CN115624499A - 一种美白抗过敏牙膏 - Google Patents
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Abstract
本发明公开一种美白抗过敏牙膏,其包括纳米羟基磷灰石、壳寡糖、乳铁蛋白、生物溶菌酶、银桂提取物、金银花提取物、铁皮石斛提取物、水合硅石等,本发明的牙膏配方合理,其采用有效组分,可对牙斑进行有效的去除,并且其中羟基磷灰石可对牙釉质磨损进行有效修复,修复受损牙齿表面,不仅使得牙齿表面更为光滑,且对牙釉质受损导致的牙齿敏感的问题进行有效的改善;并且可对引起口臭等口腔问题的细菌进行有效的抑制,从根源上对口臭等口腔问题进行改善,并且所采用的银桂提取物、金银花提取物、铁皮石斛提取物等中药成份,杀菌消炎,可对牙龈出血等问题进行改善,并且还具有提香等效果,使得口气更为清新自然。
Description
技术领域
本发明涉及牙膏技术领域,尤其涉及一种美白抗过敏牙膏。
背景技术
牙釉质是牙冠外层的白色半透明的钙化程度最高的坚硬组织,牙釉质内部并不具神经与血管,它的功用除了咬碎食物之外,也可以保护下层的牙本质,是人体中最坚硬的物质,它保护着牙齿内部的牙本质和牙髓组织。健康的牙釉质表面存在一个微弱的化学反应,处于平衡状态,通过钙离子在牙齿表面的流失与补充,实现釉质的自我修复功能。牙釉质作为牙齿的最外层,牙釉质承受着各种物理和化学侵蚀,例如咬合、磨擦、磨损以及来自饮食和细菌产生的酸蚀。牙釉质受损严重,会导致牙本质上的牙小管暴露在外使得牙本质对冷热酸甜或者机械刷牙动作等产生刺激发生的疼痛,从而引起牙齿敏感。
目前针对牙釉质受损导致的敏感的技术主要有:一、阻塞牙本质小管;二、通过钾离子降低牙髓神经的敏感性。方式二的技术存在不能真正隔绝外界刺激,只能短期麻痹神经,不能有长远持续的疗效。
而目前人们其他常见的口腔问题,也多与口腔细菌有关,例如口腔细菌摄取糖后所产生的酸能够导致蛀牙;由口腔细菌所产生的毒素,可导致牙龈出血;此外;这些细菌的代谢废物还可导致牙结石及口臭等。口臭不仅仅是牙齿不健康的表现,更是人们职场上、社交生活的一大尴尬,长期的口腔异味甚至会导致社交自卑,甚至情绪长期低落,身心健康受到很大影响。造成口臭的原因非常复杂,研究表明,80~90%的口臭来源于口腔,由于舌背的表面积大,有许多乳头、沟裂和凹陷,有利于细菌、口腔黏膜脱落上皮,实物残渣等的滞留,充当了“细菌储藏室”,细菌进行发酵产生挥发性硫化物,其中90%为硫化氢和甲硫醇,是产生口腔异味的主要原因。因此,对于某些口腔问题必须从源头除菌抑菌以进行解决。
刷牙是人们保持口腔清洁、保护牙齿健康的一种日常生活方式,刷牙用的牙膏也就成为了日常生活中的必需用品。通常,牙膏主要由摩擦剂、表面活性剂、粘合剂、保湿剂、香味剂等成分制成。牙膏产品除了达到日常的清洁口腔作用,还会通过添加不同的功效成分来达到不同的效果,但目前有些药膏的功效单一,无法对多数的口腔问题进行有效解决。
发明内容
因此,基于以上背景,本发明对现有技术改进,提供一种美白抗过敏牙膏,可针对多种口腔问题进行有效的改善。
本发明提供的技术方案为:
一种美白抗过敏牙膏,其包括如下组分及其重量百分数:
纳米羟基磷灰石4-12%、壳寡糖0.5-5%、乳铁蛋白0.1-0.5%、生物溶菌酶0.01-0.5%、银桂提取物0.5-3%、金银花提取物0.5-5%、铁皮石斛提取物0.1-3%、水合硅石15-22%、山梨糖醇52-58%、植物多肽0.1-0.5%、蜂胶0.1-0.5%、聚乙二醇-400 5-10%、月桂醇硫酸酯钠2-3%、薄荷醇0.1-0.5%、羧甲基纤维素钠0.5-3%、黄原胶0.3-0.6%、益生菌0.1-0.5%、植酸0.1-0.5%、木糖醇0.1-0.5%、三氯生0.05%~0.15%、纯化水余量。
优选地,其包括如下组分及其重量百分数:
纳米羟基磷灰石5-10%、壳寡糖0.5-2%、乳铁蛋白0.1-0.2%、生物溶菌酶0.01-0.02%、银桂提取物1-1.5%、金银花提取物1-3%、铁皮石斛提取物0.1-3%、水合硅石15-22%、山梨糖醇52-58%、植物多肽0.05-0.15%、蜂胶0.1-0.5%、聚乙二醇-400 8-10%、月桂醇硫酸酯钠2-3%、薄荷醇0.1-0.5%、羧甲基纤维素钠0.8-1.2%、黄原胶0.3-0.6%、益生菌0.1-0.5%、植酸0.1-0.5%、木糖醇0.15-0.25%、三氯生0.05%~0.15%、纯化水余量。
优选地,其包括如下组分及其重量百分数:
纳米羟基磷灰石10%、壳寡糖1%、乳铁蛋白0.1%、生物溶菌酶0.02%、银桂提取物1%、金银花提取物2%、铁皮石斛提取物2%、水合硅石25%、山梨糖醇55%、植物多肽0.15%、蜂胶0.1%、聚乙二醇-40010%、月桂醇硫酸酯钠3%、薄荷醇0.15%、羧甲基纤维素钠1%、黄原胶0.3%、益生菌0.1%、植酸0.1%、木糖醇0.2%、三氯生0.15%、纯化水余量。
优选地,其包括如下组分及其重量百分数:
纳米羟基磷灰石10%、壳寡糖1%、乳铁蛋白0.1%、生物溶菌酶0.02%、银桂提取物1.5%、金银花提取物2%、铁皮石斛提取物2%、水合硅石25%、山梨糖醇52%、植物多肽0.15%、蜂胶0.1%、聚乙二醇-40010%、月桂醇硫酸酯钠2%、薄荷醇0.15%、羧甲基纤维素钠1%、黄原胶0.5%、益生菌0.1%、植酸0.1%、木糖醇0.25%、三氯生0.05%、纯化水余量。
优选地,所述纳米羟基磷灰石的粒径<60nm。
本发明中采用的羟基磷灰石是人体骨骼和牙齿的主要组成,牙釉质中羟基磷灰石的含量在96%以上。羟基磷灰石具有优良的生物相容性,并可作为一种骨骼或牙齿的诱导因子,在口腔保健领域中对牙齿具有较好的再矿化、脱敏以及美白作用。而本发明所采用的纳米羟基磷灰石可对牙本质小管进行封堵,对脱矿的牙釉质进行修复,以改善牙釉质受损导致的牙齿敏感的问题;
壳寡糖抗菌消炎,可消除牙龈炎症,抑制牙龈出血,增强牙龈免疫力,维持牙龈血管壁厚度;还能有效的修复受损口腔黏膜,增强口腔黏膜抵抗力细菌,炎症的入侵。
乳铁蛋白杀菌抗菌,对幽门螺旋杆菌在体内体外具有一定的抑制作用,在一定程度上可对口臭等问题进行改善。
生物溶菌酶能够有效清除口腔内的有害菌,从而抑制牙菌斑、牙结石的形成,减缓口腔溃疡、牙龈出血、牙周炎等口腔问题的进程,还可以避免口腔异味、牙垢堆积和色渍沉积。
银桂提取物抗菌消炎,并且具有一定的提香作用,可有效的针对口臭及其牙痛进行治疗,又可在本发明牙膏中作为香精。
金银花提取物清火抗菌、抗炎,铁皮石斛提取物通络止痛,消肿,清新口气,可有效改善口臭及其牙龈出血等口腔问题。
水合硅石具有良好的耐磨系数,作为摩擦剂,在对牙齿磨损系数降到最低的前提下,可对牙齿表面进行有效的清洁,去除牙齿色斑。
山梨糖醇、聚乙二醇在本发明牙膏中作润湿剂。
月桂醇硫酸酯钠在本发明牙膏中作发泡剂,其洁净作用;
植酸可美白牙齿,且可有助于去除牙齿污渍;
羧甲基纤维素钠、黄原胶在本发明牙膏中作增稠剂。
木糖醇即作为甜味剂,又具有预防龋齿的作用,还能够减少牙斑的产生;
三氯生具有抗菌和抗真菌作用,可以有效减少牙斑菌、牙龈炎症和牙龈出血。
薄荷醇具有杀菌抑菌的租用,可缓解牙痛,滋养牙龈;
益生菌是一种具有抑菌作用,且对人体有益的微生物。
蜂胶不仅具有一定的抑菌作用,并且还可对口腔粘膜具有一定的保护作用。
采用本发明可实现的有益效果如下:
本发明的牙膏配方合理,其采用有效组分,可对牙斑进行有效的去除,并且其中羟基磷灰石可对牙釉质磨损进行有效修复,修复受损牙齿表面,不仅使得牙齿表面更为光滑,且对牙釉质受损导致的牙齿敏感的问题进行有效的改善;并且可对引起口臭等口腔问题的细菌进行有效的抑制,从根源上对口臭等口腔问题进行改善,并且所采用的银桂提取物、金银花提取物、铁皮石斛提取物等中药成份,杀菌消炎,可对牙龈出血等问题进行改善,并且还具有提香等效果,使得口气更为清新自然。
具体实施方式
现将详细地提供本发明实施方式的参考,其一个或多个实例描述于下文。提供每一实例作为解释而非限制本发明。实际上,对本领域技术人员而言,显而易见的是,可以对本发明进行多种修改和变化而不背离本发明的范围或精神。例如,作为一个实施方式的部分而说明或描述的特征可以用于另一实施方式中,来产生更进一步的实施方式。
因此,旨在本发明覆盖落入所附权利要求的范围及其等同范围中的此类修改和变化。本发明的其它对象、特征和方面公开于以下详细描述中或从中是显而易见的。本领域普通技术人员应理解本讨论仅是示例性实施方式的描述,而非意在限制本发明更广阔的方面。下面结合实施例对本发明做进一步说明。
实施例1:一种美白抗过敏牙膏,其包括如下组分及其重量百分数:纳米羟基磷灰石10%、壳寡糖1%、乳铁蛋白0.1%、生物溶菌酶0.02%、银桂提取物1%、金银花提取物2%、铁皮石斛提取物2%、水合硅石25%、山梨糖醇55%、植物多肽0.15%、蜂胶0.1%、聚乙二醇-400 10%、月桂醇硫酸酯钠3%、薄荷醇0.15%、羧甲基纤维素钠1%、黄原胶0.3%、益生菌0.1%、植酸0.1%、木糖醇0.2%、三氯生0.15%、纯化水余量。
实施例2:一种美白抗过敏牙膏,其包括如下组分及其重量百分数:
纳米羟基磷灰石10%、壳寡糖1%、乳铁蛋白0.1%、生物溶菌酶0.02%、银桂提取物1.5%、金银花提取物2%、铁皮石斛提取物2%、水合硅石25%、山梨糖醇52%、植物多肽0.15%、蜂胶0.1%、聚乙二醇-40010%、月桂醇硫酸酯钠2%、薄荷醇0.15%、羧甲基纤维素钠1%、黄原胶0.5%、益生菌0.1%、植酸0.1%、木糖醇0.25%、三氯生0.05%、纯化水余量。
实施例3:美白效果实验
选取50例牙齿有外源性色斑的志愿者,年龄在21-55岁,其中男性有32名,女性有18名。
志愿者采用本发明实施例1采用常规方法制成的牙膏记性刷牙,早、晚各刷一次,每次刷牙不低于1min,临床检查于基线,分别在4周、8周后,进行检查,结果见下:
评价方法:牙齿色斑采用Lobene色斑指数进行评价,用0~3的数字来评价色斑部位的大小和色斑程度。
Lobene色斑指数分级计分:
0:无色斑存在;
1:色斑不超过牙面的1/3,轻度色斑(黄色或黄褐色);
2:色斑不超过牙面的2/3,中度色斑(中等程度的棕色);
3:色斑大于牙面的2/3,重度色斑(深棕色或黑色);
结果见下:
从上可以看出,本申请的牙膏具有明显的美白效果。
实施例4:脱敏测试
(1)选取30例由于牙釉质受损导致的牙本质敏感的志愿者,年龄在21岁至65岁之间,其中男性18例,女性12例,采用本发明实施例1采用常规方法制备的牙膏,早、晚各刷一次,每次刷牙不低于1min,持续15天后,观察疗效,其中3例患者症状消失,22例均有不同程度的减轻,5例无效,有效率72.3%。
疗效标准:
消失:无牙本质过敏症状;
缓解:牙本质过敏症状有所减轻;
无效:牙本质过敏症状无好转。
以上所述实施例的各技术特征可以进行任意的组合,为使描述简洁,未对上述实施例中的各个技术特征所有可能的组合都进行描述,然而,只要这些技术特征的组合不存在矛盾,都应当认为是本说明书记载的范围。
Claims (5)
1.一种美白抗过敏牙膏,其特征在于,其包括如下组分及其重量百分数:
纳米羟基磷灰石4-12%、壳寡糖0.5-5%、乳铁蛋白0.1-0.5%、生物溶菌酶0.01-0.5%、银桂提取物0.5-3%、金银花提取物0.5-5%、铁皮石斛提取物0.1-3%、水合硅石15-22%、山梨糖醇52-58%、植物多肽0.1-0.5%、蜂胶0.1-0.5%、聚乙二醇-400 5-10%、月桂醇硫酸酯钠2-3%、薄荷醇0.1-0.5%、羧甲基纤维素钠0.5-3%、黄原胶0.3-0.6%、益生菌0.1-0.5%、植酸0.1-0.5%、木糖醇0.1-0.5%、三氯生0.05%~0.15%、纯化水余量。
2.根据权利要求1所述的一种美白抗过敏牙膏,其特征在于,其包括如下组分及其重量百分数:
纳米羟基磷灰石5-10%、壳寡糖0.5-2%、乳铁蛋白0.1-0.2%、生物溶菌酶0.01-0.02%、银桂提取物1-1.5%、金银花提取物1-3%、铁皮石斛提取物0.1-3%、水合硅石15-22%、山梨糖醇52-58%、植物多肽0.05-0.15%、蜂胶0.1-0.5%、聚乙二醇-400 8-10%、月桂醇硫酸酯钠2-3%、薄荷醇0.1-0.5%、羧甲基纤维素钠0.8-1.2%、黄原胶0.3-0.6%、益生菌0.1-0.5%、植酸0.1-0.5%、木糖醇0.15-0.25%、三氯生0.05%~0.15%、纯化水余量。
3.根据权利要求2所述的一种美白抗过敏牙膏,其特征在于,其包括如下组分及其重量百分数:
纳米羟基磷灰石10%、壳寡糖1%、乳铁蛋白0.1%、生物溶菌酶0.02%、银桂提取物1%、金银花提取物2%、铁皮石斛提取物2%、水合硅石25%、山梨糖醇55%、植物多肽0.15%、蜂胶0.1%、聚乙二醇-40010%、月桂醇硫酸酯钠3%、薄荷醇0.15%、羧甲基纤维素钠1%、黄原胶0.3%、益生菌0.1%、植酸0.1%、木糖醇0.2%、三氯生0.15%、纯化水余量。
4.根据权利要求1所述的一种美白抗过敏牙膏,其特征在于,其包括如下组分及其重量百分数:
纳米羟基磷灰石10%、壳寡糖1%、乳铁蛋白0.1%、生物溶菌酶0.02%、银桂提取物1.5%、金银花提取物2%、铁皮石斛提取物2%、水合硅石25%、山梨糖醇52%、植物多肽0.15%、蜂胶0.1%、聚乙二醇-40010%、月桂醇硫酸酯钠2%、薄荷醇0.15%、羧甲基纤维素钠1%、黄原胶0.5%、益生菌0.1%、植酸0.1%、木糖醇0.25%、三氯生0.05%、纯化水余量。
5.根据权利要求1至4任一项所述的一种美白抗过敏牙膏,其特征在于,所述纳米羟基磷灰石的粒径<60nm。
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