CN116173107B - 一种用于缓解慢性肾脏病伴急性肾损伤患者肾功能恶化的中药复合物 - Google Patents
一种用于缓解慢性肾脏病伴急性肾损伤患者肾功能恶化的中药复合物 Download PDFInfo
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Abstract
本发明提供了一种用于缓解慢性肾脏病伴急性肾损伤患者肾功能恶化的中药复合物，由黄芪、生大黄、车前子、白术、芡实、杜仲、五味子、甘草组成。本发明中黄芪益气养阴为君药；生大黄泄浊通便与之相配伍，芡实、杜仲、五味子加强补肾作用；车前子、白术化湿健脾，甘草调和，全方实现保护肾功能的作用。本发明的主要功效在于补肾泄浊。采用本发明治疗慢性肾脏病伴急性加重的患者，可以有效延缓肾功能恶化，保护患者肾功能，在临床上取得了较好的成果。
Description
技术领域
本发明属于生物医药领域，涉及一种中药组合物，具体来说是一种用于缓解慢性肾脏病伴急性肾损伤患者肾功能恶化的中药复合物。
背景技术
慢性肾脏病(chronic kidney disease)是常见的慢性非传染性疾病之一。急性肾损伤(Acute kidney injury,AKI)是慢性肾脏病加重的主要原因，对慢性肾脏病基础上合并急性肾损伤(A on C)的患者的治疗效果直接决定了患者进入终末期肾脏病的时限。
目前西医防治A on C方法较少，如在开展造影检查或治疗前进行水化处理，选择对肾损伤较轻的造影剂等。总的来说，目前西医对A on C方法有限。
发明内容
针对现有技术中的上述技术问题，本发明提供了一种用于缓解慢性肾脏病伴急性肾损伤患者肾功能恶化的中药复合物，所述的这种用于缓解慢性肾脏病伴急性肾损伤患者肾功能恶化的中药复合物要解决现有技术中的药物对于治疗A on C方法有限、疗效不明显的技术问题。
本发明提供了一种用于缓解慢性肾脏病伴急性肾损伤患者肾功能恶化的中药复合物，由如下重量份的组份制备而成：
具体的，所述的中药复合物，由如下重量份的组份制备而成：
本发明的制备方法是，将上述组份按照重量份称取，然后粉碎后混合均匀即可；
也可以制备成汤剂。
黄芪：具有健脾补中，升阳举陷，益卫固表，利尿，托毒生肌的功效，常用于治疗急慢性肾损伤。
生大黄：主要功能为攻积导滞、泻下通便，可帮助肠道排毒，减轻肾脏负担。
芡实：益肾固精、补脾止泻、祛湿止带的功效，协助黄芪扶助肾气。
杜仲：补肝肾，强筋骨，可补益肾气。
五味子：具有收敛固涩，益气生津，补肾宁心之功效，与芡实，杜仲一同补益肾脏。
白术：补气健脾、燥湿利水、止汗、安胎等功效，用于理气化湿，通调水道。
车前子：功能利水通淋、渗湿止泻，和白术一道，化湿利尿。
甘草：调和百药，为使药。
本发明中黄芪益气养阴为君药；生大黄泄浊通便与之相配伍，芡实、杜仲、五味子加强补肾作用，为臣药；车前子、白术化湿健脾为佐药，甘草调和为使药，全方实现保护肾功能的作用。本发明的主要功效在于补肾泄浊。
本发明可以为汤剂，具有治疗慢性肾脏病患者并发急性肾损伤的效果，具有良好的缓解肾功能恶化的功效。为便于患者携带、服用以及有效地控制药物质量，也可以其制备成颗粒剂。
本发明的服用方法为：每次1袋(每袋子15g)，每日2次，冲服，或遵医嘱。
本发明和已有技术相比，其技术进步是显著的。采用本发明治疗慢性肾脏病伴急性加重的患者，可以有效延缓肾功能恶化，保护患者肾功能，在临床上取得了较好的成果。
附图说明
图1显示小鼠造模后予药物灌胃4周后肌酐变化，服用颗粒剂大鼠肌酐显著低于对照组。
图2显示黄芪对小鼠UUO模型中肾纤维化的影响。
图3显示了本发明比单用黄芪更有效地缓解慢性肾脏病急性肾损伤。
具体实施方式
实施例1
本发明提供了一种用于缓解慢性肾脏病伴急性肾损伤患者肾功能恶化的中药复合物，由如下组份制备组成：
实施例2
本发明提供了一种用于缓解慢性肾脏病伴急性肾损伤患者肾功能恶化的中药复合物，由如下组份制备组成：
实施例3
本发明提供了一种用于缓解慢性肾脏病伴急性肾损伤患者肾功能恶化的中药复
合物，由如下重量份的组份组成：
实施例4
实验材料：C57BL/6背景小鼠，购自购自中科院上海实验动物中心，约20g；许可证号：SCXK(沪)2003-0003。上海交通大学实验动物中心饲养、造模和观察，自由饮食。饲养一周后，行3/4肾切除术，饲养一周。
1.随机分为三组、每组6只；
2.第一组灌胃(生理盐水)；
第二组灌胃(采用实施例3的配方制备成的中药煎剂)；
第三组灌胃(采用实施例3的配方制备成的中药颗粒剂冲泡的水剂)；
3.每日两次，每次约15-20ul；
4.以上操作构建慢性肾损伤小鼠模型；
5.两周后给小鼠尾静脉注射顺铂(默克Supelco标准品顺铂-CAS#:15663-27-1)20ug构建慢性肾脏病合并急性肾损伤模型；
6.48小时后小鼠处死取血，检测血清肌酐水平。
实验结果：见图1。结果表明，小鼠造模后予药物灌胃4周后肌酐变化，服用颗粒剂大鼠肌酐显著低于对照组。
实施例5君药黄芪研究内容
(1)目前现状:
在前期，我科开展了多项针对慢性肾脏病的基础和临床研究。2012年，前瞻性观察并统计了黄芪注射液在基础治疗上对慢性肾脏病基础上急性肾损伤的相关疗效。结果表明，黄芪注射液可显著降低患者血清肌酐、血胱抑素C、C反应蛋白、尿白蛋白和尿IgG；且未出现严重的不良反应。
表1：黄芪注射液对慢性肾脏病基础上急性肾损伤肾功能(肌酐、尿素氮、尿酸与GFR)的影响
表2：黄芪注射液对对慢性肾脏病基础上急性肾损伤血胱抑素C、C反应蛋白的影响
表3：黄芪注射液对对慢性肾脏病基础上急性肾损伤尿白蛋白、尿IgG的影响
如图2所示，在小鼠肾小管间质纤维化模型(UUO)中，探讨黄芪对慢性肾脏病肾纤维化改变的影响和机制研究，结果表明，黄芪处理的小鼠肾纤维化程度减轻，提示肾脏损伤程度减轻，发表DOI号(doi:10.1016/j.bbrc.2015.07.116.)。
进一步研究发现：除黄芪外，加用生大黄，芡实、杜仲、五味子，车前子、白术和甘草的合剂可以比单用黄芪更有效地缓解慢性肾脏病急性肾损伤，如图3所示。
组别说明：对照：使用生理盐水灌胃；黄芪：单纯使用黄芪颗粒灌胃；复合药物：使用黄芪+生大黄+芡实+杜仲+五味子+车前子+白术+甘草颗粒灌胃。
Claims (2)
1.一种用于缓解慢性肾脏病伴急性肾损伤患者肾功能恶化的中药复合物，其特征在于，由如下重量份的组份制备而成：
2.根据权利要求1所述的一种用于缓解慢性肾脏病伴急性肾损伤患者肾功能恶化的中药复合物，其特征在于，所述的中药复合物由如下重量份的组份制备而成：
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| CN107961272A (zh) * | 2017-12-22 | 2018-04-27 | 上海交通大学医学院附属仁济医院 | 一种用于慢性肾脏病的中药组合物 |
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Non-Patent Citations (2)
| Title |
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| 大黄联合黄芪治疗慢性肾衰竭的临床研究;梁庆丰等;疾病监测与控制;第5卷(第10期);631-632 * |
| 黄芪注射液防治慢性肾脏病基础上急性肾损伤的疗效观察;王琴等;中国中西医结合肾病杂志;第11卷(第10期);910-912 * |
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