CA3176768A1 - Aldose reductase inhibitors for treating sorbitol dehydrogenase deficiency - Google Patents
Aldose reductase inhibitors for treating sorbitol dehydrogenase deficiency Download PDFInfo
- Publication number
- CA3176768A1 CA3176768A1 CA3176768A CA3176768A CA3176768A1 CA 3176768 A1 CA3176768 A1 CA 3176768A1 CA 3176768 A CA3176768 A CA 3176768A CA 3176768 A CA3176768 A CA 3176768A CA 3176768 A1 CA3176768 A1 CA 3176768A1
- Authority
- CA
- Canada
- Prior art keywords
- aldose reductase
- reductase inhibitor
- sorbitol
- certain embodiments
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Ophthalmology & Optometry (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063019186P | 2020-05-01 | 2020-05-01 | |
| US63/019,186 | 2020-05-01 | ||
| US202063019738P | 2020-05-04 | 2020-05-04 | |
| US63/019,738 | 2020-05-04 | ||
| PCT/US2021/029286 WO2021222165A1 (en) | 2020-05-01 | 2021-04-27 | Aldose reductase inhibitors for treating sorbitol dehydrogenase deficiency |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3176768A1 true CA3176768A1 (en) | 2021-11-04 |
Family
ID=75954272
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3176768A Pending CA3176768A1 (en) | 2020-05-01 | 2021-04-27 | Aldose reductase inhibitors for treating sorbitol dehydrogenase deficiency |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20230121312A1 (enExample) |
| EP (1) | EP4135674A1 (enExample) |
| JP (2) | JP7788399B2 (enExample) |
| KR (1) | KR20230005944A (enExample) |
| CN (1) | CN115996725A (enExample) |
| AU (1) | AU2021264454A1 (enExample) |
| BR (1) | BR112022021845A2 (enExample) |
| CA (1) | CA3176768A1 (enExample) |
| IL (1) | IL297779A (enExample) |
| MX (1) | MX2022013658A (enExample) |
| WO (1) | WO2021222165A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL272246B2 (en) | 2017-07-28 | 2026-01-01 | Applied Therapeutics Inc | History of 2-(4-oxo/thioketone/azo-3-((substituted)benzo[d]thiazol-2-yl)methyl)- 3,4-dihydrothieno[3,4-d]pyridazin-1-yl)acetic acid for use as an aldose reductase inhibitor for the treatment of galactosemia or prevention of galactosemia-related complications |
| CA3132136A1 (en) | 2019-04-01 | 2020-10-08 | Andrew Wasmuth | Inhibitors of aldose reductase |
| JP2022531466A (ja) | 2019-05-07 | 2022-07-06 | ユニバーシティ オブ マイアミ | 遺伝性ニューロパチーおよび関連障害の処置および検出 |
| GB202400033D0 (en) | 2024-01-02 | 2024-02-14 | Nicolnson Tamara | Therapy i |
| WO2025219948A1 (en) * | 2024-04-17 | 2025-10-23 | Assia Chemical Industries Ltd. | Crystalline forms of govorestat |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4939140A (en) | 1985-11-07 | 1990-07-03 | Pfizer Inc. | Heterocyclic oxophthalazinyl acetic acids |
| JPH0495025A (ja) | 1990-08-08 | 1992-03-27 | Asahi Chem Ind Co Ltd | アルドースリダクターゼ阻害剤 |
| US5464961A (en) | 1993-09-10 | 1995-11-07 | Olin Corporation | Arcjet anode |
| US5624949A (en) | 1993-12-07 | 1997-04-29 | Eli Lilly And Company | Protein kinase C inhibitors |
| JPH11512095A (ja) | 1995-08-28 | 1999-10-19 | アメリカン・ホーム・プロダクツ・コーポレイション | アルドース還元酵素阻害薬および抗高血糖症薬としてのフェノキシ酢酸 |
| PL179170B1 (pl) | 1995-09-15 | 2000-07-31 | Inst Lekow | Nowe zwiazki,pochodne genisteiny PL PL PL PL |
| SI0776895T1 (en) | 1995-11-20 | 1999-04-30 | Eli Lilly And Company | Protein kinase C inhibitor |
| WO1998042324A2 (en) * | 1997-03-21 | 1998-10-01 | The Regents Of The University Of California | Methods for modulating neurotrophic factor-associated activity using aldose reductase inhibitors |
| GB9714274D0 (en) * | 1997-07-08 | 1997-09-10 | Zeneca Ltd | Pharmaceutical composition |
| EP0982306A3 (en) | 1998-08-21 | 2000-07-05 | Pfizer Products Inc. | Polymorph of zopolrestat monohydrate |
| US6570013B2 (en) | 2000-02-16 | 2003-05-27 | Pfizer Inc | Salts of zopolrestat |
| WO2003105864A1 (en) | 2002-06-13 | 2003-12-24 | Board Of Regents, The University Of Texas System | Methods and compositions involving aldose reductase inhibitors |
| EP2065038A1 (en) * | 2007-11-30 | 2009-06-03 | Pharnext | New therapeutic approaches for treating Charcot-Marie-Tooth disease |
| US8916563B2 (en) | 2010-07-16 | 2014-12-23 | The Trustees Of Columbia University In The City Of New York | Aldose reductase inhibitors and uses thereof |
| HRP20221430T1 (hr) | 2010-07-16 | 2023-01-06 | The Trustees Of Columbia University In The City Of New York | Inhibitori aldozoreduktaze i njihova uporaba |
| WO2017038505A1 (ja) | 2015-09-01 | 2017-03-09 | 株式会社村田製作所 | コイル内蔵部品 |
| RS61239B1 (sr) * | 2016-06-21 | 2021-01-29 | Univ Columbia | Inhibitori aldozne reduktaze i postupci korišćenja |
| IL272246B2 (en) * | 2017-07-28 | 2026-01-01 | Applied Therapeutics Inc | History of 2-(4-oxo/thioketone/azo-3-((substituted)benzo[d]thiazol-2-yl)methyl)- 3,4-dihydrothieno[3,4-d]pyridazin-1-yl)acetic acid for use as an aldose reductase inhibitor for the treatment of galactosemia or prevention of galactosemia-related complications |
-
2021
- 2021-04-27 WO PCT/US2021/029286 patent/WO2021222165A1/en not_active Ceased
- 2021-04-27 AU AU2021264454A patent/AU2021264454A1/en active Pending
- 2021-04-27 MX MX2022013658A patent/MX2022013658A/es unknown
- 2021-04-27 CA CA3176768A patent/CA3176768A1/en active Pending
- 2021-04-27 BR BR112022021845A patent/BR112022021845A2/pt unknown
- 2021-04-27 CN CN202180044285.7A patent/CN115996725A/zh active Pending
- 2021-04-27 IL IL297779A patent/IL297779A/en unknown
- 2021-04-27 KR KR1020227042040A patent/KR20230005944A/ko active Pending
- 2021-04-27 JP JP2022566358A patent/JP7788399B2/ja active Active
- 2021-04-27 EP EP21726266.6A patent/EP4135674A1/en active Pending
-
2022
- 2022-10-28 US US18/050,627 patent/US20230121312A1/en not_active Abandoned
-
2024
- 2024-02-01 US US18/429,719 patent/US20240238288A1/en active Pending
-
2025
- 2025-10-27 JP JP2025180336A patent/JP2026012262A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20230121312A1 (en) | 2023-04-20 |
| BR112022021845A2 (pt) | 2022-12-20 |
| JP2023524504A (ja) | 2023-06-12 |
| MX2022013658A (es) | 2023-03-01 |
| JP7788399B2 (ja) | 2025-12-18 |
| EP4135674A1 (en) | 2023-02-22 |
| US20240238288A1 (en) | 2024-07-18 |
| IL297779A (en) | 2022-12-01 |
| AU2021264454A1 (en) | 2022-12-08 |
| WO2021222165A1 (en) | 2021-11-04 |
| KR20230005944A (ko) | 2023-01-10 |
| CN115996725A (zh) | 2023-04-21 |
| JP2026012262A (ja) | 2026-01-23 |
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