CN115996725A - 用于治疗山梨糖醇脱氢酶缺乏症的醛糖还原酶抑制剂 - Google Patents

用于治疗山梨糖醇脱氢酶缺乏症的醛糖还原酶抑制剂 Download PDF

Info

Publication number
CN115996725A
CN115996725A CN202180044285.7A CN202180044285A CN115996725A CN 115996725 A CN115996725 A CN 115996725A CN 202180044285 A CN202180044285 A CN 202180044285A CN 115996725 A CN115996725 A CN 115996725A
Authority
CN
China
Prior art keywords
aldose reductase
reductase inhibitor
sorbitol
certain embodiments
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202180044285.7A
Other languages
English (en)
Chinese (zh)
Inventor
S·申德曼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Applied Therapy Co
Original Assignee
Applied Therapy Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Therapy Co filed Critical Applied Therapy Co
Publication of CN115996725A publication Critical patent/CN115996725A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN202180044285.7A 2020-05-01 2021-04-27 用于治疗山梨糖醇脱氢酶缺乏症的醛糖还原酶抑制剂 Pending CN115996725A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063019186P 2020-05-01 2020-05-01
US63/019,186 2020-05-01
US202063019738P 2020-05-04 2020-05-04
US63/019,738 2020-05-04
PCT/US2021/029286 WO2021222165A1 (en) 2020-05-01 2021-04-27 Aldose reductase inhibitors for treating sorbitol dehydrogenase deficiency

Publications (1)

Publication Number Publication Date
CN115996725A true CN115996725A (zh) 2023-04-21

Family

ID=75954272

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180044285.7A Pending CN115996725A (zh) 2020-05-01 2021-04-27 用于治疗山梨糖醇脱氢酶缺乏症的醛糖还原酶抑制剂

Country Status (11)

Country Link
US (2) US20230121312A1 (enExample)
EP (1) EP4135674A1 (enExample)
JP (2) JP7788399B2 (enExample)
KR (1) KR20230005944A (enExample)
CN (1) CN115996725A (enExample)
AU (1) AU2021264454A1 (enExample)
BR (1) BR112022021845A2 (enExample)
CA (1) CA3176768A1 (enExample)
IL (1) IL297779A (enExample)
MX (1) MX2022013658A (enExample)
WO (1) WO2021222165A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL272246B2 (en) 2017-07-28 2026-01-01 Applied Therapeutics Inc History of 2-(4-oxo/thioketone/azo-3-((substituted)benzo[d]thiazol-2-yl)methyl)- 3,4-dihydrothieno[3,4-d]pyridazin-1-yl)acetic acid for use as an aldose reductase inhibitor for the treatment of galactosemia or prevention of galactosemia-related complications
CA3132136A1 (en) 2019-04-01 2020-10-08 Andrew Wasmuth Inhibitors of aldose reductase
JP2022531466A (ja) 2019-05-07 2022-07-06 ユニバーシティ オブ マイアミ 遺伝性ニューロパチーおよび関連障害の処置および検出
GB202400033D0 (en) 2024-01-02 2024-02-14 Nicolnson Tamara Therapy i
WO2025219948A1 (en) * 2024-04-17 2025-10-23 Assia Chemical Industries Ltd. Crystalline forms of govorestat

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998042324A2 (en) * 1997-03-21 1998-10-01 The Regents Of The University Of California Methods for modulating neurotrophic factor-associated activity using aldose reductase inhibitors
CN1261804A (zh) * 1997-07-08 2000-08-02 曾尼卡有限公司 含有醛糖还原酶抑制剂和ace抑制剂的药物组合物
US20100310641A1 (en) * 2007-11-30 2010-12-09 Pharnext Therapeutic approaches for treating cmt and related disorders
CN109310674A (zh) * 2016-06-21 2019-02-05 纽约市哥伦比亚大学理事会 醛糖还原酶抑制剂及其使用方法
CN111065392A (zh) * 2017-07-28 2020-04-24 应用治疗公司 用于治疗半乳糖血症的组合物和方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4939140A (en) 1985-11-07 1990-07-03 Pfizer Inc. Heterocyclic oxophthalazinyl acetic acids
JPH0495025A (ja) 1990-08-08 1992-03-27 Asahi Chem Ind Co Ltd アルドースリダクターゼ阻害剤
US5464961A (en) 1993-09-10 1995-11-07 Olin Corporation Arcjet anode
US5624949A (en) 1993-12-07 1997-04-29 Eli Lilly And Company Protein kinase C inhibitors
JPH11512095A (ja) 1995-08-28 1999-10-19 アメリカン・ホーム・プロダクツ・コーポレイション アルドース還元酵素阻害薬および抗高血糖症薬としてのフェノキシ酢酸
PL179170B1 (pl) 1995-09-15 2000-07-31 Inst Lekow Nowe zwiazki,pochodne genisteiny PL PL PL PL
SI0776895T1 (en) 1995-11-20 1999-04-30 Eli Lilly And Company Protein kinase C inhibitor
EP0982306A3 (en) 1998-08-21 2000-07-05 Pfizer Products Inc. Polymorph of zopolrestat monohydrate
US6570013B2 (en) 2000-02-16 2003-05-27 Pfizer Inc Salts of zopolrestat
WO2003105864A1 (en) 2002-06-13 2003-12-24 Board Of Regents, The University Of Texas System Methods and compositions involving aldose reductase inhibitors
US8916563B2 (en) 2010-07-16 2014-12-23 The Trustees Of Columbia University In The City Of New York Aldose reductase inhibitors and uses thereof
HRP20221430T1 (hr) 2010-07-16 2023-01-06 The Trustees Of Columbia University In The City Of New York Inhibitori aldozoreduktaze i njihova uporaba
WO2017038505A1 (ja) 2015-09-01 2017-03-09 株式会社村田製作所 コイル内蔵部品

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998042324A2 (en) * 1997-03-21 1998-10-01 The Regents Of The University Of California Methods for modulating neurotrophic factor-associated activity using aldose reductase inhibitors
CN1261804A (zh) * 1997-07-08 2000-08-02 曾尼卡有限公司 含有醛糖还原酶抑制剂和ace抑制剂的药物组合物
US20100310641A1 (en) * 2007-11-30 2010-12-09 Pharnext Therapeutic approaches for treating cmt and related disorders
CN109310674A (zh) * 2016-06-21 2019-02-05 纽约市哥伦比亚大学理事会 醛糖还原酶抑制剂及其使用方法
CN111065392A (zh) * 2017-07-28 2020-04-24 应用治疗公司 用于治疗半乳糖血症的组合物和方法

Also Published As

Publication number Publication date
US20230121312A1 (en) 2023-04-20
BR112022021845A2 (pt) 2022-12-20
JP2023524504A (ja) 2023-06-12
MX2022013658A (es) 2023-03-01
JP7788399B2 (ja) 2025-12-18
EP4135674A1 (en) 2023-02-22
US20240238288A1 (en) 2024-07-18
IL297779A (en) 2022-12-01
AU2021264454A1 (en) 2022-12-08
CA3176768A1 (en) 2021-11-04
WO2021222165A1 (en) 2021-11-04
KR20230005944A (ko) 2023-01-10
JP2026012262A (ja) 2026-01-23

Similar Documents

Publication Publication Date Title
CN115996725A (zh) 用于治疗山梨糖醇脱氢酶缺乏症的醛糖还原酶抑制剂
CN114667139B (zh) 用于治疗磷酸甘露变位酶2缺乏的醛糖还原酶抑制剂
US20230346782A1 (en) Compositions and methods for treating galactosemia
US20160303061A1 (en) Compositions and methods for neuroprotection and treatment of neurodegeneration
RU2858535C2 (ru) Ингибиторы альдозоредуктазы для лечения дефицита сорбитолдегидрогеназы
BR122025019642A2 (pt) Uso de inibidores de aldose redutase para tratar deficiência em sorbitol desidrogenase
HK40113967A (en) Compositions and methods for treating galactosemia
RU2830187C2 (ru) Композиции и способы лечения галактоземии
WO2020199650A1 (zh) 依达拉奉在非酒精性脂肪肝炎治疗或预防中的应用
BR112020001755B1 (pt) Usos de um inibidor da aldose redutase para o tratamento de galactosemia
HK40030466B (en) Compositions and methods for treating galactosemia
TW201725197A (zh) 用於治療阿茲海默症和/或大腦類澱粉血管病之新穎化合物及方法

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination