CN1159051C - Hypoglycemic granule of ten ingredients and its prepn - Google Patents
Hypoglycemic granule of ten ingredients and its prepn Download PDFInfo
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- CN1159051C CN1159051C CNB02109358XA CN02109358A CN1159051C CN 1159051 C CN1159051 C CN 1159051C CN B02109358X A CNB02109358X A CN B02109358XA CN 02109358 A CN02109358 A CN 02109358A CN 1159051 C CN1159051 C CN 1159051C
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Abstract
The present invention discloses a hypoglycemic granule of ten ingredients and a preparation method thereof. The hypoglycemic granule of ten ingredients has a prescription composed of ginseng, milk vetch, wolfberry bark, pueraria root, common anemarrhena rhizome, Chinese yam, snakegourd roots, Chinese magnolivine fruit, ventriculi galli mucosa and glibenclamide. The present invention has the preparation method that the ginseng and the glibenclamide are respectively pulverized to form fine powder; water is added to the pueraria roots, the common anemarrhena rhizome, the Chinese yam, the snakegourd roots, the Chinese magnolivine fruit and the ventriculi galli mucosa for decoction, and a water solution is extracted and is concentrated to form clear paste; the fine powder of the ginseng is added to be uniformly mixed with the clear paste, and fine powder is formed by drying and pulverization; the fine powder of the clear paste and fine powder of the glibenclamide are matched with a proper amount of dextrin to be ground and are uniformly mixed, and the hypoglycemic granule is formed by granulation and drying. The present invention is characterized in that the hypoglycemic granule of ten ingredients can benefit Qi, nourish Yin and quench thirst; the hypoglycemic granule of ten ingredients can obtain obvious curative effects on people of double-deficinecy of Qi and Yin in noninsulin-dependent diabetes mellitus and reach a cure effect in clinic.
Description
Relate to the field and the present invention relates to Chinese medicine and western medicine mixture pharmaceutical technology field, particularly a kind of hypoglycemic granule of ten ingredients and method for making thereof.
The background technology diabetes are a kind of common endocrine system diseases, and its cause of disease has congenital and the branch day after tomorrow, and congenital factors is inherited genetic factors, and inherited genetic factors has determined the susceptibility of diabetes, and acquired disposition then is postnatal environmental factors and immunologic mechanism imbalance.
Diabetes are divided two kinds on I type and II type, and the I type is because islets of langerhans p cytoclasis, and the β cell granulations reduces, dysinsulinism, causing diabetes is insulin-dependent, and type ii diabetes is that insulin resistant and insulin action are not enough and cause morbidity, is non-insulin-dependent diabetes mellitus.
At present, the medicine for the treatment of diabetes both at home and abroad has two kinds in Chinese medicine and Western medicine, and the Western medicine hypoglycemic effect is better, blood sugar lowering is fast, but the life-time service side effect is big, and is big as the chlorpropamide toxic and side effects, inappropriate medication easily causes hypoglycemia, pure treatment by Chinese herbs diabetes are to adopt the principle of determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs, and compound Chinese medicinal preparation not only can controlling symptoms, and can prevent and treat various complication generations, stable curative effect, toxic and side effects is little, treating both the principal and secondary aspects of a disease, and onset is slower, for can instant effect, can reach determined curative effect again, blood sugar lowering continues, and steadily, develops the bonded hypoglycemic medicine of a kind of Chinese medicine and western medicine, treatment diabetes and various chronic complication thereof, effect is remarkable, and curative effect is steady, definitely seems very important.
One of summary of the invention purpose of the present invention provides a kind of Chinese medicine preparation hypoglycemic granule of ten ingredients for the treatment of diabetes; This electuary is to treatment diabetes and various complication determined curative effect thereof, steadily.
Two of purpose of the present invention provides a kind of method for making for the treatment of the hypoglycemic granule of ten ingredients of diabetes, and this method for making adopts the low temperature pharmacy not produce the drug effect loss, and equipment investment is low.
A kind of hypoglycemic granule of ten ingredients, it is characterized in that it is made by following crude drug: Radix Ginseng 125-175g, Radix Astragali 425-475g, Cortex Lycii 725-775g, Radix Puerariae 275-325g, Rhizoma Anemarrhenae 275-325g, Rhizoma Dioscoreae 275-325g, Radix Trichosanthis 350-400g, Fructus Schisandrae Chinensis 225-275g, Endothelium Corneum Gigeriae Galli 125-175g, glyburide 240-260mg, adjuvant are equipped with an amount of dextrin.
Above-mentioned hypoglycemic granule of ten ingredients method for making is characterized in that: Radix Ginseng, glyburide pulverize separately become fine powder, and Radix Puerariae, Fructus Schisandrae Chinensis add 75% alcohol reflux secondary, and each 2 hours, merge extractive liquid, filtered, filtrate recycling ethanol, and aqueous solution is standby; The Radix Astragali, Cortex Lycii, the Rhizoma Anemarrhenae, Rhizoma Dioscoreae, Radix Trichosanthis, Endothelium Corneum Gigeriae Galli decoct with water secondary, each 1.5 hours, merge decoction liquor, merge with above-mentioned aqueous solution, be concentrated into the clear paste of 60 ℃ of proportion 1.35-1.38, temperature, add the Radix Ginseng fine powder, the mixing drying, be ground into fine powder, with the glyburide fine powder, an amount of dextrin facing-up, mixing, powder process is drying to obtain the hypoglycemic granule of ten ingredients electuary.
Above-mentioned hypoglycemic granule, every 6g are a packaging bag.
Instructions about how to take medicine: every day three times, each one bag, take after mixing it with hot water.
Characteristics of the present invention are: but this medicine supplementing QI and nourishing YIN, and promoting the production of body fluid to quench thirst is used for non-insulin-dependent diabetes mellitus deficiency of both QI and YIN disease person, show as fatigue and weakness, spontaneous sweating, the lazy speech of breathing hard, dysphoria with feverish sensation in the chest palms and soles, palpitation and insomnia, the red constipation of urinating, red tongue with a little fluid, corpulent tongue is big, thin fur or flower stripping, stringy,thready and rapid pulse all can obtain obvious treatment and curative effect.
The hypoglycemic granule of ten ingredients clinical data
Physical data: this group patient is 10 routine patients of outpatient service diagnosis and treatment, does not have matched group.10 examples are organized in treatment, wherein male 6 examples, and women 4 examples, the oldest 72 years old, reckling 49 years old, 63.4 years old mean age, the elder of the course of disease 10 years is the shortest 3 months.
Diagnostic criteria: adopt blood sample, urine test chamber to analyze and Instrument measuring, determine the state of an illness by the diabetes diagnosis index that country formulates.
The treatment standard: it is a course of treatment that hypoglycemic granule of ten ingredients is taken January, and check blood glucose and urine sugar level descend, and continues to take blood glucose and glucose in urine and should reach the national standard of formulating.
Clinic control: it is produce effects that take medicine back blood glucose and urine sugar level return to the non-diabetic index that country formulates, and the index of take medicine back blood glucose and glucose in urine drops to improvement, the index of take medicine back blood glucose and glucose in urine do not have change into invalid.
The therapeutic outcome of this group case: obvious effective rate 92%, take a turn for the better 8%, total effective rate 100%.
Clinical case:
Case 1, patient Wang Tiehong, the woman, 65 years old, live Lishan District, ill 3 years, through how tame hospitalize, blood glucose, glucose in urine rising appear repeatedly, check blood glucose 10.0mmol/L before the clothes key medicine, glucose in urine (+++), performance polydipsia, polyuria, weak lose weight.On April 7th, 98 began to take hypoglycemic granule of ten ingredients, one time one bag, three times on the one, after taking medicine 12 days, polydipsia, polyuria, polyphagia transference cure are after the course of treatment (one month) of taking medicine, weak, transference cure, weight increase 2Kg, through hospital's chemical examination, blood glucose: 6.0mmol/L, glucose in urine (+-), continue the medication one and a half months, check that once more blood glucose is reduced to 5.4mmol/L, glucose in urine (-), time-out is taken medicine, diet control.
Case 2, patient Li Qiang, man, 52 years old, live Anshan Tiexi District nine road street, suffered from diabetes 6 years, occurred complication, retinal hemorrhage was taken Hypolycemic pellet, metformin hydrochloride tablet, glyburide, diabetes pill etc., glucose in urine (++) blood glucose 9.2mmol/L, high, the hypoglycemia symptom often appears after 2 hours after the meal, begin to take hypoglycemic granule of ten ingredients in October, 99, serve on 40 days, through chemical examination blood glucose 6.1mmol/L, glucose in urine (-), continuous use, symptomatic treatment retinal hemorrhage symptom.
Case 3, patient Wang Defeng, man, 66 years old, live south of the mountains street, Tiedong District, Anshan, suffered from diabetes 10 years, blood test on August 21st, 97 sugar 14.4mmol/L, glucose in urine (+++), urine protein (++), ketoboidies (+++), accompany the general neuropathy simultaneously, the start injection insulin, sb.'s illness took a favorable turn, inactive insulin three months, chemical examination blood glucose is increased to 8.7mmol/L again, glucose in urine (+), urine protein, ketoboidies, substantially normal, began to take hypoglycemic granule of ten ingredients one month July 19 calendar year 2001, chemical examination blood glucose 6.4mmol/L, glucose in urine (-), continue medication 2 months, add dietetic therapy, the state of an illness is controlled.
Case 4, patient Gao Zhenhai, man, 70 years old, live Anshan Jiu Baoqu, be diagnosed as type ii diabetes through the doctor in August, 2000, blood glucose 9.2mmol/L, glucose in urine (+-), subjective symptoms: xerostomia, think drink, night frequent micturition, polyphagia, easily hungry, do not take medicine, by diet control, but blood glucose is still higher always, clinical symptoms does not subtract, on October 25th, 2000 was taken hypoglycemic granule of ten ingredients, serve on 20 days, and subjective symptoms all disappears, through chemical examination blood glucose 5.6mmol/L,, glucose in urine (-), continue medication after one month, reached clinical recovery by diet control.
Case 5, Ka Yan, woman, 49 years old, live Tie Xi continent, Anshan, conscious polydipsia at the beginning of 2000, dietary amount is big, hunger, frequent micturition, in JIUYUE, 2000 is on inspection: blood glucose 9.0mmol/L, glucose in urine (+-), through glucose tolerance test, be diagnosed as type ii diabetes, diet control before this, clinical symptoms does not have obvious change.December began to take hypoglycemic granule of ten ingredients on the 19th in 2000, and subjective symptoms all disappears after the course of treatment, through chemical examination blood glucose 5.7mmol/L, glucose in urine (-), the clinical recovery from illness standard that reaches.
Case 6, patient Zhou Kexue, man, 69 years old, live garden, Tiedong District, Anshan, suffered from diabetes 8 years, once took multiple Chinese and Western hypoglycemic medicine, the Western medicine that has is taken back blood glucose shakiness, fluctuated, hypoglycemia often appears, and the informal dress Western medicine has Drug resistance, and it is not good to obey some Chinese medicine hypoglycemic effects.Blood test on March 18th, 2000 sugar 13mmol/L, glucose in urine (++) is taken hypoglycemic granule of ten ingredients blood glucose 2 courses of treatment and is reduced to 5.9mmol/L, and glucose in urine (-) reaches normal level, and strictness is kept on a diet.
Case 7, patient Jin Wantao, man, 72 years old, morbidity in 95 years was through chemical examination blood glucose 11.2mmol/L,, glucose in urine (++) is taken Western medicine chlorine sulphur ice urea for many years always, cause impaired renal function, after take glyburide again, hypoglycemia often appears when taking, renal function is affected, and is low when high when causing blood glucose, renal insufficiency, in October, 98 is through chemical examination blood glucose 10.6mmol/L, glucose in urine (++), albumen (++), back by the agency of was taken hypoglycemic granule of ten ingredients, from October 21st, 98, at 11 the end of month, obeyed altogether nearly 40 days, chemically examine blood glucose once more, 6.8mmol/L, glucose in urine (-), albumen (+), continue 2 weeks of medication, albumen (-), blood glucose drops to 6.1mmol/L.
Case 8, patient Wang Xiuying, 62 years old, suffer from diabetes in July, 99, use diet, QI GONG therapy before this, controlling symptoms, find serious xerostomia in March, 2000, happiness drinking-water, urine is many, after took Chinese medicine decoction again one month, cause stomachache, stop behind the Chinese medicine 2 months, chemical examination blood glucose 8.1mmol/, the three-many-one-little sx, take course of treatment of hypoglycemic granule of ten ingredients in May, 2000, chemical examination blood glucose 6.0mmol/L, xerostomia, happiness drink, frequent micturition transference cure, body weight descends again, continues to take medicine to change acupuncture control in one month into.
Case 9, the patient opens melts away, man, 60 years old, the steel mill workman of Anshan iron and steel plant company, the trouble diabetes were chemically examined blood glucose 8.3mmol/L at that time in 99 years, and glucose in urine (+) was taken hypoglycemic granule of ten ingredients after 15 days, blood glucose is reduced to 5.2mmol/L, and glucose in urine (-) is obeyed once more and consolidated curative effect in 15 days, reaches clinical cure.
Case 10, Zhao Surong, woman, 69 years old, type ii diabetes was suffered from Haicheng City Xiang Tang township in 98 years on inspection, blood glucose 9.8mmol/L, glucose in urine (++) merges whole body neuropathic pain, the bilateral scelalgia is taken hypoglycemic granule of ten ingredients from 19 ,-June 21,98 on May, conscious neuralgia, skelalgia disappear, chemical examination back blood glucose 6.4mmol/L, glucose in urine (-), the observation that continues to take medicine, after do not see and examine.
The specific embodiment
Embodiment 1
The hypoglycemic granule of ten ingredients electuary is made up of following raw material medicaments: Radix Ginseng 125g, Radix Astragali 425g, Cortex Lycii 725g, Radix Puerariae 275g, Rhizoma Anemarrhenae 275g, Rhizoma Dioscoreae 275g, Radix Trichosanthis 350g, Fructus Schisandrae Chinensis 225g, Endothelium Corneum Gigeriae Galli 125g, glyburide 225mg.
Its method for making is: Radix Ginseng, glyburide pulverize separately become fine powder, and Pueraria lobota is followed, Fructus Schisandrae Chinensis adds 75% alcohol reflux secondary, and each 2 hours, merge extractive liquid, filtered, filtrate recycling ethanol, and aqueous solution is standby; The Radix Astragali, Cortex Lycii, the Rhizoma Anemarrhenae, Rhizoma Dioscoreae, Radix Trichosanthis, Endothelium Corneum Gigeriae Galli decoct with water secondary, each 1.5 hours, merge decoction liquor, above-mentioned aqueous solution merges, be concentrated into the clear paste of proportion 1.35-1.38 (60 ℃), add the Radix Ginseng fine powder, the mixing drying, be ground into fine powder, with the glyburide fine powder, an amount of dextrin facing-up, mixing, powder process is drying to obtain hypoglycemic granule of ten ingredients.
Above-mentioned hypoglycemic granule, every 6g are a packaging bag.
Embodiment 2
Hypoglycemic granule of ten ingredients is made up of following raw material medicaments: Radix Ginseng 150g, Radix Astragali 450g, Cortex Lycii 750g, Radix Puerariae 300g, Rhizoma Anemarrhenae 300g, Rhizoma Dioscoreae 300g, Radix Trichosanthis 375g, Fructus Schisandrae Chinensis 250g, Endothelium Corneum Gigeriae Galli 150g, glyburide 250mg.All the other are with embodiment 1.
Embodiment 3
Hypoglycemic granule of ten ingredients is made up of following raw material: Radix Ginseng 175g, Radix Astragali 475g, Cortex Lycii 775g, Radix Puerariae 325g, Rhizoma Anemarrhenae 325g, Rhizoma Dioscoreae 325g, Radix Trichosanthis 400g, Fructus Schisandrae Chinensis 275 g, Endothelium Corneum Gigeriae Galli 175g, glyburide 260mg.All the other are with embodiment 1.
Claims (2)
1, a kind of hypoglycemic granule of ten ingredients, it is characterized in that it is made by following crude drug: Radix Ginseng 125-175g, Radix Astragali 425-475g, Cortex Lycii 725-775g, Radix Puerariae 275-325g, Rhizoma Anemarrhenae 275-325g, Rhizoma Dioscoreae 275-325g, Radix Trichosanthis 350-400g, Fructus Schisandrae Chinensis 225-275g, Endothelium Corneum Gigeriae Galli 125-175g, glyburide 240-260mg, adjuvant are equipped with an amount of dextrin.
2, according to the method for making of the described hypoglycemic granule of ten ingredients of claim 1, it is characterized in that: Radix Ginseng, glyburide pulverize separately become fine powder, and Radix Puerariae, Fructus Schisandrae Chinensis add 75% alcohol reflux secondary, each 2 hours, merge extractive liquid, filtered, filtrate recycling ethanol, aqueous solution is standby; The Radix Astragali, Cortex Lycii, the Rhizoma Anemarrhenae, Rhizoma Dioscoreae, Radix Trichosanthis, Endothelium Corneum Gigeriae Galli decoct with water secondary, each 1.5 hours, merge decoction liquor, merge with above-mentioned aqueous solution, be concentrated into the clear paste of 60 ℃ of proportion 1.35-1.38, temperature, add the Radix Ginseng fine powder, the mixing drying, be ground into fine powder, with the glyburide fine powder, an amount of dextrin facing-up, mixing, powder process is drying to obtain hypoglycemic granule of ten ingredients.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100360164C (en) * | 2005-07-13 | 2008-01-09 | 安徽济人药业有限公司 | Medicine for treating diabetes and its preparing process |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100353983C (en) * | 2006-04-04 | 2007-12-12 | 宁波诚年药业有限公司 | Chinese medicine preparation for reducing sugar |
| CN101664504B (en) * | 2008-09-03 | 2011-09-07 | 刘爱莲 | Medicament for treating diabetes and preparation method thereof |
| CN102485261B (en) * | 2010-12-03 | 2014-10-29 | 吉林吉春制药股份有限公司 | Medicine for treating diabetes and preparation method thereof |
| CN106511840A (en) * | 2016-11-15 | 2017-03-22 | 深圳市国民大健康文化传播有限公司 | Composition for consolidating and reducing blood glucose, and preparation method thereof |
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2002
- 2002-03-28 CN CNB02109358XA patent/CN1159051C/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100360164C (en) * | 2005-07-13 | 2008-01-09 | 安徽济人药业有限公司 | Medicine for treating diabetes and its preparing process |
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| CN1375318A (en) | 2002-10-23 |
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