JPWO2022045052A1 - - Google Patents

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Publication number
JPWO2022045052A1
JPWO2022045052A1 JP2022544576A JP2022544576A JPWO2022045052A1 JP WO2022045052 A1 JPWO2022045052 A1 JP WO2022045052A1 JP 2022544576 A JP2022544576 A JP 2022544576A JP 2022544576 A JP2022544576 A JP 2022544576A JP WO2022045052 A1 JPWO2022045052 A1 JP WO2022045052A1
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JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Application number
JP2022544576A
Other languages
Japanese (ja)
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JP7650279B2 (ja
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Publication date
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Publication of JPWO2022045052A1 publication Critical patent/JPWO2022045052A1/ja
Application granted granted Critical
Publication of JP7650279B2 publication Critical patent/JP7650279B2/ja
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Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
    • C07C321/12—Sulfides, hydropolysulfides, or polysulfides having thio groups bound to acyclic carbon atoms
    • C07C321/14—Sulfides, hydropolysulfides, or polysulfides having thio groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40—Y being a hydrogen or a carbon atom
    • C07C323/41—Y being a hydrogen or an acyclic carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2022544576A 2020-08-27 2021-08-23 トリスルフィド化合物 Active JP7650279B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2020143639 2020-08-27
JP2020143639 2020-08-27
PCT/JP2021/030755 WO2022045052A1 (ja) 2020-08-27 2021-08-23 トリスルフィド化合物

Publications (2)

Publication Number Publication Date
JPWO2022045052A1 true JPWO2022045052A1 (cg-RX-API-DMAC7.html) 2022-03-03
JP7650279B2 JP7650279B2 (ja) 2025-03-24

Family

ID=80353266

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022544576A Active JP7650279B2 (ja) 2020-08-27 2021-08-23 トリスルフィド化合物

Country Status (7)

Country Link
US (1) US12534432B2 (cg-RX-API-DMAC7.html)
EP (1) EP4194437B1 (cg-RX-API-DMAC7.html)
JP (1) JP7650279B2 (cg-RX-API-DMAC7.html)
CN (1) CN115943140B (cg-RX-API-DMAC7.html)
ES (1) ES3054285T3 (cg-RX-API-DMAC7.html)
PL (1) PL4194437T3 (cg-RX-API-DMAC7.html)
WO (1) WO2022045052A1 (cg-RX-API-DMAC7.html)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230009425A (ko) 2020-05-12 2023-01-17 더 제너럴 하스피탈 코포레이션 신경보호에서의 글루타티온 트리술피드 (gsssg)
CN117320709A (zh) 2021-07-08 2023-12-29 协和医药化工股份有限公司 帕金森病的预防或治疗药
US20260191823A1 (en) 2022-11-21 2026-07-09 Kyowa Hakko Bio Co., Ltd. Prophylactic or therapeutic agent for acute kidney injury induced by anticancer agent
WO2024143400A1 (ja) 2022-12-27 2024-07-04 協和ファーマケミカル株式会社 トリスルフィド化合物
WO2025070464A1 (ja) 2023-09-28 2025-04-03 協和ファーマケミカル株式会社 トリスルフィド化合物を含有する医薬組成物
WO2026058944A1 (ja) * 2024-09-13 2026-03-19 協和ファーマケミカル株式会社 非対称型のトリスルフィド化合物
WO2026127049A1 (ja) * 2024-12-11 2026-06-18 キリンホールディングス株式会社 老化細胞除去用組成物

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5088215A (cg-RX-API-DMAC7.html) * 1973-12-05 1975-07-15
JPS5328118A (en) * 1976-08-26 1978-03-16 Sogo Yatsuko Kk Method of manufacturing panthethine
JPH0585926A (ja) * 1991-09-20 1993-04-06 Pola Chem Ind Inc 皮膚外用剤
WO1996000241A1 (en) * 1994-06-27 1996-01-04 Pharmacia & Upjohn Ab Process for the preparation of peptide trisulfides
WO2020158894A1 (ja) * 2019-01-30 2020-08-06 協和発酵バイオ株式会社 ポリスルフィド化合物を含有する組成物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107652264A (zh) 2017-09-25 2018-02-02 苏州华诺医药有限公司 硫辛酸杂质a的制备方法
JP2022166333A (ja) * 2019-09-18 2022-11-02 国立大学法人 熊本大学 活性イオウ分子種生体内濃度上昇剤

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5088215A (cg-RX-API-DMAC7.html) * 1973-12-05 1975-07-15
JPS5328118A (en) * 1976-08-26 1978-03-16 Sogo Yatsuko Kk Method of manufacturing panthethine
JPH0585926A (ja) * 1991-09-20 1993-04-06 Pola Chem Ind Inc 皮膚外用剤
WO1996000241A1 (en) * 1994-06-27 1996-01-04 Pharmacia & Upjohn Ab Process for the preparation of peptide trisulfides
WO2020158894A1 (ja) * 2019-01-30 2020-08-06 協和発酵バイオ株式会社 ポリスルフィド化合物を含有する組成物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
"第一部医薬品各条 は行", 第十三改正日本薬局方解説書, vol. 第１版, JPN6025001780, 1996, pages 1986 - 1990, ISSN: 0005507266 *

Also Published As

Publication number Publication date
ES3054285T3 (en) 2026-02-02
CN115943140A (zh) 2023-04-07
EP4194437A1 (en) 2023-06-14
EP4194437A4 (en) 2024-10-02
EP4194437B1 (en) 2025-11-12
EP4194437C0 (en) 2025-11-12
US20230357141A1 (en) 2023-11-09
US12534432B2 (en) 2026-01-27
CN115943140B (zh) 2024-10-01
PL4194437T3 (pl) 2026-02-02
WO2022045052A1 (ja) 2022-03-03
JP7650279B2 (ja) 2025-03-24

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