CN116199780A - TGF-β-RII结合蛋白质 - Google Patents

TGF-β-RII结合蛋白质 Download PDF

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Publication number
CN116199780A
CN116199780A CN202211726462.2A CN202211726462A CN116199780A CN 116199780 A CN116199780 A CN 116199780A CN 202211726462 A CN202211726462 A CN 202211726462A CN 116199780 A CN116199780 A CN 116199780A
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CN
China
Prior art keywords
antibody
seq
amino acid
acid sequence
tgf
Prior art date
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Pending
Application number
CN202211726462.2A
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English (en)
Chinese (zh)
Inventor
马克·思罗斯比
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Merus BV
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Merus BV
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Publication date
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Publication of CN116199780A publication Critical patent/CN116199780A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/11—Paramyxoviridae (F); Pneumoviridae (F), e.g. respiratory syncytial virus [RSV]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN202211726462.2A 2019-12-24 2020-12-22 TGF-β-RII结合蛋白质 Pending CN116199780A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
NL2024576 2019-12-24
NL2024576 2019-12-24
PCT/NL2020/050813 WO2021133167A1 (en) 2019-12-24 2020-12-22 Tgf-beta-rii binding proteins
CN202080094188.4A CN115038497A (zh) 2019-12-24 2020-12-22 TGF-β-RII结合蛋白质

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN202080094188.4A Division CN115038497A (zh) 2019-12-24 2020-12-22 TGF-β-RII结合蛋白质

Publications (1)

Publication Number Publication Date
CN116199780A true CN116199780A (zh) 2023-06-02

Family

ID=69700252

Family Applications (3)

Application Number Title Priority Date Filing Date
CN202211726462.2A Pending CN116199780A (zh) 2019-12-24 2020-12-22 TGF-β-RII结合蛋白质
CN202080094188.4A Pending CN115038497A (zh) 2019-12-24 2020-12-22 TGF-β-RII结合蛋白质
CN202211726434.0A Pending CN116375869A (zh) 2019-12-24 2020-12-22 TGF-β-RII结合蛋白质

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN202080094188.4A Pending CN115038497A (zh) 2019-12-24 2020-12-22 TGF-β-RII结合蛋白质
CN202211726434.0A Pending CN116375869A (zh) 2019-12-24 2020-12-22 TGF-β-RII结合蛋白质

Country Status (13)

Country Link
US (1) US12570747B2 (https=)
EP (2) EP4269433A3 (https=)
JP (3) JP7633259B2 (https=)
KR (2) KR20230145542A (https=)
CN (3) CN116199780A (https=)
AR (2) AR120914A1 (https=)
AU (2) AU2020412201B2 (https=)
BR (1) BR112022012522A2 (https=)
IL (2) IL294181A (https=)
MX (2) MX2022007919A (https=)
PH (1) PH12022551527A1 (https=)
TW (2) TW202417513A (https=)
WO (1) WO2021133167A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116199780A (zh) * 2019-12-24 2023-06-02 美勒斯公司 TGF-β-RII结合蛋白质
CA3231649A1 (en) * 2021-11-19 2023-05-25 Cecilia Anna Wilhelmina Geuijen Multispecific binding moieties comprising pd-1 and tgf-brii binding domains
CN121736114A (zh) 2022-12-20 2026-03-27 美勒斯公司 FAP结合域以及结合FAP和TGF-βRII的双特异性结合部分

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001206899A (ja) * 1999-11-18 2001-07-31 Japan Tobacco Inc ＴＧＦ−βＩＩ型受容体に対するヒトモノクローナル抗体及びその医薬用途
NZ537277A (en) 2002-07-18 2008-04-30 Crucell Holland Bv Recombinant production of mixtures of antibodies
PL3456190T3 (pl) 2008-06-27 2022-06-06 Merus N.V. Wytwarzające przeciwciała transgeniczne zwierzę z gatunku myszy
JO3096B1 (ar) 2008-11-07 2017-03-15 Imclone Llc الأجسام المضادة لمستقبل ii مضاد tgfb
JP6062375B2 (ja) * 2011-01-06 2017-01-18 グラクソ グループ リミテッドＧｌａｘｏ Ｇｒｏｕｐ Ｌｉｍｉｔｅｄ Ｔｇｆ−ベータ受容体ｉｉに結合するリガンド
EP3470431A1 (en) 2012-09-27 2019-04-17 Merus N.V. Bispecific igg antibodies as t cell engagers
JP2018527903A (ja) * 2015-07-22 2018-09-27 スカラー ロック インコーポレイテッドＳｃｈｏｌａｒ Ｒｏｃｋ，Ｉｎｃ． Ｇｄｆ１１結合タンパク質およびその使用
TW201825519A (zh) 2016-10-18 2018-07-16 美商美國禮來大藥廠 TGFβ受體II抗體
MX2020010267A (es) 2018-03-30 2020-11-06 Merus Nv Anticuerpo multivalente.
CN116199780A (zh) * 2019-12-24 2023-06-02 美勒斯公司 TGF-β-RII结合蛋白质

Also Published As

Publication number Publication date
IL294181A (en) 2022-08-01
TW202128747A (zh) 2021-08-01
JP2023508202A (ja) 2023-03-01
EP4081306A1 (en) 2022-11-02
CN115038497A (zh) 2022-09-09
WO2021133167A1 (en) 2021-07-01
CA3165605A1 (en) 2021-07-01
JP7633259B2 (ja) 2025-02-19
MX2022007919A (es) 2022-07-27
US12570747B2 (en) 2026-03-10
EP4269433A2 (en) 2023-11-01
JP2023076596A (ja) 2023-06-01
KR20220117267A (ko) 2022-08-23
US20250270331A1 (en) 2025-08-28
CN116375869A (zh) 2023-07-04
AU2023200779B2 (en) 2026-02-19
EP4269433A3 (en) 2024-05-22
MX2024002182A (es) 2024-05-03
TW202417513A (zh) 2024-05-01
IL304317A (en) 2023-09-01
AR130991A2 (es) 2025-02-05
AU2020412201B2 (en) 2026-02-12
KR20230145542A (ko) 2023-10-17
JP2025083342A (ja) 2025-05-30
AR120914A1 (es) 2022-03-30
BR112022012522A2 (pt) 2022-09-06
PH12022551527A1 (en) 2024-01-29
AU2020412201A1 (en) 2022-07-14
AU2023200779A1 (en) 2023-03-09

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Inventor after: Mark Throsby

Inventor after: Lindsay Clost

Inventor after: De Kruif Cornelis Adrian

Inventor before: Mark Throsby