CN116133521A - 用于施加到皮肤上的皮肤耐受性消毒护理制剂 - Google Patents

用于施加到皮肤上的皮肤耐受性消毒护理制剂 Download PDF

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CN116133521A
CN116133521A CN202180046476.7A CN202180046476A CN116133521A CN 116133521 A CN116133521 A CN 116133521A CN 202180046476 A CN202180046476 A CN 202180046476A CN 116133521 A CN116133521 A CN 116133521A
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赖纳·波默斯海姆
丹尼斯·布鲁驰
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Merlin Ebok Lute Gebhardt And Dr Frank Ulrich Unlimited Liability Co
Turichem Ltd
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Abstract

本发明涉及用于施加到皮肤上或用于治疗皮肤的皮肤耐受性消毒护理制剂，其包含作为消毒活性物质的一种或多种水溶性氯衍生物，其中所述一种或多种氯衍生物被掺入到基础乳膏或凝胶基质中，并且另外包含用于掩蔽所述氯组分的气味的物质混合物。

Description

用于施加到皮肤上的皮肤耐受性消毒护理制剂
技术领域
本发明涉及用于施加到皮肤上并用于治疗皮肤的皮肤耐受性消毒护理制剂，其包含一种或多种水溶性氯衍生物作为消毒活性物质，基于这种制剂的乳膏，以及根据独立权利要求教导的具有这种消毒剂或者与之相关的乳膏或凝胶的分配器、罐、管或包装。
背景技术
已知有产品可以施加于皮肤，并且其由于施加于皮肤而导致消毒、减少细菌的效果。已知的制剂基于活性物质异丙醇、乙醇或其它醇类。
除液体产品外，还已知其中醇已被浓缩的凝胶。
为了在这里发展出足够的消毒效果，所述醇必须以至少70％的浓度存在。这种浓度在凝胶中可简单实现。然而，关于这些浓度，不能制造乳膏。
迄今为止已知的含有醇的用于消毒的乳膏因此在医学意义上以及在卫生方面都是不够的，并且它们的有效性有限。
从文献DE 10 2006 043 245 A1中已知含氯胺的伤口处理剂。
在那里，通过喷洒氯胺T溶液获得含10％氯胺的伤口敷料。与物理负载的沸石组分和液体可渗透覆盖材料一起，所介绍的系统可在通过氯胺水溶液进行消毒的同时主要用于治疗出血伤口。
在文献EP 1 955 591 A1中涉及苯扎氯铵，其在关于用于护理和用于抗微生物治疗皮肤的制剂的乳膏基础中作为消毒剂和抗微生物皮肤治疗剂。这种乳膏具有基于所提及的苯扎氯铵的一种单独的药用活性组分。在这个方面，在软膏中，使用粘稠到固体的石蜡，羊毛蜡和/或白色凡士林。根据EP 1 955 591 A1的制剂也被认为适用于皮肤的护理消毒，特别是对于医生或医务人员。
发明内容
从前述内容来看，本发明的任务是提出一种进一步开发的皮肤耐受性消毒护理制剂，特别是用于施加到皮肤上的乳膏，其除了良好的皮肤耐受性以及护理和润滑效果外，还显示出可验证的充分的消毒效果，其中主要关心的不是伤口消毒，而是每天用于手部消毒，并因此用于阻断可能的感染链。
从医学角度来看，乳膏被理解为是一种水包油乳液或油包水乳液，这使得成分准备好被施加。相对于软膏，乳膏粘性更小，即液体更多，并且可以很好地吸收到皮肤中。在乳膏中，通常使用乳化剂或乳液稳定剂。通俗地说，乳膏也被称为非医疗的纯粹护理产品。
根据所描述的任务定义，它是通过以下方案解决的：根据依照权利要求1的特征组合的用于施加到皮肤上或用于治疗皮肤的皮肤耐受性消毒护理制剂，根据权利要求4的乳膏或凝胶，或根据权利要求8的分配器、罐、管或包装。
与已知的溶液相比，根据本发明的制剂不依赖于醇作为消毒活性物质，而是依赖于氯衍生物。这种活性物质当被施加到皮肤上时在相应浓度内作为消毒剂是推荐的并且是适合的。
在根据本发明配制剂中使用的氯衍生物具有良好的水溶性，并且可以以推荐的浓度很好地掺入到乳膏中。
测试人员用本发明的乳膏已进行的测试证明了在良好的皮肤耐受性的同时具有杀菌效果。
因此，所述皮肤耐受性消毒护理制剂基于一种或多种作为消毒活性物质的氯衍生物。
所述一种或多种氯衍生物被掺入到基础乳膏或凝胶基质中。
此外，所述乳膏或所述凝胶含有用于掩盖所述氯组分气味的物质混合物，否则的话，所述氯组分能够被感知到。
以一种发展的方式，所述制剂具有至少一种香味剂或香味剂混合物。
在本发明的进一步发展中，可以将限定量的功能活性剂添加到规定的配制剂中。这可以例如是用于加湿或防护有害辐射(特别是紫外辐射)的活性剂。
根据本发明的基于所描述制剂的乳膏的特征在于，所使用的氯衍生物(特别是氯胺T)的量基本上为最高至5重量％，优选且特别是最高至2重量％。
所述基础乳膏至少含有甘油酯、凡士林和硬脂酸酯。所述凝胶基质至少含有聚丙烯酸钠或水。
所述消毒组分，即所述氯衍生物，如已经提及的，是氯胺T、次氯酸钠或类似物质。
所提出的制剂或相应的乳膏在所述消毒活性物质方面不含醇。不会如在普通液体消毒剂中的情况那样发生皮肤脱脂。
根据本发明的是，具有所提出制剂或相应的用于不同应用的乳膏的分配器、罐、管或类似包装，其特别用于施加到人体皮肤上。
具体实施方式
下文将借助于示例性实施方案对本发明进行更详细的解释。
所使用的基础乳膏基质组合了对于皮肤护理所需的所有成分，并确保了乳膏的润滑效果和同时确保了护理效果。
所述消毒活性物质基于水溶性氯衍生物，其是接受的消毒剂，并符合官方法规。
用于掩盖气味的物质混合物是皮肤病学认可的组分的混合物，其目的是掩盖从所述消毒活性物质释放的氯气味。
可用的气味物质使所述乳膏具有令人愉悦的气味。这些可以是精油或其它芳香物质或由它们制成的混合物。
例如，在功能活性剂中，可使用尿素来实现额外的保湿效果。同样，也可以使用吸收紫外辐射的制剂。
特别是对于基础乳膏，可以使用常规产品。
这种基础乳膏包含以下示例性成分：
甘油单硬脂酸酯60，鲸蜡醇，中链甘油三酯，白凡士林，聚乙二醇-20-甘油单硬脂酸酯，丙二醇和纯净水。
对于所述消毒活性物质，使用氯衍生物，例如氯胺T或次氯酸钠。特别对于氯胺T，在所述乳膏中的浓度为2重量％。这是无害的上限，该上限给出了可证实的充分的消毒效果。
对于用于掩盖气味的物质混合物，可以提及的是可商购产品。
以下组合物是示例性的：
成分混合物A：
2,6-二甲基辛-7-烯-2-醇、3,7-二甲基辛-3-醇、1-(1,2,3,4,5,6,7,8-八氢-2,3,8,8-四甲基-2-萘基)乙烷-1-酮、苯戊醇、水杨酸-b-甲酯、水杨酸异戊酯、3-(对乙基苯基)-2,2-二甲基丙醛、乙酸3,7-二甲基辛-3-基酯、苯丙醇、β,β,3-三甲基-2-苯基乙醇、茴香醛、(E)-4-(2,6,6-三甲基-1-环己烯-1-基)-3-丁烯-2-酮、氧杂环十六碳烯-2-酮、胡椒醛、1,4-二氧杂环十七烷-5,17-二酮、十五烷-15-内酯、乙酸己酯、3-(邻乙基苯基)-2,2-二甲基丙醛、1-甲基-4-(4-甲基戊基)环己-3-烯-1-甲醛1；
成分混合物B：
水杨酸己酯、3,7-二甲基辛-3-醇、1-(1,2,3,4,5,6,7,8-八氢-2,3,8,8-四甲基-2-萘基)乙烷-1-酮、2H-吡喃-4-醇、四氢-4-甲基-2(2-甲基丙基)-、苯戊醇、b-甲基-、苯丙醇、β,β,3-三甲基-、十五烷-15-内酯、2,6-二甲基辛-7-烯-2-醇、α-甲基-1,3-苯并二噁唑-5-丙醛、4-(4-甲基-3-戊烯基)环己-3-烯-1-甲醛、(E)-茴香脑、2-乙基-4-(2,2,3-三甲基-3-环戊烯-1-基)-2-丁烯-1-醇、1,2,3,5,6,7-六氢-1,1,2,3,3-五甲基-4H-茚-4-酮、3-(对乙基苯基)-2,2-二甲基丙醛、MUGETANOL、胡椒醛、氧杂环十六碳烯-2-酮、4-甲基-3-癸烯-5-醇、3-(邻乙基苯基)-2,2-二甲基丙醛、(环己基氧基)乙酸烯丙酯、2,4-二羟基-3,6-二甲基苯甲酸甲酯、2,6-二甲基庚-5-烯醛、八氢-7-甲基-1,4-桥亚甲基萘-6(2H)-酮、顺式-3-己烯-1-基碳酸甲酯。
作为香味剂，使用精油，例如玫瑰油，薰衣草油或类似物，或这些精油的混合物。
所提及的功能活性剂不需要是所述乳膏的组分，但可以改进其功效并有助于其它应用。
作为防护紫外辐射的手段，可以将二氧化钛添加到所述乳膏中，以确保相应的防晒因子。
作为皮肤耐受性消毒护理制剂的准备销售的乳膏至少包含基础乳膏和水溶性氯衍生物形式的消毒活性物质。
通过添加用于掩盖气味的物质混合物，所述施加是被显著更好接受的，因为令人不快的氯气味或使用的一种或多种氯衍生物被包封。
根据本发明的乳膏在制备和生产后被装瓶。装瓶可以进行到合适的分配器中，到罐、管子或类似包装中。
乳膏的使用是通过将其施加到皮肤上并轻轻摩擦使之吸收来进行的，其中发挥出消毒和同时发挥出护理效果。
所介绍的乳膏要么可以单独使用，要么可以当在先前已经使用基于醇的消毒产品时用于随后的皮肤护理。
在作为根据本发明的凝胶的实施方案中，与所介绍的乳膏相反，它是透明的或半透明的。
根据本发明的乳膏和凝胶都可以添加包封形式的其它物质。
以包封形式配置的珠产生了特殊的光学效果。特别地，所述珠的颜色与基础乳膏不同，或者相对于透明乳膏是光学上引人注目的。含有额外物质的珠漂浮在所述凝胶内或分布在所述乳膏的体积中。在一实施例中，在其中具有包封的添加剂的珠具有大体上2mm的直径。

Claims (8)

1.用于施加到皮肤上或用于治疗皮肤的皮肤耐受性消毒护理制剂，其包含一种或多种水溶性氯衍生物作为消毒活性物质，
其特征在于，
所述一种或多种氯衍生物被掺入到基础乳膏基质中或凝胶基质中，并且额外含有用于掩盖所述氯组分的气味的物质混合物。
2.根据权利要求1所述的皮肤耐受性消毒护理制剂，
其特征在于，
它含有至少一种香味剂或香味剂混合物。
3.根据权利要求1或2所述的皮肤耐受性消毒护理制剂，
其特征在于，
它在预定配制剂中具有功能活性剂，其例如用于加湿或用于防护有害辐射。
4.基于根据权利要求1至3的任一项所述制剂的乳膏或凝胶，
其特征在于，
所述氯衍生物的量基本上为最高至5重量％，特别是最高至2重量％。
5.基于根据权利要求1至3的任一项所述制剂的乳膏，
其特征在于，
所述基础乳膏至少含有甘油酯，凡士林和硬脂酸酯，和所述凝胶基质至少含有聚丙烯酸钠和水。
6.根据前述权利要求的任一项所述的制剂或乳膏，
其特征在于，
含有氯胺-T，次氯酸钠或类似的氯衍生物作为消毒组分。
7.根据前述权利要求的任一项所述的制剂或乳膏，
其特征在于，
所述消毒活性物质不含醇。
8.具有根据前述权利要求的一项或多项所述的制剂或乳膏的分配器、罐、管或包装。
CN202180046476.7A 2020-06-30 2021-06-24 用于施加到皮肤上的皮肤耐受性消毒护理制剂 Pending CN116133521A (zh)

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