CN116059296B - Preparation process of rhizoma polygonati paste - Google Patents
Preparation process of rhizoma polygonati paste Download PDFInfo
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- CN116059296B CN116059296B CN202310129229.4A CN202310129229A CN116059296B CN 116059296 B CN116059296 B CN 116059296B CN 202310129229 A CN202310129229 A CN 202310129229A CN 116059296 B CN116059296 B CN 116059296B
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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Abstract
The invention provides a preparation process of a rhizoma polygonati paste, and belongs to the technical field of rhizoma polygonati treatment. A preparation process of rhizoma polygonati paste comprises the following steps: providing clean rhizoma polygonati, soaking the rhizoma polygonati in warm water to enable the surface of the rhizoma polygonati to be slightly sticky; steaming rhizoma Polygonati in water, oven drying, and repeating steaming and oven drying for eight times; pulverizing rhizoma Polygonati into powder; decocting rhizoma Polygonati at low temperature, adding water, and decocting until the medicinal spoon is not slipped, and slowly standing to prevent adhesion to medicinal spoon; spreading the rhizoma Polygonati paste on a porcelain plate, and oven drying until the surface of the rhizoma Polygonati paste is sticky and not sticky. The invention provides a preparation process of a rhizoma polygonati paste, which is used for improving the content of rhizoma polygonati polysaccharide and improving the taste of the rhizoma polygonati paste.
Description
Technical Field
The invention belongs to the technical field of rhizoma polygonati treatment, and particularly relates to a preparation process of rhizoma polygonati paste.
Background
Rhizoma Polygonati is Polygonatum kingianum of LiliaceaePolygonatum kingianum Coll.et Hemsl.Rhizoma polygonatiPolygonatum sibiricum RedOr Polygonatum cyrtonema FallPolygonatum cyrtonema HuaAccording to its shape, the aliases are: rhizoma polygonati, herba polygoni multiflori, rhizoma polygonati, radix polygonati officinalis and the like, and belongs to rhizoma polygonatiBelongs to plants, is cylindrical and horizontally long, and expands internode.
By researching chemical components of rhizoma polygonati in recent years by a large number of well-known students at home and abroad, the chemical components are mainly rhizoma polygonati polysaccharide, flavonoid, alkaloid, volatile oil, steroid saponin and the like. Rhizoma Polygonati is also found to contain small amounts of anthraquinone chemical components. In addition, the food also contains nutrients such as 11 amino acids including lysine, aspartic acid, homoserine, diaminobutyric acid and the like, 8 trace elements and the like. Polygonatum sibiricum is sweet in nature and flat in nature, and enters spleen, lung and kidney meridians. According to the research of the rhizoma polygonati ingredient, the polysaccharide ingredient has the highest content in all chemical ingredients of the rhizoma polygonati.
Rhizoma Polygonati is combined with other materials to strengthen body constitution, treat thirst and yin deficiency, tonify liver and improve eyesight, and cure physical weakness after tuberculosis. And is antipyretic for treating intermittent febrile disease, gout and periostitis, and has antibacterial, antiviral and blood pressure lowering effects. The rhizoma polygonati is a long-standing source of traditional Chinese medicinal materials in China, can be used as medicinal materials for compatibility and food, and is a medicinal and edible plant with relatively high medicine frequency in the medicinal material market. The compendium of materia medica has been mentioned: "Jiuzhu Jiushou Huang can be eaten to allay hunger, so it is named as rice auxiliary. The rhizoma polygonati contains various nutrient substances such as starch, protein, vitamins and the like, and can nourish yin, promote the production of body fluid, nourish tendons and bones, strengthen tendons and bones and multiply strength. In some places where rhizoma polygonati grows, local people dig the rhizoma polygonati to clean, and cook the rhizoma polygonati to serve as vegetables together with rice; and the dried fruits can be produced after the dried fruits are steamed in some areas, and the dried fruits are sold as local special wild delicious snack in all places of the country, so that the dried fruits have very broad prospects in application in health care foods.
The ointment formula is taken as one of eight dosage forms commonly used in clinical science, is a dosage form with multiple functions of health care, health preservation, disease prevention and the like, and is a dosage form which can be used for health care according to different people and different time, and is very popular with various people at present. Based on the traditional technology of nine steaming and nine preparation of rhizoma polygonati, the paste formula products related to rhizoma polygonati are also continuously flushed.
For example: document CN 106889541A discloses a rhizoma polygonati Yuan paste and a preparation method thereof, wherein the rhizoma polygonati Yuan paste comprises 100-400g of Jiuhua rhizoma polygonati, 180-300g of donkey-hide gelatin, 600-1000g of black sesame, 100-250g of medlar, 400-600g of honey, 180-280g of red date, 180-300g of walnut, 600-1200g of yellow wine and 160-280g of crystal sugar, and is prepared by soaking, nine-steaming and nine-sun drying, stir-frying, crushing, stirring, steaming, cooling and packaging, and the raw materials and materials are dissolved into a whole to prepare paste.
Document CN 112385829A discloses a nine-turn rhizoma polygonati paste which comprises the following components: rhizoma polygonati, chinese angelica, medlar, honey and red date. The Jiuzhuan Polygonatum sibiricum paste is prepared by the steps of soaking, steaming, sun drying, boiling, modulating, boiling, paste collecting, cooling and packaging, has the advantages of no side effect, convenient carrying and eating, easy absorption, good price and the like, greatly improves the edible health care effect, and effectively solves the problems of weak body, insufficient essence and blood, premature senility and white hair.
The rhizoma polygonati paste needs to comprehensively consider the processing performance and the like of various medicinal materials in the preparation process, and the active ingredients of rhizoma polygonati and the taste and the like of the rhizoma polygonati are not obviously improved.
In view of this, the present invention has been made.
Disclosure of Invention
The invention aims to solve the technical problem of providing a preparation process of rhizoma polygonati paste for improving the content of rhizoma polygonati polysaccharide and improving the taste of rhizoma polygonati paste aiming at the defects of the prior art.
In order to solve the technical problems, the invention adopts the following technical scheme:
a preparation process of rhizoma polygonati paste comprises the following steps:
s01: providing clean rhizoma polygonati, soaking the rhizoma polygonati in warm water to enable the surface of the rhizoma polygonati to be slightly sticky;
s02: steaming rhizoma Polygonati, oven drying, and repeating steaming and oven drying for four-seven times;
s03: grinding the rhizoma polygonati obtained in the step S02 into powder;
s04: and (3) adding water into the rhizoma polygonati prepared in the step S03, heating, wherein the weight ratio of the rhizoma polygonati to the water is (2-5): 1, heating to 60-90 ℃, boiling until the medicine spoon is excavated and does not slide off, and slowly standing and then not adhering to the medicine spoon;
s05: spreading the rhizoma Polygonati paste obtained in the step S04 in a porcelain plate, and oven drying until the surface of the rhizoma Polygonati paste is sticky and not sticky.
In the step S01, in order to ensure the quality of the rhizoma Polygonati paste, rhizoma Polygonati is preferably selected from rhizoma Polygonati with large and thick texture, and rich meat quality, and fresh and mildew-free rhizoma Polygonati.
The sealwort is picked up and excavated with soil, the soil is washed off before soaking, the gully dyed by the soil is cut off by using a clean knife, and the bent nodules are broken off, so that the sealwort blocks tend to be regular, are easy to be heated uniformly, and remove fibrous roots.
The rhizoma polygonati is subjected to strict crude drug cleaning and production place processing before processing, so that mildew can be effectively prevented.
In the step S01, the temperature of the warm water soaking is 40-60 ℃, for example, the temperature is optional: soaking the rhizoma polygonati in warm water at a temperature of 40 ℃, 45 ℃, 50 ℃, 55 ℃ or 60 ℃ to further remove impurities, and helping moisture fully infiltrate the exterior of the rhizoma polygonati and infiltrate the interior of the rhizoma polygonati, so that the effective components in the rhizoma polygonati are "awakened" to provide a foundation for realizing a better steaming effect. The higher the temperature of soaking in warm water is, the better, the higher the temperature is, the target active ingredient of the rhizoma polygonati can be directly dissolved out, the content of the active ingredient is reduced, and the effect of soaking and activating cannot be achieved when the temperature is too low, so that the proper water temperature for soaking the rhizoma polygonati is 40-60 ℃.
Wherein, the slightly sticky substance is obtained by touching the surface of rhizoma Polygonati with hand to feel sticky. The soaking time of warm water is strictly controlled, and the overlong soaking time can increase the dissolution probability of active ingredients on one hand, and can accelerate the deterioration of the rhizoma polygonati on the other hand, and influence the quality and effect of the rhizoma polygonati, so that the soaking time is based on the fact that the surface of the rhizoma polygonati is slightly sticky.
In the step S02, the steam is a water-proof steam, and the time of the water-proof steam starts to be counted after the water is boiled. The water-proof steaming can keep the active ingredients in the rhizoma polygonati to the maximum extent, so that the temperature and time of the water-proof steaming must be strictly controlled.
In the invention, the water-proof steaming is non-pressure steaming, the temperature is 105-120 ℃ and the time is 1-3h.
Wherein, the above temperature refers to water temperature, for example, optional: 105 ℃, 110 ℃, 115 ℃ or 120 ℃.
In the step S02, the temperature of the drying is 50-65 ℃ and the time is 3-5h.
Wherein, the oven is adopted for operation in the stoving, and the temperature can be selected as: 50 ℃, 53 ℃, 55 ℃, 60 ℃, 63 ℃ or 65 ℃.
According to the invention, under the above-mentioned steaming and drying technological parameters, steaming and drying are alternately carried out for five times to eight times, the optimal number of times of repeated steaming and drying is six times or seven times, compared with the ancient method nine-steaming nine-sun processing method, the processing procedures are simpler, the processing effect is more obvious, the irritation and toxic and side effects of the raw rhizoma polygonati can be eliminated, the taste is mild, the taste is softer and glutinous, the content of active ingredients is more obvious, and the edible curative effect is more beneficial to improvement.
In the step S03, the beating pressure is controlled to be 3.33N/mm, and the beating revolution is controlled to be 1500-2500rpm. Optionally pulping rhizoma Polygonati into powder with beater; beating to promote release of active ingredients, improve taste and texture, and simultaneously provide support for efficient subsequent processes.
In the above step S04, the heating temperature is 70-80 ℃, for example: 70 ℃, 72 ℃, 75 ℃, 78 ℃ or 80 ℃. The rhizoma polygonati paste disclosed by the invention is mild in heating temperature, and the content of active ingredients of the rhizoma polygonati paste is further improved through low-temperature decoction.
In the step S05, the thickness of the rhizoma polygonati paste paved on the porcelain disc is not less than 5mm and not more than 13mm, and the distance between the edges of the four sides of the rhizoma polygonati paste and the wall of the porcelain disc is 10+/-2 mm; the drying temperature is 55-75 ℃, and the drying time is 2-3h. In the step, the tiled thickness of the rhizoma polygonati paste is controlled so as to be beneficial to molding and operation after the molding, moisture content is moderately reduced by means of drying, and the rhizoma polygonati paste is easy to cut and store and has better sensory experience.
The preparation process of the rhizoma polygonati paste further comprises the following steps: cutting the rhizoma polygonati paste prepared in the step S05 into blocks with uniform length and width so as to be convenient for eating according to the amount.
The cutting specification of the rhizoma polygonati paste is 7cm long and 2cm wide.
The preparation process of the rhizoma polygonati paste further comprises the following steps: packaging the cut rhizoma polygonati paste. Packaging for convenient storage and transportation.
The traditional processing method of the rhizoma polygonati is simple and easy, and the processing purpose is to improve the taste, reduce the irritant substances and adverse reactions and strengthen the efficacy. The Tang Dynasty "diet therapy herbal" records that "steaming, if living, the throat is pricked, the throat is exposed to dryness and is not rotten", and the Ming Dynasty "herbal original" also extends the expression; the purpose and method for processing rhizoma Polygonati are described in detail in Qing Dynasty, "medical usurping drug Property": rhizoma Polygonati, with Xin taste, has the effects of nourishing kidney and ear, and nourishing throat and kistrodon. As can be seen from the prior ancient books, the early processing of rhizoma polygonati mainly aims at eliminating the adverse effect of 'puncturing the throat'.
The traditional processing methods of rhizoma Polygonati include nine-processed rhizoma Polygonati, wine rhizoma Polygonati, radix rehmanniae Preparata rhizoma Polygonati, fructus Lycii rhizoma Polygonati and semen Sojae Atricolor rhizoma Polygonati, which are described in ancient books. Wherein, the nine-processed rhizoma polygonati is the nine-steamed and nine-sun-dried rhizoma polygonati. The processing method recorded in the book of Lei Pao Zhi Lun (Lei Ding of Lei Pao Lun) of Nandina of Nangu Liu Song is now called as "Single steaming method"; the dry method for rhizoma polygonati is recorded in Qianjin Yi Fang (Qianjin Fang) of Tang dynasty medicine Wang Sunsai far away, namely the existing "re-steaming method" lays a foundation for the later generated nine-steaming and nine-sun drying method; the method for processing the medicinal materials by nine-steaming and nine-sun-drying is adopted for the first time in the Tang dynasty Meng 'diet therapy herbal medicine', the processing method and the efficacy of the nine-steaming and nine-sun-drying rhizoma polygonati are recorded, and the discomfort caused by the pungent odor and toxic and side effects can be reduced by the nine-steaming and nine-sun-drying rhizoma polygonati; the nine-steaming and nine-sun drying method is developed to the present day, and the processing technology and the processing instrument of the nine-steaming and nine-sun drying method are improved and perfected on the basis of inheriting the traditional experience, so that the quality system and the auxiliary material quality system are gradually perfected. The traditional Chinese medicine considers that the traditional Chinese medicine changes in the processing process, and the changing process is complex, so that not only the quality and quantity change of the traditional Chinese medicine components can be influenced, but also the medicine property of the traditional Chinese medicine can be influenced to a certain extent. Modern researches have proved that Jiuzheng Jiushou plays a very important role in the chemical composition and content of Chinese medicinal materials. However, the mechanism of nine-steaming and nine-sun drying is not yet studied deeply, the processing technology is not explained, and the times of nine-steaming and nine-sun drying are questioned, so that the processing technology of the Chinese medicinal materials is also required to be explained in detail.
The polysaccharide is an important chemical component in rhizoma polygonati, and modern pharmacological researches show that the rhizoma polygonati polysaccharide can improve the immunity, the memory and learning ability, protect myocardial cells and liver and kidney functions, and has the effects of reducing blood sugar, resisting tumors, resisting bacteria and the like. Referring to the Chinese pharmacopoeia, the polysaccharide content is the only standard for evaluating the quality of rhizoma polygonati and rhizoma polygonati wine. Chen Wenhua et al (Wenhua Tan Huiying, general, etc.) and Chen Ruirui et al (Chen Ruirui, zu Yangong, dan Dingfu, etc.) and (J. Agrocybe cylindracea, 2019, 47 (18): 181-182.) respectively measure the polysaccharide content of rhizoma Polygonati in the former 3 times of steaming and sun drying, and the polysaccharide content of the latter period of steaming and sun drying is rapidly reduced, and the polysaccharide content of the latter period of steaming and sun drying is less in trend and more stable. Gan Xiaofeng et al (Gan Xiaofeng, wei Guoliang, li Tingting, et al) found that the polysaccharide content of the 2 nd polysaccharide is highest in the distilled liquid and is also higher than the total polysaccharide content of any one of the processing methods based on RSM and PMP-HPLC characteristic analysis of the polysaccharide component content variation [ J ]. Chinese herbal medicines, 2019, 50 (20): 4932-4941.) in the processing of Polygonatum sibiricum and comparison of the polysaccharide content of the distilled liquid. From the above study, it is known that the content of rhizoma Polygonati polysaccharide in the nine-steaming and nine-sun processing process varies differently.
The traditional Chinese medicine ointment has long development history, the Chinese medicine ointment is the earliest recorded medicine of the ointment prescription, the Chinese medicine ointment and the ragweed ointment are carried by the Chinese medicine yellow emperor's internal channel, animal fat is used as a main material, and the Chinese medicine ointment is used for treating trauma diseases. The Chinese medicinal composition for oral administration is recorded in the 'Jinkui Lloyd' for the first time, wherein the 'Dawu Tou decoction' and the 'Zhu Fa Ji' are taken orally. 8 paste formulas of Huatuo tiger bone paste, wu Du Shen paste and the like are recorded in the book of the elbow backup urgent prescription. In the "Xiao Pin Fang", the earliest nourishing paste formula "singly-decocted rehmannia" is described. Sunshiiao introduces the preparation method and attention points of the paste formulation in the "Qianjiao Fang Ji" in which "Dihuang Ji Jian" is not different from the modern paste formulation. Tang dynasty "Xin Xiu Ben Cao" and Song dynasty "Tai Ping Hui Min He Ji Fang" all describe nourishing paste prescriptions, such as "Chinese wolfberry decoction". The "lotus root juice paste" is described in the "Dongyuan" test effect prescription in the Jinyuan period. In the clear period, both palace and folk, the paste prescription is advocated to nourish, the paste prescription is developed rapidly and tends to be mature, the naming of the paste prescription is more normal, the manufacturing process is gradually perfected, the number is increased rapidly, and the clinical application is wider. The "leonurus ointment" in Ben Cao gang mu "and the" Fu Ling Gao "in shou Shi Bao Yuan" have been widely used until now. With the establishment of new China, the quantity of the paste prescription is continuously increased, the preparation method of the paste prescription is continuously perfected, and the clinical application is continuously enriched.
Based on the above, the processing method of the rhizoma polygonati and the edible value of the paste prescription are combined, the rhizoma polygonati is prepared into the rhizoma polygonati paste, the medicinal characteristics of the rhizoma polygonati are fully exerted, and problems of the decocting process, auxiliary materials, the ratio of the medicinal materials to the auxiliary materials and the like are researched according to the processing process, so that the high-quality formed rhizoma polygonati paste is prepared.
Compared with the prior art, the invention has the following beneficial effects:
according to the invention, the preparation process of the polygonatum sibiricum paste is improved based on the technical scheme, and the optimal processing process is obtained by reasonably selecting the processing steps of steaming, pulping, boiling, drying, spreading, drying and the like, strictly controlling the steaming temperature and time, the boiling temperature, the drying temperature and time, the slicing specification and the like, so that the indexes of the polygonatum sibiricum paste such as the content, the color, the taste, the texture, the aroma, the properties, the impurities and the like are excellent, and the scientificity of the preparation process of the polygonatum sibiricum product and the excellent quality of a polygonatum sibiricum paste product are ensured.
The rhizoma polygonati is prepared into the rhizoma polygonati paste, and can be eaten as preserved medicine, so that the rhizoma polygonati is convenient to use and instant to eat; secondly, the shelf life of the beverage can be prolonged, and the beverage is convenient to transport and store. The invention breaks the traditional process based on long-term research and experimental exploration of the rhizoma polygonati processing technology, and has obvious improvement and optimization, so that the process steps are simpler, the parameter control is more accurate, the operation and control are easy, and the product has good taste and stronger activity.
The rhizoma polygonati paste disclosed by the invention is pure in taste, uniform in color, good in color and luster, soft in texture, sticky, non-sticky, sweet and fragrant in taste, capable of obviously improving the sense of penetrating into the throat, and meanwhile, the polysaccharide content of the active ingredient is increased, the clinical curative effect is enhanced, the effects of reinforcing the spleen, moistening the lung and tonifying the kidney of the medicine are enhanced, and the rhizoma polygonati paste has various pharmacological effects of regulating immunity, resisting aging, improving and improving memory, reducing blood fat and blood sugar, resisting atherosclerosis, resisting inflammation and resisting virus and the like.
Detailed Description
For a better understanding of the present invention, the following examples are set forth to further illustrate the invention, but are not to be construed as limiting the invention. In the following description, numerous specific details are set forth in order to provide a more thorough understanding of the present invention. It will be apparent, however, to one skilled in the art that the invention may be practiced without one or more of these details.
In all examples shown and discussed herein, any specific values should be construed as merely illustrative, and not a limitation. Thus, other examples of the exemplary embodiments may have different values.
Unless otherwise indicated, all starting materials are from commercially available products and unless otherwise indicated, they do not contain other components not explicitly indicated except for unavoidable impurities.
The rhizoma Polygonati used in the following examples is obtained from rhizoma Polygonati of LiliaceaePolygonatum sibiricumIs 2015 editionThe varieties collected in the Chinese pharmacopoeia.
Example 1-example 6: preparation of rhizoma polygonati paste
Cleaning: selecting large, thick and solid rhizoma polygonati with fat meat quality and fresh and mildew-free rhizoma polygonati; washing rhizoma Polygonati to remove soil, cutting with a clean knife to remove ravines dyed by soil, breaking off the bent nodules to make rhizoma Polygonati blocks slightly regular and easy to be heated uniformly, removing fibrous roots, soaking in warm water to make the surfaces slightly sticky;
steaming: starting timing after adding water into a steamer and boiling, steaming rhizoma polygonati in a water-proof way, drying, and repeatedly and alternately operating;
pulping: beating the steamed rhizoma polygonati into powder by using a beating machine;
decocting: placing the beaten rhizoma Polygonati in a pot, adding water, decocting at low temperature until the medicine spoon is dug and does not slide, slowly standing, and stopping when the medicine spoon is not stuck;
and (3) drying: uniformly spreading the decocted rhizoma Polygonati paste into a porcelain plate, wherein the thickness is not less than 5mm and not more than 13mm, the distance between the edges of four sides of the rhizoma Polygonati paste and the wall of the porcelain plate is 10+/-2 mm, placing into a baking oven, and taking out when the surface of the rhizoma Polygonati paste is sticky and not sticky;
cutting: cooling the sealwort paste taken out of the box, and cutting the sealwort paste into blocks with the length of 7cm and the width of 2 cm;
and (3) packaging: packaging the cut rhizoma polygonati paste.
The process parameters for examples 1-6 are as follows:
。
the following is a comparative example.
Comparative example 1: unlike example 1, the following is: in the cleaning process, warm water soaking is omitted, and a corresponding step S01 is to provide clean rhizoma polygonati.
Comparative example 2: unlike example 1, the following is: in the cleaning process, normal-temperature water soaking is used for replacing warm water soaking, the temperature of the warm water is 25+/-5 ℃, and the time is 24 hours.
Comparative example 3: unlike example 1, the following is: in the steaming step, steaming is performed in a steaming box, wherein the steaming temperature is 95 ℃ and the steaming time is 50min; the temperature of the drying is 45 ℃ and the time is 8 hours; repeatedly and alternately operating to nine times of steaming and baking.
Comparative example 4: unlike example 1, the following is: in the beating process, the beating pressure was 3.33N/mm and the rotation speed was 4000rpm.
Comparative example 5: unlike example 1, the following is: in the boiling procedure, the weight ratio of the medicinal materials to the water is 1:1, decocting at 100 ℃ for 1h.
Comparative example 6: unlike example 1, the following is: in the boiling process and the drying process, the beaten rhizoma polygonati is placed in a pot according to the weight ratio of 1:1 adding honey, uniformly stirring, and decocting at 100 ℃ for 1h; then placed in a refrigerator for standing for 2 hours, and the cooling temperature is 4 ℃.
Comparative example 7: in the cleaning procedure, a large, thick and solid rhizoma polygonati with fat meat quality and fresh and mildew-free quality is selected; washing rhizoma polygonati to remove soil, cutting the gully dyed by the soil by using a clean knife, and breaking off the bent knots; no other processing is done.
The following is an effect evaluation case.
1. Sensory evaluation
The tissue professional evaluator scores the color, taste, texture, aroma, character and impurity of the sealwort paste prepared in the above examples 1-6 and comparative examples 1-6, 3 professional evaluators are arranged in each group to evaluate, the scoring results are averaged, and the scoring detail is shown in the following table:
。
the evaluation results were as follows:
。
from the results, the sealwort paste prepared by the process has balanced scores in indexes of color, taste, texture, aroma, character and impurity, and the total score is more than 9.0.
Comparative examples 1 and 2 are prepared by adjusting the warm water soaking step and/or parameters in the cleaning procedure of example 1, and the prepared rhizoma polygonati paste shows different changes and has larger index grading value difference, which indicates that the color, taste and texture of the rhizoma polygonati paste can be obviously improved by adopting warm water soaking.
Comparative example 3 is obtained by adjusting the steaming process in example 1, and the color, taste, texture, aroma and properties of the prepared rhizoma Polygonati paste are obviously different from those of example 1, which shows that steaming and drying parameters in the nine-steaming and nine-drying process have a significant influence on the quality of the rhizoma Polygonati paste.
Comparative example 4 is to adjust pulping process parameters, and the prepared rhizoma Polygonati paste has obvious change in texture, and shows that the appropriate pulping parameters are favorable for improving the texture quality of the rhizoma Polygonati paste.
Comparative example 5 is an adjustment of the decocting process, and the prepared rhizoma polygonati paste has obvious change in taste and property, which shows that reasonable setting of parameters of the decocting process has obvious influence on the taste and property of the rhizoma polygonati paste.
Comparative example 6 was prepared by adjusting the boiling process and the drying process simultaneously, and the overall score of the prepared rhizoma Polygonati paste was only 7.2 minutes, which was not ideal in appearance and poor in effect.
The results show that the steps and parameters of the preparation process of the invention are mutually supported and interacted in function, and the sealwort paste with more balanced quality and better comprehensive effect is obtained as a whole.
2. Polygonatum sibiricum polysaccharide content determination
3.2.1 Preparation of control solution
Taking 33mg of anhydrous glucose reference substance, precisely weighing, placing into a l00ml measuring flask, adding water for dissolving, diluting to scale, and shaking to obtain the final product.
3.2.2 Preparation of a Standard Curve
Precisely measuring reference solution 0.1m1, 0.2m1, 0.3ml, 0.4ml, 0.5ml and 0.6m1,
respectively placing into 10ml test tubes with scales, adding water to 2.0ml, shaking, slowly dripping 0.2% anthrone sulfuric acid solution into ice water bath to scale, mixing, cooling, placing into boiling water bath, maintaining temperature for 10 min, taking out, immediately cooling in ice water bath for 10 min, taking out, and taking out with corresponding reagent as blank. Absorbance was measured at 627nm wavelength by uv-vis spectrophotometry.
3.2.3 Preparation of sample solution of rhizoma Polygonati
Pulverizing the dried rhizoma Polygonati paste or rhizoma Polygonati respectively in pulverizer, drying, and sieving with No. 2 sieve. Precisely weighing about 0.25g of the sieved fine powder, placing into a 500ml round bottom flask, adding 150ml of 80% ethanol, heating and refluxing in a water bath for 1 hour, filtering while hot, washing residues with 80% hot ethanol for 3 times, 10ml each time, placing residues and filter paper into the flask, adding 150ml of distilled water, heating and refluxing for 1 hour, filtering while hot, washing residues and the flask with hot water for 4 times, 10ml each time, combining the filtrate and the washing liquid, cooling, transferring to a 500ml measuring flask, adding water to scale, and shaking uniformly.
3.2.4 Linear relationship investigation
The control solutions 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7ml were measured and placed in 10ml stoppered tubes in sequence, and absorbance was measured using the 3.2.2 preparative assay.
Absorbance of glucose standards of different concentrations
。
Regression was performed with the absorbance (A) as the ordinate Y and the concentration of anhydrous glucose as the abscissa (X) to obtain the regression equation Y=4.1507X+0.4205 and R2= 0.9991, indicating that the linear relationship was good in the range of 0.0033mg/ml 0.0221 mg/ml.
3.2.5 precision test:
the control solutions 0, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7ml were measured and placed in 10ml small test tubes with stopper graduations, and absorbance was measured with 3.2.2 preparative assay. The Relative Standard Deviation (RSD) of the results was 0.28%, indicating good instrument precision.
3.2.6 Stability test:
1.0ml of the sample solution is measured and placed in a test tube with a stopper, and absorbance is measured every 0.5h by a 3.2.2 preparation method. The results show that: the Relative Standard Deviation (RSD) of the absorbance values of the two solutions was 1.36%, indicating: the test solution has good stability within 2 hours.
3.2.7 sample recovery test:
weighing 6 parts of the same sample; weighing 95.45mg of anhydrous glucose, placing in a volumetric flask of 100ml, and adding water to the scale; 10.0ml of the prepared anhydrous glucose solution was measured, and 6 samples were added to measure the absorbance by a preparative assay using a 3.2.2 standard curve, and the results are shown in the following table:
anhydrous glucose sample recovery test n=6
3.2.8 Sample content determination
1.0ml of the sample solution is measured, and the measured samples are respectively placed in 10ml graduated test tubes, numbered and absorbance is measured by a preparation method similar to the 3.2.2 standard curve.
The measurement results are shown in the following table:
results of the content test of Polygonatum sibiricum sample
。
The experimental results show that the content of the rhizoma polygonati polysaccharide in the rhizoma polygonati paste prepared by the process is obviously improved compared with that of the raw material rhizoma polygonati.
From the above test, it can be derived that: in the Chinese pharmacopoeia of 2010 edition, the polysaccharide content is used as the quality control index of rhizoma Polygonati, and the product is calculated according to the dry product, wherein the polysaccharide content of rhizoma Polygonati is calculated by anhydrous glucose (C 6 H 12 O 6 ) The content of the catalyst is not less than 7.0%. The measurement result shows that the rhizoma polygonati manufactured by the manufacturing process accords with the quality standard specified by pharmacopoeia, and has excellent sensory quality.
Finally, it is noted that the above-mentioned embodiments are merely for illustrating the technical solution of the present invention, and that other modifications and equivalents thereof by those skilled in the art should be included in the scope of the claims of the present invention without departing from the spirit and scope of the technical solution of the present invention.
Claims (6)
1. A preparation process of rhizoma polygonati paste is characterized by comprising the following steps of: the method comprises the following steps:
s01: providing clean rhizoma polygonati, and soaking the rhizoma polygonati in warm water at a temperature of 40-60 ℃ to ensure that the surface of the rhizoma polygonati is slightly sticky;
s02: steaming rhizoma Polygonati, oven drying, and repeating steaming and oven drying for four-seven times;
wherein, steaming is pressureless water-proof steaming, the time begins to count after water is boiled, the temperature is 105-120 ℃, the time is 1-3h, the temperature of drying is 50-65 ℃ and the time is 3-5h;
s03: grinding the rhizoma polygonati obtained in the step S02 into powder, controlling the beating pressure at 3.33N/mm and the beating revolution at 1500-2500rpm;
s04: and (3) adding water into the rhizoma polygonati prepared in the step S03, heating, wherein the weight ratio of the rhizoma polygonati to the water is (2-5): 1, heating to 60-90 ℃, boiling until the medicine spoon is excavated and does not slide off, and slowly standing and then not adhering to the medicine spoon;
s05: spreading the rhizoma Polygonati paste obtained in the step S04 in a porcelain plate, and oven drying until the surface of the rhizoma Polygonati paste is sticky and not sticky.
2. The process for preparing the rhizoma polygonati paste as claimed in claim 1, wherein: the heating temperature in the step S04 is 70-80 ℃.
3. The process for preparing the rhizoma polygonati paste as claimed in claim 2, wherein: in the step S05, the thickness of the sealwort paste paved on the porcelain disk is not less than 5mm and not more than 13mm, and the distance between the edges of the four sides of the sealwort paste and the wall of the porcelain disk is 10+/-2 mm.
4. A process for preparing a rhizoma Polygonati paste according to claim 3, wherein: in the step S05, the drying temperature is 55-75 ℃, and the drying time is 2-3h.
5. The process for preparing a rhizoma Polygonati paste according to any one of claims 1-4, wherein: further comprises: cutting the rhizoma polygonati paste prepared in the step S05 into blocks with uniform length and width.
6. The process for preparing the rhizoma polygonati paste as claimed in claim 5, wherein: further comprises: packaging the cut rhizoma polygonati paste.
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