CN115990128A - Oral care composition - Google Patents

Abstract

The invention discloses an oral care composition which comprises the following components in parts by weight: 40-65 parts of wetting agent, 45-85 parts of preservative, 55-90 parts of surfactant, 4-12 parts of edible aromatic, 5-15 parts of thickener, 0.5-1.5 parts of sweetener, 5-15 parts of buffer, 0.5-35 parts of bacteriostat, 5-15 parts of micromolecular active peptide and 0.1-0.5 part of thymol. The oral care composition can inhibit pathogenic bacteria of oral diseases, treat the oral diseases, keep oral health and refresh breath.

Description

Oral care composition

Technical Field

The invention relates to the technical field of oral care, in particular to an oral care composition.

Background

The oral cavity is an important component of human digestion and respiratory system, and along with the aggravation of the problems of air pollution, environmental deterioration and the like, the oral diseases are in an ascending trend.

Oral diseases are general names of diseases with high incidence rate, and common diseases include oral ulcer, halitosis and the like. There are a large number of microorganisms in the human mouth, pathogenic, non-pathogenic and conditionally pathogenic, the specific species being quite complex. The presence and proliferation of pathogenic bacteria in the oral cavity is a significant cause of most oral diseases.

Disclosure of Invention

In view of the above, the present invention provides an oral care composition capable of inhibiting pathogenic bacteria of oral diseases, treating oral diseases, maintaining oral health, and freshening breath.

In order to achieve the above object, the technical scheme of the present invention is as follows.

An oral care composition comprising the following components in parts by weight:

40-65 parts of wetting agent, 45-85 parts of preservative, 55-90 parts of surfactant, 4-12 parts of edible aromatic, 5-15 parts of thickener, 0.5-1.5 parts of sweetener, 5-15 parts of buffer, 0.5-35 parts of bacteriostat, 5-15 parts of micromolecular active peptide and 0.1-0.5 part of thymol.

Further, the bacteriostat comprises 0.5-1.5 parts of glycyrrhetinic acid according to parts by weight; or the antibacterial agent comprises 0.5-1.5 parts of glycyrrhetinic acid, 5-15 parts of xiaoshanhu extract and 5-15 parts of barbed skullcap herb extract according to parts by weight.

Further, the wetting agent comprises 40-60 parts of propylene glycol and 1-2 parts of sodium hyaluronate in parts by weight.

Further, the preservative comprises 40-60 parts of EDTA disodium, 4-6 parts of potassium sorbate and 5-15 parts of benzoic acid according to parts by weight.

Further, the surfactant comprises, by weight, 1.5-2.5 parts of benzalkonium chloride, 50-70 parts of hydrogenated castor oil and 5-15 parts of polyvinylpyrrolidone.

Further, the edible aromatic comprises 1-2 parts of essence, 1-3 parts of menthol, 1-3 parts of peppermint oil and 1-3 parts of borneol according to parts by weight.

Further, the thickener comprises 5-15 parts by weight of hydroxyethyl cellulose; and/or, the sweetener comprises 0.5-1.5 parts by weight of sucralose; and/or, the buffering agent comprises 5-10 parts of sodium dihydrogen phosphate and 1-3 parts of disodium hydrogen phosphate according to parts by weight.

Further, the oral care composition comprises the following components in parts by weight:

0.5 part of glycyrrhetinic acid, 50 parts of propylene glycol, 50 parts of EDTA disodium, 1 part of sodium hyaluronate, 5 parts of potassium sorbate, 1.8 parts of benzalkonium chloride, 10 parts of benzoic acid, 10 parts of polyvinylpyrrolidone, 60 parts of hydrogenated castor oil, 10 parts of hydroxyethyl cellulose, 1 part of essence, 2 parts of menthol, 2 parts of peppermint oil, 1.5 parts of borneol, 6 parts of sodium dihydrogen phosphate, 1.8 parts of disodium hydrogen phosphate, 0.5 part of sucralose, 10 parts of small molecule active peptide, 0.1 part of thymol and the balance of water.

Further, the oral care composition comprises the following components in parts by weight:

0.5 part of glycyrrhetinic acid, 50 parts of propylene glycol, 50 parts of EDTA disodium, 1 part of sodium hyaluronate, 5 parts of potassium sorbate, 1.8 parts of benzalkonium chloride, 10 parts of benzoic acid, 10 parts of polyvinylpyrrolidone, 60 parts of hydrogenated castor oil, 10 parts of hydroxyethyl cellulose, 1 part of essence, 2 parts of menthol, 2 parts of peppermint oil, 1.5 parts of borneol, 6 parts of sodium dihydrogen phosphate, 1.8 parts of disodium hydrogen phosphate, 0.5 part of sucralose, 10 parts of small molecule active peptide, 0.1 part of thymol, 10 parts of tiger extract, 10 parts of barbed skullcap herb extract and the balance of water.

The invention also provides a method of preparing an oral care composition comprising the steps of:

dissolving the raw materials in water according to the formula amount, stirring until the raw materials are completely dissolved and uniformly dispersed;

standing at room temperature for a predetermined time, and filtering to obtain the oral care product.

In the present invention, glycyrrhetinic acid: has antiviral infection, antitussive and expectorant effects, and can effectively inhibit harmful bacteria in oral cavity, maintain oral flora balance, prevent and treat excessive internal heat in oral cavity, stomatitis, and antitussive and expectorant effects.

Thymol: the invention is commonly used for preparing spice, medicine, indicator and the like, and the invention can improve the effect of inhibiting pathogenic bacteria of oral diseases by synergistic effect with glycyrrhetinic acid and other components.

Small molecule active peptide: the peptide is a biochemical substance between amino acid and protein, has smaller molecular weight than protein and larger molecular weight than amino acid, is a fragment of protein, has strong biological activity, and in the embodiment, the micromolecular active peptide, sodium hyaluronate, glycyrrhetinic acid, thymol and other components are synergistic, so that the peptide has good regulation and control, nutrition and repair promotion effects on tissue cells, can treat oral diseases such as dental ulcer, promote wound healing, and can enhance the antibacterial effects of the glycyrrhetinic acid and the thymol.

Extract of Kadsura longepedunculata: has effects in dispelling pathogenic wind, removing heat, cooling blood, removing toxic substances, removing food stagnation, resolving hard mass, relieving inflammation, and relieving pain, and can be used for treating common cold, fever, cough, traumatic injury, chest pain due to mistaking for silk, dysentery, icteric hepatitis, neurasthenia, sore, furuncle, carbuncle, snake bite, and snake bite furuncle; it is indicated for skin sore, furuncle, swelling and pain, carbuncle, snake bite, breast pain of women.

An extract of Scutellaria barbata: has effects in clearing away heat and toxic materials, promoting blood circulation, dispelling blood stasis, relieving swelling and pain, and resisting cancer. The herb contains multiple vitamins, trace elements, amino acids and other components. Has effects of cooling blood, removing toxic substances, removing blood stasis, relieving pain, relieving swelling, clearing heat and promoting diuresis.

The synergistic effect of the xiaoshanhu extract, the barbed skullcap herb extract, the thymol, the small molecular active peptide and the glycyrrhetinic acid and other components can more effectively inhibit harmful bacteria in the oral cavity, maintain the balance of oral flora, prevent and treat excessive internal heat in the oral cavity, and relieve cough and eliminate phlegm.

Propylene glycol: is used as a humectant.

Sodium hyaluronate: the oral liquid has the functions of slow release, absorption promotion and synergy on other added active ingredients, has antibacterial and anti-inflammatory effects, is beneficial to daily health care of the oral cavity, prevention and treatment of oral diseases, nursing of the throat, moisture preservation and wound healing promotion.

Disodium EDTA is used as a preservative.

Potassium sorbate: can effectively inhibit the activity of mould, aerobic bacteria and saccharomycetes, and can also prevent the propagation of microorganisms such as staphylococcus, clostridium botulinum, salmonella and the like.

Benzoic acid: has antibacterial and bacteria growth inhibiting effects.

Benzalkonium chloride: used as a surfactant.

Hydrogenated castor oil: in particular polyoxyethylene 40 hydrogenated castor oil, is used as a surfactant.

Polyvinylpyrrolidone: has excellent solubility and physiological compatibility, and can be used as surfactant.

The essence, menthol, peppermint oil and borneol act synergistically to make the oral cavity fresh for a long time, and generate a cool feeling to relieve discomfort and pain.

Hydroxyethyl cellulose: has good thickening, suspending, dispersing, emulsifying, binding, film forming, moisture protection, protective colloid providing and other characteristics, and can be used as a thickening agent.

Sucralose: the sweetener has the advantages of no energy, high sweetness, pure sweetness, high safety and the like, and is an ideal sweetener.

Sodium dihydrogen phosphate and disodium hydrogen phosphate are used as buffering agents to regulate the pH value of the mobile phase, so as to play a role in buffering.

The beneficial effects of the invention are as follows: compared with the prior art, the oral care composition provided by the invention can effectively inhibit harmful oral bacteria and maintain the balance of oral flora, treat oral diseases such as dental ulcer and the like and promote wound healing through the synergistic effect of the micromolecular active peptide, thymol and other components, so that the oral care composition can inhibit pathogenic bacteria of oral diseases, treat oral diseases, keep oral health and refresh breath.

Detailed Description

The invention is further described in detail in order to make the objects, technical solutions and advantageous effects of the invention more clear. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the scope of the invention.

An oral care composition comprising the following components in parts by weight:

40-65 parts of wetting agent, 45-85 parts of preservative, 55-90 parts of surfactant, 4-12 parts of edible aromatic, 5-15 parts of thickener, 0.5-1.5 parts of sweetener, 5-15 parts of buffer, 0.5-35 parts of bacteriostat, 5-15 parts of micromolecular active peptide, 0.1-0.5 part of thymol and the balance of water. In this example, the water is purified water.

In some embodiments, the bacteriostat comprises 0.5-1.5 parts by weight of glycyrrhetinic acid.

Or, in other embodiments, the bacteriostat comprises 0.5-1.5 parts by weight of glycyrrhetinic acid, 5-15 parts by weight of xiaoshanhu extract and 5-15 parts by weight of barbed skullcap herb extract.

In some embodiments, the wetting agent comprises 40-60 parts by weight propylene glycol, 1-2 parts sodium hyaluronate.

In some embodiments, the preservative comprises 40-60 parts by weight of disodium EDTA, 4-6 parts by weight of potassium sorbate, and 5-15 parts by weight of benzoic acid.

In some embodiments, the surfactant comprises, by weight, 1.5-2.5 parts benzalkonium chloride, 50-70 parts hydrogenated castor oil, 5-15 parts polyvinylpyrrolidone.

In some embodiments, the edible flavoring agent comprises 1-2 parts by weight of essence, 1-3 parts by weight of menthol, 1-3 parts by weight of peppermint oil, and 1-3 parts by weight of borneol.

In some embodiments, the thickener comprises 5-15 parts by weight of hydroxyethyl cellulose. It will be appreciated that other components that achieve similar results may be employed as thickeners.

In some embodiments, the sweetener comprises 0.5-1.5 parts by weight of sucralose. It will be appreciated that other components that achieve similar effects may be employed as sweeteners.

In some embodiments, the buffer comprises 5-10 parts by weight of sodium dihydrogen phosphate, 1-3 parts by weight of disodium hydrogen phosphate. It will be appreciated that other components capable of achieving similar effects may be employed as buffers.

In some embodiments, an oral care composition comprises the following components in parts by weight:

0.5 part of glycyrrhetinic acid, 50 parts of propylene glycol, 50 parts of EDTA disodium, 1 part of sodium hyaluronate, 5 parts of potassium sorbate, 1.8 parts of benzalkonium chloride, 10 parts of benzoic acid, 10 parts of polyvinylpyrrolidone, 60 parts of hydrogenated castor oil, 10 parts of hydroxyethyl cellulose, 1 part of essence, 2 parts of menthol, 2 parts of peppermint oil, 1.5 parts of borneol, 6 parts of sodium dihydrogen phosphate, 1.8 parts of disodium hydrogen phosphate, 0.5 part of sucralose, 10 parts of small molecule active peptide, 0.1 part of thymol and the balance of water.

In some embodiments, an oral care composition comprises the following components in parts by weight:

0.5 part of glycyrrhetinic acid, 50 parts of propylene glycol, 50 parts of EDTA disodium, 1 part of sodium hyaluronate, 5 parts of potassium sorbate, 1.8 parts of benzalkonium chloride, 10 parts of benzoic acid, 10 parts of polyvinylpyrrolidone, 60 parts of hydrogenated castor oil, 10 parts of hydroxyethyl cellulose, 1 part of essence, 2 parts of menthol, 2 parts of peppermint oil, 1.5 parts of borneol, 6 parts of sodium dihydrogen phosphate, 1.8 parts of disodium hydrogen phosphate, 0.5 part of sucralose, 10 parts of small molecule active peptide, 0.1 part of thymol, 10 parts of a xiaoshanhu extract, 10 parts of a barbed skullcap herb extract and the balance of water.

The invention also provides a method of preparing an oral care composition comprising the steps of:

dissolving the raw materials in water according to the formula amount, stirring until the raw materials are completely dissolved and uniformly dispersed;

standing at room temperature for a predetermined time, and filtering to obtain oral care composition.

Compared with the prior art, the oral care composition provided by the invention can effectively inhibit harmful oral bacteria and maintain the balance of oral flora, treat oral diseases such as dental ulcer and the like and promote wound healing through the synergistic effect of the micromolecular active peptide, thymol and other components, so that the oral care composition can inhibit pathogenic bacteria of oral diseases, treat oral diseases, keep oral health and refresh breath.

The oral care compositions of the present invention will be specifically described below with reference to specific examples.

Example 1

Step one: accurately weighing various raw materials according to the formula amount, and placing the raw materials in a clean and sterilized vessel;

step two: according to the weight parts, 0.5 part of glycyrrhetinic acid, 50 parts of propylene glycol, 50 parts of EDTA disodium, 1 part of sodium hyaluronate, 5 parts of potassium sorbate, 1.8 parts of benzalkonium chloride, 10 parts of benzoic acid, 10 parts of polyvinylpyrrolidone, 60 parts of polyoxyethylene 40 hydrogenated castor oil, 10 parts of hydroxyethyl cellulose, 1 part of essence, 2 parts of menthol, 2 parts of peppermint oil, 1.5 parts of borneol, 6 parts of sodium dihydrogen phosphate, 1.8 parts of disodium hydrogen phosphate, 0.5 part of sucralose, 10 parts of small molecule active peptide and 0.1 part of thymol are dissolved in 776.8 parts of water, heated and stirred until the mixture is completely dissolved and uniformly dispersed;

step three: standing at room temperature for 30 min, filtering, and packaging into sprayer to obtain oral cavity spray product.

Example 2

Step one: accurately weighing various raw materials according to the formula amount, and placing the raw materials in a clean and sterilized vessel;

step two: 1 part of glycyrrhetinic acid, 40 parts of propylene glycol, 40 parts of EDTA disodium, 1.5 parts of sodium hyaluronate, 4 parts of potassium sorbate, 1.5 parts of benzalkonium chloride, 5 parts of benzoic acid, 5 parts of polyvinylpyrrolidone, 50 parts of polyoxyethylene 40 hydrogenated castor oil, 5 parts of hydroxyethyl cellulose, 1.5 parts of essence, 1 part of menthol, 1 part of peppermint oil, 1 part of borneol, 5 parts of sodium dihydrogen phosphate, 1 part of disodium hydrogen phosphate, 1 part of sucralose, 5 parts of small molecule active peptide and 0.3 part of thymol are dissolved in 830.2 parts of water, heated and stirred until the small molecule active peptide and the thymol are completely dissolved and uniformly dispersed;

step three: standing at room temperature for 30 min, filtering, and packaging into sprayer to obtain oral cavity spray product.

Example 3

Step one: accurately weighing various raw materials according to the formula amount, and placing the raw materials in a clean and sterilized vessel;

step two: 1.5 parts of glycyrrhetinic acid, 60 parts of propylene glycol, 60 parts of EDTA disodium, 2 parts of sodium hyaluronate, 6 parts of potassium sorbate, 2.5 parts of benzalkonium chloride, 15 parts of benzoic acid, 15 parts of polyvinylpyrrolidone, 70 parts of polyoxyethylene 40 hydrogenated castor oil, 15 parts of hydroxyethyl cellulose, 2 parts of essence, 3 parts of menthol, 3 parts of peppermint oil, 3 parts of borneol, 10 parts of sodium dihydrogen phosphate, 3 parts of disodium hydrogen phosphate, 1.5 parts of sucralose, 15 parts of small molecule active peptide and 0.5 part of thymol are dissolved in 712 parts of water, heated and stirred until the small molecule active peptide and the thymol are completely dissolved and uniformly dispersed;

step three: standing at room temperature for 30 min, filtering, and packaging into sprayer to obtain oral cavity spray product.

Example 4

Step one: accurately weighing various raw materials according to the formula amount, and placing the raw materials in a clean and sterilized vessel;

step two: according to the weight parts, 0.5 part of glycyrrhetinic acid, 50 parts of propylene glycol, 50 parts of EDTA disodium, 1 part of sodium hyaluronate, 5 parts of potassium sorbate, 1.8 parts of benzalkonium chloride, 10 parts of benzoic acid, 10 parts of polyvinylpyrrolidone, 60 parts of polyoxyethylene 40 hydrogenated castor oil, 10 parts of hydroxyethyl cellulose, 1 part of essence, 2 parts of menthol, 2 parts of peppermint oil, 1.5 parts of borneol, 6 parts of sodium dihydrogen phosphate, 1.8 parts of disodium hydrogen phosphate, 0.5 part of sucralose, 10 parts of small molecule active peptide, 0.1 part of thymol, 10 parts of a kadsura extract and 10 parts of a barbed skullcap herb extract are dissolved in 756.8 parts of water, heated and stirred until the mixture is completely dissolved and dispersed uniformly;

step three: standing at room temperature for 30 min, filtering, and packaging into sprayer to obtain oral cavity spray product.

Example 5

Step one: accurately weighing various raw materials according to the formula amount, and placing the raw materials in a clean and sterilized vessel;

step two: 1 part of glycyrrhetinic acid, 40 parts of propylene glycol, 40 parts of EDTA disodium, 1.5 parts of sodium hyaluronate, 4 parts of potassium sorbate, 1.5 parts of benzalkonium chloride, 5 parts of benzoic acid, 5 parts of polyvinylpyrrolidone, 50 parts of polyoxyethylene 40 hydrogenated castor oil, 5 parts of hydroxyethyl cellulose, 1.5 parts of essence, 1 part of menthol, 1 part of peppermint oil, 1 part of borneol, 5 parts of sodium dihydrogen phosphate, 1 part of disodium hydrogen phosphate, 1 part of sucralose, 5 parts of small molecule active peptide, 0.3 part of thymol, 5 parts of a xiaoshanhu extract and 5 parts of a barbed skullcap herb extract are dissolved in 820.2 parts of water, heated and stirred until the mixture is completely dissolved and uniformly dispersed;

step three: standing at room temperature for 30 min, filtering, and packaging into sprayer to obtain oral cavity spray product.

Example 6

Step one: accurately weighing various raw materials according to the formula amount, and placing the raw materials in a clean and sterilized vessel;

step two: 1.5 parts of glycyrrhetinic acid, 60 parts of propylene glycol, 60 parts of EDTA disodium, 2 parts of sodium hyaluronate, 6 parts of potassium sorbate, 2.5 parts of benzalkonium chloride, 15 parts of benzoic acid, 15 parts of polyvinylpyrrolidone, 70 parts of polyoxyethylene 40 hydrogenated castor oil, 15 parts of hydroxyethyl cellulose, 2 parts of essence, 3 parts of menthol, 3 parts of peppermint oil, 3 parts of borneol, 10 parts of sodium dihydrogen phosphate, 3 parts of disodium hydrogen phosphate, 1.5 parts of sucralose, 15 parts of small molecule active peptide, 0.5 part of thymol, 15 parts of a xiaoshanhu extract and 15 parts of a barbed skullcap herb extract are dissolved in 682 parts of water, heated and stirred until the mixture is completely dissolved and uniformly dispersed;

step three: standing at room temperature for 30 min, filtering, and packaging into sprayer to obtain oral cavity spray product.

Comparative example 1

Control example 1 is a control test example in which no small molecule active peptide was added, and other components are referred to in example 1.

Step one: accurately weighing various raw materials, and placing the raw materials in a clean and sterilized vessel;

step two: according to the weight parts, 0.5 part of glycyrrhetinic acid, 50 parts of propylene glycol, 50 parts of EDTA disodium, 1 part of sodium hyaluronate, 5 parts of potassium sorbate, 1.8 parts of benzalkonium chloride, 10 parts of benzoic acid, 10 parts of polyvinylpyrrolidone, 60 parts of polyoxyethylene 40 hydrogenated castor oil, 10 parts of hydroxyethyl cellulose, 1 part of essence, 2 parts of menthol, 2 parts of peppermint oil, 1.5 parts of borneol, 6 parts of sodium dihydrogen phosphate, 1.8 parts of disodium hydrogen phosphate, 0.5 part of sucralose and 0.1 part of thymol are dissolved in 786.8 parts of water, heated and stirred until the mixture is completely dissolved and uniformly dispersed;

step three: standing at room temperature for 30 min, filtering, and packaging into sprayer to obtain oral cavity spray product.

Comparative example 2

Control 2 is a control test without thymol added, and other ingredients are referred to in example 1.

Step one: accurately weighing various raw materials, and placing the raw materials in a clean and sterilized vessel;

step two: according to the weight parts, 0.5 part of glycyrrhetinic acid, 50 parts of propylene glycol, 50 parts of EDTA disodium, 1 part of sodium hyaluronate, 5 parts of potassium sorbate, 1.8 parts of benzalkonium chloride, 10 parts of benzoic acid, 10 parts of polyvinylpyrrolidone, 60 parts of polyoxyethylene 40 hydrogenated castor oil, 10 parts of hydroxyethyl cellulose, 1 part of essence, 2 parts of menthol, 2 parts of peppermint oil, 1.5 parts of borneol, 6 parts of sodium dihydrogen phosphate, 1.8 parts of disodium hydrogen phosphate, 0.5 part of sucralose and 10 parts of small molecule active peptide are dissolved in 776.7 parts of water, heated and stirred until the mixture is completely dissolved and uniformly dispersed;

step three: standing at room temperature for 30 min, filtering, and packaging into sprayer to obtain oral cavity spray product.

Comparative example 3

Comparative example 3 a commercially available oral spray was prepared by adding 10 parts by weight of a small molecule active peptide and 0.1 part by weight of thymol and stirring the mixture uniformly.

Comparative example 4

Comparative example 4A comparative test example was prepared by adding 10 parts by weight of Xiaoshanhu extract and 10 parts by weight of Scutellaria barbata extract to a commercial oral spray and stirring the mixture uniformly.

Experiment one: determination of safety of oral care compositions of embodiments of the invention

The spray products of examples 1-6 were used to perform a lavage test on mice (C57 BL,19-21 g), respectively, and the spray products of each example were used to perform a lavage corresponding to a group of mice, for a total of 6 groups of mice, each group of 6 mice, at 0.5 mL/day for 30 consecutive days, no abnormal behavior of the mice was observed, and no significant changes in absolute organ coefficients and relative organ coefficients were observed.

Experiment II: determination of antibacterial Properties of oral Care compositions of the examples of the invention

1. Staphylococcus aureus (available from ATCC under the trade designation 25923) was cultured in LB medium (tryptone 10g/L, yeast extract 5g/L, sodium chloride 10 g/L) to a logarithmic phase, and the cell concentration was adjusted to 10 with LB medium ⁶ The total concentration of the bacterial liquid is L/L, and the bacterial liquid is used as bacterial liquid containing staphylococcus aureus. )

The spray products of examples 1 to 6 and the spray products of comparative examples 1 to 4 were added to 10m bacterial solutions, respectively, and the mixture was cultured at 37℃for 6 hours to obtain bacteriostatic samples.

The number of viable cells in the above-mentioned bacteriostatic sample was measured by plate count method according to the method specified in GB4789.10-2010 (food microbiology test staphylococcus aureus test), and the results are shown in Table 1.

TABLE 1

	Number of viable cells (cfu/mL) obtained by plate count method
		Spray product of example 1	5×10 3
Example 2 spray product	8×10 3
		Example 3 spray product	7×10 3
Example 4 spray product	2×10 3
		Example 5 spray product	4×10 3
Example 6 spray product	3×10 3
		Spray product of comparative example 1	9×10 3
Spray product of comparative example 2	8×10 4
		Spray product of comparative example 3	8×10 5
Spray product of comparative example 4	7×10 5

From the data in table 1, it can be seen that the oral care composition of the present invention has an effective antibacterial effect and a remarkable antibacterial effect, and the antibacterial effect of the spray products prepared in examples 4 to 6, in which the xiaoshanhu extract and the sculellaria barbata extract are added, is more remarkable.

The comparison between comparative example 1 and example 1 shows that the antibacterial effect is obviously weakened when the small molecular active peptide is absent, so that the antibacterial effect can be improved through the arrangement of the small molecular active peptide.

It can be seen from comparison of comparative example 2 and example 1 that the antibacterial effect is significantly reduced in the absence of thymol, so that the antibacterial effect can be improved by arranging thymol.

It can be seen from a comparison of comparative example 3 with examples 1-6 that, instead of the small molecule active peptide and thymol alone, the antibacterial effect is enhanced, the small molecule active peptide and thymol are required to cooperate with other components of the oral care composition of the present invention to enhance the antibacterial effect.

It can be seen from comparison of comparative example 4 with examples 3 to 6 that the antibacterial effect is improved not by simply adding the xiaoshan tiger extract and the barbed skullcap herb extract, but by synergistic action of the xiaoshan tiger extract and the barbed skullcap herb extract with other components of the oral care composition of the present invention.

2. The 1:1 dilution to concentration of the oral care compositions of examples 1-6 of the present invention was 2.76X10 ⁴ The cfu/mL of the bacterial suspension for the escherichia coli test acts for 20 min, and the antibacterial rate of each time is more than 90%, so that the oral care composition has a strong antibacterial effect on escherichia coli.

The 1:1 dilution to concentration of the oral care compositions of examples 1-6 of the present invention was 2.42X10 ⁴ The cfu/mL candida albicans test bacterial suspension acts for 20 min, and the antibacterial rate of each time is more than 90%, so that the oral care composition has a strong antibacterial effect on candida albicans.

Experiment III: clinical trials were performed on 100 patients with oral disease

1. Basic patient condition:

of the 100 patients, 56 men and 44 women, with a minimum age of 18 years and a maximum age of 64 years, were divided into 5 groups of 20 persons each. Each patient has at least one symptom of canker sore, halitosis, glossitis and sphagitis, and the number of patients suffering from the same disorder is controlled to be consistent.

2. Treatment process.

The oral spray prepared using example 1 of the present invention was used for treatment of a first group of patients, each patient being used 4 times a day every 3 hours.

The oral spray prepared using inventive example 4 was used for treatment of a second group of patients, each patient being used every 3 hours, 4 times a day.

The oral spray prepared in comparative example 1 was used for the treatment of a third group of patients, each patient being used once every 3 hours, 4 times a day.

The oral spray prepared in comparative example 2 was used for treatment of a fourth group of patients, each patient being used once every 3 hours, 4 times a day.

The oral spray of comparative example 3 was used for treatment of a fifth group of patients, each patient being used every 3 hours, 4 times a day.

3. The treatment results are shown in table 2.

TABLE 2

As can be seen from the data in table 2, the oral care composition of the present invention has remarkable therapeutic and alleviating effects on oral problems such as oral ulcer, halitosis, glossitis, and sphagitis, and can effectively treat oral diseases and maintain oral health, as compared with the existing oral spray. In addition, the spray product prepared in the embodiment 4 added with the xiaoshan tiger extract and the barbed skullcap herb extract has more obvious treatment effect and higher cure rate.

The data in the third, fourth and fifth groups show that the therapeutic effect is improved not by the small molecule active peptide and thymol alone, but by the synergistic effect of the small molecule active peptide and thymol with other components of the oral care composition, so that the oral care composition has more obvious therapeutic effect and higher cure rate.

The above embodiments are merely preferred embodiments of the present invention, and are not intended to limit the present invention, but any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should be included in the scope of the present invention.

Claims (10)

1. An oral care composition, comprising the following components in parts by weight:

40-65 parts of wetting agent, 45-85 parts of preservative, 55-90 parts of surfactant, 4-12 parts of edible aromatic, 5-15 parts of thickener, 0.5-1.5 parts of sweetener, 5-15 parts of buffer, 0.5-35 parts of bacteriostat, 5-15 parts of micromolecular active peptide and 0.1-0.5 part of thymol.

2. The oral care composition according to claim 1, wherein the antibacterial agent comprises 0.5-1.5 parts by weight of glycyrrhetinic acid; or alternatively, the process may be performed,

the bacteriostatic agent comprises 0.5-1.5 parts of glycyrrhetinic acid, 5-15 parts of xiaoshanhu extract and 5-15 parts of barbed skullcap herb extract according to parts by weight.

3. The oral care composition of claim 1, wherein the humectant comprises, in parts by weight, 40-60 parts propylene glycol, 1-2 parts sodium hyaluronate.

4. The oral care composition of claim 1, wherein the preservative comprises, in parts by weight, 40-60 parts disodium EDTA, 4-6 parts potassium sorbate, 5-15 parts benzoic acid.

5. The oral care composition of claim 1, wherein the surfactant comprises, in parts by weight, 1.5-2.5 parts benzalkonium chloride, 50-70 parts hydrogenated castor oil, 5-15 parts polyvinylpyrrolidone.

6. The oral care composition of claim 1, wherein the edible flavoring comprises, in parts by weight, 1-2 parts of flavor, 1-3 parts of menthol, 1-3 parts of peppermint oil, and 1-3 parts of borneol.

7. The oral care composition according to claim 1, wherein the thickener comprises 5-15 parts by weight of hydroxyethyl cellulose; and/or the number of the groups of groups,

the sweetener comprises 0.5-1.5 parts by weight of sucralose; and/or the number of the groups of groups,

the buffering agent comprises 5-10 parts by weight of sodium dihydrogen phosphate and 1-3 parts by weight of disodium hydrogen phosphate.

8. The oral care composition according to claim 1, comprising the following components in parts by weight:

0.5 part of glycyrrhetinic acid, 50 parts of propylene glycol, 50 parts of EDTA disodium, 1 part of sodium hyaluronate, 5 parts of potassium sorbate, 1.8 parts of benzalkonium chloride, 10 parts of benzoic acid, 10 parts of polyvinylpyrrolidone, 60 parts of hydrogenated castor oil, 10 parts of hydroxyethyl cellulose, 1 part of essence, 2 parts of menthol, 2 parts of peppermint oil, 1.5 parts of borneol, 6 parts of sodium dihydrogen phosphate, 1.8 parts of disodium hydrogen phosphate, 0.5 part of sucralose, 10 parts of small molecule active peptide, 0.1 part of thymol and the balance of water.

9. The oral care composition according to claim 1, comprising the following components in parts by weight:

0.5 part of glycyrrhetinic acid, 50 parts of propylene glycol, 50 parts of EDTA disodium, 1 part of sodium hyaluronate, 5 parts of potassium sorbate, 1.8 parts of benzalkonium chloride, 10 parts of benzoic acid, 10 parts of polyvinylpyrrolidone, 60 parts of hydrogenated castor oil, 10 parts of hydroxyethyl cellulose, 1 part of essence, 2 parts of menthol, 2 parts of peppermint oil, 1.5 parts of borneol, 6 parts of sodium dihydrogen phosphate, 1.8 parts of disodium hydrogen phosphate, 0.5 part of sucralose, 10 parts of small molecule active peptide, 0.1 part of thymol, 10 parts of tiger extract, 10 parts of barbed skullcap herb extract and the balance of water.

10. A method of preparing the oral care composition of any one of claims 1-9, comprising the steps of:

dissolving the raw materials in water according to the formula amount, stirring until the raw materials are completely dissolved and uniformly dispersed;

standing at room temperature for a predetermined time, and filtering to obtain the oral care product.