CN115943140B - 三硫化物化合物 - Google Patents

三硫化物化合物 Download PDF

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Publication number
CN115943140B
CN115943140B CN202180050867.6A CN202180050867A CN115943140B CN 115943140 B CN115943140 B CN 115943140B CN 202180050867 A CN202180050867 A CN 202180050867A CN 115943140 B CN115943140 B CN 115943140B
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China
Prior art keywords
pantethine
trisulfide
solution
compound
salt
Prior art date
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Application number
CN202180050867.6A
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English (en)
Chinese (zh)
Other versions
CN115943140A (zh
Inventor
朝长昌一郎
矶部贵弘
大岛悦男
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xiehe Pharmaceutical Chemical Co ltd
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Xiehe Pharmaceutical Chemical Co ltd
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Publication of CN115943140A publication Critical patent/CN115943140A/zh
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40—Y being a hydrogen or a carbon atom
    • C07C323/41—Y being a hydrogen or an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
    • C07C321/12—Sulfides, hydropolysulfides, or polysulfides having thio groups bound to acyclic carbon atoms
    • C07C321/14—Sulfides, hydropolysulfides, or polysulfides having thio groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN202180050867.6A 2020-08-27 2021-08-23 三硫化物化合物 Active CN115943140B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2020143639 2020-08-27
JP2020-143639 2020-08-27
PCT/JP2021/030755 WO2022045052A1 (ja) 2020-08-27 2021-08-23 トリスルフィド化合物

Publications (2)

Publication Number Publication Date
CN115943140A CN115943140A (zh) 2023-04-07
CN115943140B true CN115943140B (zh) 2024-10-01

Family

ID=80353266

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CN202180050867.6A Active CN115943140B (zh) 2020-08-27 2021-08-23 三硫化物化合物

Country Status (7)

Country Link
US (1) US12534432B2 (cg-RX-API-DMAC7.html)
EP (1) EP4194437B1 (cg-RX-API-DMAC7.html)
JP (1) JP7650279B2 (cg-RX-API-DMAC7.html)
CN (1) CN115943140B (cg-RX-API-DMAC7.html)
ES (1) ES3054285T3 (cg-RX-API-DMAC7.html)
PL (1) PL4194437T3 (cg-RX-API-DMAC7.html)
WO (1) WO2022045052A1 (cg-RX-API-DMAC7.html)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230009425A (ko) 2020-05-12 2023-01-17 더 제너럴 하스피탈 코포레이션 신경보호에서의 글루타티온 트리술피드 (gsssg)
CN117320709A (zh) 2021-07-08 2023-12-29 协和医药化工股份有限公司 帕金森病的预防或治疗药
US20260191823A1 (en) 2022-11-21 2026-07-09 Kyowa Hakko Bio Co., Ltd. Prophylactic or therapeutic agent for acute kidney injury induced by anticancer agent
WO2024143400A1 (ja) 2022-12-27 2024-07-04 協和ファーマケミカル株式会社 トリスルフィド化合物
WO2025070464A1 (ja) 2023-09-28 2025-04-03 協和ファーマケミカル株式会社 トリスルフィド化合物を含有する医薬組成物
WO2026058944A1 (ja) * 2024-09-13 2026-03-19 協和ファーマケミカル株式会社 非対称型のトリスルフィド化合物
WO2026127049A1 (ja) * 2024-12-11 2026-06-18 キリンホールディングス株式会社 老化細胞除去用組成物

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020158894A1 (ja) * 2019-01-30 2020-08-06 協和発酵バイオ株式会社 ポリスルフィド化合物を含有する組成物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS532931B2 (cg-RX-API-DMAC7.html) 1973-12-05 1978-02-01
JPS5819673B2 (ja) * 1976-08-26 1983-04-19 相互薬工業株式会社 パンテチンの製造方法
JP2928414B2 (ja) 1991-09-20 1999-08-03 ポーラ化成工業株式会社 皮膚外用剤
SE9402253D0 (sv) * 1994-06-27 1994-06-27 Pharmacia Ab Process
CN107652264A (zh) 2017-09-25 2018-02-02 苏州华诺医药有限公司 硫辛酸杂质a的制备方法
JP2022166333A (ja) * 2019-09-18 2022-11-02 国立大学法人 熊本大学 活性イオウ分子種生体内濃度上昇剤

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020158894A1 (ja) * 2019-01-30 2020-08-06 協和発酵バイオ株式会社 ポリスルフィド化合物を含有する組成物

Also Published As

Publication number Publication date
ES3054285T3 (en) 2026-02-02
CN115943140A (zh) 2023-04-07
EP4194437A1 (en) 2023-06-14
EP4194437A4 (en) 2024-10-02
EP4194437B1 (en) 2025-11-12
EP4194437C0 (en) 2025-11-12
US20230357141A1 (en) 2023-11-09
JPWO2022045052A1 (cg-RX-API-DMAC7.html) 2022-03-03
US12534432B2 (en) 2026-01-27
PL4194437T3 (pl) 2026-02-02
WO2022045052A1 (ja) 2022-03-03
JP7650279B2 (ja) 2025-03-24

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