CN116098818A - Double-dosage form soothing and repairing essence and application method thereof - Google Patents

Double-dosage form soothing and repairing essence and application method thereof Download PDF

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Publication number
CN116098818A
CN116098818A CN202211614723.1A CN202211614723A CN116098818A CN 116098818 A CN116098818 A CN 116098818A CN 202211614723 A CN202211614723 A CN 202211614723A CN 116098818 A CN116098818 A CN 116098818A
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soothing
agent
phase
oil
raw material
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刘春雨
王军
侯丽明
王晓玲
何国洲
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Guangzhou Xiaotan Technology Co ltd
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Guangzhou Xiaotan Technology Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/342—Alcohols having more than seven atoms in an unbroken chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/673—Vitamin B group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/678—Tocopherol, i.e. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/005—Preparations for sensitive skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/26—Optical properties
    • A61K2800/262—Transparent; Translucent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/88—Two- or multipart kits
    • A61K2800/884—Sequential application
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The invention relates to A61K8, in particular to a two-agent type soothing and repairing essence and a use method thereof, wherein the two-agent type soothing and repairing essence comprises an oil agent and a water agent, and the weight ratio of the oil agent to the water agent is 1: (3.8-6.2) or 1: (8.5-9.7). The double-agent essence provided by the invention has the combination mode of transparent essence water and transparent essence oil, the combination mode can provide a certain moisture degree for skin, and the water-soluble active substance and the oil-soluble active substance in the double-agent essence can be separated, so that the stability of the active substance is not influenced when the product is not used, and the product is milder and more suitable for sensitive skin.

Description

Double-dosage form soothing and repairing essence and application method thereof
Technical Field
The invention relates to A61K8, in particular to a two-agent type soothing and repairing essence and a use method thereof.
Background
In recent years, the number of people with sensitive skin is increased, and researches show that the female sensitive skin accounts for 36.1%, and the trend of the female sensitive skin is continuously growing. The causes of the sensitive skin are mainly studied at present: the skin barrier is damaged, the sensitivity of the sensory nerve is increased, and the expression of inflammatory factors of the epidermis of the skin is increased, so that the skin can be provided with sensitive symptoms of different degrees under the combined action of the three components. Under the influence of the outside (such as physical factors including alternating seasons, large day and night temperature difference, and chemical factors including frequent use of cleaning products, and the like), the phenomena of redness, itching, peeling, dandruff, tightness, and the like of subjectively sensitive skin are easy to occur, the percutaneous water loss rate of the sensitive skin is increased, and the water content of the skin is reduced. Aiming at the reasons, in order to relieve the problem of the sensitive skin, a product capable of effectively relieving the redness, the itching and the stinging of the sensitive skin is needed to be developed.
The patent No. CN110179711A provides an essence for repairing skin cuticle barrier and a use method thereof, and ceramide and surfactants such as cetylstearyl oleate, sorbitan oleate, hydrogenated lecithin, sucrose stearate and the like are mixed, so that the effect of repairing skin ravines can be achieved in 6-14 days. The patent No. CN112569151A provides an anti-allergic repair barrier composition, a use method and application thereof, wherein centella asiatica extract, phoenix single-cluster tea volatile oil and a surfactant are mixed to achieve an anti-allergic effect.
Therefore, the existing light essence on the market is mainly aqua essence, and the dosage form is usually added with surface active agent to achieve the aim that the oil-soluble extract can be completely dissolved in water. However, the surfactant may stimulate sensitive skin cells with impaired barrier due to its own characteristics. To solve the problem, one of the purposes of the present invention is to provide a two-agent essence which is a combination of transparent essence water and transparent essence oil.
Disclosure of Invention
In order to solve the problems, the first aspect of the invention provides a two-dosage form soothing and repairing essence, which comprises an oil agent and a water agent, wherein the weight ratio of the oil agent to the water agent is 1: (3.8-6.2) or 1: (8.5-9.7).
Preferably, the weight ratio of the oil agent to the water agent is 1:4 or 1:5.7 or 1:9.
as a preferable technical scheme of the invention, the oil is prepared by mixing an A-phase raw material and a B-phase raw material at 45-52 ℃.
Preferably, the preparation method of the oiling agent comprises the following steps: (1) Adding the phase A raw material into an oil phase pot, stirring at 70-75deg.C until no insoluble substances exist, and maintaining the temperature for 10min; (2) cooling to 50 ℃, sequentially adding the phase B raw materials, and stirring; and (3) cooling to below 40 ℃ and discharging.
As a preferable technical scheme of the invention, the A-phase raw material comprises basic grease, a vitamin component and an emollient; the weight ratio of the base oil to the vitamin component to the emollient is (55-65): (7-15): (10-20).
Preferably, the weight ratio of base oil, vitamin component and emollient is 62:11:15.
as a preferable technical scheme of the invention, the base grease is one or two selected from squalane and jojoba oil.
Preferably, the base oil is squalane.
As a preferable technical scheme of the invention, the vitamin component is dioctyl carbonate and/or stearyl glycyrrhetinate.
Preferably, the vitamin component is dioctyl carbonate and stearyl glycyrrhetinate, and the weight ratio of the dioctyl carbonate to the stearyl glycyrrhetinate is (8-12): 1.
further preferably, the weight ratio of dioctyl carbonate to stearyl glycyrrhetinate is 10:1.
preferably, the emollient is tri (ethylhexanoate) glycerol.
As a preferable technical scheme of the invention, the phase B raw material is a protective composition, and the protective composition comprises octyl dodecanol, plantain leaf-cynara scolymus seed oil, sunflower seed oil unsaponifiable matter, an extract of the flower/leaf/vine of the decumbent vender and tocopherol.
Preferably, the weight ratio of the phase A raw material to the phase B raw material is (85-90): (1-2).
Further preferably, the weight ratio of the phase a material to the phase B material is 88:1.5.
as a preferable technical scheme of the invention, the aqueous solution is prepared by mixing a C-phase raw material, a D-phase raw material, an E-phase raw material and an F-phase raw material.
Preferably, the weight ratio of the C phase raw material, the D phase raw material, the E phase raw material and the F phase raw material is (80-95): (1-2): (2-6): 2.
further preferably, the weight ratio of the C phase raw material, the D phase raw material, the E phase raw material, and the F phase raw material is 92.1:1.6:4.3:2.
as a preferred embodiment of the present invention, the C-phase material comprises allantoin.
Preferably, the C phase material comprises water, 1, 3-butanediol and allantoin.
Further preferably, the weight ratio of water, 1, 3-butanediol and allantoin is (85-88): 6: (0.01-0.1).
As a preferable technical scheme of the invention, the D-phase raw material comprises vitamin B5 derivatives, vitamin B8 derivatives and anti-allergic agents.
Preferably, the weight ratio of vitamin B5 derivative, vitamin B8 derivative and anti-sensitizer is 0.5:1:0.1.
further preferably, the vitamin B5 derivative is panthenol, the vitamin B8 derivative is inositol, and the antiallergic agent is dipotassium glycyrrhizinate.
Preferably, the E phase raw material comprises kava extract, cornflower extract, olive leaf extract and moisturizing factor, wherein the weight ratio of the kava extract to the cornflower extract to the olive leaf extract to the moisturizing factor is 1:1: (0.2-0.4): (0.3-0.5).
Since the addition of surfactants can irritate the skin, studies have shown that surfactants account for about 15% of the sensitizers, and especially for sensitive skin, this irritation is more severe. Thus, the present application intends to develop a kind of surfactant-free soothing and repairing essence. Generally, if a surfactant is not added to the raw materials of cosmetics, compatibility between the raw materials is deteriorated, and thus, phenomena such as delamination, oil separation, water separation, discoloration, precipitation and the like are caused in the products. Thus, the applicant considered to prepare a two-component essence, and the oil and water solutions were prepared separately and then mixed for use. Although the water-oil delamination does not introduce a surfactant, when a user mixes an oil and a water agent, there is a problem that the permeability is lowered due to uneven mixing, and the cell repair ability is lowered. Through extensive experimental thought, the applicant found that the weight ratio of base oil, vitamin component and emollient in the control oil was (55-65): (7-15): on the premise of (10-20), the water aqua comprises the following components in percentage by weight: 1: (0.2-0.4): the kava extract, cornflower extract, olive leaf extract and moisturizing factor of (0.3-0.5) can overcome the problem of reduced permeability caused by uneven mixing of the aqueous agent and the oil agent and the problem of reduced cell repair ability, and the applicant has also unexpectedly found that, in particular, the weight ratio of the oil agent to the aqueous agent is 1: (3.8-6.2) or 1: (8.5-9.7), it also enables the essence to have excellent heat resistance and cycle stability. Even if the oil agent and the water agent are mixed by shaking and are kept stand for a plurality of times, the problem of color change can not occur. This is probably because the animal fat and the vitamin-stabilized component have a certain iodine value and saponification value after being mixed, so that the system has a specific unsaturation degree, and even if the plant extract and the moisturizing factor in the form of water are added, the plant extract and the moisturizing factor are not easy to oxidize and deteriorate in the air, and meanwhile, saponification reaction is not easy to occur. When the water aqua is used, the weight ratio is 1:1: (0.2-0.4): (0.3-0.5) the kava extract, cornflower extract, olive leaf extract and moisturizing factor act on skin cells, the dissolution of intercellular lipids and fat in the stratum corneum is affected, the compatibility between essential molecules and adjacent cells is changed, and the permeability and repairability of the essence are affected.
The F phase raw materials are p-hydroxyacetophenone, 1, 3-butanediol and 1, 2-hexanediol, and the weight ratio of the p-hydroxyacetophenone, the 1, 3-butanediol to the 1, 2-hexanediol is 0.5:1:0.5.
preferably, the preparation method of the water aqua comprises the following steps: (1) Dissolving p-hydroxyacetophenone in the F phase in 1, 3-butanediol at 60-65 ℃, cooling to 40-45 ℃, and adding 1, 2-hexanediol to obtain the F phase; (2) Adding the C phase raw material into a water phase pot, stirring at 70-75deg.C until no insoluble substances exist, and maintaining the temperature for 20min; (3) Cooling to 50-55deg.C, sequentially adding phase D materials into the water phase pot, and stirring; (3) cooling to 45 ℃, sequentially adding the E-phase raw materials, and stirring; (4) adding the phase F and stirring.
The second aspect of the invention provides a use method of the two-agent type soothing and repairing essence, wherein the use method is that the aqueous oil agent is used in combination or the aqueous oil agent is used singly.
Compared with the prior art, the invention has the following beneficial effects:
the weight ratio of the basic grease, the vitamin component and the emollient in the oil control agent is (55-65): (7-15): on the premise of (10-20), the water aqua comprises the following components in percentage by weight: 1: (0.2-0.4): the kava extract, cornflower extract, olive leaf extract and moisturizing factor of (0.3-0.5) can overcome the problem of reduced permeability caused by uneven mixing of water and oil, and reduce the cell repairing ability, and can make the essence have excellent heat resistance and circulation stability. Even if the oil agent and the water agent are mixed by shaking and are kept stand for a plurality of times, the problem of color change can not occur. The double-agent type soothing and repairing essence can reduce the expression of inflammatory factors, reduce the percutaneous water loss rate, improve the water content of skin, reduce the pain of sensitive myoreceptive nerves and reduce the secondary injury caused by scratching the skin while relieving inflammatory symptoms.
The double-agent essence provided by the invention has the combination mode of transparent essence water and transparent essence oil, the combination mode can provide a certain moisture degree for skin, and the water-soluble active substance and the oil-soluble active substance in the double-agent essence can be separated, so that the stability of the active substance is not influenced when the product is not used, and the product is milder and more suitable for sensitive skin.
Detailed Description
Examples
The compositions of the examples were all prepared from commercial sources, wherein the protective composition was purchased from RAHN AG, the protective composition included octyldodecanol, plantain seed oil, sunflower seed oil unsaponifiables, bell (Cardiospermum halicacabum l.) flower/leaf/vine extract and tocopherol, kava (Piper methysticum) extract was purchased from xianting, cornflower (Centaurea cyanus l.) flower extract was purchased from sepic, olive (olena europaea l.) leaf extract was purchased from HALLSTAR, and the moisturizing factor was purchased from zhejiang biotechnology limited, and the moisturizing factor source included water, 1, 3-butanediol, schizophyllan, 1, 2-hexanediol, p-hydroxyacetophenone, ethylhexyl glycerol, caprylic glycol and glucose.
Example 1
The example provides a two-agent type relief and repair essence, which comprises an oil agent and a water agent in a weight ratio of 1:4.
the oil is prepared by mixing the phase A raw material and the phase B raw material at 50 ℃.
The preparation method of the oil agent comprises the following steps: (1) Adding the phase A raw material into an oil phase pot, stirring at 70 ℃ until no insoluble substances exist, and preserving heat for 10min; (2) cooling to 50 ℃, sequentially adding the phase B raw materials, and stirring; and (3) cooling to 37 ℃ and discharging.
The A phase raw material comprises basic grease, a vitamin component and an emollient; the weight ratio of the basic grease, the vitamin component and the emollient is 62:11:15.
the base oil is squalane. The vitamin stabilizing component comprises dioctyl carbonate and stearyl glycyrrhetinate, and the weight ratio of the dioctyl carbonate to the stearyl glycyrrhetinate is 10:1. the emollient is tri (ethyl hexanoic acid) ester of glycerol.
The B phase raw material is a protective composition.
The weight ratio of the phase A raw material to the phase B raw material is 88:1.5.
the water aqua is prepared by mixing a C-phase raw material, a D-phase raw material, an E-phase raw material and an F-phase raw material. The weight ratio of the C phase raw material, the D phase raw material, the E phase raw material and the F phase raw material is 92.1:1.6:4.3:2.
the C phase material comprises water, 1, 3-butanediol and allantoin.
The weight ratio of water, 1, 3-butanediol and allantoin is 86.02:6:0.08.
the D phase material comprises vitamin B5 derivative, vitamin B8 derivative and antiallergic agent. The weight ratio of the vitamin B5 derivative, the vitamin B8 derivative and the anti-allergic agent is 0.5:1:0.1.
the vitamin B5 derivative is panthenol, the vitamin B8 derivative is inositol, and the anti-allergic agent is dipotassium glycyrrhizinate.
The E phase raw materials comprise kava extract, cornflower extract, olive leaf extract and moisturizing factor, wherein the weight ratio of the kava extract to the cornflower extract to the olive leaf extract to the moisturizing factor is 1:1: (0.2-0.4): (0.3-0.5).
The F phase raw materials are p-hydroxyacetophenone, 1, 3-butanediol and 1, 2-hexanediol, and the weight ratio of the p-hydroxyacetophenone, the 1, 3-butanediol to the 1, 2-hexanediol is 0.5:1:0.5.
the preparation method of the water aqua comprises the following steps: (1) Dissolving p-hydroxyacetophenone in the F phase in 1, 3-butanediol at 60 ℃, cooling to 40 ℃, and adding 1, 2-hexanediol to obtain the F phase; (2) Adding the C phase raw material into a water phase pot, stirring at 70 ℃ until no insoluble substances exist, and preserving heat for 20min; (3) Cooling to 50deg.C, sequentially adding phase D materials into the water phase pot, and stirring; (3) cooling to 45 ℃, sequentially adding the E-phase raw materials, and stirring; (4) adding the phase F and stirring.
Example 2
The present example provides a two-pack type soothing and repairing essence, which is different from example 1 in that the weight ratio of the oil agent to the water agent is 1:5.7.
example 3
The present example provides a two-pack type soothing and repairing essence, which is different from example 1 in that the weight ratio of the oil agent to the water agent is 1:9.
example 4
This example provides a two-part soothing and repairing essence, differing from example 1 in that the weight ratio of base oil, vitamin component and emollient is 50:13:20. the vitamin stabilizing component comprises dioctyl carbonate and stearyl glycyrrhetinate, and the weight ratio of the dioctyl carbonate to the stearyl glycyrrhetinate is 12:1.
example 5
The present example provides a two-agent type soothing and repairing essence, which is different from example 1 in that the weight ratio of kava extract, cornflower extract, olive leaf extract and moisturizing factor is 1:1:0.8:0.4.
example 6
The present example provides a two-pack type soothing and repairing essence, which is different from example 1 in that the weight ratio of the oil agent to the water agent is 1:2.
example 7
The present example provides a soothing and repairing essence, which is different from example 1 in that the weight ratio of the oil agent to the water agent is 0:1 (i.e. only aqueous).
Example 8
The present example provides a soothing and repairing essence, which is different from example 1 in that the weight ratio of the oil agent to the water agent is 1:0 [ i.e. oil only ].
Performance test:
1. TNF-alpha inhibition assay
(1) Test purpose:
TNF- α is an inflammatory cytokine found in the tumor inflammatory microenvironment, and is secreted primarily by activated monocytes/macrophages, which can initiate a chronic inflammatory response. TNF-alpha regulates inflammatory response through activating two inflammatory signal pathways of nuclear transcription factor kB (NF-kB) and activated protein 1 (AP-1), is an important inflammatory factor, participates in pathological injury of certain autoimmune diseases, and can evaluate the relieving efficacy performance of a test substance by verifying the inhibition rate of the test substance on the TNF-alpha.
(2) Research method
And (3) cells: the mouse mononuclear macrophage leukemia cell line RAW264.7 is derived from American type Material center (ATCC) and is selected from ATCC TIB-71.
Culture conditions: 0.25% pancreatin solution was mixed 1:1 with 0.02mol/L EDTA solution.
Stimulus: bacterial lipopolysaccharide (from LPS e.coli);
positive control: dexamethasone;
materials, instruments: a 96-well plate; TNF-a ELISA detection kit (ELISA kit); and (5) an enzyme label instrument.
The detection method comprises the following steps: reference is made to T/SHRH 034-2021.
The calculation method comprises the following steps: using a chart software, the OD was measured at the concentration of the standard 450 The value is the abscissa, a standard curve is produced according to the OD of the sample 450 The value, the corresponding concentration was found. Or the concentration and OD of the standard substance 450 Calculating regression equation of standard curve, and OD of sample 450 Values are substituted into the equation and the TNF-alpha content of the sample is calculated. The average of 3 wells of each group was finally taken as the final TNF-alpha content result.
TNF- α inhibition calculation formula:
Figure BDA0004000094520000071
t-average value of TNF-alpha content of the test substance;
average value of TNF-alpha content of C-negative control.
(3) The test results are shown in Table 1
TABLE 1
Figure BDA0004000094520000072
As can be seen from the above data, the TNF-. Alpha.inhibition rates of examples 1 to 3 were each more than 2-fold higher than that of examples 4 to 8.
2. Human efficacy testing
(1) Purpose of testing
The efficacy of the test sample in relieving aspect is evaluated by using the test sample for 28 consecutive days under normal conditions of Asian adult female subjects, analyzing the red-skin differential value by adopting a face image analyzer VISIA to shoot images, analyzing to obtain the change condition of the characteristic count of the red-skin differential value.
(2) Test method
The efficacy of the test samples in relieving aspect is evaluated by using 30 Asian adult female subjects aged 20-40 years to continuously use the test samples for 28 days under normal conditions, analyzing skin red area values by adopting a face image analyzer VISIA to shoot images, analyzing to obtain red area characteristic count change conditions.
The application part is as follows: the entire face;
frequency of use and period of use: each dose is used for 1 time in the morning and evening every day for 28 days continuously;
the using method comprises the following steps: after cleaning the skin, a proper amount of the product is taken and evenly smeared on the facial skin, and is gently massaged until being absorbed.
Subject inclusion criteria: asian adult healthy women aged 20 to 40 years; the people who self consider sensitive skin have the habits of using skin care products and cleansing faces; the facial is accompanied with redness/red blood streak symptoms, and the lactic acid stinging score is more than or equal to 3 minutes; the skin of the test area has no obvious skin damage, scar, hair and other conditions; the test can be matched according to the requirement, the product can be used according to the requirement, and the living regularity can be maintained during the research.
(3) Test results:
the average value of the characteristic counts of the red areas of the skin is shown in Table 2;
TABLE 2
Figure BDA0004000094520000081
Among them, examples 1-3 were significantly different (P < 0.05) from the comparison before the use of the samples.
Skin red area change rate is shown in table 3, wherein change rate = [ (pre-use-post-use)/pre-use ]/100%;
TABLE 3 Table 3
Figure BDA0004000094520000091
The 30 subjects using the soothing and repairing essence (examples 1-3) showed a significant difference in the red area count of the cheek area decreased by 52.00%, 46.15% and 46.15% respectively after 28 days of the sample compared to the prior use; the red area count of the cheek area of 30 subjects using the soothing and repairing essence (examples 6-8) was reduced by 9.09%, 8.70% and 4.17%, respectively, with no obvious difference; from this, it can be judged that the soothing effect of examples 1 to 3 is superior to that of examples 6 to 8.

Claims (10)

1. The two-agent type soothing and repairing essence comprises an oiling agent and a water agent, and is characterized in that the weight ratio of the oiling agent to the water agent is 1: (3.8-6.2) or 1: (8.5-9.7).
2. The two-part soothing and repairing essence according to claim 1, wherein the oil is prepared by mixing a phase raw material and a phase raw material at 45-52 ℃.
3. The two-part soothing and repairing concentrate of claim 2, wherein the phase a material comprises a base oil, a vitamin component, and an emollient; the weight ratio of the base oil to the vitamin component to the emollient is (55-65): (7-15): (10-20).
4. A two-part soothing and repairing essence according to claim 3, wherein said base oil is selected from one or two of squalane and jojoba oil.
5. A two-part soothing and repairing concentrate according to claim 3, wherein the vitamin component is dioctyl carbonate and/or stearyl glycyrrhetinate.
6. The dual-type soothing and repairing essence according to any one of claims 2 to 4, wherein the B phase material is a protective composition comprising octyldodecanol, psyllium seed oil, sunflower seed oil unsaponifiables, extract of senega/leaf/vine and tocopherol.
7. The two-part soothing and repairing essence according to claim 1, wherein the aqueous agent is prepared by mixing a C-phase raw material, a D-phase raw material, an E-phase raw material and an F-phase raw material.
8. The two-part soothing and repairing concentrate of claim 7, wherein the C-phase material comprises allantoin.
9. The two-part soothing and repairing essence according to claim 7 or 8, wherein the D-phase raw material comprises vitamin B5 derivative, vitamin B8 derivative and an anti-sensitizer.
10. A method of using the two-part soothing and repairing essence according to any one of claims 1 to 9, wherein the method of use is a combination of aqueous oils or an aqueous oil alone.
CN202211614723.1A 2022-12-15 2022-12-15 Double-dosage form soothing and repairing essence and application method thereof Pending CN116098818A (en)

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