JP7849304B2 - 補体タンパク質の検出 - Google Patents

補体タンパク質の検出

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Publication number
JP7849304B2
JP7849304B2 JP2022567280A JP2022567280A JP7849304B2 JP 7849304 B2 JP7849304 B2 JP 7849304B2 JP 2022567280 A JP2022567280 A JP 2022567280A JP 2022567280 A JP2022567280 A JP 2022567280A JP 7849304 B2 JP7849304 B2 JP 7849304B2
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JP
Japan
Prior art keywords
complement
seq
protein
peptides
level
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JP2022567280A
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English (en)
Japanese (ja)
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JP2023524130A5 (enExample
JP2023524130A (ja
Inventor
ビショップ，ポール
クラーク，サイモン
アンウィン，リチャード
Original Assignee
コンプリメント・セラピューティクス・リミテッド
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Publication of JP2023524130A publication Critical patent/JP2023524130A/ja
Publication of JP2023524130A5 publication Critical patent/JP2023524130A5/ja
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Publication of JP7849304B2 publication Critical patent/JP7849304B2/ja
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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4716—Complement proteins, e.g. anaphylatoxin, C3a, C5a
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433—Serine endopeptidases (3.4.21)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2022567280A 2020-05-07 2021-05-06 補体タンパク質の検出 Active JP7849304B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB2006789.8 2020-05-07
GBGB2006789.8A GB202006789D0 (en) 2020-05-07 2020-05-07 Detection of complement proteins
PCT/EP2021/062077 WO2021224430A1 (en) 2020-05-07 2021-05-06 Detection of complement proteins

Publications (3)

Publication Number Publication Date
JP2023524130A JP2023524130A (ja) 2023-06-08
JP2023524130A5 JP2023524130A5 (enExample) 2024-05-17
JP7849304B2 true JP7849304B2 (ja) 2026-04-21

Family

ID=71134867

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022567280A Active JP7849304B2 (ja) 2020-05-07 2021-05-06 補体タンパク質の検出

Country Status (8)

Country Link
US (1) US20230400470A1 (enExample)
EP (1) EP4147057A1 (enExample)
JP (1) JP7849304B2 (enExample)
CN (1) CN115997127A (enExample)
AU (1) AU2021267650A1 (enExample)
CA (1) CA3177760A1 (enExample)
GB (1) GB202006789D0 (enExample)
WO (1) WO2021224430A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201800620D0 (en) 2018-01-15 2018-02-28 Univ Manchester C3b Binding Polypeptide
GB202203627D0 (en) * 2022-03-16 2022-04-27 Univ Manchester Agents for treating complement-related disorders
JP2026501750A (ja) 2023-01-05 2026-01-16 コンプリメント・セラピューティクス・リミテッド 補体疾患を処置するための薬剤および方法
WO2025083211A1 (en) * 2023-10-20 2025-04-24 Institut National de la Santé et de la Recherche Médicale Use of factor h for the treatment of dementia
LU103244B1 (en) 2024-02-14 2025-08-14 Univ Hamburg Eppendorf Uke Deletion of the mouse homolog of human FHR1 (FHRE) protects ApoE-/- mice from atherosclerosis

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005211063A (ja) 2004-01-30 2005-08-11 Junko Maekuroshima ブレンドノニ茶
US20110136160A1 (en) 2008-08-28 2011-06-09 Universite De Geneve Analysis of glycated proteins
US20120276570A1 (en) 2006-07-03 2012-11-01 The Johns Hopkins University Peptide Antibody Depletion and its Application to Mass Spectrometry Sample Preparation
KR20160052377A (ko) 2014-10-29 2016-05-12 차의과학대학교 산학협력단 C3 또는 C1r 보체를 분비하는 태반 유래 세포 및 이를 포함하는 조성물
WO2019178280A1 (en) 2018-03-13 2019-09-19 Amgen Inc. Sequential digestion of polypeptides for mass spectrometric analysis
WO2019215330A1 (en) 2018-05-10 2019-11-14 The University Of Manchester Methods for assessing macular degeneration

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009059321A2 (en) 2007-11-01 2009-05-07 University Of Iowa Research Foundation Rca locus analysis to assess susceptibility to amd and mpgnii
GB201709222D0 (en) 2017-06-09 2017-07-26 Univ Manchester C3b Inactivating Polypeptide
GB201800620D0 (en) 2018-01-15 2018-02-28 Univ Manchester C3b Binding Polypeptide

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005211063A (ja) 2004-01-30 2005-08-11 Junko Maekuroshima ブレンドノニ茶
US20120276570A1 (en) 2006-07-03 2012-11-01 The Johns Hopkins University Peptide Antibody Depletion and its Application to Mass Spectrometry Sample Preparation
US20110136160A1 (en) 2008-08-28 2011-06-09 Universite De Geneve Analysis of glycated proteins
KR20160052377A (ko) 2014-10-29 2016-05-12 차의과학대학교 산학협력단 C3 또는 C1r 보체를 분비하는 태반 유래 세포 및 이를 포함하는 조성물
WO2019178280A1 (en) 2018-03-13 2019-09-19 Amgen Inc. Sequential digestion of polypeptides for mass spectrometric analysis
WO2019215330A1 (en) 2018-05-10 2019-11-14 The University Of Manchester Methods for assessing macular degeneration

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CAMPAGNE, M.L., et al.，Age-related macular degeneration: Complement in action，Immunobiology，NL，2016年06月，Vol.221, No.6，pp.733-739
ZHANG, P., et al.，A novel, multiplexed targeted mass spectrometry assay for quantification of complement factor H (CFH) variants and CFH-related proteins 1-5 in human plasma，Proteomics，2017年03月，Vol.17, No.6，pp.1-10，<DOI: 10.1002/pmic.201600237>

Also Published As

Publication number Publication date
CA3177760A1 (en) 2021-11-11
GB202006789D0 (en) 2020-06-24
CN115997127A (zh) 2023-04-21
WO2021224430A1 (en) 2021-11-11
US20230400470A1 (en) 2023-12-14
AU2021267650A1 (en) 2023-01-19
EP4147057A1 (en) 2023-03-15
JP2023524130A (ja) 2023-06-08

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