CN116057181A - 用于修饰和递送淋巴细胞的方法和组合物 - Google Patents

用于修饰和递送淋巴细胞的方法和组合物 Download PDF

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CN116057181A
CN116057181A CN202080076199.XA CN202080076199A CN116057181A CN 116057181 A CN116057181 A CN 116057181A CN 202080076199 A CN202080076199 A CN 202080076199A CN 116057181 A CN116057181 A CN 116057181A
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cells
cell
modified
replication defective
recombinant retroviral
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格雷戈里·伊恩·弗罗斯特
詹姆斯·约瑟夫·奥努弗
法扎德·哈里扎德
弗雷德里克·维根特
阿尼邦·昆都
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Exsuma Biotechnology
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Exsuma Biotechnology
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CN202080076199.XA 2019-09-01 2020-08-31 用于修饰和递送淋巴细胞的方法和组合物 Pending CN116057181A (zh)

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
US201962894849P 2019-09-01 2019-09-01
US201962894853P 2019-09-01 2019-09-01
US201962894852P 2019-09-01 2019-09-01
US62/894,852 2019-09-01
US62/894,849 2019-09-01
US62/894,853 2019-09-01
US201962894926P 2019-09-02 2019-09-02
PCT/US2019/049259 WO2020047527A2 (en) 2018-09-02 2019-09-02 Methods and compositions for genetically modifying lymphocytes in blood or in enriched pbmcs
USPCT/US2019/049259 2019-09-02
US62/894,926 2019-09-02
US201962943207P 2019-12-03 2019-12-03
US62/943,207 2019-12-03
US202062985741P 2020-03-05 2020-03-05
US62/985,741 2020-03-05
PCT/US2020/048843 WO2021042072A1 (en) 2019-09-01 2020-08-31 Methods and compositions for the modification and delivery of lymphocytes

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CN116057181A true CN116057181A (zh) 2023-05-02

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US (1) US20220340927A1 (https=)
EP (1) EP4022035A4 (https=)
JP (2) JP2022546101A (https=)
KR (1) KR20220070449A (https=)
CN (1) CN116057181A (https=)
AU (1) AU2020336230B2 (https=)
BR (1) BR112022003617A2 (https=)
CA (1) CA3152780A1 (https=)
MX (1) MX2022002521A (https=)
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CN113840911A (zh) * 2018-09-02 2021-12-24 埃克苏马生物技术公司 用于在血液中或在富集pbmc中基因修饰淋巴细胞的方法和组合物

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US11111505B2 (en) 2016-03-19 2021-09-07 Exuma Biotech, Corp. Methods and compositions for transducing lymphocytes and regulating the activity thereof
US11325948B2 (en) 2016-03-19 2022-05-10 Exuma Biotech Corp. Methods and compositions for genetically modifying lymphocytes to express polypeptides comprising the intracellular domain of MPL
US12590321B2 (en) 2016-03-19 2026-03-31 Exuma Biotech Corp. Methods and compositions for genetically modifying and expanding lymphocytes and regulating the activity thereof
WO2021231569A1 (en) * 2020-05-14 2021-11-18 Seattle Children's Hospital (dba Seattle Children's Research Institute) Dual promoter systems
WO2023015310A2 (en) * 2021-08-06 2023-02-09 Seattle Children's Hospital D/B/A Seattle Children's Research Institute T-cell manufacturing methods
EP4463135A2 (en) 2022-01-10 2024-11-20 Sana Biotechnology, Inc. Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses
EP4469586A1 (en) * 2022-03-01 2024-12-04 Exuma Biotech Corp. Viral particles with membrane-bound hyaluronidase
WO2024026377A1 (en) 2022-07-27 2024-02-01 Sana Biotechnology, Inc. Methods of transduction using a viral vector and inhibitors of antiviral restriction factors
IL320156A (en) * 2022-10-10 2025-06-01 Kite Pharma Inc New large scale car-t immune cell manufacturing method utilizing lentiviral vector transfection
IL326194A (en) * 2023-07-31 2026-03-01 Bio4T2 Llc Methods for the expansion and in vivo uptake of CAR cells mediated by blood cells
EP4589007A1 (en) * 2024-01-17 2025-07-23 Revvity Gene Delivery GmbH Production of viral vectors
WO2025213071A1 (en) * 2024-04-05 2025-10-09 Baylor College Of Medicine Synthetic gene expression regulatory switches

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