CN116159113A - Composition for regulating uric acid to treat gout and preparation method thereof - Google Patents
Composition for regulating uric acid to treat gout and preparation method thereof Download PDFInfo
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- CN116159113A CN116159113A CN202211728813.3A CN202211728813A CN116159113A CN 116159113 A CN116159113 A CN 116159113A CN 202211728813 A CN202211728813 A CN 202211728813A CN 116159113 A CN116159113 A CN 116159113A
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Abstract
The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a composition for regulating uric acid to treat gout and a preparation method thereof. The composition is prepared from the following raw materials, by weight, 10-20 parts of coix seed, 10-20 parts of liquorice, 10-20 parts of radix puerariae, 10-20 parts of lily, 10-20 parts of chicory, 10-20 parts of mulberry leaf, 10-20 parts of cape jasmine, 10-20 parts of poria cocos and 10-20 parts of dandelion. The invention selects organic mixed solvent for extraction, and the obtained organic solvent extract has much stronger uric acid reducing effect than the extract obtained by adopting conventional ethanol and water extraction. Experiments prove that the composition has stronger uric acid reducing effect; compared with the common uric acid reducing medicines, the composition provided by the invention can not cause liver and kidney injury, and has milder uric acid reducing effect and safer effect.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a composition for regulating uric acid to treat gout and a preparation method thereof.
Background
With the improvement of the living standard of people, the structure in the diet of people in daily life is also changed greatly. The eating of a large amount of meat, seafood, viscera, alcohol and the like causes the characteristics of high calorie, high protein and high fat of people's diet. These characteristics lead to overnutrition of people, so that uric acid content generated by metabolism of organisms is increased, and gout is finally generated.
Gout is a complex type of arthritis. When pain is generated, a patient can wake up in the middle night of deep sleep, and the most frequently generated joint is the big toe, but the generated joint is not limited to the big toe, and is also commonly generated in joints, knees, elbows and the like of hands; the affected joints are finally red and inflamed, the tissues become soft after edema, the movement of the patient is limited, and finally the daily life of the patient is affected.
Chinese patent CN113455655 a discloses a food and pharmaceutical composition for reducing uric acid to treat gout, which has good analgesic and uric acid reducing effects, and it claims to make tea by using 10g of the composition, the uric acid level is 650, the high uric acid level history is many years, the tea is also drunk twice daily, after three days of drinking, the uric acid level is reduced to 490, after five days of drinking, the uric acid level is reduced to 390. And not to mention whether it actually achieves this effect, if uric acid actually decreases, it is clear whether it may induce gout flares if uric acid decreases too rapidly, or the patient himself suffers from gout, which may result in exacerbation.
Disclosure of Invention
Aiming at the problems in the background technology, the invention provides a composition for regulating uric acid to treat gout and a preparation method thereof.
The technical scheme adopted for realizing the purpose of the invention is as follows: the composition for regulating uric acid to treat gout is prepared from the following raw materials, by weight, 10-20 parts of coix seed, 10-20 parts of liquorice, 10-20 parts of radix puerariae, 10-20 parts of lily, 10-20 parts of chicory, 10-20 parts of mulberry leaf, 10-20 parts of gardenia, 10-20 parts of poria cocos and 10-20 parts of dandelion.
As a preferred embodiment of the invention, the composition is prepared from the following raw materials, by weight, 18 parts of coix seed, 15 parts of liquorice, 15 parts of kudzuvine root, 16 parts of lily, 18 parts of chicory, 13 parts of mulberry leaf, 13 parts of cape jasmine, 15 parts of poria cocos, and 18 parts of dandelion.
As a preferred embodiment of the invention, the composition is prepared from the following raw materials, by weight, 10 parts of coix seed, 20 parts of liquorice, 10 parts of kudzuvine root, 20 parts of lily, 20 parts of chicory, 20 parts of mulberry leaf, 10 parts of cape jasmine, 10 parts of poria cocos, and 20 parts of dandelion.
As a preferred embodiment of the invention, the composition is prepared from the following raw materials, by weight, 20 parts of coix seed, 10 parts of liquorice, 20 parts of kudzuvine root, 10 parts of lily, 10 parts of chicory, 10 parts of mulberry leaf, 20 parts of cape jasmine, 20 parts of poria cocos, and 10 parts of dandelion.
As a preferred embodiment of the invention, the composition is prepared from the following raw materials, by weight, 20 parts of coix seed, 10 parts of liquorice, 14 parts of kudzuvine root, 12 parts of lily, 15 parts of chicory, 18 parts of mulberry leaf, 16 parts of gardenia, 20 parts of poria cocos, and 20 parts of dandelion.
The invention relates to a preparation method of a composition for regulating uric acid to treat gout, which comprises the following specific steps:
1) Pretreating raw materials, cleaning Coicis semen, glycyrrhrizae radix, radix Puerariae, bulbus Lilii, herba Cichorii, folium Mori, fructus Gardeniae, poria, and herba Taraxaci with cold water;
2) Mixing the raw materials, pulverizing Coicis semen, glycyrrhrizae radix, radix Puerariae, bulbus Lilii, herba Cichorii, folium Mori, fructus Gardeniae, poria, and herba Taraxaci to obtain a mixture;
3) Extracting the mixture obtained in the step 2) by using an organic mixed solvent to obtain an extracting solution;
4) Concentrating the extractive solution to a relative density of 1.30-1.40 to obtain extract.
Preferably, the particle size of the crushed particles obtained in step 2) is less than 1cm.
Preferably, the mixture of step 3) of the present invention and the organic solvent mixture are used in a ratio of 1g: 10-15 mL, wherein the organic mixed solvent is a mixed solvent consisting of n-butanol and ethyl acetate.
Preferably, the dosage of the n-butanol and the ethyl acetate is (3-6): 1.
preferably, the extraction in the step 3) is carried out at 70-75 ℃ for 2-4 hours.
Compared with the prior art, the invention has the technical advantages that:
1) The composition product of the invention has the effects of clearing heat and detoxicating, inducing diuresis and detumescence, nourishing yin and promoting the production of body fluid, nourishing yin and clearing heat, replenishing qi and strengthening spleen, relaxing tendons and dredging collaterals, and removing blood stasis and dampness. Meanwhile, the product can promote metabolism, reduce uric acid and regulate metabolism. Is suitable for adjuvant treatment of hyperuricemia, gout and gout complications, promotes metabolism, and improves immunity.
2) After the composition product is taken, the time for eliminating gout edema can be shortened, and the pain of patients can be improved.
3) The invention selects organic mixed solvent for extraction, and the obtained organic solvent extract has much stronger uric acid reducing effect than the extract obtained by adopting conventional ethanol and water extraction.
4) Experiments prove that the composition has stronger uric acid reducing effect; compared with the common uric acid reducing medicines, the composition provided by the invention can not cause liver and kidney injury, and has milder uric acid reducing effect and safer effect.
Detailed Description
The invention is further described below with reference to examples.
The invention relates to a composition for regulating uric acid to treat gout, which is prepared from the following raw materials, by weight, 10-20 parts of coix seed, 10-20 parts of liquorice, 10-20 parts of radix puerariae, 10-20 parts of lily, 10-20 parts of chicory, 10-20 parts of mulberry leaf, 10-20 parts of gardenia, 10-20 parts of poria cocos and 10-20 parts of dandelion.
Example 1
1) The preparation method comprises the following steps of: 18 parts of coix seed, 15 parts of liquorice, 15 parts of kudzuvine root, 16 parts of lily, 18 parts of chicory, 13 parts of mulberry leaf, 13 parts of cape jasmine, 15 parts of poria cocos and 18 parts of dandelion, and cleaning;
2) Pulverizing Coicis semen, glycyrrhrizae radix, radix Puerariae, bulbus Lilii, herba Cichorii, folium Mori, fructus Gardeniae, poria, and herba Taraxaci with pulverizer, and making granule diameter smaller than 1cm to obtain mixture;
3) Extracting 100g of the obtained mixture with 150mL of organic mixed solvent at 70deg.C for 4h to obtain extractive solution; the organic mixed solvent is n-butanol and ethyl acetate according to the volume ratio of 3:1, a mixed solvent consisting of the components;
4) Concentrating the extractive solution to a relative density of about 1.35 to obtain extract.
Example 2
1) The preparation method comprises the following steps of: 10 parts of coix seed, 20 parts of liquorice, 10 parts of radix puerariae, 20 parts of lily, 20 parts of chicory, 20 parts of mulberry leaf, 10 parts of gardenia, 10 parts of poria cocos, and 20 parts of dandelion;
2) Pulverizing Coicis semen, glycyrrhrizae radix, radix Puerariae, bulbus Lilii, herba Cichorii, folium Mori, fructus Gardeniae, poria, and herba Taraxaci with pulverizer, and making granule diameter smaller than 1cm to obtain mixture;
3) Extracting 100g of the obtained mixture with 100mL of organic mixed solvent at 75deg.C for 2h to obtain extractive solution; the organic mixed solvent is n-butanol and ethyl acetate according to the volume ratio of 6:1, a mixed solvent consisting of the components;
4) Concentrating the extractive solution to relative density of about 1.40 to obtain extract.
Example 3
1) The preparation method comprises the following steps of: 20 parts of coix seed, 10 parts of liquorice, 20 parts of radix puerariae, 10 parts of lily, 10 parts of chicory, 10 parts of mulberry leaf, 20 parts of gardenia, 20 parts of poria cocos, and 10 parts of dandelion;
2) Pulverizing Coicis semen, glycyrrhrizae radix, radix Puerariae, bulbus Lilii, herba Cichorii, folium Mori, fructus Gardeniae, poria, and herba Taraxaci with pulverizer, and making granule diameter smaller than 1cm to obtain mixture;
3) Extracting 100g of the obtained mixture with 120mL of organic mixed solvent at 72 ℃ for 3h to obtain an extract; the organic mixed solvent is n-butanol and ethyl acetate according to the volume ratio of 5:1, a mixed solvent consisting of the components;
4) Concentrating the extractive solution to relative density of about 1.30 to obtain extract.
Example 4
1) The preparation method comprises the following steps of: 20 parts of coix seed, 10 parts of liquorice, 14 parts of kudzuvine root, 12 parts of lily, 15 parts of chicory, 18 parts of mulberry leaf, 16 parts of gardenia, 20 parts of poria cocos and 20 parts of dandelion;
2) Pulverizing Coicis semen, glycyrrhrizae radix, radix Puerariae, bulbus Lilii, herba Cichorii, folium Mori, fructus Gardeniae, poria, and herba Taraxaci with pulverizer, and making granule diameter smaller than 1cm to obtain mixture;
3) Extracting 100g of the obtained mixture with 150mL of organic mixed solvent at 75deg.C for 4h to obtain extractive solution; the organic mixed solvent is n-butanol and ethyl acetate according to the volume ratio of 4:1, a mixed solvent consisting of the components;
4) Concentrating the extractive solution to relative density of about 1.40 to obtain extract.
Comparative example 1
The extraction in step 3) was performed by directly selecting an ethanol solvent, and the rest was the same as in example 3.
Comparative example 2
The extraction in step 3) was directly carried out by steam extraction with water, the remainder being as in example 3.
Comparative example 3
Mixing the organic mixed solvent in the step 3), and mixing n-butanol and ethyl acetate according to a volume ratio of 10:1, and the rest is the same as in example 3.
The uric acid lowering effect was evaluated for the compositions of examples 1 to 4 and comparative examples 1 to 3.
Taking male Kunming mice with the weight of 20+/-2 g, and continuously perfusing the stomach with the suspension of the potassium oxazinate for 10 days under the condition of guaranteeing normal diet and drinking water to establish a hyperuricemia animal model of the mice.
Mice with uric acid content of 160-165 mu mol/L in serum are selected as high uric acid model mice and are used as experimental objects. 21 male hyperuricemia model mice are randomly divided into 7 groups of 3 mice; the extracts with uric acid reducing effect prepared in examples 1 to 4 and comparative examples 1 to 3 are respectively added with water to prepare suspension; then, the stomach-lavage administration is carried out to the mice in 1 to 7 groups of experimental groups according to the amount of 100 mg/kg.d; the model control group was perfused with an equal amount of distilled water. The administration is continued for 10 days; 1h after the end of the administration on day 10, taking blood of the mice, and measuring the uric acid content in serum of the mice; the test results are shown in Table 1.
Table 1 shows the results of uric acid lowering experiments with the extracts of the present invention.
| Grouping | Serum uric acid content, mu mol/L |
| Model control group | 163.6 |
| Example 1 | 32.2 |
| Example 2 | 28.8 |
| Example 3 | 31.2 |
| Example 4 | 29.1 |
| Comparative example 1 | 70.2 |
| Comparative example 2 | 82.3 |
| Comparative example 3 | 42.1 |
As can be seen from Table 1, the examples 1 to 4 of the present invention obtained a good uric acid lowering effect. In contrast, the comparative examples 1 and 2 have limited uric acid reducing effect due to the selection of conventional ethanol and water solvents, while the comparative example 3 has a better effect due to the selection of organic solvents with different proportions, but is less remarkable than the example 3.
Claims (10)
1. A composition for regulating uric acid to treat gout, characterized in that: the composition is prepared from the following raw materials, by weight, 10-20 parts of coix seed, 10-20 parts of liquorice, 10-20 parts of radix puerariae, 10-20 parts of lily, 10-20 parts of chicory, 10-20 parts of mulberry leaf, 10-20 parts of cape jasmine, 10-20 parts of poria cocos and 10-20 parts of dandelion.
2. A composition for modulating uric acid in the treatment of gout in accordance with claim 1, wherein: the composition is prepared from the following raw materials in parts by weight: 18 parts of coix seed, 15 parts of liquorice, 15 parts of kudzuvine root, 16 parts of lily, 18 parts of chicory, 13 parts of mulberry leaf, 13 parts of gardenia, 15 parts of poria cocos and 18 parts of dandelion.
3. A composition for modulating uric acid in the treatment of gout in accordance with claim 1, wherein: the composition is prepared from the following raw materials in parts by weight: 10 parts of coix seed, 20 parts of liquorice, 10 parts of kudzuvine root, 20 parts of lily, 20 parts of chicory, 20 parts of mulberry leaf, 10 parts of gardenia, 10 parts of tuckahoe and 20 parts of dandelion.
4. A composition for modulating uric acid in the treatment of gout in accordance with claim 1, wherein: the composition is prepared from the following raw materials in parts by weight: 20 parts of coix seed, 10 parts of liquorice, 20 parts of kudzuvine root, 10 parts of lily, 10 parts of chicory, 10 parts of mulberry leaf, 20 parts of gardenia, 20 parts of poria cocos and 10 parts of dandelion.
5. A composition for modulating uric acid in the treatment of gout in accordance with claim 1, wherein: the composition is prepared from the following raw materials in parts by weight: 20 parts of coix seed, 10 parts of liquorice, 14 parts of kudzuvine root, 12 parts of lily, 15 parts of chicory, 18 parts of mulberry leaf, 16 parts of gardenia, 20 parts of poria cocos and 20 parts of dandelion.
6. A method of preparing a uric acid modulating composition for the treatment of gout according to any of claims 1-5, comprising: the method comprises the following specific steps:
pretreating raw materials, cleaning Coicis semen, glycyrrhrizae radix, radix Puerariae, bulbus Lilii, herba Cichorii, folium Mori, fructus Gardeniae, poria, and herba Taraxaci with cold water;
mixing the raw materials, pulverizing Coicis semen, glycyrrhrizae radix, radix Puerariae, bulbus Lilii, herba Cichorii, folium Mori, fructus Gardeniae, poria, and herba Taraxaci to obtain a mixture;
3) Extracting the mixture obtained in the step 2) by using an organic mixed solvent to obtain an extracting solution;
4) Concentrating the extractive solution to a relative density of 1.30-1.40 to obtain extract.
7. The method of manufacturing according to claim 6, wherein: the crushing in the step 2) is carried out, and the particle size of the crushed particles is smaller than 1cm.
8. The method of manufacturing according to claim 7, wherein: the ratio of the mixture in the step 3) to the organic mixed solvent is 1g: 10-15 mL, wherein the organic mixed solvent is a mixed solvent consisting of n-butanol and ethyl acetate.
9. The method of manufacturing according to claim 8, wherein: the volume ratio of the n-butyl alcohol to the ethyl acetate is (3-6): 1.
10. the method of manufacturing according to claim 7, wherein: the extraction in the step 3) is carried out at 70-75 ℃ for 2-4 h.
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Cited By (1)
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| CN116746680A (en) * | 2023-06-17 | 2023-09-15 | 广东善百年特医食品有限公司 | Uric acid-reducing gout-relieving diglyceride composition and preparation method and application thereof |
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| CN108159312A (en) * | 2018-01-04 | 2018-06-15 | 大连美通生物技术有限公司 | A kind of composite plant activity drink and preparation method that can treat gout |
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| CN116746680A (en) * | 2023-06-17 | 2023-09-15 | 广东善百年特医食品有限公司 | Uric acid-reducing gout-relieving diglyceride composition and preparation method and application thereof |
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