CN116196252A

CN116196252A - Hand-washing-free disinfection gel and preparation method and application thereof

Info

Publication number: CN116196252A
Application number: CN202211650158.4A
Authority: CN
Inventors: 晏家瑛; 陈岩冰; 何天平; 蔡君; 胡仕林
Original assignee: Chongqing Daily Chemical Industry Research Institute Co ltd; Chongqing Academy of Science and Technology
Current assignee: Chongqing Daily Chemical Industry Research Institute Co ltd; Chongqing Academy of Science and Technology
Priority date: 2022-12-21
Filing date: 2022-12-21
Publication date: 2023-06-02

Abstract

The invention belongs to the technical field of sanitary and disinfecting products, and particularly relates to a hand-washing-free disinfecting gel and a preparation method and application thereof. The hand-washing-free disinfection gel comprises the following components in percentage by weight: 1-5% of zingiber corallinum extract, 60-80% of ethanol, 6-20% of polyoxyethylene sorbitan monolaurate, 2-8% of propylene glycol, 2-8% of glycerol, 0.1-2% of triethanolamine, 0.1-1% of carbomer and the balance of water. The hand-washing-free disinfection gel has ideal disinfection effects on candida albicans, pseudomonas aeruginosa, staphylococcus aureus and escherichia coli, and the killing rate is over 99 percent; the paint is nontoxic and is beneficial to environmental protection; and can keep skin moist, has weak irritation and is mild.

Description

Hand-washing-free disinfection gel and preparation method and application thereof

Technical Field

The invention belongs to the technical field of sanitary and disinfecting products, and particularly relates to a hand-washing-free disinfecting gel, a preparation method and application thereof.

Background

75% alcohol spraying (hand) and 84 disinfectant are commonly used in all places to kill and prevent epidemic in relevant public places. However, 75% ethanol has good disinfection effect, but presents the potential safety hazard of dry skin and flammability; 84 disinfectant has a pungent smell, belongs to a chlorine-containing preparation, has certain corrosiveness, and cannot be used for hand washing and disinfection.

For example, the patent with publication number CN 104873432A discloses a hand-protecting type no-clean disinfection gel and a preparation method thereof, wherein the hand-protecting type no-clean disinfection gel comprises the following raw materials in parts by mass: 0.1 to 0.5 percent of bactericide, 2.1 to 3.5 percent of cosolvent, 0.10 to 0.25 percent of thickener, 0.01 to 2.0 percent of emollient, 1.8 to 3.0 percent of essence, 0.02 to 0.15 percent of pH regulator, 39 to 54 percent of ethanol and the balance of water; the bactericide is 2,4, -trichloro-2, -hydroxydiphenyl ether and p-chlorom-dimethylphenol according to the following formula (3.8-2.2): 1. The active ingredients of the hand-protecting type no-clean disinfecting gel, namely 2,4, -trichloro-2, -hydroxydiphenyl ether and parachlorometaxylenol, can be harmful to the environment.

For another example, the patent with publication number CN101953779a discloses a medical disinfection gel, which is composed of o-phenylphenol, ethanol, thickener, humectant, pH regulator and deionized water, wherein the mass percentages of the components are: 1.0 to 5.0 percent of o-phenylphenol, 55 to 65 percent of ethanol, 1.0 to 5.0 percent of thickener, 3.0 to 8.0 percent of humectant, 1.0 to 3.0 percent of pH regulator and the balance of deionized water. The o-phenylphenol as an active ingredient in the patent has carcinogenicity, can generate harm to the environment and is not beneficial to environmental protection.

In summary, the existing disinfection products have the defects of pungent odor, corrosiveness and environmental protection, and it is necessary to develop a mild and environmental-friendly hand-washing-free disinfection gel.

Disclosure of Invention

Aiming at the problems, the invention aims to provide the hand-washing-free disinfection gel which is the coral ginger extract disinfection gel and has ideal disinfection effects on candida albicans, pseudomonas aeruginosa, staphylococcus aureus and escherichia coli. Under the optimized scheme, the killing rate is over 99 percent; and the skin moistening agent is non-toxic, is beneficial to environmental protection, can keep skin moist, and is not irritated.

In order to achieve the above purpose, the present invention may adopt the following technical scheme:

in one aspect, the invention provides a hand-free disinfecting gel comprising, by weight: 1-5% of zingiber corallinum extract, 60-80% of ethanol, 6-20% of polyoxyethylene sorbitan monolaurate, 2-8% of propylene glycol, 2-8% of glycerol, 0.1-2% of triethanolamine, 0.1-1% of carbomer and the balance of water.

The technical scheme can also be understood as that the coral ginger extract comprises, by weight, 1-5 parts of a coral ginger extract, 60-80 parts of ethanol, 6-20 parts of polyoxyethylene sorbitan monolaurate, 2-8 parts of propylene glycol, 2-8 parts of glycerol, 0.1-2 parts of triethanolamine, 0.1-1 part of carbomer and water in corresponding parts by weight.

In another aspect, the present invention provides a method for preparing the hand-free disinfecting gel, which comprises: firstly, uniformly mixing carbomer, polyoxyethylene sorbitan monolaurate, propylene glycol, glycerol and water to obtain a mixture a; uniformly mixing the rhizoma zingiberis corallinae extract with ethanol, and filtering to obtain a mixture b; and (3) mixing the mixture a and the mixture b, uniformly stirring, adding triethanolamine, and homogenizing and mixing to obtain the hand-washing-free disinfection gel.

In a further aspect, the invention provides the use of a hand-free disinfecting gel as described above in the preparation of a disinfecting product.

The beneficial effects of the invention include:

(1) The hand-washing-free disinfection gel provided by the invention has very ideal disinfection effects on candida albicans, pseudomonas aeruginosa, staphylococcus aureus and escherichia coli, and the killing rate is over 99 percent; the paint is nontoxic and is beneficial to environmental protection; the skin can be kept moist, the irritation is weak, and the skin is mild;

(2) The hand-washing-free disinfection gel provided by the invention can directly act on hand skin, is free from washing hands and is convenient to use.

Detailed Description

The examples are presented for better illustration of the invention, but the invention is not limited to the examples. Those skilled in the art will appreciate that various modifications and adaptations of the embodiments described above are possible in light of the above teachings and are intended to be within the scope of the invention.

The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the disclosure. Unless the context clearly differs, singular forms of expression include plural forms of expression. As used herein, it is understood that terms such as "comprising," "having," "including," and the like are intended to indicate the presence of a feature, number, operation, component, part, element, material, or combination. The terms of the present invention are disclosed in the specification and are not intended to exclude the possibility that one or more other features, numbers, operations, components, elements, materials or combinations thereof may be present or added. As used herein, "/" may be interpreted as "and" or "as appropriate.

The embodiment of the invention provides a hand-washing-free disinfection gel, which comprises the following components in percentage by weight: 1-5% of zingiber corallinum extract, 60-80% of ethanol, 6-20% of polyoxyethylene sorbitan monolaurate, 2-8% of propylene glycol, 2-8% of glycerol, 0.1-2% of triethanolamine, 0.1-1% of carbomer and the balance of water.

The rhizoma Zingiberis recens (Zingiber Corallinum Hance) is rhizome of Zingiberaceae plant Zingiber corallinum Hance, called YINJIANG, perennial herb, and is a common medicinal material for Miao nationality. The rhizome is used as a medicine, has the effects of clearing heat, detoxicating, detumescence, antibiosis and the like, is used for treating common cold, cough, lumbago, abdominal pain, diarrhea and other symptoms in folk, and has high medicinal value; can be used for treating food stagnation, abdominal pain, nausea, emesis, hepatosplenomegaly, and hot air wet pain. In addition, the existing researches show that the essential oil of the zingiber corallinum hance has obvious antibacterial effect on various common drug-resistant bacteria, and terpinen-4-ol is a main antibacterial component of the essential oil; the antibacterial activity of the coral ginger oil is also researched and reported in a large number, and the coral ginger oil has an inhibitory effect on common bacteria (staphylococcus aureus, escherichia coli, candida albicans, klebsiella pneumoniae, bacillus cloacae and acinetobacter baumannii), fungi, mosquitoes, mites and the like, and particularly has an inhibitory effect on bacteria and fungi.

In some embodiments, in the above gel, the Zingiber corallinum Hance extract is preferably extracted by supercritical extraction. It should be noted that, for a long time, most of the extraction methods and processes of the active ingredients of the medicinal plants adopt traditional methods and processes of decoction, steam distillation, organic solvent extraction and the like. The obtained substances have the advantages of low purity and low yield, and the problems of easiness in decomposition and destruction of active ingredients, excessive organic solvent residues, limited application range and the like exist, so that the quality and economic benefits of the products are directly affected, and potential harm is brought to the health of consumers. The supercritical extraction technology is a novel chemical separation technology which is internationally emerging, utilizes the fluid with the critical pressure and the critical temperature above to have the specifically increased high dissolution capacity and high penetration capacity to extract and separate certain components in substances, is an internationally advanced physical extraction technology at present, has the advantages of greenness, high efficiency, safety and the like, and can meet the requirements of people on green environment-friendly products. But also can be widely applied to a plurality of industries such as the pharmaceutical industry, the extraction of medicinal plant resources, the food industry, the cosmetic industry and the like. In addition, the coral ginger extract obtained by the supercritical extraction technology has special medicine fragrance, wherein the main active ingredient, terpinen-4-ol, is high in content, is a natural antibacterial ingredient, is a medicinal main ingredient, can also provide fragrance for the hand-washing-free disinfection gel, has relatively long fragrance retention time, can also prolong the efficacy time of antibacterial and bacteriostatic, and achieves the disinfection effect.

The coral ginger extract in the hand-washing-free disinfection gel is derived from medicinal materials, is natural and green, and is harmless to human bodies.

In some embodiments, the hand-free disinfecting gel preferably comprises, in weight percent: 1% of zingiber corallinum extract, 60% -80% of ethanol, 6% -20% of polyoxyethylene sorbitan monolaurate, 2% -8% of propylene glycol, 2% -8% of glycerol, 0.1% -2% of triethanolamine, 0.1% -1% of carbomer and the balance of water.

In some embodiments, the hand-free disinfecting gel preferably comprises, in weight percent: 1-5% of zingiber corallinum extract, 70% of ethanol, 6-20% of polyoxyethylene sorbitan monolaurate, 2-8% of propylene glycol, 2-8% of glycerol, 0.1-2% of triethanolamine, 0.1-1% of carbomer and the balance of water.

In some embodiments, the hand-free disinfecting gel preferably comprises, in weight percent: 1 to 5 percent of coral ginger extract, 60 to 80 percent of ethanol, 14 percent of polyoxyethylene sorbitan monolaurate, 2 to 8 percent of propylene glycol, 2 to 8 percent of glycerol, 0.1 to 2 percent of triethanolamine, 0.1 to 1 percent of carbomer and the balance of water.

In some embodiments, the hand-free disinfecting gel preferably comprises, in weight percent: 1% of zingiber corallinum extract, 70% of ethanol, 14% of polyoxyethylene sorbitan monolaurate, 2% -8% of propylene glycol, 2% -8% of glycerol, 0.1% -2% of triethanolamine, 0.1% -1% of carbomer and the balance of water.

In some embodiments, the hand-free disinfecting gel preferably comprises, in weight percent: 4% of zingiber corallinum extract, 75% of ethanol, 10% of polyoxyethylene sorbitan monolaurate, 5% of propylene glycol, 2% of glycerol, 0.5% of triethanolamine, 0.5% of carbomer and the balance of water.

In some embodiments, the hand-free disinfecting gel preferably comprises, in weight percent: 2% of zingiber corallinum extract, 70% of ethanol, 16% of polyoxyethylene sorbitan monolaurate, 4% of propylene glycol, 3% of glycerol, 1% of triethanolamine, 0.5% of carbomer and the balance of water.

In some embodiments, the hand-free disinfecting gel preferably comprises, in weight percent: 1% of zingiber corallinum extract, 70% of ethanol, 14% of polyoxyethylene sorbitan monolaurate, 4% of propylene glycol, 3% of glycerol, 1% of triethanolamine, 0.5% of carbomer and the balance of water.

The hand-washing-free disinfection gel has ideal disinfection effects on candida albicans, pseudomonas aeruginosa, staphylococcus aureus and escherichia coli, and the disinfection rate is over 99 percent; and is nontoxic, and can clean and disinfect hand skin, not only keep skin moist, but also prevent bacterial and fungal infection.

The preparation method of the hand-washing-free disinfection gel only needs mixing and stirring, has the advantages of simple preparation method and process, less equipment investment, easy control of the production process, easy mass production, direct action on hand skin, hand washing free and convenient use. In addition, the filtration, stirring, etc. operations in the present invention are those conventionally used in the art.

In a further aspect, the invention provides the use of a hand-free disinfecting gel as described above in the preparation of a disinfecting product. It should be noted that the hand-free disinfection gel of the invention can also be added with other auxiliary materials or other disinfection active ingredients to prepare disinfection products. Of course, it should be understood that the hand-free disinfecting gel may also be used alone as a disinfecting product.

For a better understanding of the present invention, the content of the present invention is further elucidated below in connection with the specific examples, but the content of the present invention is not limited to the examples below.

1. Preparation of washing-free disinfection gel

Example 1

(1) Formulation of

A washing-free disinfectant gel containing rhizoma Zingiberis Corallini extract is provided: 4% of zingiber corallinum extract, 75% of ethanol, 10% of polyoxyethylene sorbitan monolaurate, 5% of propylene glycol, 2% of glycerol, 0.5% of triethanolamine, 0.5% of carbomer and the balance of water.

(2) Preparation method

Firstly, uniformly mixing carbomer, polyoxyethylene sorbitan monolaurate, propylene glycol, glycerol and water to obtain a mixture a; uniformly mixing the rhizoma zingiberis corallinae extract with ethanol, and filtering to obtain a mixture b; and (3) mixing the mixture a and the mixture b, uniformly stirring, adding triethanolamine, and homogenizing and mixing to obtain the washing-free disinfection gel.

Example 2

(1) Formulation of

A washing-free disinfectant gel containing rhizoma Zingiberis Corallini extract is provided: 2% of zingiber corallinum extract, 70% of ethanol, 16% of polyoxyethylene sorbitan monolaurate, 4% of propylene glycol, 3% of glycerol, 1% of triethanolamine, 0.5% of carbomer and the balance of water.

(2) Preparation method

Example 3

(1) Formulation of

A washing-free disinfectant gel containing rhizoma Zingiberis Corallini extract is provided: 1% of zingiber corallinum extract, 70% of ethanol, 14% of polyoxyethylene sorbitan monolaurate, 4% of propylene glycol, 3% of glycerol, 1% of triethanolamine, 0.5% of carbomer and the balance of water.

(2) Preparation method

Comparative example 1

(1) Formulation of

Washing-free disinfection gel: 75% of ethanol, 14% of polyoxyethylene sorbitan monolaurate, 4% of propylene glycol, 3% of glycerol, 1% of triethanolamine, 0.5% of carbomer and the balance of water.

(2) Preparation method

Firstly, uniformly mixing carbomer, polyoxyethylene sorbitan monolaurate, propylene glycol, glycerol and water; and mixing the mixture with ethanol, stirring uniformly, adding triethanolamine, and homogenizing and mixing to obtain the washing-free disinfection gel.

2. Test experiment of Using Effect

Example 4 sensory evaluation test

The leave-on disinfectant gels prepared in examples 1-3 and comparative example 1 were each tried by a tester consisting of 40 persons aged 25-65 years. The trial staff uniformly smears a proper amount of the no-clean disinfection gel on the surface of the hand skin, and respectively performs comprehensive scoring after the smearing is finished and the hand skin stays for 10 minutes.

According to the smell and skin comfort level of the washing-free disinfection gel by a tester, scoring is carried out at room temperature, and the scoring is recorded, wherein the evaluation standard is as follows: regarding smell (50 points): the gel is not harsh in smell, and can accept the smell; the smell was perceived as bad; regarding skin comfort (50 points): the gel is free from washing, does not irritate skin, and is good in skin relief; the leave-on antiseptic gel is perceived as not good at irritating the skin. The scoring results are shown in table 1.

Table 1 scoring table

As is clear from table 1 above, example 2, example 3, was more effective in terms of odor, whereas example 1 and comparative example 1 were less effective in terms of odor because of the higher odor. Example 3 is superior to example 2 in terms of skin comfort. The effect of example 3 was optimal in terms of smell and skin comfort.

Example 5 physical and chemical index and microbial index test

The washing-free disinfection gel of example 3 was subjected to product testing, and physicochemical index and microorganism index tests were performed with reference to "disinfection technical Specification (2002 edition), GB 27951-2011" skin disinfectant health requirement "and" cosmetic safety technical Specification (2015 edition), and the test results are shown in Table 2 below.

Table 2 product testing

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Example 6 test of sterilizing Effect

The washing-free disinfection gel of the example 3 is subjected to a sterilization effect test by referring to the technical specification of disinfection (2002 edition), 3 times of repeated tests show that the washing-free disinfection gel of the example 3 has the effect of 0.5min, 1.0min and 1.5min under the constant temperature experimental condition of 20 ℃, and the results show that the sterilization effect on candida albicans, pseudomonas aeruginosa, staphylococcus aureus and escherichia coli on a carrier is very ideal, the sterilization number value is more than 3.00, the sterilization rate is more than 99.99%, and the test data are as follows.

TABLE 3 killing effect on Candida albicans

TABLE 4 killing Effect on Pseudomonas aeruginosa

TABLE 5 killing effect on Staphylococcus aureus

TABLE 6 killing effect on E.coli

Above, the gel of example 3 has no-wash disinfection effect for 1.0min, average killing log value of natural bacteria on hand surface of 30 subjects >1.00, killing rate over 99%, and test data are as follows.

TABLE 7 hand disinfection field test results

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Note that: the negative control was grown aseptically.

Example 7 toxicology test

Application example 3 washing-free sterilizing gel of Zingiber corallinum Hance according to the sterilizing technical Specification (2002 edition) 2.3.1, acute oral toxicity test, LD ₅₀ >The toxicity classification was practically non-toxic at 5000mg/kg body weight, and the test data are as follows.

TABLE 8 acute oral toxicity test results of KM mice

Finally, it is noted that the above embodiments are only for illustrating the technical solution of the present invention and not for limiting the same, and although the present invention has been described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications and equivalents may be made thereto without departing from the spirit and scope of the technical solution of the present invention, which is intended to be covered by the scope of the claims of the present invention.

Claims

1. A hand-free disinfecting gel, comprising, in weight percent: 1-5% of zingiber corallinum extract, 60-80% of ethanol, 6-20% of polyoxyethylene sorbitan monolaurate, 2-8% of propylene glycol, 2-8% of glycerol, 0.1-2% of triethanolamine, 0.1-1% of carbomer and the balance of water.

2. A hand-free disinfecting gel according to claim 1, comprising, in weight percent: 1% of zingiber corallinum extract, 60-80% of ethanol, 6-20% of polyoxyethylene sorbitan monolaurate, 2-8% of propylene glycol, 2-8% of glycerol, 0.1-2% of triethanolamine, 0.1-1% of carbomer and the balance of water.

3. A hand-free disinfecting gel according to claim 1, comprising, in weight percent: 1-5% of zingiber corallinum extract, 70% of ethanol, 6-20% of polyoxyethylene sorbitan monolaurate, 2-8% of propylene glycol, 2-8% of glycerol, 0.1-2% of triethanolamine, 0.1-1% of carbomer and the balance of water.

4. A hand-free disinfecting gel according to claim 1, comprising, in weight percent: 1 to 5 percent of coral ginger extract, 60 to 80 percent of ethanol, 14 percent of polyoxyethylene sorbitan monolaurate, 2 to 8 percent of propylene glycol, 2 to 8 percent of glycerol, 0.1 to 2 percent of triethanolamine, 0.1 to 1 percent of carbomer and the balance of water.

5. A hand-free disinfecting gel according to claim 1, comprising, in weight percent: 1% of zingiber corallinum extract, 70% of ethanol, 14% of polyoxyethylene sorbitan monolaurate, 2% -8% of propylene glycol, 2% -8% of glycerol, 0.1% -2% of triethanolamine, 0.1% -1% of carbomer and the balance of water.

6. A hand-free disinfecting gel according to claim 1, comprising, in weight percent: 4% of zingiber corallinum extract, 75% of ethanol, 10% of polyoxyethylene sorbitan monolaurate, 5% of propylene glycol, 2% of glycerol, 0.5% of triethanolamine, 0.5% of carbomer and the balance of water.

7. A hand-free disinfecting gel according to claim 1, comprising, in weight percent: 2% of zingiber corallinum extract, 70% of ethanol, 16% of polyoxyethylene sorbitan monolaurate, 4% of propylene glycol, 3% of glycerol, 1% of triethanolamine, 0.5% of carbomer and the balance of water.

8. A hand-free disinfecting gel according to claim 1, comprising, in weight percent: 1% of zingiber corallinum extract, 70% of ethanol, 14% of polyoxyethylene sorbitan monolaurate, 4% of propylene glycol, 3% of glycerol, 1% of triethanolamine, 0.5% of carbomer and the balance of water.

9. A method of preparing a hand-free disinfecting gel according to any one of claims 1 to 8, comprising: firstly, uniformly mixing carbomer, polyoxyethylene sorbitan monolaurate, propylene glycol, glycerol and water to obtain a mixture a; uniformly mixing the rhizoma zingiberis corallinae extract with ethanol, and filtering to obtain a mixture b; and (3) mixing the mixture a and the mixture b, uniformly stirring, adding triethanolamine, and homogenizing and mixing to obtain the hand-washing-free disinfection gel.

10. Use of a hand-free disinfecting gel according to any one of claims 1 to 8 for the preparation of a disinfecting article.