CN113893213A - 防龋齿儿童牙膏及其制备方法 - Google Patents
防龋齿儿童牙膏及其制备方法 Download PDFInfo
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Abstract
本发明公开了防龋齿儿童牙膏及其制备方法，包括下列重量份数的组分：厚朴12‑20份、茶多酚6‑12份、山茶花提取物10‑15份、金银花提取物8‑12份、松花粉8‑12份、乳清蛋白6‑10份、蜂胶提取物0.5‑1.5份、复合氨基酸3‑6份、薄荷醇1‑3份、山梨糖醇6‑8份、甘油6‑9份、银耳多糖1‑3份、硅石6‑10份、添加剂3‑7份和去离子水12‑20份。本发明涉及儿童牙膏技术领域，具体提供了一种可为牙釉质的发育提供丰富营养，且氟含量低的防龋齿儿童牙膏及其制备方法。
Description
技术领域
本发明涉及儿童牙膏技术领域，具体为防龋齿儿童牙膏及其制备方法。
背景技术
龋齿是一种由口腔中多种因素复合作用导致的牙齿硬组织进行性病损，表现为无机质脱矿和有机质分解，随病程发展而从色泽改变到形成实质性病损的演变过程。龋齿是细菌性疾病，因此它可以继发牙髓炎和根尖周炎，甚至能引起牙槽骨和颌骨炎症。儿童喜欢吃零食和甜食，很容易患龋病，3～6岁是儿童患龋的高峰期，该阶段牙间隙逐渐增加，易造成食物嵌塞，引发邻面龋。若不注重儿童口腔健康，很有可能导致儿童过早地出现牙齿龋坏、疼痛等口腔疾病。龋齿应以保健预防为主。
牙膏是洁牙制品的一种，一般呈凝胶状，通常会抹在牙刷上，借助牙刷的机械摩擦的作用清洁牙齿表面，对牙齿及其周边进行清洁，使口腔净化清爽，牙膏已成为人类日常生活的必需品。成人牙膏磨料硬度高、摩擦力大，容易损伤儿童正处于生长发育中钙化程度较低的牙齿表面；配方成分没有针对性，某些成分可能会破坏儿童娇嫩的口腔生态环境，而大部分含氟牙膏的氟剂量相对于儿童而言明显偏高，对孩子健康存在安全隐患。因此，儿童刷牙最好使用儿童专用牙膏，而不宜使用成人牙膏。
虽然目前市面上存在多种儿童用防龋齿牙膏，但是目前所用的防龋药物主要是含氟化合物，包含氟化钠、氟化亚锡和酸性磷酸氟，但是长期使用高含氟牙膏会引起氟牙症和氟骨症等。
发明内容
针对上述情况，为弥补上述现有缺陷，本发明提供了一种可为牙釉质的发育提供丰富营养，且氟含量低的防龋齿儿童牙膏及其制备方法。
本发明提供如下的技术方案：本发明提出的防龋齿儿童牙膏，包括下列重量份数的组分：厚朴12-20份、茶多酚6-12份、山茶花提取物10-15份、金银花提取物8-12份、松花粉8-12份、乳清蛋白6-10份、蜂胶提取物0.5-1.5份、复合氨基酸3-6份、薄荷醇1-3份、山梨糖醇6-8份、甘油6-9份、银耳多糖1-3份、硅石6-10份、添加剂3-7份和去离子水12-20份。
作为优选地，防龋齿儿童牙膏，包括下列重量份数的组分：厚朴14-18份、茶多酚8-10份、山茶花提取物12-13份、金银花提取物9-11份、松花粉9-11份、乳清蛋白7-9份、蜂胶提取物0.8-1.2份、复合氨基酸4-5份、薄荷醇1.5-2.5份、山梨糖醇6.5-7.5份、甘油7-8份、银耳多糖1.5-2.5份、硅石7-9份、添加剂4-6份和去离子水15-17份。
作为优选地，防龋齿儿童牙膏，包括下列重量份数的组分：厚朴16份、茶多酚9份、山茶花提取物12.5份、金银花提取物10份、松花粉10份、乳清蛋白8份、蜂胶提取物1份、复合氨基酸4.5份、薄荷醇2份、山梨糖醇7份、甘油7.5份、银耳多糖2份、硅石8份、添加剂5份和去离子水16份。
进一步地，所述复合氨基酸为丙氨酸、缬氨酸、异亮氨酸、天冬氨酸和精氨酸的组合物。
进一步地，所述添加剂包括增稠剂和发泡剂，所述增稠剂选用黄原胶和羧甲基纤维素中的一种或两种，所述发泡剂为月桂醇硫酸酯钠。
本发明防龋齿儿童牙膏的制备方法，具体包括下列步骤：
(1)将厚朴和松花粉清洗之后分别置于真空冷冻干燥机中冷冻干燥至含水率低于3％；
(2)将步骤(1)烘干得到的厚朴和松花粉放在粉碎碾磨机中粉碎碾磨，过1200目筛；
(3)将厚朴、茶多酚、山茶花提取物、金银花提取物、松花粉、乳清蛋白、蜂胶提取物、复合氨基酸和银耳多糖混合均匀，得到组合物A；
(4)将薄荷醇、山梨糖醇、甘油、硅石、添加剂和总质量10％的去离子水置入真空混合罐中，高速搅拌7-10min，之后加入组合物A以及剩余的去离子水，中速搅拌均匀；
(5)在真空度为-0.6Mpa条件下对真空混合罐抽真空，低速搅拌，10min后关闭真空泵，静置30-40min即可得到防龋齿儿童牙膏。
进一步地，步骤(4)所述高速搅拌速度为6000-8000r/min，步骤(4)所述中速搅拌速度为2500-4000r/min。
进一步地，步骤(5)所述低速搅拌速度为800-1000r/min。
采用上述结构本发明取得的有益效果如下：本发明提出的防龋齿儿童牙膏及其制备方法，通过添加含有多种氨基酸、维生素和微量元素的松花粉、复合氨基酸和银耳多糖，提高了牙膏的防护营养性能，为牙釉质的发育提供营养，有效预防口腔炎症；并通过天然的厚朴和茶多酚的添加替代了传统含氟化学物质，提高了牙膏的安全性；同时，通过山茶花提取物、金银花提取物、蜂胶提取物、的添加，使牙膏具有消炎、抗炎止痛的功能，且通过添加少了乳清蛋白，使牙膏具备清除幽门螺杆菌的功能，更适宜儿童使用。
具体实施方式
下面将结合本发明的实施例，对本发明的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例；基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
实施例1
防龋齿儿童牙膏，包括下列重量份数的组分：厚朴16份、茶多酚9份、山茶花提取物12.5份、金银花提取物10份、松花粉10份、乳清蛋白8份、蜂胶提取物1份、复合氨基酸4.5份、薄荷醇2份、山梨糖醇7份、甘油7.5份、银耳多糖2份、硅石8份、添加剂5份和去离子水16份。
其中，所述复合氨基酸为丙氨酸、缬氨酸、异亮氨酸、天冬氨酸和精氨酸的组合物。所述添加剂包括增稠剂和发泡剂，所述增稠剂选用黄原胶和羧甲基纤维素中的一种或两种，所述发泡剂为月桂醇硫酸酯钠。
本发明防龋齿儿童牙膏的制备方法，具体包括下列步骤：
(1)将厚朴和松花粉清洗之后分别置于真空冷冻干燥机中冷冻干燥至含水率低于3％；
(2)将步骤(1)烘干得到的厚朴和松花粉放在粉碎碾磨机中粉碎碾磨，过1200目筛；
(3)将厚朴、茶多酚、山茶花提取物、金银花提取物、松花粉、乳清蛋白、蜂胶提取物、复合氨基酸和银耳多糖混合均匀，得到组合物A；
(4)将薄荷醇、山梨糖醇、甘油、硅石、添加剂和总质量10％的去离子水置入真空混合罐中，7000r/min转速条件下搅拌7-10min，之后加入组合物A以及剩余的去离子水，3000r/min转速条件下搅拌均匀；
(5)在真空度为-0.6Mpa条件下对真空混合罐抽真空，900r/min搅拌10min后关闭真空泵，静置30-40min即可得到防龋齿儿童牙膏。
实施例2
防龋齿儿童牙膏，包括下列重量份数的组分：厚朴12份、茶多酚6份、山茶花提取物10份、金银花提取物8份、松花粉8份、乳清蛋白6份、蜂胶提取物0.5份、复合氨基酸3份、薄荷醇1份、山梨糖醇6份、甘油6份、银耳多糖1份、硅石6份、添加剂3份和去离子水12份。
其中，所述复合氨基酸为丙氨酸、缬氨酸、异亮氨酸、天冬氨酸和精氨酸的组合物。所述添加剂包括增稠剂和发泡剂，所述增稠剂选用黄原胶和羧甲基纤维素中的一种或两种，所述发泡剂为月桂醇硫酸酯钠。
本发明防龋齿儿童牙膏的制备方法，具体包括下列步骤：
(1)将厚朴和松花粉清洗之后分别置于真空冷冻干燥机中冷冻干燥至含水率低于3％；
(2)将步骤(1)烘干得到的厚朴和松花粉放在粉碎碾磨机中粉碎碾磨，过1200目筛；
(3)将厚朴、茶多酚、山茶花提取物、金银花提取物、松花粉、乳清蛋白、蜂胶提取物、复合氨基酸和银耳多糖混合均匀，得到组合物A；
(4)将薄荷醇、山梨糖醇、甘油、硅石、添加剂和总质量10％的去离子水置入真空混合罐中，7000r/min转速条件下搅拌7-10min，之后加入组合物A以及剩余的去离子水，3000r/min转速条件下搅拌均匀；
(5)在真空度为-0.6Mpa条件下对真空混合罐抽真空，900r/min搅拌，10min后关闭真空泵，静置30-40min即可得到防龋齿儿童牙膏。
实施例3
防龋齿儿童牙膏，包括下列重量份数的组分：厚朴20份、茶多酚12份、山茶花提取物15份、金银花提取物12份、松花粉12份、乳清蛋白10份、蜂胶提取物1.5份、复合氨基酸6份、薄荷醇3份、山梨糖醇8份、甘油9份、银耳多糖3份、硅石10份、添加剂7份和去离子水20份。
其中，所述复合氨基酸为丙氨酸、缬氨酸、异亮氨酸、天冬氨酸和精氨酸的组合物。所述添加剂包括增稠剂和发泡剂，所述增稠剂选用黄原胶和羧甲基纤维素中的一种或两种，所述发泡剂为月桂醇硫酸酯钠。
本发明防龋齿儿童牙膏的制备方法，具体包括下列步骤：
(1)将厚朴和松花粉清洗之后分别置于真空冷冻干燥机中冷冻干燥至含水率低于3％；
(2)将步骤(1)烘干得到的厚朴和松花粉放在粉碎碾磨机中粉碎碾磨，过1200目筛；
(3)将厚朴、茶多酚、山茶花提取物、金银花提取物、松花粉、乳清蛋白、蜂胶提取物、复合氨基酸和银耳多糖混合均匀，得到组合物A；
(4)将薄荷醇、山梨糖醇、甘油、硅石、添加剂和总质量10％的去离子水置入真空混合罐中，7000r/min转速条件下搅拌7-10min，之后加入组合物A以及剩余的去离子水，3000r/min转速条件下搅拌均匀；
(5)在真空度为-0.6Mpa条件下对真空混合罐抽真空，900r/min转速条件下搅拌，10min后关闭真空泵，静置30-40min即可得到防龋齿儿童牙膏。
征得家长的同意下，邀请40名3-8周岁的儿童作为受试者，20名儿童每天早晚仅采用清水漱口方式清洁牙齿(空白对照组)；20名儿童采用本发明提供的防龋齿儿童牙膏每天早晚两次刷牙(实验组)，测试周期为3个月。
3个月后，对儿童口腔进行检查，检查结果表明，实验组儿童口腔内的变形链球菌、放线菌属和乳杆菌和菌斑数量均明显少于空白对照组儿童口腔内的变形链球菌、放线菌属和乳杆菌和菌斑数量。
要说明的是，在本文中，诸如第一和第二等之类的关系术语仅仅用来将一个实体或者操作与另一个实体或操作区分开来，而不一定要求或者暗示这些实体或操作之间存在任何这种实际的关系或者顺序。而且，术语“包括”、“包含”或者其任何其他变体意在涵盖非排他性的包含，从而使得包括一系列要素的过程、方法、物料或者设备不仅包括那些要素，而且还包括没有明确列出的其他要素，或者是还包括为这种过程、方法、物料或者设备所固有的要素。
尽管已经示出和描述了本发明的实施例，对于本领域的普通技术人员而言，可以理解在不脱离本发明的原理和精神的情况下可以对这些实施例进行多种变化、修改、替换和变型，本发明的范围由所附权利要求及其等同物限定。
Claims (8)
1.防龋齿儿童牙膏，其特征在于，包括下列重量份数的组分：厚朴12-20份、茶多酚6-12份、山茶花提取物10-15份、金银花提取物8-12份、松花粉8-12份、乳清蛋白6-10份、蜂胶提取物0.5-1.5份、复合氨基酸3-6份、薄荷醇1-3份、山梨糖醇6-8份、甘油6-9份、银耳多糖1-3份、硅石6-10份、添加剂3-7份和去离子水12-20份。
2.根据权利要求1所述的防龋齿儿童牙膏，其特征在于，包括下列重量份数的组分：厚朴14-18份、茶多酚8-10份、山茶花提取物12-13份、金银花提取物9-11份、松花粉9-11份、乳清蛋白7-9份、蜂胶提取物0.8-1.2份、复合氨基酸4-5份、薄荷醇1.5-2.5份、山梨糖醇6.5-7.5份、甘油7-8份、银耳多糖1.5-2.5份、硅石7-9份、添加剂4-6份和去离子水15-17份。
3.根据权利要求1所述的防龋齿儿童牙膏，其特征在于，厚朴16份、茶多酚9份、山茶花提取物12.5份、金银花提取物10份、松花粉10份、乳清蛋白8份、蜂胶提取物1份、复合氨基酸4.5份、薄荷醇2份、山梨糖醇7份、甘油7.5份、银耳多糖2份、硅石8份、添加剂5份和去离子水16份。
4.根据权利要求1所述的防龋齿儿童牙膏，其特征在于，所述复合氨基酸为丙氨酸、缬氨酸、异亮氨酸、天冬氨酸和精氨酸的组合物。
5.根据权利要求1所述的防龋齿儿童牙膏，其特征在于，所述添加剂包括增稠剂和发泡剂，所述增稠剂选用黄原胶和羧甲基纤维素中的一种或两种，所述发泡剂为月桂醇硫酸酯钠。
6.根据权利要求1～5任一项所述的防龋齿儿童牙膏的制备方法，其特征在于，具体包括下列步骤：
(1)将厚朴和松花粉清洗之后分别置于真空冷冻干燥机中冷冻干燥至含水率低于3％；
(2)将步骤(1)烘干得到的厚朴和松花粉放在粉碎碾磨机中粉碎碾磨，过1200目筛；
(3)将厚朴、茶多酚、山茶花提取物、金银花提取物、松花粉、乳清蛋白、蜂胶提取物、复合氨基酸和银耳多糖混合均匀，得到组合物A；
(4)将薄荷醇、山梨糖醇、甘油、硅石、添加剂和总质量10％的去离子水置入真空混合罐中，高速搅拌7-10min，之后加入组合物A以及剩余的去离子水，中速搅拌均匀；
(5)在真空度为-0.6Mpa条件下对真空混合罐抽真空，低速搅拌，10min后关闭真空泵，静置30-40min即可得到防龋齿儿童牙膏。
7.根据权利要求6所述的防龋齿儿童牙膏的制备方法，其特征在于，步骤(4)所述高速搅拌速度为6000-8000r/min，步骤(4)所述中速搅拌速度为2500-4000r/min。
8.根据权利要求6所述的防龋齿儿童牙膏的制备方法，其特征在于，步骤(5)所述低速搅拌速度为800-1000r/min。
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| CN115554334A (zh) * | 2022-09-23 | 2023-01-03 | 拜斯特药业(广州)有限公司 | 可施用在牙齿上的具有舒缓效果的防龋齿涂膜剂及其制备方法 |
| CN116211768A (zh) * | 2023-03-17 | 2023-06-06 | 合肥贝壳派创新科技有限公司 | 一种银耳多糖洁牙护理液及其制备工艺 |
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