CN116036290A - 用于治疗皮肤病的联合疗法 - Google Patents

用于治疗皮肤病的联合疗法 Download PDF

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Publication number
CN116036290A
CN116036290A CN202310057791.0A CN202310057791A CN116036290A CN 116036290 A CN116036290 A CN 116036290A CN 202310057791 A CN202310057791 A CN 202310057791A CN 116036290 A CN116036290 A CN 116036290A
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CN
China
Prior art keywords
substituted
composition
unsubstituted diindolylmethane
combination therapy
monotherapy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202310057791.0A
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English (en)
Chinese (zh)
Inventor
迈克尔·C·斯凯夫
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Skintech Life Science Ltd
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Skintech Life Science Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Skintech Life Science Ltd filed Critical Skintech Life Science Ltd
Publication of CN116036290A publication Critical patent/CN116036290A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/203—Retinoic acids ; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN202310057791.0A 2017-01-20 2018-01-19 用于治疗皮肤病的联合疗法 Pending CN116036290A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762448808P 2017-01-20 2017-01-20
US62/448,808 2017-01-20
PCT/IB2018/000109 WO2018134683A1 (en) 2017-01-20 2018-01-19 Combination therapy for treatment of skin diseases
CN201880019777.9A CN110446505A (zh) 2017-01-20 2018-01-19 用于治疗皮肤病的联合疗法

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201880019777.9A Division CN110446505A (zh) 2017-01-20 2018-01-19 用于治疗皮肤病的联合疗法

Publications (1)

Publication Number Publication Date
CN116036290A true CN116036290A (zh) 2023-05-02

Family

ID=61731720

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202310057791.0A Pending CN116036290A (zh) 2017-01-20 2018-01-19 用于治疗皮肤病的联合疗法
CN201880019777.9A Pending CN110446505A (zh) 2017-01-20 2018-01-19 用于治疗皮肤病的联合疗法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201880019777.9A Pending CN110446505A (zh) 2017-01-20 2018-01-19 用于治疗皮肤病的联合疗法

Country Status (8)

Country Link
US (2) US11241467B2 (enExample)
EP (1) EP3570889A1 (enExample)
JP (2) JP7123058B2 (enExample)
CN (2) CN116036290A (enExample)
AU (1) AU2018209393B2 (enExample)
BR (1) BR112019014942A2 (enExample)
CA (1) CA3050208A1 (enExample)
WO (1) WO2018134683A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018051183A1 (en) * 2016-09-15 2018-03-22 Skintech Life Science Limited Sublingual or buccal administration of dim for treatment of skin diseases
AU2018209393B2 (en) 2017-01-20 2024-02-15 Skintech Life Science Limited Combination therapy for treatment of skin diseases
WO2025097063A1 (en) * 2023-11-01 2025-05-08 Skintech Life Science Limited Topical dim compositions and uses thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030082203A1 (en) * 2001-10-30 2003-05-01 Farley Michael D. Immune functions
US6599913B1 (en) * 2001-06-29 2003-07-29 Schering Corporation Treating allergic and inflammatory conditions
CN103458888A (zh) * 2011-04-12 2013-12-18 雀巢产品技术援助有限公司 用于改善肠屏障功能的包含支链脂肪酸的营养组合物
CN103501772A (zh) * 2011-03-25 2014-01-08 Iiaa有限公司 用于治疗皮肤病症的包含二吲哚基甲烷和类视黄醇的组合物
WO2014177123A1 (de) * 2013-04-30 2014-11-06 Melnik Bodo C Akne-medikament und verfahren zu seiner herstellung

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5665367A (en) * 1996-09-27 1997-09-09 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Skin care compositions containing naringenin and/or quercetin and a retinoid
US20030166583A1 (en) * 2002-02-22 2003-09-04 Oliver Yoa-Pu Hu Dermal cytochrome P450 1A inhibitors and enhancers
WO2008057253A2 (en) * 2006-10-27 2008-05-15 Bioresponse, L.L.C. Anti-parasitic methods and compositions utilizing diindolylmethane-related indoles
FR2908604B1 (fr) * 2006-11-16 2013-06-28 Physcience Complement alimentaire pour la prevention ou la lutte contre la chute des cheveux, l'acne, l'hirsutisme et la secretion sudorale apocrine excessive.
RU2419426C1 (ru) * 2010-04-26 2011-05-27 Всеволод Иванович Киселев Лекарственное средство на основе дииндолилметана (dim) с повышенной биодоступностью и его использование в лечении гиперпластических и воспалительных заболеваний человека
US20160051536A1 (en) * 2013-04-08 2016-02-25 Virginia Commonwealth University Compositions to alleviate presystemic metabolism of opioids
GB2528482A (en) * 2014-07-23 2016-01-27 Skintech Life Science Ltd Pharmaceutical agent
WO2018051183A1 (en) * 2016-09-15 2018-03-22 Skintech Life Science Limited Sublingual or buccal administration of dim for treatment of skin diseases
AU2018209393B2 (en) 2017-01-20 2024-02-15 Skintech Life Science Limited Combination therapy for treatment of skin diseases

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6599913B1 (en) * 2001-06-29 2003-07-29 Schering Corporation Treating allergic and inflammatory conditions
US20030082203A1 (en) * 2001-10-30 2003-05-01 Farley Michael D. Immune functions
CN103501772A (zh) * 2011-03-25 2014-01-08 Iiaa有限公司 用于治疗皮肤病症的包含二吲哚基甲烷和类视黄醇的组合物
CN103458888A (zh) * 2011-04-12 2013-12-18 雀巢产品技术援助有限公司 用于改善肠屏障功能的包含支链脂肪酸的营养组合物
WO2014177123A1 (de) * 2013-04-30 2014-11-06 Melnik Bodo C Akne-medikament und verfahren zu seiner herstellung

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
和凡等: ""槲皮素、山奈酚、芦丁对大鼠肝微粒体细胞色素P450 酶的诱导作用"", 《中国医院药学杂志》, vol. 30, no. 9, 31 May 2010 (2010-05-31), pages 728 - 731 *

Also Published As

Publication number Publication date
AU2018209393A1 (en) 2019-08-08
CA3050208A1 (en) 2018-07-26
JP7481402B2 (ja) 2024-05-10
US20220193167A1 (en) 2022-06-23
JP7123058B2 (ja) 2022-08-22
US11241467B2 (en) 2022-02-08
RU2019124938A (ru) 2021-02-20
US20200138884A1 (en) 2020-05-07
BR112019014942A2 (pt) 2020-04-14
AU2018209393B2 (en) 2024-02-15
WO2018134683A1 (en) 2018-07-26
JP2022169626A (ja) 2022-11-09
RU2019124938A3 (enExample) 2021-05-27
JP2020506169A (ja) 2020-02-27
EP3570889A1 (en) 2019-11-27
CN110446505A (zh) 2019-11-12

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