CN111214416A - Hand-washing-free skin-care disinfection gel and preparation method thereof - Google Patents
Hand-washing-free skin-care disinfection gel and preparation method thereof Download PDFInfo
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- CN111214416A CN111214416A CN202010160153.8A CN202010160153A CN111214416A CN 111214416 A CN111214416 A CN 111214416A CN 202010160153 A CN202010160153 A CN 202010160153A CN 111214416 A CN111214416 A CN 111214416A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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Abstract
The invention relates to a disinfectant, in particular to a hand-washing-free skin-care disinfection gel and a preparation method thereof. The hand-washing-free skin-care disinfection gel is prepared from the following raw materials in percentage by mass: 55-60% of ethanol; 0.2-0.3% of carbomer; 0.1-0.2% of triethylamine; 1-2% of glycerol; 0.5-1% of elsholtzia oil; 1-3% of aloe extract and the balance of deionized water. The hand-free disinfectant disclosed by the invention is prepared by compounding ethanol and elsholtzia oil and adding the moisture-preserving and skin-protecting components, so that the hand-free disinfectant not only has a good synergistic effect and a good disinfection effect, but also has a long killing time and a good skin-protecting function.
Description
Technical Field
The invention relates to a disinfectant, in particular to a hand-washing-free skin-care disinfection gel and a preparation method thereof.
Background
The disinfectant is used for killing pathogenic microorganisms on a transmission medium, so that the requirement of harmlessness is met, the pathogenic microorganisms are killed out of a human body, the transmission path of infectious diseases is cut off, and the purpose of controlling the infectious diseases is achieved. Most of disinfectants used in the current market are liquid, are easy to leak and splash during use, have large medicament damage and pollute the environment.
The hand-washing-free disinfection gel is generally widely applied to medical places, is gradually and more widely used in daily family life along with the continuous improvement of disinfection concept of people at present, is simple in use method and obvious in effect, and can effectively remove bacteria on hands. The present hand-washing-free disinfection gel sold in the market mainly uses trichlorohydroxydiphenyl ether (triclosan) and ethanol as main effective disinfection components. Triclosan has broad killing and inhibiting effects on gram-positive and gram-negative bacteria, chlamydia, spirochete, mycoplasma, fungi and viruses (such as hepatitis A, hepatitis B, HIV, etc.), etc., and has instantaneous and lasting bactericidal effects, however, once triclosan reacts with chlorine-containing tap water, a substance called "Golomar" can be formed, i.e., chloroform. Chloroform is listed as a suspicious carcinogen which has potential threat to human body by international cancer research center and America, and the substance has potential threat to human body health, disturbs human endocrine system and causes various diseases.
Therefore, it is of great practical significance to develop a hand-free disinfecting gel which is safe and effective to use and has protection to the skin of the user.
Disclosure of Invention
The invention aims to provide a hand-free skin-care disinfection gel and a preparation method thereof, the disinfectant improves the disinfection effect and action time, and simultaneously, the traditional Chinese medicine skin-care ingredients are added, so that the health of the skin is protected while the disinfection is carried out; the invention also provides a preparation method thereof.
The invention relates to a hand-washing-free skin-care disinfection gel which is prepared from the following raw materials in percentage by mass:
the neutralizing agent is triethylamine and carbomer neutralizing agent, and the neutralized product is in gel form, so that rapid volatilization of ethanol is effectively prevented.
The aloe extract is a skin-care component, and the product has obvious antioxidant characteristics and good skin-care performance.
The bactericide is the elsholtzia oil, the elsholtzia oil and the ethanol have good synergistic bactericidal effect, and after the ethanol is exerted, the elsholtzia oil continues to exert the bactericidal effect, so that the lasting bactericidal effect can be achieved.
The preparation method of the hand-free disinfection gel comprises the following steps:
uniformly dispersing carbomer in deionized water, standing for swelling until carbomer is transparent and has no particles, standing overnight, stirring to uniform, adding ethanol to disperse uniformly, adding herba Moslae oil, glycerol, Aloe extract and deionized water, adding triethylamine neutralizer to neutralize to gel state to obtain hand-washing-free skin care disinfecting gel, bottling, and sealing.
The invention has the following beneficial effects:
to eliminate the adverse effects of ethanol during use, we developed this new hand-free disinfecting gel. The disinfectant has the greatest advantage that the aloe extract moisturizing and skin-care ingredients are added while the ethanol disinfection effect is ensured, so that the good hand feeling is ensured. In addition, the invention adopts a mild neutral formula, and the pH value is between 6 and 8.
Meanwhile, the elsholtzia oil and the ethanol have good synergistic effect, and the disinfection effect is improved. The elsholtzia oil ensures the lasting sterilization effect and makes up the defect of short sterilization time caused by the volatile ethanol.
The invention can effectively kill common pathogenic bacteria and viruses on the surface of the skin. Cleaning hand, and collecting product
On the palm, then quickly rub and scrub the palm of each handThe hand sanitizer can kill more than 99 percent of natural bacteria on hands in 30 seconds per part, has no abnormal change to the skin of the hands, and has good hand disinfection effect and skin care function.
The hand-washing-free disinfectant disclosed by the invention is prepared by compounding ethanol and elsholtzia oil and adding the moisture-preserving and skin-protecting components, so that the hand-washing-free disinfectant not only has a good synergistic effect and a long-lasting sterilizing effect, but also has a good skin-protecting function.
Detailed Description
The present invention is further described below with reference to examples.
Example 1
Uniformly dispersing 0.3g of carbomer in deionized water, standing and swelling until the carbomer is transparent and has no particles, standing overnight, stirring uniformly, adding 60g of ethanol to be uniformly dispersed, then adding 0.8g of the bactericide elsholtzia oil, 2g of glycerol, 3g of the aloe extract and the balance of deionized water, finally adding 0.2g of triethylamine neutralizer to neutralize to be gelatinous to prepare the hand-washing-free skin-care disinfection gel, filling and sealing to obtain the finished product.
Example 2
Uniformly dispersing 0.3g of carbomer in deionized water, standing and swelling until the carbomer is transparent and has no particles, standing overnight, stirring uniformly, adding 55g of ethanol to uniformly disperse, then adding 1g of the bactericide elsholtzia oil, 1.5g of glycerol, 2g of aloe extract and the balance of deionized water, finally adding 0.15g of triethylamine neutralizer to neutralize to be gelatinous to prepare the hand-washing-free skin-care disinfection gel, filling and sealing to obtain the finished product.
Example 3
Uniformly dispersing 0.2g of carbomer in deionized water, standing and swelling until the carbomer is transparent and has no particles, standing overnight, stirring uniformly, adding 56g of ethanol to be uniformly dispersed, then adding 0.5g of the bactericide elsholtzia oil, 1g of glycerol, 1g of the aloe extract and the balance of deionized water, finally adding 0.1g of triethylamine neutralizer to neutralize to be gelatinous to prepare the hand-washing-free skin-care disinfection gel, filling and sealing to obtain the finished product.
Example 4
Uniformly dispersing 0.2g of carbomer in deionized water, standing and swelling until the carbomer is transparent and has no particles, standing overnight, stirring uniformly, adding 58g of ethanol to be uniformly dispersed, then adding 1g of the bactericide elsholtzia oil, 2g of glycerol, 2.5g of the aloe extract and the balance of deionized water, finally adding 0.16g of triethylamine neutralizer to neutralize to be gelatinous to prepare the hand-washing-free skin-care disinfection gel, filling and sealing to obtain the finished product.
Example 5
Uniformly dispersing 0.25g of carbomer in deionized water, standing and swelling until the carbomer is transparent and has no particles, standing overnight, stirring uniformly, adding 60g of ethanol to be uniformly dispersed, then adding 0.9g of the bactericide elsholtzia oil, 1.8g of glycerol, 2g of the aloe extract and the balance of deionized water, finally adding 0.2g of triethylamine neutralizer to neutralize to be gelatinous to prepare the hand-washing-free skin-care disinfection gel, filling and sealing to obtain the finished product.
Example 6
Uniformly dispersing 0.25g of carbomer in deionized water, standing and swelling until the carbomer is transparent and has no particles, standing overnight, stirring uniformly, adding 57g of ethanol to be uniformly dispersed, then adding 0.6g of the bactericide elsholtzia oil, 1.2g of glycerol, 1.5g of the aloe extract and the balance of deionized water, finally adding 0.16g of triethylamine neutralizer to neutralize to be gelatinous to prepare the hand-washing-free skin-care disinfection gel, filling and sealing to obtain the finished product.
The killing and use effects of the products of examples 1-6 on microorganisms (natural bacteria on hands) are shown in the following table 1:
table 1 usage effect table
| Item | Skin care effect | Action time (S) | Sterilization Rate (%) of the above-mentioned Natural bacteria |
| Example 1 | Lubricating and moisturizing | 30 | 99.9 |
| Example 2 | Lubricating and moisturizing | 30 | 99.7 |
| Example 3 | Lubricating and moisturizing | 30 | 99.3 |
| Example 4 | Lubricating and moisturizing | 30 | 99.5 |
| Example 5 | Lubricating and moisturizing | 30 | 99.8 |
| Example 6 | Lubricating and moisturizing | 30 | 99.6 |
According to the data, the hand sanitizer can finish hand disinfection and has good moisturizing effect within 30 seconds, and is worthy of use and popularization.
Claims (4)
1. The hand-washing-free disinfection gel is characterized by being prepared from the following raw materials in percentage by mass:
2. a hand-free disinfecting gel as claimed in claim 1, wherein: the neutralizing agent is triethylamine.
3. A hand-free disinfecting gel as claimed in claim 2, wherein: the bactericide is Elsholtzia oil.
4. A method of preparing a no-hand sanitizing gel as described in any one of claims 1-3, comprising the steps of:
uniformly dispersing carbomer in deionized water, standing for swelling until carbomer is transparent and has no particles, standing overnight, stirring to be uniform, adding ethanol to be uniformly dispersed, then adding the bactericide of elsholtzia oil, glycerin, aloe extract and the balance of deionized water, and finally adding triethylamine neutralizer to neutralize to be gelatinous to prepare the hand-washing-free skin-care disinfection gel.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010160153.8A CN111214416A (en) | 2020-03-05 | 2020-03-05 | Hand-washing-free skin-care disinfection gel and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010160153.8A CN111214416A (en) | 2020-03-05 | 2020-03-05 | Hand-washing-free skin-care disinfection gel and preparation method thereof |
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| Publication Number | Publication Date |
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| CN111214416A true CN111214416A (en) | 2020-06-02 |
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| CN202010160153.8A Pending CN111214416A (en) | 2020-03-05 | 2020-03-05 | Hand-washing-free skin-care disinfection gel and preparation method thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111544337A (en) * | 2020-06-17 | 2020-08-18 | 广东中科天元新能源科技有限公司 | Hyaluronic acid-containing moisturizing and skin-moistening no-wash gel disinfectant and preparation method thereof |
| CN111714424A (en) * | 2020-08-07 | 2020-09-29 | 泰州市榕兴医疗用品股份有限公司 | Hand-washing-free disinfection gel |
| CN111973535A (en) * | 2020-09-10 | 2020-11-24 | 李时珍国灸集团蕲艾产业(蕲春)有限公司 | Folium artemisiae argyi washing-free disinfection gel and preparation method thereof |
| CN112006921A (en) * | 2020-07-23 | 2020-12-01 | 南京庭布苏新型材料研究院有限公司 | Wash-free alcohol gel with skin care function and preparation method thereof |
| CN113967179A (en) * | 2020-07-23 | 2022-01-25 | 山东菏泽三仪生物工程有限公司 | Washing-free hand disinfection gel with skin care effect and preparation method thereof |
| CN115645329A (en) * | 2022-10-25 | 2023-01-31 | 佛山市南海奥帝精细化工有限公司 | Washing-free hand-cleaning antibacterial gel and preparation method thereof |
-
2020
- 2020-03-05 CN CN202010160153.8A patent/CN111214416A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111544337A (en) * | 2020-06-17 | 2020-08-18 | 广东中科天元新能源科技有限公司 | Hyaluronic acid-containing moisturizing and skin-moistening no-wash gel disinfectant and preparation method thereof |
| CN112006921A (en) * | 2020-07-23 | 2020-12-01 | 南京庭布苏新型材料研究院有限公司 | Wash-free alcohol gel with skin care function and preparation method thereof |
| CN113967179A (en) * | 2020-07-23 | 2022-01-25 | 山东菏泽三仪生物工程有限公司 | Washing-free hand disinfection gel with skin care effect and preparation method thereof |
| CN111714424A (en) * | 2020-08-07 | 2020-09-29 | 泰州市榕兴医疗用品股份有限公司 | Hand-washing-free disinfection gel |
| CN111973535A (en) * | 2020-09-10 | 2020-11-24 | 李时珍国灸集团蕲艾产业(蕲春)有限公司 | Folium artemisiae argyi washing-free disinfection gel and preparation method thereof |
| CN111973535B (en) * | 2020-09-10 | 2023-08-08 | 李时珍国灸集团蕲艾产业(蕲春)有限公司 | Mugwort leaf washing-free disinfection gel and preparation method thereof |
| CN115645329A (en) * | 2022-10-25 | 2023-01-31 | 佛山市南海奥帝精细化工有限公司 | Washing-free hand-cleaning antibacterial gel and preparation method thereof |
| CN115645329B (en) * | 2022-10-25 | 2024-02-02 | 佛山市南海奥帝精细化工有限公司 | No-wash hand-cleaning antibacterial gel and preparation method thereof |
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