CN116211765B - Anti-hair loss shampoo and preparation method thereof - Google Patents
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Abstract
The invention provides an anti-hair loss shampoo and a preparation method thereof, which belong to the technical field of shampoos and are prepared from the following raw materials in parts by weight: 3-5 parts of anti-drop essence, 0.2-0.5 part of guar hydroxypropyl trimethyl ammonium chloride, 1-1.2 parts of glycol distearate, 0.1-0.2 part of EDTA disodium, 1-2 parts of sodium chloride, 0.01-0.1 part of citric acid, 1-2 parts of glycerol, 0.1-0.4 part of panthenol, 1-2 parts of jojoba oil and 50-70 parts of deionized water. The anti-hair loss shampoo prepared by the invention can specifically kill scalp bacteria, microorganisms and the like, protect scalp health, has good anti-inflammation and antipruritic effects on the dermatitis, further realizes good hair loss inhibition and hair loss prevention effects, has wide raw material sources and simple preparation method, and has wide application prospects.
Description
Technical Field
The invention relates to the technical field of shampoos, in particular to an anti-hair-loss shampoo and a preparation method thereof.
Background
The shampoo, also called shampoo, shampoo or shampoo, has the main function of cleaning hair and scalp, and lays a foundation for hair finishing and styling. The purpose of shampooing is to remove dirt and excess grease from the hair and scalp. However, the existing shampoo is difficult to inhibit the hair from being damaged by the outside after being used, and is difficult to improve the circulation of the scalp, so that the hair loss phenomenon is easy to occur.
Chinese patent application CN103655262a discloses a care shampoo comprising sodium dodecyl polyoxyethylene ether sulfate, coconut monoethanolamide, small particle size silicone emulsion, seaweed extract and deionized water. When the care shampoo is used, silicone oil can be well attached to hair due to inertia and adsorption, the damaged parts of hair scales are filled, the surface of hair is smoother, and therefore the damaged hair is repaired, but the shampoo has no effect on hair loss.
Disclosure of Invention
The invention aims to provide an anti-hair loss shampoo and a preparation method thereof, aiming at eliminating and killing scalp bacteria, microorganisms and the like, protecting scalp health, having good anti-inflammation and antipruritic effects on the dermatitis, further realizing good effects of inhibiting hair loss and preventing hair loss, having wide raw material sources and simple preparation method, and having wide application prospects.
The technical scheme of the invention is realized as follows:
the invention provides a preparation method of anti-drop essence, which comprises the following steps:
s1, preparing a traditional Chinese medicine water extract: cleaning folium Mori, rhizoma Ligustici Chuanxiong, cortex Mori, and Polygoni Multiflori radix, drying, pulverizing to obtain Chinese medicinal powder, decocting in water, filtering, and concentrating the filtrate to obtain Chinese medicinal water extract;
s2, activating strains: respectively inoculating streptococcus lactis and lactobacillus reuteri into a Gao's medium, and performing activation culture to obtain strain seed liquid;
s3, preparing a traditional Chinese medicine fermentation medium: mixing the filter residue, the carbon source and the nitrogen source in the step S1, adding sterile water, and sterilizing to obtain a traditional Chinese medicine fermentation medium;
s4, fermenting: inoculating the seed solution of the streptococcus lactis and the lactobacillus reuteri strains in the step S2 into the traditional Chinese medicine fermentation medium in the step S3, fermenting and culturing, filtering, and freeze-drying the filtrate to obtain a fermentation product;
s5, preparation of anti-drop essence: and (3) adding the fermentation product obtained in the step (S4) into the traditional Chinese medicine water extract obtained in the step (S1), and uniformly stirring and mixing to obtain the anti-drop essence.
As a further improvement of the invention, in the step S1, the mass ratio of the mulberry leaves, the ligusticum wallichii, the white mulberry root-bark and the polygonum multiflorum is 5-10:2-4:3-7:7-12, the solid-liquid ratio of the traditional Chinese medicine powder and the water is 1:5-10g/mL, the extraction time is 3-5h, the extraction times are 1-2, and the concentration is carried out until the relative density is 1.1-1.2.
As a further improvement of the invention, the condition of the activation culture in the step S2 is 35-37 ℃ for 10-14 hours, and the bacterial content of the bacterial seed liquid is 10 7 -10 8 cfu/mL。
As a further improvement of the invention, in the step S3, the mass ratio of the filter residue to the carbon source to the nitrogen source to the sterile water is 20-30:7-10:3-5:200-500, the sterilization method is ultraviolet sterilization, and the carbon source is at least one of glucose, maltose, fructose, isomaltose, sucrose and water-soluble starch; the nitrogen source is at least one selected from peptone, urea, sodium nitrate, potassium nitrate, ammonium chloride and ammonium sulfate.
As a further improvement of the invention, the inoculation amount of the streptococcus lactis and lactobacillus reuteri strain seed liquid in the step S4 is 2-4% and 1-2% respectively, and the fermentation culture condition is 36-38 ℃ for 36-48h.
As a further improvement of the invention, the mass ratio of the fermentation product to the Chinese medicine water extract in the step S5 is 3-5:12-15.
The invention further protects the anti-drop essence prepared by the preparation method.
The invention further protects an anti-hair loss shampoo which contains the anti-hair loss essence.
As a further improvement of the invention, the invention is prepared from the following raw materials in parts by weight: 3-5 parts of anti-drop essence, 0.2-0.5 part of guar hydroxypropyl trimethyl ammonium chloride, 1-1.2 parts of glycol distearate, 0.1-0.2 part of EDTA disodium, 1-2 parts of sodium chloride, 0.01-0.1 part of citric acid, 1-2 parts of glycerol, 0.1-0.4 part of panthenol, 1-2 parts of jojoba oil and 50-70 parts of deionized water.
The invention further provides a preparation method of the anti-hair loss shampoo, which comprises the following steps: mixing guar hydroxypropyl trimethyl ammonium chloride, glycol distearate, glycerol, panthenol, jojoba oil and deionized water, heating to 50-60 ℃, stirring for 20-30min, adding sodium chloride, citric acid and EDTA disodium, stirring for 10-15min, cooling to room temperature, adding anti-hair loss essence, and continuing stirring for 5-10min to obtain anti-hair loss shampoo.
The invention has the following beneficial effects: alopecia is mainly a skin hair incidence due to hair loss caused by seborrhea over time, and is accompanied by other symptoms such as seborrheic dermatitis. The invention selects 4 traditional Chinese medicines including mulberry leaf, szechuan lovage rhizome, white mulberry root-bark and tuber fleeceflower root, wherein the mulberry leaf is: slight, slightly bitter, sweet, bitter and cold in taste. It enters lung and liver meridians. Dispelling wind-heat, clearing lung-heat, moistening dryness, removing liver-fire, and improving eyesight. Is used for treating wind-heat type common cold, lung heat type cough, dizziness and headache, conjunctival congestion and dizziness; ligusticum wallichii: pungent and warm. It has effects in promoting blood circulation, activating qi-flowing, dispelling pathogenic wind, and relieving pain. Can be used for treating chest pain, hypochondrium pain, traumatic injury, menoxenia, amenorrhea, dysmenorrhea, abdominal pain, headache, rheumatalgia; cortex Mori: sweet and cold. Enter lung meridian. Purging lung and relieving asthma, inducing diuresis and alleviating edema. Can be used for treating cough and asthma due to lung heat, edema, oliguria, and edema of facial skin; polygonum multiflorum Thunb: has effects in tranquilizing, nourishing blood, activating collaterals, removing toxic substances, invigorating essence and blood, blackening hair and beard, strengthening tendons and bones, and nourishing liver and kidney.
The invention can produce a large amount of antibacterial and anti-inflammatory products including active substances such as the nisin, short chain fatty acid, short peptide and the like by fermenting traditional Chinese medicine dregs with the streptococcus lactis and the lactobacillus reuteri, and the nisin can inhibit most gram positive bacteria and has a strong inhibition effect on spores of bacillus, so that after the shampoo is added, the traditional Chinese medicine water extract can play a good role in killing microorganisms, bacteria and the like which cause scalp inflammation, and the traditional Chinese medicine water extract can also play a good role in diminishing inflammation and relieving itching of the dermatitis, thereby effectively inhibiting hair loss and preventing hair loss.
The anti-hair loss shampoo prepared by the invention can specifically kill scalp bacteria, microorganisms and the like, protect scalp health, has good anti-inflammation and antipruritic effects on the dermatitis, further realizes good hair loss inhibition and hair loss prevention effects, has wide raw material sources and simple preparation method, and has wide application prospects.
Description of the embodiments
The following description of the technical solutions in the embodiments of the present invention will be clear and complete, and it is obvious that the described embodiments are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Example 1
The embodiment provides a preparation method of anti-drop essence, which comprises the following steps:
s1, preparing a traditional Chinese medicine water extract: cleaning 5 parts by weight of mulberry leaves, 2 parts by weight of ligusticum wallichii, 3 parts by weight of cortex mori radicis and 7 parts by weight of polygonum multiflorum, drying, crushing to obtain traditional Chinese medicine powder, adding water, boiling and extracting for 3 hours for 1 time, filtering, and concentrating the filtrate until the relative density is 1.1, thereby obtaining a traditional Chinese medicine water extract;
s2, activating strains: inoculating Streptococcus lactis and Lactobacillus reuteri respectively into Gao's medium, and performing activation culture at 35deg.C for 10 hr to obtain strain seed solution with bacterial content of 10 7 cfu/mL；
S3, preparing a traditional Chinese medicine fermentation medium: mixing 20 parts by weight of filter residues in the step S1, 7 parts by weight of glucose and 3 parts by weight of peptone, adding 200 parts by weight of sterile water, and sterilizing by ultraviolet rays to obtain a traditional Chinese medicine fermentation medium;
s4, fermenting: inoculating the streptococcus lactis and lactobacillus reuteri seed solution in the step S2 into the traditional Chinese medicine fermentation medium in the step S3, wherein the inoculum sizes of the streptococcus lactis and lactobacillus reuteri seed solution are respectively 2% and 1%, fermenting and culturing for 36 hours at 36 ℃, filtering, and freeze-drying filtrate to obtain a fermentation product;
s5, preparation of anti-drop essence: and 3 parts by weight of the fermentation product prepared in the step S4 is added into 12 parts by weight of the traditional Chinese medicine water extract prepared in the step S1, and the mixture is stirred and mixed uniformly to obtain the anti-drop essence.
Example 2
The embodiment provides a preparation method of anti-drop essence, which comprises the following steps:
s1, preparing a traditional Chinese medicine water extract: cleaning 10 parts by weight of mulberry leaves, 4 parts by weight of ligusticum wallichii, 7 parts by weight of white mulberry root-bark and 12 parts by weight of polygonum multiflorum, drying, crushing to obtain traditional Chinese medicine powder, adding water, boiling and extracting for 5 hours, wherein the extraction times are 2 times, the solid-to-liquid ratio of the traditional Chinese medicine powder to the water is 1:10g/mL, filtering, and concentrating the filtrate until the relative density is 1.2, thus obtaining the traditional Chinese medicine water extract;
s2, activating strains: inoculating Streptococcus lactis and Lactobacillus reuteri to Gao's culture respectivelyActivating and culturing in culture medium at 37deg.C for 14 hr to obtain strain seed solution with a bacterial content of 10 8 cfu/mL；
S3, preparing a traditional Chinese medicine fermentation medium: mixing 30 parts by weight of filter residues in the step S1, 3 parts by weight of sucrose, 7 parts by weight of glucose, 2 parts by weight of urea and 3 parts by weight of peptone, adding 500 parts by weight of sterile water, and sterilizing by ultraviolet rays to obtain a traditional Chinese medicine fermentation medium;
s4, fermenting: inoculating the streptococcus lactis and lactobacillus reuteri seed solution in the step S2 into the traditional Chinese medicine fermentation medium in the step S3, fermenting and culturing at 38 ℃ for 48 hours, filtering, and freeze-drying the filtrate to obtain a fermentation product;
s5, preparation of anti-drop essence: and 5 parts by weight of the fermentation product prepared in the step S4 is added into 15 parts by weight of the traditional Chinese medicine water extract prepared in the step S1, and the mixture is stirred and mixed uniformly to obtain the anti-drop essence.
Example 3
The embodiment provides a preparation method of anti-drop essence, which comprises the following steps:
s1, preparing a traditional Chinese medicine water extract: cleaning 7 parts by weight of mulberry leaves, 3 parts by weight of ligusticum wallichii, 5 parts by weight of white mulberry root-bark and 10 parts by weight of polygonum multiflorum, drying, crushing to obtain traditional Chinese medicine powder, adding water, boiling and extracting for 4 hours, wherein the extraction times are 2 times, the solid-to-liquid ratio of the traditional Chinese medicine powder to the water is 1:7g/mL, filtering, and concentrating the filtrate until the relative density is 1.15, thus obtaining the traditional Chinese medicine water extract;
s2, activating strains: inoculating Streptococcus lactis and Lactobacillus reuteri respectively into Gao's medium, and performing active culture at 36deg.C for 12 hr to obtain strain seed solution with bacterial content of 10 8 cfu/mL；
S3, preparing a traditional Chinese medicine fermentation medium: mixing 25 parts by weight of filter residues in the step S1, 6 parts by weight of glucose, 2.5 parts by weight of fructose, 1 part by weight of ammonium nitrate, 1 part by weight of urea and 2 parts by weight of peptone, adding 350 parts by weight of sterile water, and performing ultraviolet sterilization to obtain a traditional Chinese medicine fermentation medium;
s4, fermenting: inoculating the streptococcus lactis and lactobacillus reuteri seed solution in the step S2 into the traditional Chinese medicine fermentation medium in the step S3, wherein the inoculum sizes of the streptococcus lactis and lactobacillus reuteri seed solution are respectively 3% and 1.5%, fermenting and culturing for 42 hours at 37 ℃, filtering, and freeze-drying filtrate to obtain a fermentation product;
s5, preparation of anti-drop essence: and (3) adding 4 parts by weight of the fermentation product prepared in the step (S4) into 13.5 parts by weight of the traditional Chinese medicine water extract prepared in the step (S1), and uniformly stirring and mixing to obtain the anti-drop essence.
Comparative example 1
In comparison with example 3, the difference is that no mulberry leaf is added in step S1.
Comparative example 2
In comparison with example 3, the difference is that no polygonum multiflorum is added in step S1.
Comparative example 3
The difference compared to example 3 is that in step S4, streptococcus lactis is not inoculated.
Comparative example 4
The difference compared to example 3 is that lactobacillus reuteri is not inoculated in step S4.
Comparative example 5
In comparison with example 3, the difference is that steps S2-S5 are not performed.
Example 4
The embodiment provides an anti-hair loss shampoo.
The raw materials comprise the following components in parts by weight: 3 parts of anti-drop essence prepared in example 1, 0.2 part of guar hydroxypropyl trimethyl ammonium chloride, 1 part of ethylene glycol distearate, 0.1 part of EDTA disodium, 1 part of sodium chloride, 0.01 part of citric acid, 1 part of glycerol, 0.1 part of panthenol, 1 part of jojoba oil and 50 parts of deionized water.
The preparation method comprises the following steps: mixing guar hydroxypropyl trimethyl ammonium chloride, glycol distearate, glycerol, panthenol, jojoba oil and deionized water, heating to 50deg.C, stirring for 20min, adding sodium chloride, citric acid and EDTA disodium, stirring for 10min, cooling to room temperature, adding anti-hair loss essence, and stirring for 5min to obtain anti-hair loss shampoo.
Example 5
The embodiment provides an anti-hair loss shampoo.
The raw materials comprise the following components in parts by weight: 5 parts of anti-drop essence prepared in example 2, 0.5 part of guar hydroxypropyl trimethyl ammonium chloride, 1.2 parts of ethylene glycol distearate, 0.2 part of EDTA disodium, 2 parts of sodium chloride, 0.1 part of citric acid, 2 parts of glycerol, 0.4 part of panthenol, 2 parts of jojoba oil and 70 parts of deionized water.
The preparation method comprises the following steps: mixing guar hydroxypropyl trimethyl ammonium chloride, glycol distearate, glycerol, panthenol, jojoba oil and deionized water, heating to 60 ℃, stirring for 30min, adding sodium chloride, citric acid and EDTA disodium, stirring for 15min, cooling to room temperature, adding anti-hair loss essence, and continuing stirring for 10min to obtain anti-hair loss shampoo.
Example 6
The embodiment provides an anti-hair loss shampoo.
The raw materials comprise the following components in parts by weight: 4 parts of anti-drop essence prepared in example 3, 0.35 part of guar hydroxypropyl trimethyl ammonium chloride, 1.1 part of ethylene glycol distearate, 0.15 part of EDTA disodium, 1.5 parts of sodium chloride, 0.05 part of citric acid, 1.5 parts of glycerol, 0.2 part of panthenol, 1.5 parts of jojoba oil and 60 parts of deionized water.
The preparation method comprises the following steps: mixing guar hydroxypropyl trimethyl ammonium chloride, glycol distearate, glycerol, panthenol, jojoba oil and deionized water, heating to 55deg.C, stirring for 25min, adding sodium chloride, citric acid and EDTA disodium, stirring for 12min, cooling to room temperature, adding anti-hair loss essence, and stirring for 7min to obtain anti-hair loss shampoo.
Comparative example 6
The difference compared to example 6 is that the anti-run-off essence was prepared from comparative example 1.
Comparative example 7
The difference compared to example 6 is that the anti-run-off essence was prepared from comparative example 2.
Comparative example 8
The difference compared to example 6 is that the anti-run-off essence was prepared from comparative example 3.
Comparative example 9
The difference compared to example 6 is that the anti-run-off essence was prepared from comparative example 4.
Comparative example 10
The difference compared to example 6 is that the anti-run-off essence was prepared from comparative example 5.
Test example 1
A total of 60 qualified volunteers with alopecia trouble are selected to participate in the test, and the test samples are the anti-hair loss shampoos prepared in the invention examples 4-6 and the comparative examples 6-10 and the like products on the market. The test results were all judged to be valid, with experimental statistics shown in table 1.
TABLE 1
Annotation: "- -" means no effect; "-" means that a weak effect is produced; "-" means that a small amount of effect is produced; "+" indicates that a partial effect is produced; "++" indicates that most effects are produced; "+". ++'s representation of producing good results.
From the above table, the anti-hair loss shampoo prepared in the embodiments 1 to 3 has remarkable anti-hair loss effect, and can ensure that hair roots are not separated from scalp after the shampoo is stopped.
The foregoing description of the preferred embodiments of the invention is not intended to be limiting, but rather is intended to cover all modifications, equivalents, alternatives, and improvements that fall within the spirit and scope of the invention.
Claims (6)
1. The preparation method of the anti-drop essence is characterized by comprising the following steps of:
s1, preparing a traditional Chinese medicine water extract: cleaning folium Mori, rhizoma Ligustici Chuanxiong, cortex Mori, and Polygoni Multiflori radix, drying, pulverizing to obtain Chinese medicinal powder, decocting in water, filtering, and concentrating the filtrate to obtain Chinese medicinal water extract; the mass ratio of the mulberry leaves to the ligusticum wallichii to the cortex mori to the polygonum multiflorum is 5-10:2-4:3-7:7-12; the solid-liquid ratio of the traditional Chinese medicine powder to water is 1:5-10g/mL, the extraction time is 3-5h, the extraction times are 1-2 times, and the concentration is carried out until the relative density is 1.1-1.2;
s2, activating strains: respectively inoculating streptococcus lactis and lactobacillus reuteri into a Gao's medium, and performing activation culture to obtain strain seed liquid; the conditions of the activation culture are 35-37 ℃ and the time is 10-14h, and the bacterial content of the bacterial seed liquid is 10 7 -10 8 cfu/mL；
S3, preparing a traditional Chinese medicine fermentation medium: mixing the filter residue, the carbon source and the nitrogen source in the step S1, adding sterile water, and sterilizing to obtain a traditional Chinese medicine fermentation medium; the mass ratio of the filter residue to the carbon source to the nitrogen source to the sterile water is 20-30:7-10:3-5:200-500;
s4, fermenting: inoculating the seed solution of the streptococcus lactis and the lactobacillus reuteri strains in the step S2 into the traditional Chinese medicine fermentation medium in the step S3, fermenting and culturing, filtering, and freeze-drying the filtrate to obtain a fermentation product; the inoculation amount of the seed solution of the streptococcus lactis and the lactobacillus reuteri strains is 2-4v/v% and 1-2v/v%, respectively, and the fermentation culture condition is 36-38 ℃ for 36-48h;
s5, preparation of anti-drop essence: adding the fermentation product obtained in the step S4 into the traditional Chinese medicine water extract obtained in the step S1, and uniformly stirring and mixing to obtain anti-drop essence; the mass ratio of the fermentation product to the traditional Chinese medicine water extract is 3-5:12-15.
2. The method according to claim 1, wherein the sterilization method in step S3 is ultraviolet sterilization, and the carbon source is at least one selected from glucose, maltose, fructose, isomaltose, sucrose, and water-soluble starch; the nitrogen source is at least one selected from peptone, urea, sodium nitrate, potassium nitrate, ammonium chloride and ammonium sulfate.
3. An anti-run essence produced by the production method as claimed in claim 1 or 2.
4. An anti-hair loss shampoo comprising the anti-hair loss essence of claim 3.
5. The anti-hair loss shampoo according to claim 4, which is prepared from the following raw materials in parts by weight: 3-5 parts of anti-drop essence, 0.2-0.5 part of guar hydroxypropyl trimethyl ammonium chloride, 1-1.2 parts of ethylene glycol distearate, 0.1-0.2 part of EDTA disodium, 1-2 parts of sodium chloride, 0.01-0.1 part of citric acid, 1-2 parts of glycerol, 0.1-0.4 part of panthenol, 1-2 parts of joba oil and 50-70 parts of deionized water.
6. A method of preparing the anti-hair loss shampoo of claim 5, comprising the steps of: mixing guar hydroxypropyl trimethyl ammonium chloride, glycol distearate, glycerol, panthenol, jojoba oil and deionized water, heating to 50-60 ℃, stirring for 20-30min, adding sodium chloride, citric acid and EDTA disodium, stirring for 10-15min, cooling to room temperature, adding anti-hair loss essence, and continuing stirring for 5-10min to obtain anti-hair loss shampoo.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310101849.7A CN116211765B (en) | 2023-02-13 | 2023-02-13 | Anti-hair loss shampoo and preparation method thereof |
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| CN202310101849.7A CN116211765B (en) | 2023-02-13 | 2023-02-13 | Anti-hair loss shampoo and preparation method thereof |
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| CN116211765A CN116211765A (en) | 2023-06-06 |
| CN116211765B true CN116211765B (en) | 2023-10-10 |
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| CN114224807A (en) * | 2022-01-28 | 2022-03-25 | 蒋文昌 | Shampoo containing Chinese honeylocust fruits and bitter apricot seeds and preparation method thereof |
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| KR102394638B1 (en) * | 2015-09-30 | 2022-05-09 | (주)아모레퍼시픽 | Composition comprising lactic acid bacteria derived extracellular vesicles for preventing hair loss or promoting hair growth |
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| CN106309225A (en) * | 2016-08-31 | 2017-01-11 | 黄荣波 | Anti-hair-loss shampoo |
| CN108771654A (en) * | 2018-08-17 | 2018-11-09 | 四川自然菲科技有限公司 | A kind of moist type shampoo of no silicone oil |
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| CN112871036A (en) * | 2021-01-16 | 2021-06-01 | 浙江神英科技股份有限公司 | Preparation method of shampoo |
| CN113208997A (en) * | 2021-04-19 | 2021-08-06 | 绽妍生物科技有限公司 | Children moistening and skin-protecting shampoo and shower gel containing lactobacillus fermentation extract and preparation method thereof |
| CN114224807A (en) * | 2022-01-28 | 2022-03-25 | 蒋文昌 | Shampoo containing Chinese honeylocust fruits and bitter apricot seeds and preparation method thereof |
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