CN115919675A - Skin anti-aging composition, skin care product and preparation method - Google Patents
Skin anti-aging composition, skin care product and preparation method Download PDFInfo
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Abstract
The invention relates to a skin anti-aging composition, which comprises the following components: 0.5 to 5 portions of saccharide isomerate, 0.5 to 5 portions of sphingosine monad fermentation product extract, 0.5 to 5 portions of ceramide, 0.5 to 5 portions of hydroxy pinacolone retinoic acid ester, 0.5 to 5 portions of phytosphingosine and 0.4 to 5 portions of anti-allergic agent. The skin care product prepared by the invention has the effects of resisting skin aging, fading fine lines, improving skin relaxation and wrinkle problems, and forming a multi-dimensional anti-aging effect system.
Description
Technical Field
The invention relates to the technical field of skin care products, and relates to a skin anti-aging composition, a skin care product and a preparation method thereof.
Background
Skin aging is largely classified into natural aging and photoaging. Natural aging is caused by the action of intrinsic factors of the body, which are commonly found in exposed and unexposed areas and is characterized by the appearance of wrinkles and sagging skin. Photoaging refers to the accumulation of ultraviolet damage during skin aging, manifested by roughness of exposed skin, increased and thickened wrinkles, abnormal structure, pigmentation, vasodilatation, and epidermal keratosis. Skin aging is the result of the combined action of endogenous factors (natural aging) and exogenous factors. The youth trend of the anti-aging population is gradually obvious, and the survey shows that: since the age of 20 years (especially for women), the aging of skin is concerned, so the anti-aging skin care product is increasingly becoming one of the urgent products for consumers.
At present, cosmetics on the market have a plurality of types and functions, but are limited by the action mechanism and the channel of a single raw material, most of the existing products only act on a certain target point of skin, only can realize a certain specific skin care function, and the skin care effect is very limited. In response to this problem, researchers in the industry have proposed some novel compositions, but as research and application progress, the disadvantages of these compositions have gradually appeared, and the efficacy is difficult to maximize, and even the interference among components may occur, which affects the use effect of the final cosmetic product.
Disclosure of Invention
Based on the above, there is a need for a skin anti-aging composition, which has synergistic effects of the components, and can deeply resist skin aging, fade fine lines, improve skin laxity and wrinkle problems, and form a multi-dimensional anti-aging efficacy system.
In a first aspect of the invention, there is provided a skin anti-ageing composition comprising the following components: 0.5 to 5 portions of saccharide isomerate, 0.5 to 5 portions of sphingosine monad fermentation product extract, 0.5 to 5 portions of ceramide, 0.5 to 5 portions of hydroxy pinacolone retinoic acid ester, 0.5 to 5 portions of phytosphingosine and 0.4 to 5 portions of anti-allergic agent.
In one embodiment, the skin anti-aging composition comprises the following components: 1 to 3 portions of saccharide isomerate, 1 to 4 portions of sphingosine monad fermentation product extract, 0.5 to 3 portions of ceramide, 0.5 to 2 portions of hydroxy pinacolone retinoic acid ester, 0.5 to 3 portions of phytosphingosine and 0.4 to 3 portions of anti-allergic agent.
In one embodiment, the skin anti-aging composition comprises the following components: 2 parts of saccharide isomer, 3 parts of sphingomonas fermentation product extract, 0.5 part of ceramide, 2 parts of hydroxy pinacolone retinoic acid ester, 0.5 part of phytosphingosine and 0.4 part of anti-allergy agent.
In one embodiment, the ceramide is ceramide NP.
In one embodiment, the anti-allergic agent is selected from one or more of dipotassium glycyrrhizinate, aloe extract, gentian root extract, honey extract, green tea extract, purslane extract, scutellaria extract and cactus extract.
In a second aspect of the invention, a skin care product is provided, which comprises the skin anti-aging composition, formula auxiliary agents and water.
In one embodiment, the formulation auxiliary is selected from one or more of a preservative, a chelating agent, an emollient, a humectant, a thickener, a pH regulator and an emulsifier.
In one embodiment, the skin care product comprises, by mass, 4% -25% of the skin anti-aging composition, 3% -10% of a humectant, 3% -8% of an emulsifier, 0.5% -2% of a thickening agent, 0.1% -1% of a preservative, 0.02% -0.1% of a chelating agent, 8% -15% of an emollient, 0.1% -0.2% of a pH regulator and 39% -81% of water.
In one embodiment, the skin care product comprises, by mass, 5% to 9% of the skin anti-aging composition, 5% to 8% of a humectant, 1% to 4% of an emulsifier, 0.2% to 0.5% of a thickener, 0.5% to 1% of a preservative, 0.02% to 0.06% of a chelating agent, 10% to 15% of an emollient, 0.15% to 0.2% of a pH regulator, and 64% to 79% of water.
In a third aspect of the present invention, a method for preparing a skin care product is provided, comprising the steps of:
mixing the emollient, the emulsifier, the thickener, the chelating agent, the humectant and the pH regulator to obtain a premix; adding to said premix a preservative and said saccharide isomer, sphingomonas fermentation product extract, ceramide, hydroxyppinacolone retinoic acid ester, phytosphingosine, and an anti-sensitization agent.
Compared with the traditional technology, the invention has the beneficial effects that:
the skin anti-aging composition provided by the invention comprises saccharide isomerate, sphingomonas fermentation product extract, ceramide, hydroxy pinatone retinoic acid ester, phytosphingosine and gentian root extract, can improve rough skin texture, tighten and relax the skin effect, supplements skin ceramide, can greatly reduce the TEWL value of human skin, can improve the hydration degree of the skin, and can improve the water holding capacity of the skin. The skin care product prepared by the skin anti-aging composition forms a multi-dimensional anti-aging effect system through the synergistic interaction of the components, and has the effects of deeply resisting skin aging, fading fine lines, improving facial contours and improving the problem of skin flabbiness and wrinkles.
Detailed Description
The present invention will be described in detail with reference to the following embodiments in order to make the above objects, features and advantages of the present invention more comprehensible. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein, as those skilled in the art will recognize without departing from the spirit and scope of the present invention.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
Term(s) for
Unless otherwise stated or contradicted, terms or phrases used herein have the following meanings:
the scope of the invention, as used herein, is intended to include any and all combinations of two or more of the associated listed items, including any and all combinations of any two or more of the associated listed items, any and all combinations of any and all of the associated listed items, or any and all combinations of all of the associated listed items. It should be noted that when at least three items are connected by at least two conjunctive combinations selected from "and/or", "or/and", "and/or", it should be understood that the technical solutions of this embodiment implicitly include the technical solutions all connected by "logic and" and also implicitly include the technical solutions all connected by "logic or". For example, "A and/or B" includes three parallel schemes of A, B and A + B. For example, a reference to "a, and/or, B, and/or, C, and/or, D" includes any one of a, B, C, and D (i.e., all connected by "logical or"), any and all combinations of a, B, C, and D (i.e., any two or any three of a, B, C, and D), and any four combinations of a, B, C, and D (i.e., all connected by "logical and").
In the present invention, the terms "plurality", "plural", and the like mean, unless otherwise specified, 2 or more in number or 2. For example, "one or more" means one or two or more.
In the present invention, references to "preferably", "better" and "preferable" are only used to describe better embodiments or examples, and it should be understood that the scope of the present invention is not limited by these references.
In the present invention, references to "further", "still further", "specifically", etc. are used for descriptive purposes and to indicate differences in content, but should not be construed as limiting the scope of the present invention.
In the present invention, references to "optionally", "optional", refer to the presence or absence, i.e., to any one of the two juxtapositions "present" or "absent". If multiple optional parts appear in one technical scheme, if no special description exists, and no contradiction or mutual constraint relation exists, each optional part is independent.
In the present invention, the terms "first", "second", "third", "fourth", etc., in relation to "first aspect", "second aspect", "third aspect", "fourth aspect", etc., are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance or quantity, nor as implying that importance or quantity is indicative of the technical features indicated. Also, "first," "second," "third," "fourth," etc. are used for non-exhaustive enumeration of description purposes only and should not be construed as a closed limitation to the number.
In the present invention, the technical features described in the open type include a closed technical solution including the listed features, and also include an open technical solution including the listed features.
In the present invention, where a range of values (i.e., a numerical range) is recited, unless otherwise specified, alternative distributions of values within the range are considered to be continuous, and include both the numerical endpoints of the range (i.e., the minimum and maximum values), and each numerical value between the numerical endpoints. Unless otherwise specified, when a numerical range is directed to only integers within the numerical range, both endpoints of the numerical range, and each integer between the two endpoints, is included herein in the equivalent of a direct recitation of each integer, such as t being an integer selected from 1 to 10, meaning t being any integer selected from the group of integers consisting of 1,2, 3, 4, 5, 6, 7, 8, 9, and 10. Further, when multiple range-describing features or characteristics are provided, the ranges may be combined. In other words, unless otherwise indicated, the ranges disclosed herein are to be understood to include any and all subranges subsumed therein.
The temperature parameter in the present invention is not particularly limited, and is allowed to be constant temperature treatment or to vary within a certain temperature range. It will be appreciated that the described thermostatic process allows the temperature to fluctuate within the accuracy of the instrument control. Allowing fluctuations in the range of, for example,. + -. 5 deg.C,. + -. 4 deg.C,. + -. 3 deg.C,. + -. 2 deg.C, + -. 1 deg.C.
In the present invention, the percentage content refers to both mass percentage for solid-liquid mixing and solid-solid phase mixing and volume percentage for liquid-liquid phase mixing, unless otherwise specified.
In the present invention, the percentage concentrations are referred to as final concentrations unless otherwise specified. The final concentration refers to the ratio of the added component in the system after the component is added.
In a first aspect of the invention, there is provided a skin anti-ageing composition comprising the following components: 0.5 to 5 portions of saccharide isomerate, 0.5 to 5 portions of sphingosine monad fermentation product extract, 0.5 to 5 portions of ceramide, 0.5 to 5 portions of hydroxy pinacolone retinoic acid ester, 0.5 to 5 portions of phytosphingosine and 0.4 to 5 portions of anti-allergic agent.
Optionally, the skin anti-aging composition comprises the following components: 1 to 3 parts of saccharide isomerate, 1 to 4 parts of sphingosine monad fermentation product extract, 0.5 to 3 parts of ceramide, 0.5 to 2 parts of hydroxy pinacolone retinoic acid ester, 0.5 to 3 parts of phytosphingosine and 0.4 to 3 parts of anti-allergic agent.
Preferably, 2 parts of saccharide isomer, 3 parts of sphingomonas fermentation product extract, 0.5 part of ceramide, 2 parts of hydroxy pinacolone retinoic acid ester, 0.5 part of phytosphingosine and 0.4 part of anti-allergy agent.
Preferably, the ceramide is ceramide NP.
Optionally, the anti-allergic agent is selected from one or more of dipotassium glycyrrhizinate, aloe extract, gentian extract, honey extract, green tea extract, purslane extract, scutellaria extract and cactus extract.
In a second aspect of the invention, a skin care product is provided, which comprises the skin anti-aging composition, formula auxiliary agents and water.
Optionally, the formulation auxiliary agent is selected from one or more of a preservative, a chelating agent, an emollient, a humectant, a thickener, a pH adjuster and an emulsifier.
Optionally, the skin care product comprises, by mass, 4% -25% of the skin anti-aging composition, 3% -10% of a humectant, 3% -8% of an emulsifier, 0.5% -2% of a thickener, 0.1% -1% of a preservative, 0.02% -0.1% of a chelating agent, 8% -15% of an emollient, 0.1% -0.2% of a pH regulator, and 39% -81% of water.
Optionally, the skin care product comprises, by mass, 5% to 9% of the skin anti-aging composition, 5% to 8% of a humectant, 1% to 4% of an emulsifier, 0.2% to 0.5% of a thickener, 0.5% to 1% of a preservative, 0.02% to 0.06% of a chelating agent, 10% to 15% of an emollient, 0.15% to 0.2% of a pH regulator, and 64% to 79% of water.
In a third aspect of the present invention, a method for preparing a skin care product is provided, which comprises the following steps:
mixing the emollient, the emulsifier, the thickener, the chelating agent, the humectant and the pH regulator to obtain a premix; adding to said premix a preservative and said saccharide isomer, sphingomonas fermentation product extract, ceramide, hydroxy pinacolate, phytosphingosine and an anti-sensitization agent.
Optionally, the emollient is selected from one or more of isononyl isononanoate, ethylhexyl cetyl alcohol, caprylic/capric triglyceride, caprylic/capric/stearic triglyceride, caprylic/capric/lauric triglyceride, pentaerythritol tetraester, neopentyl glycol diester, isopropyl palmitate, isopropyl myristate, octyldodecanol, phytosterol/octyldodecanol lauroyl glutamate, ethylhexyl palmitate, squalane, phytosterol oleate, tocopheryl acetate, polydimethylsiloxane, dimethiconol, jojoba seed oil, sweet almond oil and sunflower seed oil.
Optionally, the emulsifier is selected from one or more of cetearyl alcohol, ceteareth-21, glyceryl stearate, PEG-100 stearate, PEG-15 glyceryl stearate, PEG-20 glyceryl stearate, PEG-30 glyceryl stearate, PEG-40 glyceryl stearate, polysorbate-20, polysorbate-40, polysorbate-60, polysorbate-80, polysorbate-85, polyglyceryl-10 diisostearate, polyglyceryl-10 distearate, polyglyceryl-10 myristate, polyglyceryl-10 isostearate, polyglyceryl-10 laurate, polyglyceryl-10 stearate, polyglyceryl-10 oleate, polyglyceryl-5 stearate, beheneth-10, beheneth-20, beheneth-25, beheneth-30, cetearyl glucoside, and sorbitan olivate.
Optionally, the humectant is selected from one or more of sodium hyaluronate, sodium polyglutamate, betaine, trehalose, glycerol, propylene glycol, butylene glycol, pentylene glycol, 1, 2-pentylene glycol, 1, 3-butylene glycol, dipropylene glycol and methyl propylene glycol.
Optionally, the preservative is selected from one or more of 1, 2-hexanediol, p-hydroxyacetophenone and ethylhexyl glycerin.
Optionally, the thickening agent is selected from one or two of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer and xanthan gum.
Preferably, the chelating agent is disodium EDTA.
Preferably, the pH adjusting agent is arginine.
In the following, the raw materials referred to in the following specific examples are commercially available, unless otherwise specified, the equipment used, and the processes referred to, unless otherwise specified, are all routinely selected by those skilled in the art.
The following are specific examples.
Example 1
The present embodiment provides a skin care product.
1. Composition of raw materials
A skin care product comprises, by mass, 6.4% of a skin anti-aging composition, 7.05% of a humectant, 3% of an emulsifier, 0.38% of a thickener, 1% of a preservative, 0.05% of a chelating agent, 13.35% of an emollient, 0.18% of a pH regulator and 68.59% of water.
The skin care product comprises the following raw materials in parts by weight:
skin anti-aging composition: 2 parts of saccharide isomer, 2 parts of sphingomonas fermentation product extract, 0.5 part of ceramide NP, 1 part of hydroxy pinacolone retinoic acid ester, 0.5 part of phytosphingosine and 0.4 part of gentian root extract.
And (3) an emollient: 4 parts of ethylhexyl palmitate, 3 parts of caprylic/capric triglyceride, 2 parts of squalane, 2 parts of polydimethylsiloxane, 2 parts of dimethiconol, 0.3 part of phytosterol oleate and 0.05 part of tocopheryl acetate.
Emulsifier: cetearyl glucoside 0.825 parts, sorbitan olivate 0.6 parts, cetearyl alcohol 0.075 parts, glyceryl stearate 0.75 parts, PEG-100 stearate 0.75 parts.
Humectant: 4 parts of propylene glycol, 3 parts of butanediol and 0.05 part of sodium hyaluronate.
Thickening agent: xanthan gum 0.08 parts, acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer 0.3 parts.
pH regulator: 0.18 part of arginine.
Preservative: 0.5 part of p-hydroxyacetophenone and 0.5 part of 1, 2-hexanediol.
Chelating agent: 0.05 part of EDTA disodium.
Deionized water: 68.59 parts.
2. Preparation method
(1) Mixing the emollient and the emulsifier, heating to 85 ℃, stirring and melting into liquid, and then stirring for 20 minutes to obtain a mixture 1, and keeping the temperature for later use;
(2) Uniformly dispersing the thickening agent, the chelating agent and the humectant, adding the mixture into water, heating to 85 ℃ until the mixture is completely dissolved uniformly, homogenizing for 15 minutes, preserving heat for 20 minutes, sterilizing and defoaming to obtain a mixture 2 for later use;
(3) Starting homogenization, slowly adding the mixture 2 in the step (2) into the mixture 1 in the step (1), homogenizing for 10 minutes until complete and uniform emulsification is achieved, defoaming, cooling to 70 ℃, adding a pre-dissolved pH value regulator, and homogenizing for 5 minutes until uniform;
(4) Cooling to 45 deg.C, adding antiseptic and skin antiaging composition, stirring thoroughly for 10 min;
(5) Sampling, detecting, and discharging after the product is qualified.
Example 2
The present embodiment provides a skin care product.
1. Composition of raw materials
A skin care product comprises 4.9% of a skin anti-aging composition, 7.05% of a humectant, 3% of an emulsifier, 0.38% of a thickener, 1% of a preservative, 0.05% of a chelating agent, 13.35% of an emollient, 0.18% of a pH regulator and 70.09% of water by mass percentage.
The skin care product comprises the following raw materials in parts by weight:
skin anti-aging composition: 2 parts of saccharide isomer, 1 part of sphingomonas fermentation product extract, 0.5 part of ceramide NP, 0.5 part of hydroxy pinacolone retinoic acid ester, 0.5 part of phytosphingosine and 0.4 part of gentian root extract.
And (3) an emollient: 4 parts of ethylhexyl palmitate, 3 parts of caprylic/capric triglyceride, 2 parts of squalane, 2 parts of polydimethylsiloxane, 2 parts of dimethiconol, 0.3 part of phytosterol oleate and 0.05 part of tocopheryl acetate.
Emulsifier: cetearyl glucoside 0.825 parts, sorbitan olivate 0.6 parts, cetearyl alcohol 0.075 parts, glyceryl stearate 0.75 parts, PEG-100 stearate 0.75 parts.
Humectant: 4 parts of propylene glycol, 3 parts of butanediol and 0.05 part of sodium hyaluronate.
Thickening agent: 0.08 part of xanthan gum and 0.3% of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer.
pH regulator: 0.18 part of arginine.
Preservative: 0.5 part of p-hydroxyacetophenone and 0.5 part of 1, 2-hexanediol.
Chelating agent: 0.05 part of EDTA disodium.
Deionized water: 70.09 parts.
2. Preparation method
(1) Mixing the emollient and the emulsifier, heating to 85 ℃, stirring and melting into liquid, and then stirring for 20 minutes to obtain a mixture 1, and keeping the temperature for later use;
(2) Uniformly dispersing the thickening agent, the chelating agent and the humectant, adding the mixture into water, heating to 85 ℃ until the mixture is completely dissolved uniformly, homogenizing for 15 minutes, preserving heat for 20 minutes, sterilizing and defoaming to obtain a mixture 2 for later use;
(3) Starting homogenization, slowly adding the mixture 2 in the step (2) into the mixture 1 in the step (1), homogenizing for 10 minutes until complete and uniform emulsification is achieved, defoaming, cooling to 70 ℃, adding a pre-dissolved pH value regulator, and homogenizing for 5 minutes until uniform;
(4) Cooling to 45 deg.C, adding antiseptic and skin antiaging composition, stirring thoroughly for 10 min;
(5) Sampling, detecting, and discharging after the product is qualified.
Example 3
The present embodiment provides a skin care product.
1. Composition of raw materials
A skin care product comprises 8.4% of a skin anti-aging composition, 7.05% of a humectant, 3% of an emulsifier, 0.38% of a thickener, 1% of a preservative, 0.05% of a chelating agent, 13.35% of an emollient, 0.18% of a pH regulator and 66.59% of water in percentage by mass.
The skin care product comprises the following raw materials in parts by weight:
skin anti-aging composition: 2 parts of saccharide isomer, 3 parts of sphingomonas fermentation product extract, 0.5 part of ceramide NP, 2 parts of hydroxy pinacolone retinoic acid ester, 0.5 part of phytosphingosine and 0.4 part of gentian root extract.
And (3) an emollient: 4 parts of ethylhexyl palmitate, 3 parts of caprylic/capric triglyceride, 2 parts of squalane, 2 parts of polydimethylsiloxane, 2 parts of dimethiconol, 0.3 part of phytosterol oleate and 0.05 part of tocopheryl acetate.
Emulsifier: 0.825 parts of cetearyl glucoside, 0.6 parts of sorbitan olivate oleate, 0.075 parts of cetearyl alcohol, 0.75 parts of glyceryl stearate and 0.75 parts of PEG-100 stearate.
Humectant: 4 parts of propylene glycol, 3 parts of butanediol and 0.05 part of sodium hyaluronate.
Thickening agent: 0.08 part of xanthan gum and 0.3 part of acrylic acid (ester)/C10-30 alkanol acrylate crosslinked polymer.
pH regulator: 0.18 part of arginine.
Preservative: 0.5 part of p-hydroxyacetophenone and 0.5 part of 1, 2-hexanediol.
Chelating agent: 0.05 part of disodium EDTA.
Deionized water: 66.59 parts.
2. Preparation method
(1) Mixing the emollient and the emulsifier, heating to 85 ℃, stirring and melting into liquid, and then stirring for 20 minutes to obtain a mixture 1, and keeping the temperature for later use;
(2) Uniformly dispersing the thickener, the chelating agent and the humectant, adding into water, heating to 85 ℃ until the components are completely and uniformly dissolved, homogenizing for 15 minutes, preserving heat for 20 minutes, sterilizing, and defoaming to obtain a mixture 2 for later use;
(3) Starting homogenization, slowly adding the mixture 2 in the step (2) into the mixture 1 in the step (1), homogenizing for 10 minutes until complete emulsification is uniform, defoaming, cooling to 70 ℃, adding a pre-dissolved pH value regulator, and homogenizing for 5 minutes until uniform;
(4) Cooling to 45 deg.C, adding antiseptic and skin antiaging composition, stirring thoroughly for 10 min;
(5) Sampling, detecting, and discharging after the product is qualified.
The raw materials and parts by weight of examples 1 to 3 are summarized in Table 1
TABLE 1
Comparative example 1
This comparative example 1 provides a skin care product. The raw material composition and preparation method of the skin care product of comparative example 1 are similar to those of example 1, except that: no skin antiaging composition is added.
Comparative example 2
Comparative example 2 provides a skin care product. The raw material composition and preparation method of the skin care product of comparative example 2 are similar to those of example 1, except that: the sphingomonas ferment product extract and the hydroxy pinacolone retinoic acid ester in the skin anti-aging composition are not added.
Comparative example 3
Comparative example 3 provides a skin care product. The raw material composition and preparation method of the skin care product of comparative example 3 are similar to those of example 1, except that: adenosine is used to replace sphingomonas fermentation product extract in skin antiaging composition.
Comparative example 4
Comparative example 4 provides a skin care product. The raw material composition and preparation method of the skin care product of comparative example 4 are similar to those of example 1, except that: replacement of hydroxy pinacolone retinoic acid ester in skin anti-aging compositions with palmitoyl tripeptide-5.
Comparative example 5
Comparative example 5 provides a skin care product. The raw material composition and preparation method of the skin care product of comparative example 5 are similar to those of example 1, except that: ceramide NP in the skin antiaging composition is not added.
Comparative example 6
Comparative example 6 provides a skin care product. The raw material composition and preparation method of the skin care product of comparative example 6 are similar to those of example 1, except that: the phytosphingosine in the skin antiaging composition is not added.
Comparative example 7
Comparative example 7 provides a skin care product. The raw material composition and preparation method of the skin care product of comparative example 7 are similar to those of example 1 except that: the radix Gentianae extract in the skin antiaging composition is not added.
Comparative example 8
Comparative example 8 is a commercial sample 1, and the composition of the commercial sample 1 is: water, niacinamide, glycerin, isohexadecane, polydimethylsiloxane, dimethiconol, isopropyl isostearate, panthenol, stearyl alcohol, tocopheryl acetate, cetyl alcohol, arachidyl alcohol, behenyl alcohol, PEG-100 stearate, palmitoyl pentapeptide-4, benzyl alcohol, carbomer, allantoin, carnosine, cetostearyl alcohol, cetostearyl glucoside, ethylparaben, sodium hydroxide, disodium EDTA, stearic acid, palmitic acid, pyridoxine dipalmitate, propylparaben, citric acid, perfume, sodium hyaluronate, peach (PRUNUS PERSICA) fruit extract, butylene glycol, CI 19140, CI 17200.
Comparative example 9
Comparative example 9 is a commercially available sample 2, and the composition of the commercially available sample 2 was: water, hydrogenated polydecene, glycerol, dipropylene glycol, cyclopentyldimethicone, ethylhexyl palmitate, butylene glycol, betaine, cetyl PEG/PPG-10/1 dimethicone, propylene glycol, propylene carbonate, cyclopentyldimethicone, disteardimonium hectorite, synthetic beeswax, petrolatum, squalane, sucrose, sodium chloride, acetyl chitosamine, palmitoyl tetrapeptide-7, palmitoyl oligopeptide, polysorbate-20, carbomer, acetyl hexapeptide-8, caprylyl glycol, dipeptide diaminobutyryl benzylamide diacetate, caprylic/capric triglyceride, and mixtures thereof ceramide 3, hydrogenated lecithin, cetyl N-palmitoyl hydroxyproline, hexyldecanol, stearic acid, canola (BRASSICA campestis) sterols, bisabolol, yeast extract, THERMUS thermophilus (THERMUS thermophilus) fermentation product, ethylhexyl glycerol, phenoxyethanol, sodium hyaluronate, retinol palmitate, panthenol, methylsilanol mannuronate, allantoin, dipotassium glycyrrhizinate, tocopherol acetate, isostearic acid, glyceryl behenate/eicosanoate, cellulose gum, essence, p-hydroxyacetophenone, sodium metabisulfite, disodium EDTA.
Performance test
1 human body anti-wrinkle efficacy test: the anti-aging effect of the skin care products prepared in the above examples 1 to 3 and comparative examples 1 to 9 is explored by a volunteer test, which specifically comprises the following steps:
1.1 volunteer screening: 28 volunteers were selected, all volunteers were randomly divided into 7 groups of 4 persons per group, and the skin care products prepared in examples 1 to 3 and comparative examples 1 to 9 were tried on each group of volunteers.
(1) Inclusion volunteer criteria were: age 38-55 years old, female; hormone drugs and immunosuppressants have not been used in the last month; the tested part does not participate in other clinical testers at present or in nearly 30 days; can be well matched with testers; the system can read and understand all contents of the informed consent and voluntarily sign the informed consent; during the test period, the consent was not to use any cosmetics, drugs and nutraceuticals that have an impact on the outcome.
(2) Exclusion criteria: patients with open wounds or erosive faces; those with high allergic constitution; those with a history of cosmetic allergy; a female who is pregnant, lactating, or intended to be pregnant during the test; severe center of gravity, liver and kidney function damage and severe immunologic hypofunction; those with mental disorders, severe endocrine disorders, and oral contraceptives; the patients who participate in the drug clinical testers or other testers within 30 days, or the patients who have systemic drugs which have influence on the test results within about 1 week; those who had oral and topical cosmetic products within 2 weeks that may have an effect on the outcome of the test; the investigator considered not appropriate for attending the investigator.
(3) Abort and exit criteria: smearing the tested sample or recording the revisit according to the requirement during the test period; has serious diseases or serious adverse reactions during the use period.
1.2 test methods: the volunteers use the product on the whole face for 28 days after cleaning the face in the morning and at night every day; before use, the wrinkles were tested using a VISIA skin test instrument, and after 28 consecutive days, the wrinkles were again tested using a VISIA skin test instrument, and the transdermal water loss rate, the subcutaneous 0.5mm water content, the relative change in the average width of the wrinkles, the relative change in the average depth of the wrinkles, the relative change in the total size of the wrinkles, and the wrinkle reduction rate calculated by automatic analysis using the VISIA skin test instrument were obtained and recorded as shown in tables 2 and 3 below:
TABLE 2
TABLE 3
The following conclusions are drawn from the comparison of the data of comparative examples 1 to 9 with examples 1 to 3, with reference to tables 2 and 3:
data of examples 1-3 and comparative examples 1-7 show that saccharide isomers, sphingomonas fermentation product extract, ceramide, hydroxypivalonone retinoic acid ester, phytosphingosine and gentian root extract in the skin anti-aging composition can improve rough skin texture, tighten and relax skin efficacy, supplement skin ceramide, greatly reduce TEWL value of human skin, improve skin hydration degree and improve skin water holding capacity. In examples 1 to 3, with the increase in the addition of sphingomonas ferment product extract and hydroxyppinacolone retinoic acid ester, the water loss of the skin is reduced, the subcutaneous water content of 0.5mm is increased, the skin-lightening effect is improved, and the relative change values of the average width of wrinkles and the total size of wrinkles are gradually reduced.
The data of examples 1-3 and comparative examples 8-9 show that the use of commercial sample 1 resulted in a higher water split loss, a poorer enhancement of the skin lightening effect of commercial sample 2, and a weaker wrinkle lightening effect of both commercial sample 1 and commercial sample 2 than the skin care products of the examples. The anti-aging effect of the skin care product prepared by the invention is superior to that of a market competitive product 1 and a market competitive product 2.
The conclusion shows that the skin care product prepared by the skin anti-aging composition can form a multi-dimensional anti-aging efficacy system through the synergistic interaction of the components of the skin anti-aging composition, and can deeply resist skin aging, fade fine lines, improve facial contours and improve the problem of loose wrinkles of skin.
2 the test of the patch on the skin,
2.1 volunteer screening:
after screening by the dermatologist, 30 subjects were included in the group, and 30 subjects were finally counted, the age was 18 to 49 years, the mean age was (25.10 ± 7.88) years, and all the completed subjects satisfied the following inclusion criteria and exclusion criteria, and the subject information is shown in table 4.
Inclusion criteria were: the age of healthy male and female is 18-55 years old; the content of the informed consent can be read and understood in cooperation with experimental tests, and the informed consent can be voluntarily signed;
exclusion criteria: those who use antihistamines for nearly one week or immunosuppressants for nearly one month; in the last two months, any anti-inflammatory drug is applied to the tested part; the subject has a clinically unvulcanized inflammatory skin condition; insulin dependent diabetes mellitus patients; patients suffering from asthma or other chronic respiratory diseases undergoing treatment; those receiving anti-cancer chemotherapy within approximately 6 months; patients with immunodeficiency or autoimmune disease; lactating or pregnant women; bilateral mastectomy and bilateral underarm lymph node resection; the judgment of the test result is influenced by scars, pigments, atrophy, port wine stains or other flaws on the skin to be tested; participation in other clinical trial investigators; those with high constitutional sensitivity; non-volunteer participants or those who cannot complete the prescribed content as required by the trial.
TABLE 4
2.2 test methods:
the selected area is not more than 50mm 2 A qualified spot tester with the depth of about 1mm is prepared by adding 0.025g of pale yellow milky ointment into a spot tester, sticking the ointment on the curved side of the forearm of a tested person by using hypoallergenic adhesive tape, lightly pressing the ointment with a palm to uniformly stick the ointment on the skin, removing the tested person after 24h, observing skin reactions for 0.5h, 24h and 48h after the removal (after the indentation disappears), and recording the results according to the skin reaction grading standard in technical Specification for safety of cosmetics (2015 year edition). The grading criteria for adverse skin reactions are shown in Table 5.
TABLE 5
2.3. And (3) test results:
30 subjects were enrolled in total, and the 30 subjects completed the test, with adverse skin reactions as shown in table 6 and scoring results as shown in table 7.
TABLE 6
TABLE 7
Referring to the classification standard of adverse skin reactions in human safety tests specified in 2015 edition of technical Specification for cosmetic safety, 0 of 30 people have adverse skin reactions, so that the skin care product has no adverse skin reactions to human bodies.
All possible combinations of the technical features of the above embodiments may not be described for the sake of brevity, but should be considered as within the scope of the present disclosure as long as there is no contradiction between the combinations of the technical features.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that various changes and modifications can be made by those skilled in the art without departing from the spirit of the invention, and these changes and modifications are all within the scope of the invention.
Claims (10)
1. A skin anti-aging composition, wherein the skin anti-aging composition comprises the following components: 0.5 to 5 portions of saccharide isomerate, 0.5 to 5 portions of sphingosine monad fermentation product extract, 0.5 to 5 portions of ceramide, 0.5 to 5 portions of hydroxy pinacolone retinoic acid ester, 0.5 to 5 portions of phytosphingosine and 0.4 to 5 portions of anti-allergic agent.
2. The skin antiaging composition according to claim 1, characterized by comprising the following components: 1 to 3 parts of saccharide isomerate, 1 to 4 parts of sphingosine monad fermentation product extract, 0.5 to 3 parts of ceramide, 0.5 to 2 parts of hydroxy pinacolone retinoic acid ester, 0.5 to 3 parts of phytosphingosine and 0.4 to 3 parts of anti-allergic agent.
3. The skin antiaging composition according to claim 2, characterized by comprising the following components: 2 parts of saccharide isomer, 3 parts of sphingomonas fermentation product extract, 0.5 part of ceramide, 2 parts of hydroxy pinacolone retinoic acid ester, 0.5 part of phytosphingosine and 0.4 part of anti-allergy agent.
4. The anti-aging composition for skin as claimed in any one of claims 1 to 3, wherein the ceramide is ceramide NP.
5. The anti-aging composition for skin according to any one of claims 1 to 3, wherein the anti-allergic agent is one or more selected from dipotassium glycyrrhizinate, aloe extract, gentian root extract, honey extract, green tea extract, purslane extract, scutellaria baicalensis extract and cactus extract.
6. A skin care product comprising the anti-aging skin composition according to any one of claims 1 to 5, formulation auxiliaries and water.
7. The skin care product of claim 6, wherein the formulation aid is one or more selected from the group consisting of a preservative, a chelating agent, an emollient, a humectant, a thickener, a pH adjuster, and an emulsifier.
8. The skin care product according to claim 7, characterized by comprising, by mass, 4% to 25% of the skin anti-aging composition, 3% to 10% of a moisturizing agent, 3% to 8% of an emulsifying agent, 0.5% to 2% of a thickening agent, 0.1% to 1% of a preservative, 0.02% to 0.1% of a chelating agent, 8% to 15% of an emollient, 0.1% to 0.2% of a pH regulator, and 39% to 81% of water.
9. The skin care product according to claim 8, characterized by comprising, by mass, 5% to 9% of the skin anti-aging composition, 5% to 8% of a moisturizing agent, 1% to 4% of an emulsifying agent, 0.2% to 0.5% of a thickening agent, 0.5% to 1% of a preservative, 0.02% to 0.06% of a chelating agent, 10% to 15% of an emollient, 0.15% to 0.2% of a pH regulator, and 64% to 79% of water.
10. The preparation method of the skin care product is characterized by comprising the following steps:
mixing the emollient of any of claims 6-9, emulsifier, thickener, chelating agent, humectant, and pH adjuster to form a premix; adding to the premix a preservative and the saccharide isomer of any of claims 1-9, sphingomonas fermentation product extract, ceramide, hydroxyppinacolone retinoic acid ester, phytosphingosine, and an anti-sensitization agent.
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