CN116018522B - 白细胞捕获设备 - Google Patents

白细胞捕获设备

Info

Publication number
CN116018522B
CN116018522B CN202180054466.8A CN202180054466A CN116018522B CN 116018522 B CN116018522 B CN 116018522B CN 202180054466 A CN202180054466 A CN 202180054466A CN 116018522 B CN116018522 B CN 116018522B
Authority
CN
China
Prior art keywords
layer
capturing
white blood
chip
width
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN202180054466.8A
Other languages
English (en)
Chinese (zh)
Other versions
CN116018522A (zh
Inventor
中村麻子
高桥健太
小森隆幸
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nok Corp
Ibaraki University NUC
Original Assignee
Nok Corp
Ibaraki University NUC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nok Corp, Ibaraki University NUC filed Critical Nok Corp
Publication of CN116018522A publication Critical patent/CN116018522A/zh
Application granted granted Critical
Publication of CN116018522B publication Critical patent/CN116018522B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/16—Microfluidic devices; Capillary tubes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Fluid Mechanics (AREA)
  • Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • External Artificial Organs (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CN202180054466.8A 2020-09-29 2021-09-10 白细胞捕获设备 Active CN116018522B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2020-163378 2020-09-29
JP2020163378 2020-09-29
PCT/JP2021/033343 WO2022070841A1 (ja) 2020-09-29 2021-09-10 白血球捕捉デバイス

Publications (2)

Publication Number Publication Date
CN116018522A CN116018522A (zh) 2023-04-25
CN116018522B true CN116018522B (zh) 2025-09-16

Family

ID=80951360

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180054466.8A Active CN116018522B (zh) 2020-09-29 2021-09-10 白细胞捕获设备

Country Status (5)

Country Link
US (1) US12599903B2 (https=)
EP (1) EP4224170A4 (https=)
JP (1) JP7455339B2 (https=)
CN (1) CN116018522B (https=)
WO (1) WO2022070841A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116324367A (zh) * 2020-09-29 2023-06-23 Nok株式会社 微颗粒捕获装置
JP7729536B2 (ja) * 2022-03-28 2025-08-26 国立大学法人茨城大学 白血球捕捉デバイス

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015095395A1 (en) * 2013-12-17 2015-06-25 The General Hospital Corporation Microfluidic devices for isolating particles

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JP2003102710A (ja) * 2001-09-30 2003-04-08 Hiroshi Otsuka 血液の分析方法ならびに分析装置
AU2003224817B2 (en) 2002-04-01 2008-11-06 Fluidigm Corporation Microfluidic particle-analysis systems
WO2004038367A2 (en) * 2002-10-22 2004-05-06 Surface Logix, Inc. Biological assays using gradients formed in microfluidic systems
DE10352535A1 (de) 2003-11-07 2005-06-16 Steag Microparts Gmbh Mikrostrukturierte Trennvorrichtung und Verfahren zum Abtrennen von flüssigen Bestandteilen aus einer Partikel enthaltenden Flüssigkeit
EP1874920A4 (en) * 2005-04-05 2009-11-04 Cellpoint Diagnostics DEVICES AND METHOD FOR ENRICHING AND CHANGING CIRCULATING TUMOR CELLS AND OTHER PARTICLES
US20070059781A1 (en) 2005-09-15 2007-03-15 Ravi Kapur System for size based separation and analysis
EP1931800A4 (en) 2005-09-15 2011-06-15 Artemis Health Inc SYSTEMS AND METHOD FOR ENRICHING ANALYTES
JP5231782B2 (ja) 2007-10-26 2013-07-10 学校法人常翔学園 固液分離機能を有する装置及びその製造方法
US9480935B2 (en) * 2008-02-01 2016-11-01 Lawrence Livermore National Security, Llc Systems and methods for separating particles and/or substances from a sample fluid
WO2009102783A1 (en) * 2008-02-11 2009-08-20 Massachusetts Institute Of Technology Particle capture devices and methods of use thereof
US8318574B2 (en) 2010-07-30 2012-11-27 International Business Machines Corporation SOI trench DRAM structure with backside strap
JP5626727B2 (ja) 2010-09-21 2014-11-19 国立大学法人東京農工大学 微量血液からの白血球ポピュレーション解析法
KR101768123B1 (ko) 2010-12-03 2017-08-16 삼성전자주식회사 수력학 필터, 이를 구비한 필터링 장치 및 이에 의한 필터링 방법
US9222870B2 (en) * 2010-12-10 2015-12-29 The Regents Of The University Of California Method and device for multi-parameter imaging within a single fluorescent channel
CN102360010B (zh) * 2011-08-05 2014-01-01 上海交通大学 一种全血癌细胞捕获集成微流控芯片
WO2016094715A2 (en) * 2014-12-10 2016-06-16 Berkeley Lights, Inc. Movement and selection of micro-objects in a microfluidic apparatus
JP6615499B2 (ja) 2015-06-05 2019-12-04 国立大学法人 東京大学 細胞またはリポソーム粒子の分離捕捉装置
CN205067292U (zh) 2015-09-11 2016-03-02 上海交通大学 一种循环肿瘤细胞检测试剂盒
CN105462834B (zh) * 2016-01-22 2019-03-19 苏州汶颢芯片科技有限公司 肿瘤细胞捕获微流控芯片和肿瘤细胞捕获方法
CN109196094A (zh) 2016-03-17 2019-01-11 伯克利之光生命科技公司 微流体装置中t淋巴细胞的选择和克隆
US20190247030A1 (en) 2018-02-13 2019-08-15 Trophodiagnostics, Llc System and Method for Collecting, Enriching and Isolating Trophoblast Cells From Endocervical Canal
WO2019069900A1 (ja) 2017-10-03 2019-04-11 Nok株式会社 細胞捕捉装置
JP7192221B2 (ja) 2018-03-07 2022-12-20 株式会社豊田中央研究所 細胞トラップ構造体及びその利用
JP7455296B2 (ja) 2019-03-26 2024-03-26 群馬県 酸性白土を主成分とする難脱硫性硫黄化合物除去剤、除去剤の製法及び除去方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015095395A1 (en) * 2013-12-17 2015-06-25 The General Hospital Corporation Microfluidic devices for isolating particles

Also Published As

Publication number Publication date
US20230364613A1 (en) 2023-11-16
CN116018522A (zh) 2023-04-25
JPWO2022070841A1 (https=) 2022-04-07
WO2022070841A1 (ja) 2022-04-07
EP4224170A4 (en) 2024-11-13
JP7455339B2 (ja) 2024-03-26
US12599903B2 (en) 2026-04-14
EP4224170A1 (en) 2023-08-09

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