CN115997127A - 检测补体蛋白 - Google Patents

检测补体蛋白 Download PDF

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Publication number
CN115997127A
CN115997127A CN202180033713.6A CN202180033713A CN115997127A CN 115997127 A CN115997127 A CN 115997127A CN 202180033713 A CN202180033713 A CN 202180033713A CN 115997127 A CN115997127 A CN 115997127A
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CN
China
Prior art keywords
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ser
leu
val
lys
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Pending
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CN202180033713.6A
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English (en)
Chinese (zh)
Inventor
P·比绍普
S·克拉克
R·恩文
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Manshou Pharmaceutical Co ltd
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Manshou Pharmaceutical Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Manshou Pharmaceutical Co ltd filed Critical Manshou Pharmaceutical Co ltd
Publication of CN115997127A publication Critical patent/CN115997127A/zh
Pending legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4716—Complement proteins, e.g. anaphylatoxin, C3a, C5a
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433—Serine endopeptidases (3.4.21)

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN202180033713.6A 2020-05-07 2021-05-06 检测补体蛋白 Pending CN115997127A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB2006789.8 2020-05-07
GBGB2006789.8A GB202006789D0 (en) 2020-05-07 2020-05-07 Detection of complement proteins
PCT/EP2021/062077 WO2021224430A1 (en) 2020-05-07 2021-05-06 Detection of complement proteins

Publications (1)

Publication Number Publication Date
CN115997127A true CN115997127A (zh) 2023-04-21

Family

ID=71134867

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180033713.6A Pending CN115997127A (zh) 2020-05-07 2021-05-06 检测补体蛋白

Country Status (8)

Country Link
US (1) US20230400470A1 (enExample)
EP (1) EP4147057A1 (enExample)
JP (1) JP7849304B2 (enExample)
CN (1) CN115997127A (enExample)
AU (1) AU2021267650A1 (enExample)
CA (1) CA3177760A1 (enExample)
GB (1) GB202006789D0 (enExample)
WO (1) WO2021224430A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201800620D0 (en) 2018-01-15 2018-02-28 Univ Manchester C3b Binding Polypeptide
GB202203627D0 (en) * 2022-03-16 2022-04-27 Univ Manchester Agents for treating complement-related disorders
JP2026501750A (ja) 2023-01-05 2026-01-16 コンプリメント・セラピューティクス・リミテッド 補体疾患を処置するための薬剤および方法
WO2025083211A1 (en) * 2023-10-20 2025-04-24 Institut National de la Santé et de la Recherche Médicale Use of factor h for the treatment of dementia
LU103244B1 (en) 2024-02-14 2025-08-14 Univ Hamburg Eppendorf Uke Deletion of the mouse homolog of human FHR1 (FHRE) protects ApoE-/- mice from atherosclerosis

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2044443A2 (en) * 2006-07-03 2009-04-08 The Johns Hopkins University Peptide antibody depletion and its application to mass spectrometry sample preparation
US20110136160A1 (en) * 2008-08-28 2011-06-09 Universite De Geneve Analysis of glycated proteins

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005211063A (ja) 2004-01-30 2005-08-11 Junko Maekuroshima ブレンドノニ茶
WO2009059321A2 (en) 2007-11-01 2009-05-07 University Of Iowa Research Foundation Rca locus analysis to assess susceptibility to amd and mpgnii
WO2016068616A1 (ko) 2014-10-29 2016-05-06 차의과학대학교 산학협력단 C3 또는 c1r 보체를 분비하는 태반 유래 세포 및 이를 포함하는 조성물
GB201709222D0 (en) 2017-06-09 2017-07-26 Univ Manchester C3b Inactivating Polypeptide
GB201800620D0 (en) 2018-01-15 2018-02-28 Univ Manchester C3b Binding Polypeptide
KR102775717B1 (ko) 2018-03-13 2025-03-06 암젠 인크 질량 분광 분석을 위한 폴리펩티드의 순차적 소화
WO2019215330A1 (en) 2018-05-10 2019-11-14 The University Of Manchester Methods for assessing macular degeneration

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2044443A2 (en) * 2006-07-03 2009-04-08 The Johns Hopkins University Peptide antibody depletion and its application to mass spectrometry sample preparation
US20110136160A1 (en) * 2008-08-28 2011-06-09 Universite De Geneve Analysis of glycated proteins

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JASON M. SHOHET 等: "Identification of a Major Binding Site for Complement C3 on the IgG1 Heavy Chain", 《THE JOURNAL OF BIOLOGICAL CHEMIST》, vol. 268, no. 8, 15 March 1993 (1993-03-15), pages 5866 - 5871, XP055812544 *
MONIKA JUSKO 等: "Staphylococcal Proteases Aid in Evasion of the Human Complement System", 《J INNATE IMMUN》, vol. 6, 3 July 2013 (2013-07-03), pages 31 *

Also Published As

Publication number Publication date
CA3177760A1 (en) 2021-11-11
GB202006789D0 (en) 2020-06-24
WO2021224430A1 (en) 2021-11-11
US20230400470A1 (en) 2023-12-14
AU2021267650A1 (en) 2023-01-19
EP4147057A1 (en) 2023-03-15
JP7849304B2 (ja) 2026-04-21
JP2023524130A (ja) 2023-06-08

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