, and the sleep-aiding effect is obvious. The active substances in the spray are all selected from natural plants, do not contain harmful substances, have no side effect, are natural and safe, and can be used for a long time. Meanwhile, when the sleep-aiding spray is used, the fragrance is released more quickly and mildly, and the fragrance is released more comprehensively. The product of the invention has simple preparation process, controllable proportion of the aroma components and low cost, and is suitable for industrial production.

Description

Composition with sleep-aiding effect, spray and preparation method thereof

Technical Field

The invention belongs to the technical field of cosmetics. More particularly, relates to a composition with sleep-aiding efficacy, a spray and a preparation method thereof.

Background

Sleep disorder is the main manifestation of insomnia, and can be early stage insomnia (difficult to fall asleep), middle stage insomnia (light sleep and easy wakefulness), end stage insomnia (early wakefulness), dreaminess, nightmare, no sleep feeling, no fatigue after sleep, and the like, and the symptoms can also exist in a mixed way. Nowadays, sleep disorder has become a modern urban disease, and more a considerable social problem. The Chinese sleep index report of 2019 shows that 21.5% of Chinese people often have insomnia. In the population after 90%, 31% of people have a late sleep habit, more than 60% of people feel that the sleep is insufficient, and only 5% of people think that the people can enjoy good sleep. In addition, according to the 2019 national health white paper published by the clove doctor in association with the health newspaper mobile health research institute, 96% of the investigated persons indicate that the persons have health-related troubles, wherein the sleep problem is listed in the third place.

When sleep became a luxury, the sleep market with great potential was also induced. According to the research report of Chinese sleep medical market analysis and investment prospect in 2018 and 2023 published by Bosi data, the market scale of the Chinese sleep improvement industry in 2017 reaches about 2797 hundred million yuan. Wherein, the sleep apparatus occupies 89.3 percent of the market, and the sleep medicine, the sleep health care product and the sleep service occupy 4.8 percent, 4.6 percent and 1.3 percent in sequence. Pillow, mattress, fragrance, and other sleep-assisting tools are also preferred by many people with insomnia. Among them, aromatherapy such as aromatherapy is a method which is purely natural, has little side effect, has the effects of relaxing the body and mind and relieving pressure, and has great market demand.

Aromatic plants have a long history of use for calming nerves and promoting sleep, such as lavender, clary sage, sandalwood and the like, which all contain aromatic compounds with tranquilizing and sleep-promoting effects, such as linalyl acetate, linalool and the like in lavender essential oil, which are effective in promoting sleep. For example, patent CN111195295A discloses a compound essential oil for aiding sleep, which comprises bergamot essential oil, true lavender essential oil, roman chamomile essential oil, bitter orange leaf essential oil, bitter orange flower essential oil, and sandalwood essential oil. However, the aromatic massage essential oil has the defect of inconvenient use and has potential irritation to the skin, and more convenient, safe and efficient sleep-aiding external products are urgently needed. Patent CN109364124A discloses a spray with sedative and hypnotic effects and its preparation method, comprising lavender essential oil, geranium essential oil, balm essential oil, sandalwood essential oil, chamomile extract and kava pepper active preparation. However, according to market research, many consumers reflect that the lavender essential oil has no effects of soothing the nerves and helping sleep but has the effect of refreshing the mind and the brain when used. Moreover, the raw materials in the essential oil market have different quality and unclear production area, so that the ratio of effective fragrant components in the essential oil is greatly different, and the final effect of the essential oil product cannot be effectively exerted. In addition, when a spray having a sedative and hypnotic effect is prepared, many insoluble substances are generated after the perfume components, ethanol and water are mixed, various chemical reactions such as transesterification, and acetalization are easily generated, and acetaldehyde generated prevents perception of other odors in the spray, and reduces the hypnotic effect.

Disclosure of Invention

Aiming at the defects of the prior art, the utility model provides a spray with sleep-aiding efficacy. The sleep-aiding spray disclosed by the invention utilizes the mutual cooperation of selected natural perfume components to cooperatively play a sleep-aiding effect, is an external sleep-aiding cosmetic with a relaxed and relaxed smell and no drug dependence, and is a spray which is more convenient to carry and use and prepared by adjusting a preparation process and adding a filter aid, so that the fragrance release speed is higher and milder, and the stimulation effect of high-concentration perfume components on the skin is effectively avoided.

The invention aims to provide a composition with sleep-aiding efficacy.

It is a second object of the present invention to provide a sleep aid spray comprising the above composition.

The third purpose of the invention is to provide a preparation method of the sleep-aiding spray.

The above purpose of the invention is realized by the following technical scheme:

a composition with sleep-aiding efficacy comprises the following components in percentage by mass: sandalwood oil: butter oil: bitter orange flower oil: the rosewood oil is 2-4: 1-2: 1-2: 1 to 2.

The sandalwood oil is preferably sandalwood oil (ear sandalwood oil), and the sandalwood essential oil is a volatile component obtained by distilling a heartwood of a sandalwood tree, and is from a root, a hip, a trunk to a branch. The sweetness of sandalwood is due to the inclusion of two santalols (α -santalol and β -santalol), in addition to many other sesquiterpenes and sesquiterpene alcohols contributing to the overall aroma characteristics of sandalwood oil. The isolated alpha-santalol and beta-santalol drugs have similar pharmacological activity to chlorpromazine and may be considered antipsychotics. Both alpha-santalol and beta-santalol show obvious sedative and analgesic effects.

The mastic oil is preferably a somarie mastic oil extracted from a resin of boswellia carterii (boswellia carterii) grown in somarie. The boswellia serrata grows in arid and barren areas, the trunk is thick and strong, and branches are twisted and thorny. The bark is cut to produce milky sap, which becomes gradually hard to become yellowish brown translucent resin when exposed to air. The composition of frankincense varies from one source to another. The soma oil contains higher n-caprylate acetate and higher diol, can help relaxation and regulate hormone, and has relatively sweet smell.

The neroli oil is preferably mediterranean neroli oil extracted from flowers of citrus aurantium (citrus aurantium) grown in the mediterranean region. The bitter orange trees with the age of more than 20 years can distill out neroli essential oil with good quality, and the main odor characteristics of the bitter orange trees are precious trace aromatic molecules. The orange flower has fragrant and elegant smell and is easy to feel. The linalool and limonene contained in the neroli essential oil can also soothe dysphoria and depression caused by endocrine dyscrasia or menopause, and improve sleep, especially sleep quality.

The rosewood oil is preferably Brazilian rosewood oil, and the rosewood oil mainly contains dextrorotation linalool and has the content of about 80-95%. The contained aromatic ketone causes the rosewood to have delicate fragrance like lily; it also has a smell similar to Mimosa pudica and Hawthorn fruit, and has a silky smell. The oxide (eucalyptol) also makes the rose wood smell in the flower fragrance, adding the smell of costus root and wind. The rosewood has the advantages that the whole fragrance is stable and warm, people can be well soothed, people who are excessively stressed and in a hurry can be quickly calmed and relaxed, and particularly under the condition of excessive emotional burden, the rosewood can quickly reduce excessively secreted stress hormones and soothe the skin and nervous systems.

According to the invention, through selecting natural spices, sandalwood oil, frankincense oil, bitter orange flower oil and rosewood oil are combined together in a specific ratio, and the active ingredients of the spices interact with each other, so that the most pleasant fragrance can be emitted, spontaneous sleep can be promoted, and sleep disorder can be effectively broken.

Preferably, the composition with sleep-aiding efficacy comprises the following components in percentage by mass: butter oil: bitter orange flower oil: the rosewood oil is 2: 1: 1: 1.

preferably, in the composition with sleep-aiding efficacy, by mass, the santalol in the sandalwood oil is not less than 20%, and the australian white sandalwood alcohol is not less than 3%; in the mastic oil, the content of n-caprylic acid acetate is not less than 38%, the content of santalol is not less than 5%, the content of d-limonene is not less than 3%, and the content of alpha-terpineol is not less than 1%; linalool in the neroli oil is not less than 38%, dextrolimonene is not less than 10%, and alpha-terpineol is not less than 3%; the linalool content in rosewood oil is not less than 78%.

According to the invention, through a large number of experiments, the selected active ingredients of the natural perfume are analyzed, and the result shows that when the santalol in the sandalwood oil is not less than 20 percent, the santalol is not less than 3 percent; in the mastic oil, the content of n-caprylic acid acetate is not less than 38%, the content of santalol is not less than 5%, the content of d-limonene is not less than 3%, and the content of alpha-terpineol is not less than 1%; linalool in the neroli oil is not less than 38%, dextrolimonene is not less than 10%, and alpha-terpineol is not less than 3%; when the linalool content in the rosewood oil is not less than 78%, the combination of the sandalwood oil, the frankincense oil, the bitter orange flower oil and the rosewood oil can effectively ensure the sleep-aiding effect of the natural perfume, so that the mind and body of a person are relieved, and the high-quality sleep quality is ensured.

Preferably, the composition with sleep-aiding efficacy further comprises a cannabis leaf extract, wherein the weight ratio of the sandalwood oil: butter oil: bitter orange flower oil: rose wood oil: the cannabis leaf extract is 2-4: 1-2: 1-2: 1-2: 1 to 10.

Preferably, the composition with sleep-aiding efficacy further comprises a cannabis leaf extract, wherein the weight ratio of the sandalwood oil: butter oil: bitter orange flower oil: rose wood oil: the cannabis leaf extract is 2: 1: 1: 1: 1.

preferably, the cannabidiol in the cannabis leaf extract is not less than 3% by mass.

The cannabis leaf extract is supplied by domestic industrial cannabis manufacturers by law, and the content of non-psychoactive component Cannabidiol (CBD) which is more positive and beneficial to health is extracted and separated from industrial cannabis, and is not lower than 3%. Cannabidiol (CBD) has good neuroprotective effect, anti-inflammatory effect, anti-oxidation effect, anti-tumor effect, anti-liver injury effect, immunoregulation effect and the like, and is widely used in the fields of medicines, health products, functional beverages, cosmetics and the like. According to a large number of experimental researches, the hemp leaf extract and plant essential oil (sandalwood oil, frankincense oil, neroli oil, rosewood oil and the like) are combined for use, so that a synergistic effect is generated, the sleep-aiding effect is remarkably improved, and good effects of relieving and relaxing and improving the sleep quality are achieved.

The invention also provides a spray with sleep-aiding efficacy, which comprises the composition.

Preferably, the sleep-aiding composition excluding the hemp leaf extract is added in an amount of less than or equal to 10% by mass percentage. According to the invention, a large amount of researches show that when the addition amount of the sleep-aiding composition not including the hemp leaf extract in the spray is less than or equal to 10%, the sprayed fragrance is softest and gentler, and the body and mind can be quickly soothed to enable people to be more relaxed.

Preferably, the spray with sleep-aiding efficacy further comprises cannabis leaf extract.

Preferably, the spray with sleep-aiding efficacy further comprises a filter aid Quidex.

In the preparation process, the fragrance ingredients of sandalwood oil, frankincense oil, bitter orange flower oil and rosewood oil are mixed with the solvent of ethanol and water to generate a plurality of insoluble substances, so that the fragrance ingredients need to be aged and filtered. During the aging process, various chemical reactions such as ester exchange, ester formation, acetal reaction and the like can occur, the acetaldehyde which reacts most intensely is generated, and the generated acetaldehyde can block people from smelling other components in the spray and sensing other odors after the generated acetaldehyde fills the olfactory cells. The present invention therefore overcomes the above technical problem by adding a filter aid, preferably Quidex. Quidex is purchased from AEESEEA, Brazil, and can directly and rapidly react with precipitates to remove the most volatile and strongly reactive acetaldehyde in sleep-aiding spray, and can accelerate the aging of aroma components, so that the aging time is shortened from 1-3 months to 15 minutes, the same effect as that of traditional aging is achieved, and after the filter aid is added, the aroma is also refined, thick and soft from the original roughness and hardness.

Preferably, the spray comprises the following components in percentage by mass: 0.4-4% of sandalwood oil, 0.2-2% of frankincense oil, 0.2-2% of bitter orange flower oil, 0.2-2% of rosewood oil, 1-10% of hemp leaf extract, 0.5-2% of filter aid Quidex and the balance of solvent, wherein the solvent is deionized water and odorless ethanol.

Further, preferably, the spray with the sleep-aiding efficacy comprises the following components in percentage by mass: 1-4% of sandalwood oil, 1-2% of mastic oil, 1-2% of bitter orange flower oil, 1-2% of rosewood oil, 2-5% of hemp leaf extract, 1-1.5% of filter aid Quidex and the balance of solvent.

More preferably, the spray with the sleep-aiding efficacy comprises the following components in percentage by mass: 4% of sandalwood oil, 2% of frankincense oil, 2% of bitter orange flower oil, 2% of rosewood oil, 2% of hemp leaf extract, filter aid Quidex 1%, 58% of odorless ethanol and the balance of deionized water.

As a preferable mode, the present invention provides a method for preparing the spray with sleep-aiding efficacy, which specifically comprises the following steps:

(1) mixing solvent and folium Cannabis extract uniformly;

(2) mixing lignum Santali albi oil, oleum Sesami, flos Citri Junoris oil, and oleum Rosae Rugosae uniformly;

(3) and (3) pouring the mixture prepared in the step (2) into the mixture prepared in the step (1), uniformly stirring, adding a filter aid, uniformly stirring, standing for 15min, and filtering to obtain the filter aid.

The invention also provides a using method of the sleep-aiding spray, and particularly relates to a method for spraying the sleep-aiding spray on bedding (such as a pillow, a quilt and the like), entering the internal circulation of a human body in a sniffing mode and playing the effects of relieving and calming, calming the nerves and aiding sleep.

The invention has the following beneficial effects:

according to the invention, the natural perfume ingredients are selected strictly, and the hemp leaf extract and the natural perfume are matched with each other to cooperatively play a sleep-aiding effect, so that the smell is relaxed and relaxed, and the sleep-aiding effect is obvious. The active substances in the spray are all selected from natural plants, do not contain harmful substances, have no side effect, are natural and safe, and can be used for a long time.

In addition, the preparation process of the sleep-aiding spray is improved, and Quidex filter aid is selectively added through a large amount of researches, so that the influence of the irritant odor which is generated in the process and has the influence on the use and the effect of the sleep-aiding spray and is generated by insoluble substances, acetaldehyde and the like and has the influence on the fragrance components is overcome, and the fragrance components are more mellow. Meanwhile, when the sleep-aiding spray is used, the fragrance is released more quickly and mildly, and the fragrance is released more comprehensively. The product of the invention has simple preparation process, controllable proportion of the aroma components and low cost, and is suitable for industrial production.

Detailed Description

The present invention is further illustrated by the following specific examples, which are not intended to limit the invention in any way. Reagents, methods and apparatus used in the present invention are conventional in the art unless otherwise indicated.

Unless otherwise indicated, reagents and materials used in the following examples are commercially available.

In the examples, cannabis extracts were purchased from Yunnan green New Biopharmaceutical industries, Inc., and Quidex was purchased from Brazil AEESEEA.

The peak area contents of the main components detected by GC gas chromatography in selected sandalwood oils are shown in table 1.

TABLE 1

Components	Content/%
		Sandalwood alcohol	21.8
α bisabolol	7.1
		α bergamotol	3.6
Farnesol	14.4
		Torreya grandis alcohol	6.1
Pterocarpan	3.7

The peak area contents of the main components in selected soymilus oil measured by GC gas chromatography are shown in Table 2.

TABLE 2

Components	Content/%
		Acetic acid n-octanoic acid ester	42.36
Sandalwood alcohol	6.41
		Dextro-limonene	3.82
α terpineol	1.52

The peak area contents of the main components in selected neroli mediterrae oil by GC are shown in Table 3.

TABLE 3

Components	Content/%
		Linalool	40.22
Dextro-limonene	12.39
		Nerol	9.18
α terpineol	4.08

The peak area contents of the main components in the selected brazilian rose oil measured by GC gas chromatography are shown in table 4.

TABLE 4

The embodiment of the invention provides a spray with sleep-aiding effect, wherein the addition amount of the composition of sandalwood oil, frankincense oil, bitter orange flower oil and rosewood oil is less than or equal to 10 percent;

the spray with the sleep-aiding efficacy comprises the following components in percentage by mass: 0.4-4% of sandalwood oil, 0.2-2% of frankincense oil, 0.2-2% of bitter orange flower oil, 0.2-2% of rosewood oil, 1-10% of hemp leaf extract, 0.5-2% of filter aid and the balance of solvent.

Wherein the solvent is deionized water and odorless ethanol.

The preparation method of the sleep-aiding spray matched with the natural perfume comprises the following steps:

(1) mixing solvent and folium Cannabis extract uniformly;

(2) mixing lignum Santali albi oil, oleum Sesami, flos Citri Junoris oil, and oleum Rosae Rugosae uniformly;

(3) and (3) pouring the mixture prepared in the step (2) into the mixture prepared in the step (1), uniformly stirring, adding a filter aid, uniformly stirring, standing for 15min, and filtering to obtain the filter aid.

Examples 1-5 Natural fragrance-matched sleep-aid spray and preparation thereof

The mass percentage formulation of the sleep-assisting sprays containing the natural perfumes of examples 1 to 5 is shown in table 5.

TABLE 5

Composition (I)	Example 1	Example 2	Example 3	Example 4	Example 5
						Cannabis leaf extract	2.0	3.0	2.0	2.0	4.0
Sandalwood oil	4.0	3.0	2.0	1.0	0.4
						Mastic oil	2.0	1.5	1.0	0.5	0.2
Bitter orange flower oil	2.0	1.5	1.0	0.5	0.2
						Rose wood oil	2.0	1.5	1.0	0.5	0.2
QUIDEX	1	1.5	1	1	2.0
						Special grade odorless ethanol	58	40	48	38	30
Deionized water	To 100	To 100	To 100	To 100	To 100

The method for preparing a sleep-assisting spray containing natural perfume of examples 1 to 4 includes the steps of:

(1) mixing solvent and folium Cannabis extract uniformly;

(2) mixing lignum Santali albi oil, oleum Sesami, flos Citri Junoris oil, and oleum Rosae Rugosae uniformly;

(3) and (3) pouring the mixture prepared in the step (2) into the mixture prepared in the step (1), uniformly stirring, adding a filter aid, uniformly stirring, standing for 15min, and filtering with a 400-mesh sieve to obtain the filter aid.

The mass ratio of the components of the sleep-aiding fragrance in the sleep-aiding sprays containing the natural perfumes of examples 1 to 4 was analyzed and shown in table 6.

Table 6 sleep-aiding fragrance ingredients (mass%)

Aroma component	Example 1	Example 2	Example 3	Example 4	Example 5
						Sandalwood alcohol	1.0002	0.7501	0.5001	0.2500	0.1000
Pterocarpan	0.1480	0.1110	0.0740	0.0370	0.0148
						Linalool	2.4568	1.8426	1.2284	0.6142	0.2457
Acetic acid n-octanoic acid ester	0.8472	0.6354	0.4236	0.2118	0.0847
						Dextro-limonene	0.3242	0.2432	0.1621	0.0811	0.0324
α terpineol	0.1120	0.0840	0.0560	0.0280	0.0112
						Cannabidiol	0.0600	0.0900	0.0600	0.0600	0.1200

Comparative examples 1-9 sleep-aid sprays and their preparation

The mass percentage formulations of the sleep-aid sprays of comparative examples 1 to 9 are shown in table 7.

TABLE 7

The methods for producing sleep-assisting sprays of comparative examples 1 to 9 refer to the methods for producing sleep-assisting sprays of examples 1 to 4.

Example 6 sensory evaluation of sleep aid spray

50 subjects (18 men and 32 women) with different sleep quality problems are randomly selected to score the preference degree and the relaxation degree of the sleep-aid spray odor of the examples 1-6 and the comparative examples 1-9 (the evaluation is completed within 72 hours after the sample plate in the laboratory is manufactured), the score range is 1-10, and the higher the score is, the more popular the product odor is, and the more relaxing effect is. The scores for each group were averaged and the results are shown in Table 8.

TABLE 8

Group of	Smell(s)	Degree of relief
			Example 1	9.5	9.7
Example 2	9.1	8.9
			Example 3	8.8	8.4
Example 4	8.7	8.5
			Example 5	8.3	8.1
Comparative example 1	7.6	7.5
			Comparative example 2	7.2	5.9
Comparative example 3	5.8	5.2
			Comparative example 4	6.7	6.3
Comparative example 5	5.3	4.9
			Comparative example 6	7.5	7.3
Comparative example 7	7.7	7.5
			Comparative example 8	7.6	7.3
Comparative example 9	8.0	7.2

From the results in table 8, it can be seen that the sleep-aiding spray prepared according to the present invention has a good odor and gives better relaxation after inhalation. After the hemp leaf extract is added, the sleep-aiding spray has a synergistic interaction effect with the sleep-aiding composition in the effects of relieving and relaxing immediately; the lack of any natural perfume in the sleep-aid composition and the addition of too low or too high of any natural perfume greatly reduces the overall smell and the relaxing effect of the sleep-aid spray.

In addition, as can be seen from the comparison of the results of example 1 and comparative example 9, the use of the filter aid QUIDEX in the manufacturing process significantly improves the overall fragrance smoothness of the sleep aid spray, and allows the user to relax more.

Example 7 sleep aid efficacy testing of a sleep aid spray

Office workers with Sleep disorders in 6-2020 in 2019 are selected as study objects and randomly divided into blank control groups, examples 1-5 groups and comparative examples 1-8 groups, and commercial British brand This Works Deep Sleep pilowSpray natural Sleep spray (mainly comprising lavender oil, vetiver oil, geranium, lemon oil, vetiver and chamomile oil) for study, wherein 40 cases are selected for each group, the age is 25-45 years, and the proportion of men and women is balanced.

Using method and frequency: turning off electronic equipment such as a mobile phone 15 minutes before sleeping at night, shaking up and spraying uniformly, spraying for 2-3 times at a distance of 20-30cm from the pillow, and deeply breathing to relax mood.

Each group of testers was followed by using Pittsburgh Sleep Quality Index (PSQI) from a test table, and data statistics were collected after continuous use for 1 month. The statistical results are shown in Table 9, respectively.

TABLE 9

Group of	PSQI average score
		Blank control group	10.1±3.17
Example 1	6.42±1.49
		Example 2	6.68±1.45
Example 3	6.96±1.62
		Example 4	7.17±1.66
Example 5	7.47±2.03
		Comparative example 1	7.95±1.62
Comparative example 2	8.16±1.97
		Comparative example 3	8.34±2.75
Comparative example 4	8.13±1.97
		Comparative example 5	8.91±2.94
Comparative example 6	8.33±2.75
		Comparative example 7	8.05±1.62
Comparative example 8	7.86±3.05
		Commercially available spray	7.50±1.49

Note: the PSQI score ranges from 0 l to 2l, and the higher the score is, the worse the sleep quality is. PSQI < 8 indicates good sleep quality.

From the results in table 9, the average PSQI scores of examples 1-5 were significantly lower than those of the blank control, indicating that the spray of the present invention has a significant sleep-aiding effect, and the greater the amount of the perfume component base added, the more helpful the sleep-aiding effect. And the integral effect of the Sleep-aiding Spray is better than that of a Sleep-aiding Spray product 'This Works Deep Sleep Pillow Spray natural Sleep Spray' which takes lavender as a main essential oil component and has good feedback in the market.

From the results of examples 1 to 5 and comparative examples 2 to 5, it can be seen that the PSQI average score is significantly improved and the sleep-aiding effect is deteriorated after the perfume components are changed, while the sleep-aiding effect is rather decreased when the amount of the perfume is too high (more than 10%), indicating that the optimal range of perfume addition can achieve better sleep-aiding effect. Meanwhile, as can be seen from the results of example 1 and comparative example 1, the cannabis leaf extract has a synergistic effect on the fragrance sleep-aiding effect, and can significantly improve the sleep quality.

In addition, through long-term investigation of testers, if the testers insist on using the sleep-aiding pillow spray of the invention every night, the sleep-aiding pillow has a remarkable improvement effect on the overall sleep quality of contemporary people, particularly office workers with high stress. Moreover, the sleep-aiding pillow spray can be matched with perfume components with different concentration ratios according to the severity of people with sleep disorder, and drug dependence can not occur after long-term use.

The above embodiments are preferred embodiments of the present invention, but the present invention is not limited to the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be construed as equivalents thereof, and all such changes, modifications, substitutions, combinations, and simplifications are intended to be included in the scope of the present invention.

Claims (10)

1. The composition with the sleep-aiding effect is characterized by comprising the following components in percentage by mass: sandalwood oil: butter oil: bitter orange flower oil: the rosewood oil is 2-4: 1-2: 1-2: 1 to 2.

2. The composition with sleep-aiding efficacy according to claim 1, wherein the sandalwood oil: butter oil: bitter orange flower oil: the rosewood oil is 2: 1: 1: 1.

3. the composition with sleep-aiding efficacy according to claim 2, wherein the sandalwood oil contains not less than 20% of santalol and not less than 3% of santalol by mass percent; in the mastic oil, the content of n-caprylic acid acetate is not less than 38%, the content of santalol is not less than 5%, the content of d-limonene is not less than 3%, and the content of alpha-terpineol is not less than 1%; linalool in the neroli oil is not less than 38%, dextrolimonene is not less than 10%, and alpha-terpineol is not less than 3%; the linalool content in rosewood oil is not less than 78%.

4. A composition with sleep-aiding efficacy according to claim 3, further comprising cannabis leaf extract, wherein the composition comprises the following components in mass ratio: sandalwood oil: butter oil: bitter orange flower oil: rose wood oil: the cannabis leaf extract is 2-4: 1-2: 1-2: 1-2: 1 to 10.

5. A composition with sleep promoting effect as claimed in claim 4, wherein cannabidiol is not less than 3% by mass of the cannabis leaf extract.

6. A spray with sleep-aiding effect, which comprises the composition of any one of claims 1 to 3, and the composition is added in an amount of less than or equal to 10% by mass.

7. The spray with sleep-aiding efficacy according to claim 6, further comprising cannabis leaf extract and filter aid Quidex.

8. The spray with the sleep-aiding efficacy according to claim 7, characterized in that the spray comprises the following components in percentage by mass: 0.4-4% of sandalwood oil, 0.2-2% of frankincense oil, 0.2-2% of bitter orange flower oil, 0.2-2% of rosewood oil, 1-10% of hemp leaf extract, 0.5-2% of filter aid Quidex and the balance of solvent, wherein the solvent is deionized water and odorless ethanol.

9. The spray with the sleep-aiding efficacy according to claim 8, characterized in that the spray comprises the following components in percentage by mass: 4% of sandalwood oil, 2% of frankincense oil, 2% of bitter orange flower oil, 2% of rosewood oil, 2% of hemp leaf extract, 1% of filter aid Quidex, 58% of odorless ethanol and the balance of deionized water.

10. The method for preparing a spray with sleep-aiding efficacy according to claim 8 or 9, characterized by comprising the following steps:

(1) mixing solvent and folium Cannabis extract uniformly;

(2) mixing lignum Santali albi oil, oleum Sesami, flos Citri Junoris oil, and oleum Rosae Rugosae uniformly;

(3) and (3) pouring the mixture prepared in the step (2) into the mixture prepared in the step (1), uniformly stirring, adding a filter aid, uniformly stirring, standing for 15min, and filtering to obtain the filter aid.