CN116211768A - 一种银耳多糖洁牙护理液及其制备工艺 - Google Patents
一种银耳多糖洁牙护理液及其制备工艺 Download PDFInfo
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- CN116211768A CN116211768A CN202310259888.XA CN202310259888A CN116211768A CN 116211768 A CN116211768 A CN 116211768A CN 202310259888 A CN202310259888 A CN 202310259888A CN 116211768 A CN116211768 A CN 116211768A
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- tremella polysaccharide
- tooth cleaning
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- Cosmetics (AREA)
Abstract
本发明涉及口腔护理技术领域，尤其涉及一种银耳多糖洁牙护理液，按照重量份计算包括如下组分原料：乙二胺四乙酸二钠0.05‑0.15份、十二烷基硫酸钠0.10‑1.00份、甘草酸二钾0.05‑0.15份、C8‑16烷基糖苷15.00‑35.00份、丙二醇5.00‑15.00份、薄荷脑0.05‑0.25份、对羟基苯甲酸甲酯0.01‑1.50份、聚甘油‑10月桂酸酯1.00‑3.00份、丹皮酚0.05‑0.15份、柠檬酸0.10‑1.00份、西吡氯铵0.05‑0.15份、功能辅助成分0.5‑5份、银耳多糖0.01‑1.50份、糖精钠0.10‑1.00份、茉莉花提取物0.05‑0.25份、氨甲环酸0.05‑1.00份、忍冬花提取物0.05‑1.00份，纯化水补充至100份。本发明的洁牙护理液中加入了功能辅助成分，能够有效的降低牙龈指数和牙本质敏感程度。
Description
技术领域
本发明涉及口腔护理技术领域，尤其涉及一种银耳多糖洁牙护理液及其制备工艺。
背景技术
口腔护理用品是人们日常生活中不可或缺的清洁、护理及保健用品，这一类产品种类繁多，包括洁牙护理液、牙膏、口香糖、漱口水、牙粉、口腔喷雾剂等，主要用于保持口腔和牙齿清洁、促进口气清新、护理牙龈、维护口腔良好微环境、缓解口腔不适症状等。洁牙护理液是口腔护理用品的一种，借助牙刷的机械摩擦的作用清洁牙齿表面，对牙齿及其周边进行清洁，使口腔净化清爽。
许多成人有不同程度的牙本质敏感症。牙本质敏感症是指暴露的牙本质因受温度、机械、化学或渗透压等外界刺激而产生的短暂并尖锐的牙齿酸痛症状，具有发作迅速、疼痛尖锐、时间短暂等特点，是一种常见的口腔病症，患病率较高，严重影响患者的生活质量。造成牙本质敏感的原因很多，包括能使釉质完整性受到破坏，牙本质暴露的各种牙体疾病，如磨耗、楔状缺损、牙折、龋病以及牙周萎缩致牙颈部暴露等均可发生牙齿感觉过敏症。
因此、需要开发一种洁牙护理液，针对性的去解决牙本质敏感症的问题。
发明内容
为了解决上述背景技术中提到的问题，本发明提供一种银耳多糖洁牙护理液，按照重量份计算包括如下组分原料：乙二胺四乙酸二钠0.05-0.15份、十二烷基硫酸钠0.10-1.00份、甘草酸二钾0.05-0.15份、C8-16烷基糖苷15.00-35.00份、丙二醇5.00-15.00份、薄荷脑0.05-0.25份、对羟基苯甲酸甲酯0.01-1.50份、聚甘油-10月桂酸酯1.00-3.00份、丹皮酚0.05-0.15份、柠檬酸0.10-1.00份、西吡氯铵0.05-0.15份、功能辅助成分0.5-5份、银耳多糖0.01-1.50份、糖精钠0.10-1.00份、茉莉花提取物0.05-0.25份、氨甲环酸0.05-1.00份、忍冬花提取物0.05-1.00份，纯化水补充至100份。
优选的，所述功能辅助成分包括组分A、组分B和组分C，所述组分A的制备方法如下：
复合材料的制备
将碳纳米管加入浓硝酸、浓硫酸混合体系中拌均匀，加热、超声处理，冷却后过滤、洗涤、烘干，得到酸化的碳纳米管，将酸化的碳纳米管分散到无水乙醇中，加入壳聚糖，加热、超声处理，过滤、洗涤、烘干，得到碳纳米管-壳聚糖复合材料；
改性复合材料的制备
使用氯化钙溶液浸渍上述复合材料，搅拌均匀，调节pH至碱性，添加右旋泛酸钙、L-赖氨酸、烟酰胺后搅拌均匀，过滤、洗涤、烘干，得到改性复合材料，即组分A；
所述组分B的制备方法如下：
使用氯化镁溶液浸渍羟基磷灰石，搅拌均匀，调节pH至碱性，添加氯化锶搅拌均匀，过滤、洗涤、烘干，得到改性羟基磷灰石，即组分B；
所述组分C为氢化钙；
将组分A、组分B、组分C充分混合均匀，得到功能辅助成分。
优选的，所述组分A、组分B、组分C的混合重量比例为1：(0.5-2)：(0.1-0.2)。
优选的，所述茉莉花提取物的制备方法如下：
取新鲜茉莉花在120℃条件下杀青5min，50℃干燥10min，研磨至过100目筛，得茉莉花粉；
按固液比1:10的质量比将茉莉花粉分散在水中，在15MPa条件下处理5min，加入茉莉花粉质量0.1％的十二烷基硫酸钠搅拌混合均匀，60℃提取10min，5000rpm离心5min、过滤，取滤液A；
向滤液A中加入无水乙醇至含醇量30％，搅拌均匀后4℃静置1h，过滤，去除沉淀，得滤液B，90℃减压蒸馏，得到茉莉花提取物。
优选的，所述忍冬花提取物的制备方法如下：
取新鲜忍冬花在120℃条件下杀青5min，50℃干燥10min，研磨至过100目筛，得忍冬花粉；
按固液比1:10的质量比将忍冬花粉分散在水中，在15MPa条件下处理5min，加入忍冬花粉质量0.1％的十二烷基硫酸钠搅拌混合均匀，60℃提取10min，5000rpm离心5min、过滤，取滤液C；
向滤液C中加入无水乙醇至含醇量30％，搅拌均匀后4℃静置1h，过滤，去除沉淀，得滤液D，90℃减压蒸馏，得到忍冬花提取物。
本发明还提供一种银耳多糖洁牙护理液制备工艺，按照质量份计算，将乙二胺四乙酸二钠、十二烷基硫酸钠、甘草酸二钾，纯化水按照配比在85℃乳化、保温20min，降温至60℃，按配比添加C8-16烷基糖苷、丙二醇、薄荷脑、对羟基苯甲酸甲酯、聚甘油-10月桂酸酯、丹皮酚、柠檬酸搅拌均匀，降温至50℃，按配比添加西吡氯铵、功能辅助成分搅拌均匀，降温至45℃，按配比添加银耳多糖、糖精钠、茉莉花提取物搅拌均匀，接着按配比加入氨甲环酸、忍冬花提取物搅拌均匀，灌装，得到银耳多糖洁牙护理液。
有益效果：
1、本发明的洁牙护理液中加入了功能辅助成分，能够有效的降低牙龈指数和牙本质敏感程度，在动物实验中可知，采用实施例1的配方的洁牙护理液产生了很好的效果，使用两周后的牙龈指数降低至0，牙本质敏感程度降低至0.1，在人体临床试验中也产生了很好的效果，有94％的患者，牙本质敏感程度降低至0-0.5。
2、本发明的功能辅助成分包括组分A，在碱性条件下将右旋泛酸钙、L-赖氨酸、烟酰胺填充在碳纳米管-壳聚糖多孔复合材料的内部空隙中，组分A能够很好的与牙组织黏附，减少牙髓神经刺激，抑制牙石、菌斑的形成，结合西吡氯铵、氨甲环酸的使用，能够明显的提高口腔内部清洁能力，降低牙石、菌斑的产生，起到抑菌消炎的效果，再通过右旋泛酸钙、L-赖氨酸、烟酰胺营养牙齿，使牙齿再矿化，增加牙齿的耐酸性，提高抗敏作用，能够预防或辅助治疗牙周炎引起的牙龈萎缩。
3、本发明的功能辅助成分包括组分B，在碱性条件下将氯化锶填充在羟基磷灰石的内部空隙中，组分B能够很好的与牙组织黏附，通过吸附内源性锶盐、钙磷成为牙本质矿物质阻塞牙本质小管，用于降低治疗牙本质敏感，促进牙本质小管再修复。
4、本发明的功能辅助成分包括组分C，组分C为氢化钙，氢化钙在口腔中遇水会分解，产生微量的氢气和钙离子，氢气可以调节碳纳米管-壳聚糖多孔复合材料和羟基磷灰石空隙中功能物质的释放速度，使功能物质可以在口腔中长时间的保持有效浓度，产生了协同增效的配合作用，使得牙齿长时间处于保护状态。
5、本发明的牙膏中使用了银耳多糖、茉莉花提取物、忍冬花提取物气味清洗，香味宜人，具有很好的使用体验。
具体实施方式
制备例1
功能辅助成分的制备，所述功能辅助成分包括组分A、组分B和组分C，所述组分A的制备方法如下：
复合材料的制备
将50g碳纳米管分批(每批10g)加入浓硝酸、浓硫酸(体积比3:1，总体积400ml)混合体系中拌均匀，加热至70℃、超声处理2h，冷却后过滤、蒸馏水洗涤、60℃烘干，得到酸化的碳纳米管，将30g酸化的碳纳米管分散到1000ml无水乙醇中，加入50g壳聚糖，加热至50℃、超声处理1h，过滤、无水乙醇洗涤、60℃烘干，得到碳纳米管-壳聚糖复合材料；
改性复合材料的制备
使用500ml质量分数为10％氯化钙溶液浸渍上述50g复合材料，1000rpm搅拌30min，搅拌状态下滴加氨水调节pH至9，添加10g右旋泛酸钙、5gL-赖氨酸、2g烟酰胺后搅拌2h，过滤、无水乙醇洗涤、50℃烘干，得到改性复合材料，即组分A；
所述组分B的制备方法如下：
使用500ml质量分数为5％氯化镁溶液浸渍50g羟基磷灰石，搅拌状态下滴加氨水调节pH至9，添加10g氯化锶搅拌2h，过滤、无水乙醇洗涤、60℃烘干，得到改性羟基磷灰石，即组分B；
所述组分C为氢化钙；
将20g组分A、10g组分B、1g组分C充分混合均匀，得到功能辅助成分。
制备例2
茉莉花提取物的制备方法如下：
取新鲜茉莉花在120℃条件下杀青5min，50℃干燥10min，研磨至过100目筛，得茉莉花粉；
按固液比1:10的质量比将50g茉莉花粉分散在500ml水中，在15MPa条件下处理5min，加入茉莉花粉质量0.1％的十二烷基硫酸钠搅拌混合均匀，60℃提取10min，5000rpm离心5min、过滤，取滤液A；
向滤液A中加入无水乙醇至含醇量30％，搅拌均匀后4℃静置1h，过滤，去除沉淀，得滤液B，90℃减压蒸馏，得到茉莉花提取物。
制备例3
忍冬花提取物的制备方法如下：
取新鲜忍冬花在120℃条件下杀青5min，50℃干燥10min，研磨至过100目筛，得忍冬花粉；
按固液比1:10的质量比将50g忍冬花粉分散在水中，在15MPa条件下处理5min，加入忍冬花粉质量0.1％的十二烷基硫酸钠搅拌混合均匀，60℃提取10min，5000rpm离心5min、过滤，取滤液C；
向滤液C中加入无水乙醇至含醇量30％，搅拌均匀后4℃静置1h，过滤，去除沉淀，得滤液D，90℃减压蒸馏，得到忍冬花提取物。
实施例1
一种银耳多糖洁牙护理液制备工艺，按照质量份计算，将乙二胺四乙酸二钠0.1份、十二烷基硫酸钠0.5份、甘草酸二钾0.1份，适量纯化水(补足100份)在85℃乳化、保温20min，降温至60℃，添加C8-16烷基糖苷20份、丙二醇10份、薄荷脑0.1份、对羟基苯甲酸甲酯1份、聚甘油-10月桂酸酯2份、丹皮酚0.1份、柠檬酸0.5份搅拌均匀，降温至50℃，按配比添加西吡氯铵0.1份、功能辅助成分3份搅拌均匀，降温至45℃，按配比添加银耳多糖1份、糖精钠0.5份、茉莉花提取物0.1份搅拌均匀，接着按配比加入氨甲环酸0.5份、忍冬花提取物0.5份搅拌均匀，灌装，得到含银耳多糖的洁牙护理液。
实施例2
本实施例与实施例1不同之处在于“功能辅助成分0.5份”，其余部分与实施例1完全相同。
实施例3
本实施例与实施例1不同之处在于“功能辅助成分1份”，其余部分与实施例1完全相同。
实施例3
本实施例与实施例1不同之处在于“功能辅助成分2份”，其余部分与实施例1完全相同。
实施例4
本实施例与实施例1不同之处在于“功能辅助成分4份”，其余部分与实施例1完全相同。
实施例5
本实施例与实施例1不同之处在于“功能辅助成分5份”，其余部分与实施例1完全相同。
实施例6
一种银耳多糖洁牙护理液制备工艺，按照质量份计算，将乙二胺四乙酸二钠0.05份、十二烷基硫酸钠0.1份、甘草酸二钾0.05份，适量纯化水(补足100份)在85℃乳化、保温20min，降温至60℃，添加C8-16烷基糖苷15份、丙二醇5份、薄荷脑0.05份、对羟基苯甲酸甲酯0.1份、聚甘油-10月桂酸酯1份、丹皮酚0.05份、柠檬酸0.01份搅拌均匀，降温至50℃，按配比添加西吡氯铵0.05份、功能辅助成分3份搅拌均匀，降温至45℃，按配比添加银耳多糖0.1份、糖精钠0.1份、茉莉花提取物0.05份搅拌均匀，接着按配比加入氨甲环酸0.05份、忍冬花提取物0.05份搅拌均匀，灌装，得到银耳多糖洁牙护理液。
实施例7
一种银耳多糖洁牙护理液制备工艺，按照质量份计算，将乙二胺四乙酸二钠0.15份、十二烷基硫酸钠1.00份、甘草酸二钾0.15份，适量纯化水(补足100份)在85℃乳化、保温20min，降温至60℃，添加C8-16烷基糖苷35份、丙二醇15份、薄荷脑0.25份、对羟基苯甲酸甲酯1.5份、聚甘油-10月桂酸酯3份、丹皮酚0.15份、柠檬酸1.00份搅拌均匀，降温至50℃，按配比添加西吡氯铵0.015份、功能辅助成分3份搅拌均匀，降温至45℃，按配比添加银耳多糖1.5份、糖精钠1.00份、茉莉花提取物0.25份搅拌均匀，接着按配比加入氨甲环酸1.00份、忍冬花提取物1.00份搅拌均匀，灌装，得到银耳多糖洁牙护理液。
对比例1
本实施例与实施例1不同之处在于“功能辅助成分0份”，其余部分与实施例1完全相同。
对比例2
本实施例与实施例1不同之处在于“功能辅助成分10份”，其余部分与实施例1完全相同。
一、牙周炎治疗效果试验
牙周炎动物模型：6-8周龄的雄性C57BL/6J小鼠先适应性喂养一周，第8天进行牙周炎造模。配制7％质量体积的水合氯醛，按0.5mL/100g的剂量腹腔注射麻醉小鼠。置小鼠于固定器，悬吊下颌，暴露口腔，显露上颌后牙，显微外科镊将5-0的慕斯线结扎于小鼠双侧上颌第二磨牙颈部，舌侧打结，饮用15％高糖水，使其形成牙周炎，造模2周后，经牙周炎临床指标检测，筛选出牙龈指数为1.8的小鼠70只，去除丝线后，随机分成10组，其中7组为实验组、2组为对比组，1组为空白组；
实验方法：实验组1-7小鼠适配实施例1-7制备的洁牙护理液(例如试验组1对应实施例1的洁牙护理液，试验组2对应实施例2的洁牙护理液)，每日上、下午牙龈局部涂抹洁牙护理液，涂抹厚度为0.1-0.2mm，给药时间为2min，连续给药3周。对比组1、2小鼠适配对比例1、2的牙膏，按照同法涂抹洁牙护理液，空白组按照同法涂抹蒸馏水，在涂抹洁牙护理液前、涂抹洁牙护理液后1周和2周，检测牙龈指数和牙本质敏感程度，结果见表1。
牙龈指数：采用GI分析牙龈颜色和质的改变，评价标准：0＝无炎症；1＝轻度炎症,探诊无出血,牙龈色泽和质地略有变化；2＝中度炎症,探诊出血,牙龈光亮,红肿、增生；3＝重度炎症，牙龈有自发性出血,明显发红、增生；
牙本质敏感程度：采用Schiff冷空气敏感指数评估牙本质敏感度程度：0＝刺激时不引起疼痛；1＝可诱发轻度疼痛或不适；2＝可诱发明显疼痛，停止刺激后不引发疼痛；3＝可诱发剧烈疼痛，停止刺激后仍疼痛。
表1
从表1中可知，本发明制备的洁牙护理液可以有效的降低牙龈指数，其中效果最好的是实施例1制备的洁牙护理液，一周后牙龈指数降低至0.8，两周后牙龈指数降至0，牙龈指数的降低带来了牙本质敏感程度的降低，相对比对比例和对照组，使用了本发明实施例1-7的洁牙护理液，牙本质敏感程度均产生了明显得降低，效果最好的是实施例1制备的洁牙护理液，一周后牙本质敏感程度降低至1.0，两周后牙龈指数降至0.1。
二、实施例1制备的洁牙护理液临床效果检测
选取2022年10月-12月就诊于某口腔医院的患者50名，牙龈指数在2.0，全身健康状况良好、无重要的全身系统性疾病，年龄在18周岁-60周岁。每人每天早晚各1次，每次2克牙膏，刷牙3分钟。持续使用2周。结果见表2。
表2
| 牙本质敏感程度 | 人数 |
| 0-0.5 | 47 |
| 0.6-1.0 | 2 |
| 1.1-1.5 | 1 |
| 1.6-2.0 | 0 |
从表2中可知，本发明制备的洁牙护理液临床效果非常好，所有的患者均产生了不同程度的改善，94％的患者牙本质敏感程度降低至0-0.5。
以上所述，仅为本发明较佳的具体实施方式，但本发明的保护范围并不局限于此，任何熟悉本技术领域的技术人员在本发明揭露的技术范围内，根据本发明的技术方案及其发明构思加以等同替换或改变，都应涵盖在本发明的保护范围之内。
Claims (6)
1.一种银耳多糖洁牙护理液，其特征在于，按照重量份计算包括如下组分原料：乙二胺四乙酸二钠0.05-0.15份、十二烷基硫酸钠0.10-1.00份、甘草酸二钾0.05-0.15份、C8-16烷基糖苷15.00-35.00份、丙二醇5.00-15.00份、薄荷脑0.05-0.25份、对羟基苯甲酸甲酯0.01-1.50份、聚甘油-10月桂酸酯1.00-3.00份、丹皮酚0.05-0.15份、柠檬酸0.10-1.00份、西吡氯铵0.05-0.15份、功能辅助成分0.5-5份、银耳多糖0.01-1.50份、糖精钠0.10-1.00份、茉莉花提取物0.05-0.25份、氨甲环酸0.05-1.00份、忍冬花提取物0.05-1.00份，纯化水补充至100份。
2.根据权利要求1所述的一种银耳多糖洁牙护理液，其特征在于，所述功能辅助成分包括组分A、组分B和组分C，所述组分A的制备方法如下：
复合材料的制备
将碳纳米管加入浓硝酸、浓硫酸混合体系中拌均匀，加热、超声处理，冷却后过滤、洗涤、烘干，得到酸化的碳纳米管，将酸化的碳纳米管分散到无水乙醇中，加入壳聚糖，加热、超声处理，过滤、洗涤、烘干，得到碳纳米管-壳聚糖复合材料；
改性复合材料的制备
使用氯化钙溶液浸渍上述复合材料，搅拌均匀，调节pH至碱性，添加右旋泛酸钙、L-赖氨酸、烟酰胺后搅拌均匀，过滤、洗涤、烘干，得到改性复合材料，即组分A；
所述组分B的制备方法如下：
使用氯化镁溶液浸渍羟基磷灰石，搅拌均匀，调节pH至碱性，添加氯化锶搅拌均匀，过滤、洗涤、烘干，得到改性羟基磷灰石，即组分B；
所述组分C为氢化钙；
将组分A、组分B、组分C充分混合均匀，得到功能辅助成分。
3.根据权利要求1所述的一种银耳多糖洁牙护理液，其特征在于，所述组分A、组分B、组分C的混合重量比例为1：(0.5-2)：(0.1-0.2)。
4.根据权利要求1所述的一种银耳多糖洁牙护理液，其特征在于，所述茉莉花提取物的制备方法如下：
取新鲜茉莉花在120℃条件下杀青5min，50℃干燥10min，研磨至过100目筛，得茉莉花粉；
按固液比1:10的质量比将茉莉花粉分散在水中，在15MPa条件下处理5min，加入茉莉花粉质量0.1％的十二烷基硫酸钠搅拌混合均匀，60℃提取10min，5000rpm离心5min、过滤，取滤液A；
向滤液A中加入无水乙醇至含醇量30％，搅拌均匀后4℃静置1h，过滤，去除沉淀，得滤液B，90℃减压蒸馏，得到茉莉花提取物。
5.根据权利要求1所述的一种银耳多糖洁牙护理液，其特征在于，所述忍冬花提取物的制备方法如下：
取新鲜忍冬花在120℃条件下杀青5min，50℃干燥10min，研磨至过100目筛，得忍冬花粉；
按固液比1:10的质量比将忍冬花粉分散在水中，在15MPa条件下处理5min，加入忍冬花粉质量0.1％的十二烷基硫酸钠搅拌混合均匀，60℃提取10min，5000rpm离心5min、过滤，取滤液C；
向滤液C中加入无水乙醇至含醇量30％，搅拌均匀后4℃静置1h，过滤，去除沉淀，得滤液D，90℃减压蒸馏，得到忍冬花提取物。
6.一种银耳多糖洁牙护理液制备工艺，其特征在于，按照质量份计算，将乙二胺四乙酸二钠、十二烷基硫酸钠、甘草酸二钾，纯化水按照配比在85℃乳化、保温20min，降温至60℃，按配比添加C8-16烷基糖苷、丙二醇、薄荷脑、对羟基苯甲酸甲酯、聚甘油-10月桂酸酯、丹皮酚、柠檬酸搅拌均匀，降温至50℃，按配比添加西吡氯铵、功能辅助成分搅拌均匀，降温至45℃，按配比添加银耳多糖、糖精钠、茉莉花提取物搅拌均匀，接着按配比加入氨甲环酸、忍冬花提取物搅拌均匀，灌装，得到银耳多糖洁牙护理液。
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20070010469A (ko) * | 2005-07-19 | 2007-01-24 | 전북대학교산학협력단 | 카본나노튜브-키토산 복합체 및 그의 제조방법 |
| CN103462847A (zh) * | 2013-09-18 | 2013-12-25 | 韩秀英 | 一种口腔护理用漱口液 |
| CN106389205A (zh) * | 2016-10-31 | 2017-02-15 | 广东科玮生物技术股份有限公司 | 一种含有叶绿素铜钠盐的漱口水 |
| CN109568193A (zh) * | 2017-09-28 | 2019-04-05 | 刘琼 | 一种含金银花提取物的漱口水 |
| CN113893213A (zh) * | 2021-11-29 | 2022-01-07 | 福建省梦娇兰日用化学品有限公司 | 防龋齿儿童牙膏及其制备方法 |
| CN114159320A (zh) * | 2021-12-17 | 2022-03-11 | 上海纳米技术及应用国家工程研究中心有限公司 | 一种漱口液 |
| KR20220117720A (ko) * | 2021-02-17 | 2022-08-24 | 충남대학교산학협력단 | 하이드록시 아파타이트를 포함하는 분말형 구강청결제 |
-
2023
- 2023-03-17 CN CN202310259888.XA patent/CN116211768A/zh active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20070010469A (ko) * | 2005-07-19 | 2007-01-24 | 전북대학교산학협력단 | 카본나노튜브-키토산 복합체 및 그의 제조방법 |
| CN103462847A (zh) * | 2013-09-18 | 2013-12-25 | 韩秀英 | 一种口腔护理用漱口液 |
| CN106389205A (zh) * | 2016-10-31 | 2017-02-15 | 广东科玮生物技术股份有限公司 | 一种含有叶绿素铜钠盐的漱口水 |
| CN109568193A (zh) * | 2017-09-28 | 2019-04-05 | 刘琼 | 一种含金银花提取物的漱口水 |
| KR20220117720A (ko) * | 2021-02-17 | 2022-08-24 | 충남대학교산학협력단 | 하이드록시 아파타이트를 포함하는 분말형 구강청결제 |
| CN113893213A (zh) * | 2021-11-29 | 2022-01-07 | 福建省梦娇兰日用化学品有限公司 | 防龋齿儿童牙膏及其制备方法 |
| CN114159320A (zh) * | 2021-12-17 | 2022-03-11 | 上海纳米技术及应用国家工程研究中心有限公司 | 一种漱口液 |
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