CN108815364A - 一种治疗猪便秘的益生菌发酵中药制剂及其制备方法 - Google Patents
一种治疗猪便秘的益生菌发酵中药制剂及其制备方法 Download PDFInfo
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Abstract
本发明提供一种治疗猪便秘的益生菌发酵中药制剂及其制备方法,所述的中药制剂包括的中药组分如下:火麻仁、杏仁、白芍、大黄、枳实、川厚朴、连翘、麦冬、桔梗、元参、甘草;制备方法一:将所有中药混合再粉碎,后按比例加入EM菌液,混合装入呼吸袋中发酵;制作方法二:将所有中药熬煮后,浓缩汤液再加入EM菌液,混合后装入呼吸袋发酵。本发明的益生菌发酵中药制剂可有效治愈猪便秘,恢复猪肠道微生物生态平衡,且本发明中药制剂制备方法简单,成本低廉易推广。
Description
技术领域
本发明涉及一种治疗猪便秘的益生菌发酵中药制剂及其制备方法。
背景技术
目前治疗猪便秘最常用的中药药物为芒硝,但芒硝药效过强,且易复发。有田谷生于《湖北畜牧兽医》期刊1984年03期30页发表《使用厚朴、枳实治疗猪便秘》,其中提到以厚朴(即川厚朴)、枳实,津亏便秘加麦冬、生地,玉竹,瘟热不散加玄参,连翘治疗猪便秘。此配方中枳实功效为积消化痞,但枳实的食用易导致猪血压升高,不利于健康生长,且脾胃虚弱的猪慎用;且配方中枳实与厚朴配比10:7,枳实配比过重,药效过猛,脾胃虚,津亏便秘所加生地并不适于食少,腹满便溏的猪;配方中麦冬:性微寒,有养阴润肺的功效,但不宜长期服用,脾胃虚寒、感冒的猪食用反而会加重病情,但此配方中没有增加其他配方温和麦冬药性。
胡麻仁与火麻仁属两种不同的中药,现有技术多采用胡火麻仁为治疗猪便秘配方之一,但胡麻仁功效较猛,一般在病后体虚、眩晕乏力的情况下使用,用火麻仁与胡麻仁具有同样润燥滑肠通便的功效,但更温和,更适合一般便秘猪食用。
在常见中草药中:杏仁有止咳平喘,润肠通便,有润肺之功效;大黄有攻积滞、清湿热、泻火、凉血、祛瘀、解毒之功效;桔梗有宣肺,利咽,祛痰,排脓之功效;玄参即元参,能入血分而清热凉血;甘草:清热解毒,用于心气虚,心悸怔忡,脉结代,以及脾胃气虚,倦怠乏力;白芍可平肝止痛,用于血虚萎黄,腹痛,胁痛;连翘用于泻心火,除脾胃湿热,治中部血证。
另外用中药制剂治疗猪便秘所用中药虽然药理上对猪便秘有治疗作用,但传统食用方法中,中草药本身成分因分子较大并不能完全被猪肠胃吸收,对药效有一定影响。
发明内容
本发明在于提供一种治疗猪便秘的益生菌发酵中药制剂及其制备方法,该益生菌发酵中药制剂配方温和,具有治疗猪便秘、恢复猪肠道微生物生态平衡的功能,该方法过程简单、易控制,可实现工业化生产,且生产出的益生菌发酵中药制剂治疗猪便秘效果良好。
本发明的技术方案如下:
一种治疗猪便秘的益生菌发酵中药制剂,所述的益生菌发酵中药制剂原料包括:火麻仁、杏仁、白芍、大黄、枳实、川厚朴、连翘、麦冬、桔梗、元参、甘草及EM菌液;所述中药原料的质量百分比组分为:火麻仁6-9%,杏仁9-13%,白芍6-9%,大黄6-9%,枳实6-9%,川厚朴9-13%,连翘6-9%,麦冬9-13%,桔梗6-9%,元参9-13%,甘草9-13%,各中药组分的质量百分比之和为100%。
本发明提供了上述一种治疗猪便秘的益生菌发酵中药制剂的制备方法,所述益生菌发酵中药制剂中所包含的原料如下:火麻仁、杏仁、白芍、大黄、枳实、川厚朴、连翘、麦冬、桔梗、元参、甘草;
制备方法如下:
(1)称取中药原料并混合粉碎
(2)粉碎的中药原料中加入中药组分总重50-60%的EM菌液,混合后装至呼吸袋内进行发酵,发酵条件为:PH3.0-4.0,温度10-40℃,时间5-15天,即得本发明的益生菌中药制剂。
本发明还提供了上述一种治疗猪便秘的益生菌发酵中药制剂的制备方法,所述益生菌发酵中药制剂中所包含的原料如下:火麻仁、杏仁、白芍、大黄、枳实、川厚朴、连翘、麦冬、桔梗、元参、甘草;
制备方法如下:
(1)将所有中药原料加水至覆盖所有中药熬煮40-60分钟,过滤取汤液,再将汤液熬煮浓缩至原汤液三分之一至四分之一重量;
(2)浓缩的汤液放凉至温度在40℃以下后加入熬煮前中药组分总重5-6%的EM菌液混合,装至呼吸瓶内发酵;发酵条件:PH3.0-4.0,温度10-40℃,时间5-15天。
进一步的,所述的任意一种治疗猪便秘的益生菌发酵中药制剂的制备方法中药原料组分的质量百分比如下:
火麻仁6-9%,杏仁9-13%,白芍6-9%,大黄6-9%,枳实6-9%,川厚朴9-13%,连翘6-9%,麦冬9-13%,桔梗6-9%,元参9-13%,甘草9-13%,其中各中药组份的质量百分比之和为100%。
本发明的有益效果有:
1、发酵时间短,最短5天即可制成;
2、提升疗效,中药成分经过益生菌转化,由大分子变成小分子,无中药药渣,中药利用率百分百,提升疗效;
3、发酵过程分解中药毒性,真正无毒副作用;
4、改善中药口味,使“良药不苦口”,生猪爱吃,促进生长;
5、改善猪只体质,纯中药制剂,通过益生菌转化更易吸收,改善猪肠道微生物群,从根本上改善便秘状况,4-10小时见效,连续3天服用治愈率达90%以上;
6、针对猪仔及不易喂养饲料的猪,本发明提供的制作方法二为液体药物,方便猪仔灌药及减少猪仔对药渣的消化负担;
7、方法简单,成本低廉易推广。
具体实施方式
本发明涉及一种治疗猪便秘的益生菌发酵中药制剂,所述的益生菌发酵中药制剂原料包括:火麻仁、杏仁、白芍、大黄、枳实、川厚朴、连翘、麦冬、桔梗、元参、甘草及EM菌液;所述中药原料的质量百分比组分为:火麻仁6-9%,杏仁9-13%,白芍6-9%,大黄6-9%,枳实6-9%,川厚朴9-13%,连翘6-9%,麦冬9-13%,桔梗6-9%,元参9-13%,甘草9-13%,各中药组分的质量百分比之和为100%。
所述的益生菌中药制剂制成后可根据需要直接拌饲料喂食或者进一步提炼制成汤剂、散剂、口服液、水合丸剂、颗粒剂、片剂、胶剂或糖浆剂中的任意一种。
本发明还涉及一种治疗猪便秘的益生菌发酵中药制剂的制备方法,具体制备方法如下:
(1)称取中药原料并混合粉碎
(2)粉碎的中药原料中加入中药组分总重50-60%的EM菌液,混合后装至呼吸袋内进行发酵,发酵条件为:PH4.0-6.0,温度20-40℃,时间5-15天。
针对猪仔不易喂养饲料的猪,本发明还提供了一种治疗猪便秘的益生菌发酵中药制剂的制备方法,制备方法如下:
(1)将所有中药原料加水至覆盖所有中药熬煮40-60分钟,过滤取汤液,再将汤液熬煮浓缩至原汤液三分之一至四分之一重量;
(2)浓缩的汤液放凉至温度在40℃以下后加入汤液总重量5-6%的EM菌液混合,装袋至呼吸袋内发酵;发酵条件:PH3.0-4.0,温度10-40℃,时间5-15天。
下面结合具体实施例对本发明作进一步的说明。
实施例一
(1)称取中药原料火麻仁60g、杏仁90g、白芍60g、大黄60g、枳实60g、川厚朴90g、连翘60g、麦冬90g、桔梗60g、元参90g、甘草90g,混合并粉碎。
(2)粉碎的中药原料中加入405gEM菌液,混合后装至呼吸膜内进行发酵,发酵条件为:PH3.0-4.0,温度40℃,时间5天。
发酵完成,制得本发明的益生菌发酵中药制剂。
选取福建省龙岩地区养殖场育肥阶段的便秘猪50头,拌料给药,拌入本发明中药制剂重量为饲料重量的0.4%,一日三次,连续拌料喂养三天,记录结果有:第一次喂养后4-10小时内出现第一次正常排粪的猪有43头,喂养三天后便秘症状消失的猪有46头,余下4头便秘症状全部有所好转。
实施例二
(1)称取中药原料火麻仁75g、杏仁110g、白芍75g、大黄110g、枳实75g、川厚朴110g、连翘75g、麦冬110g、桔梗75g、元110g、甘草110g,混合并粉碎。
(2)粉碎的中药原料中加入570gEM菌液,混合后装至呼吸袋内进行发酵,发酵条件为:PH3.0-4.0,温度25℃,时间8天。
发酵完成,制得本发明的益生菌发酵中药制剂。
选取福建省龙岩地区养殖场育肥阶段的便秘猪50头,拌料给药,拌入本发明中药制剂重量为饲料重量的0.4%,一日三次,连续拌料喂养三天,记录结果有:第一次喂养后4-10小时内出现第一次正常排粪的猪有41头,喂养三天后便秘症状消失的猪有45头,余下5头便秘症状好转的4头。
实施例三
(1)称取中药原料火麻仁90g、杏仁130g、白芍90g、大黄90g、枳实90g、川厚朴130g、连翘90g、麦冬130g、桔梗90g、元参130g、甘草130g,混合并粉碎。
(2)粉碎的中药原料中加入714gEM菌液,混合后装至呼吸袋内进行发酵,发酵条件为:PH3.0-4.0,温度10℃,时间15天。
发酵完成,制得益生菌发酵中药制剂。
选取福建省龙岩地区养殖场育肥阶段的便秘猪57头,拌料给药,拌入本发明中药制剂重量为饲料重量的0.4%,一日三次,连续拌料喂养三天,记录结果有:第一次喂养后4-10小时内出现第一次正常排粪的猪有46头,喂养三天后便秘症状消失的猪有53头,余下4头便秘症状好转的4头。
表1.本发明方法对猪便秘的治疗效果表
注:治疗结果判断标准:正常排粪:粪便成细香肠样,一天4-6次排粪;便秘:常表现排粪姿势,但排出一些稀粪水或少量粪块,且粪块为干硬球状。
实施例四
(1)称取中药原料火麻仁60g、杏仁90g、白芍60g、大黄60g、枳实60g、川厚朴90g、连翘60g、麦冬90g、桔梗60g、元参90g、甘草90g,混合后将所有中药原料加水至覆盖所有中药熬煮60分钟,过滤取汤液,再将汤液熬煮浓缩至原汤液三分之一量;
(2)浓缩的汤液放凉后加入40gEM菌液混合,装至呼吸瓶内发酵;发酵条件:PH3.0-4.0,温度40℃,时间5天。
发酵完成,制得本发明的益生菌发酵中药制剂。
选取福建省龙岩地区养殖场的便秘猪仔20头,直接给药,一次10ml,一日一次,连续拌料喂养三天,记录结果有:第一次喂养后4-10小时内出现第一次正常排粪的猪有15头,喂养三天后便秘症状消失的猪有19头,余下1头便秘症状好转。
实施例五
(1)称取中药原料火麻仁75g、杏仁110g、白芍75g、大黄110g、枳实75g、川厚朴110g、连翘75g、麦冬110g、桔梗75g、元110g、甘草110g,混合后将所有中药原料加水至覆盖所有中药熬煮50分钟,过滤取汤液,再将汤液熬煮浓缩至原汤液三分之一重量。
(2)浓缩的汤液放凉后加入57gEM菌液混合,装至呼吸瓶内发酵;发酵条件:PH3.0-4.0,温度25℃,时间8天。
发酵完成,制得本发明的益生菌发酵中药制剂。
选取福建省龙岩地区养殖场的便秘猪仔20头,直接给药,一次10ml,一日一次,连续拌料喂养三天,记录结果有:第一次喂养后4-10小时内出现第一次正常排粪的猪有16头,喂养三天后便秘症状消失的猪有20头。
实施例六
(1)称取中药原料火麻仁90g、杏仁130g、白芍90g、大黄90g、枳实90g、川厚朴130g、连翘90g、麦冬130g、桔梗90g、元参130g、甘草130g,混合后将所有中药原料加水至覆盖所有中药熬煮40分钟,过滤取汤液,再将汤液熬煮浓缩至原汤液四分之一重量。
(2)浓缩的汤液放凉后加入71gEM菌液混合,装至呼吸瓶内进行发酵,发酵条件为:PH3.0-4.0,温度10℃,时间15天。
发酵完成,制得益生菌发酵中药制剂。
选取福建省龙岩地区养殖场的便秘猪仔20头,直接给药,一次10ml,一日一次,连续拌料喂养三天,记录结果有:第一次喂养后4-10小时内出现第一次正常排粪的猪有16头,喂养三天后便秘症状消失的猪有18头,余下2头便秘均有好转。
表2.本发明方法对猪仔便秘的治疗效果表
注:治疗结果判断标准:正常排粪:粪便成细香肠样,一天4-6次排粪;便秘:常表现排粪姿势,但排出一些稀粪水或少量粪块,且粪块为干硬球状。
通过以上实施例可看出本发明的益生菌中药制剂对猪便秘可达到喂食4-10小时见效,三天内基本治愈或好转。
本发明的原理在于:1、配方上采用纯中药制剂,同时不使用药性过猛的芒硝;通过火麻仁代替传统胡麻仁温和药性;通过降低枳实的配比来减轻副作用;通过胡麻仁、枳实、川厚朴三种药物来增强润肠通便的功能,通过麦冬、桔梗、元参、连翘达到清湿热、泻火、排脓、润肺的功效,再通过甘草、大黄、白芍、杏仁进行温补、调理、解毒,改进了现有技术中药性过猛或者药效不足的问题;
2、在药物配比上,通过增加厚朴的分量调和枳实用量较小的问题;通过增加甘草的分量来调解药物配方中的毒性,增大调理温补的功效;
3、按实际需要进行制备,针对猪仔及不易通过饲养喂药的猪进行熬制药物再发酵制备,方面给药,同时减少了猪仔对药渣的消化负担;
4、通过EM菌液的发酵,将大分子中药转化成小分子,不改变药性,保持了原中药作用的同时使得药物分子更易被猪肠胃吸收,充分发挥药物作用,同时有益菌在猪肠道内能改善猪肠道微生物群组成,促进猪健康发展。
虽然以上描述了本发明的具体实施方式,但是熟悉本技术领域的技术人员应当理解,我们所描述的具体实施例只是说明性,而不是对本发明的范围的限定,熟悉本领域的技术人员在依照本发明的精神所作的等效的修饰以及变化,都应当涵盖在本发明的权利要求保护的范围内。
Claims (4)
1.一种治疗猪便秘的益生菌发酵中药制剂,其特征在于:所述的益生菌发酵中药制剂原料包括:火麻仁、杏仁、白芍、大黄、枳实、川厚朴、连翘、麦冬、桔梗、元参、甘草及EM菌液;所述中药原料的质量百分比组分为:火麻仁6-9%,杏仁9-13%,白芍6-9%,大黄6-9%,枳实6-9%,川厚朴9-13%,连翘6-9%,麦冬9-13%,桔梗6-9%,元参9-13%,甘草9-13%,各中药组分的质量百分比之和为100%。
2.一种治疗猪便秘的益生菌发酵中药制剂的制备方法,其特征在于:所述益生菌发酵中药制剂所包含的原料如下:火麻仁、杏仁、白芍、大黄、枳实、川厚朴、连翘、麦冬、桔梗、元参、甘草;
制备方法如下:
(1)称取中药原料并混合粉碎
(2)粉碎的中药原料中加入中药组分总重50-60%的EM菌液,混合后装至呼吸袋内进行发酵,发酵条件为:PH3.0-4.0,温度10-40℃,时间5-15天。
3.一种治疗猪便秘的益生菌发酵中药制剂的制备方法,其特征在于:所述益生菌发酵中药制剂所包含的原料如下:火麻仁、杏仁、白芍、大黄、枳实、川厚朴、连翘、麦冬、桔梗、元参、甘草;
制备方法如下:
(1)将所有中药原料加水至覆盖所有中药熬煮40-60分钟,过滤取汤液,再将汤液熬煮浓缩至原汤液三分之一至四分之一的重量;
(2)浓缩的汤液加入熬煮前中药组分总重5-6%的EM菌液混合,装至呼吸瓶内发酵;发酵条件:PH3.0-4.0,温度10-40℃,时间5-15天。
4.根据权利要求2、3所述的任意一种治疗猪便秘的益生菌发酵中药制剂的制备方法,其特征在于:所述中药原料组分的质量百分比如下:
火麻仁6-9%,杏仁9-13%,白芍6-9%,大黄6-9%,枳实6-9%,川厚朴9-13%,连翘6-9%,麦冬9-13%,桔梗6-9%,元参9-13%,甘草9-13%,其中各中药组份的质量百分比之和为100%。
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