CN115916351A - 修饰的信号素3a、包含其的组合物及其用途 - Google Patents

修饰的信号素3a、包含其的组合物及其用途 Download PDF

Info

Publication number
CN115916351A
CN115916351A CN202180040643.7A CN202180040643A CN115916351A CN 115916351 A CN115916351 A CN 115916351A CN 202180040643 A CN202180040643 A CN 202180040643A CN 115916351 A CN115916351 A CN 115916351A
Authority
CN
China
Prior art keywords
modified
sema3a
polypeptide
semaphorin
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202180040643.7A
Other languages
English (en)
Chinese (zh)
Inventor
扎哈瓦·瓦达兹
埃利亚斯·图比
纳斯伦·艾萨
阿迪·萨巴格
格拉·纽费尔德
奥夫拉·凯斯勒
E·伊温妮·琼斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Oxford
Medical Research And Development Fund For Health Services At Bunazion Medical Center
Technion Research and Development Foundation Ltd
Original Assignee
University of Oxford
Medical Research And Development Fund For Health Services At Bunazion Medical Center
Technion Research and Development Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Oxford, Medical Research And Development Fund For Health Services At Bunazion Medical Center, Technion Research and Development Foundation Ltd filed Critical University of Oxford
Publication of CN115916351A publication Critical patent/CN115916351A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN202180040643.7A 2020-06-04 2021-06-03 修饰的信号素3a、包含其的组合物及其用途 Pending CN115916351A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063034476P 2020-06-04 2020-06-04
US63/034,476 2020-06-04
PCT/IL2021/050660 WO2021245670A1 (en) 2020-06-04 2021-06-03 Modified semaphorin 3a, compositions comprising the same and uses thereof

Publications (1)

Publication Number Publication Date
CN115916351A true CN115916351A (zh) 2023-04-04

Family

ID=78830160

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180040643.7A Pending CN115916351A (zh) 2020-06-04 2021-06-03 修饰的信号素3a、包含其的组合物及其用途

Country Status (8)

Country Link
US (1) US20230272020A1 (https=)
EP (1) EP4161659A4 (https=)
JP (1) JP2023532415A (https=)
CN (1) CN115916351A (https=)
AU (1) AU2021284697A1 (https=)
CA (1) CA3185618A1 (https=)
IL (1) IL298678A (https=)
WO (1) WO2021245670A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115947817B (zh) * 2023-02-22 2024-07-02 甘肃中肽生物科技有限公司 一种肿瘤相关多肽及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5288931A (en) * 1991-12-06 1994-02-22 Genentech, Inc. Method for refolding insoluble, misfolded insulin-like growth factor-I into an active conformation
GB9912350D0 (en) * 1999-05-26 1999-07-28 European Molecular Biology Lab Embl Modified cytokine
FI117667B (fi) * 2001-07-05 2007-01-15 Univ Zuerich Farmaseuttinen koostumus, joka soveltuu käytettäväksi ortopediassa ja hammaslääketieteessä
AU2012212047A1 (en) * 2011-02-03 2013-08-22 Xoma Technology Ltd. Methods and materials for enhancing functional protein expression in bacteria
WO2014199364A1 (en) * 2013-06-13 2014-12-18 Bnai Zion Medical Center Semaphorin 3a for treatment and prognosis of systemic lupus erythematosus
RU2722832C2 (ru) * 2015-02-23 2020-06-04 Сигалл Терапьютикс Сас Неприродные семафорины класса 3 и их медицинское применение

Also Published As

Publication number Publication date
WO2021245670A1 (en) 2021-12-09
IL298678A (en) 2023-01-01
AU2021284697A1 (en) 2023-01-19
CA3185618A1 (en) 2021-12-09
US20230272020A1 (en) 2023-08-31
EP4161659A4 (en) 2024-03-06
EP4161659A1 (en) 2023-04-12
JP2023532415A (ja) 2023-07-28

Similar Documents

Publication Publication Date Title
KR102777151B1 (ko) 인터루킨-2의 부분 효능제
JP6514259B2 (ja) 抗炎症活性を有するペプチド、及びそれを含む組成物
JP2022001591A (ja) 抗炎症活性を有するペプチド、及びそれを含む組成物
JP2001524814A (ja) ２８種類のヒト分泌タンパク質
JP2005218453A (ja) ８７個のヒト分泌タンパク質
JP2003531918A (ja) 抗炎症化合物及びその利用
WO2001019999A1 (en) A GENE ENCODING A NOVEL THREONYL-tRNA SYNTHETASE, ITS USES AND THE PREPARING METHODS
JP2026035742A (ja) 生体高分子標的特異的補体阻害剤及びその製造方法と応用
EP4310188A1 (en) Gene coding for chimeric receptor for anti-acetylcholine receptor autoantibody
CN114846024A (zh) Il-37融合蛋白及其用途
CN115916351A (zh) 修饰的信号素3a、包含其的组合物及其用途
CN102030822A (zh) 人类新细胞因子VSTM1-v2及其应用
KR20240128579A (ko) Cd38 또는 이의 단편을 포함하는 자가면역질환 치료용 조성물
CN1649897A (zh) Falp蛋白
US6780986B1 (en) RIP60 nucleic acid and polypeptide sequences and uses therefor
EP2032601B1 (en) Peptides regulating the surface expression of the t cell receptor
US20100111913A1 (en) Method of enhancing migration of neural precursor cells
KR20050111346A (ko) 분비 단백질 계통
WO2001038522A1 (fr) Nouveau polypeptide, histone humaine h2a.21, et polynucleotide codant pour ce polypeptide
US6908765B1 (en) Polypeptide—human SR splicing factor 52 and a polynucleotide encoding the same
HK40103877A (en) Gene coding for chimeric receptor for anti-acetylcholine receptor autoantibody
HK40068945A (en) Il-37 fusion proteins and uses thereof
WO2001023423A1 (fr) Nouveau gene comprenant le domaine ww et codant le polypeptide humain interagissant avec l'huntingtine, methode de production dudit gene et application correspondante
WO2001027148A1 (fr) Nouveau polypeptide, facteur homo 56 riche en glutamine(q), et polynucleotide codant pour ce polypeptide
CN1301761A (zh) 新的人趋化因子——巨噬细胞炎性蛋白、其编码序列及用途

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination