CN102485261B - Medicine for treating diabetes and preparation method thereof - Google Patents
Medicine for treating diabetes and preparation method thereof Download PDFInfo
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- CN102485261B CN102485261B CN201010571764.8A CN201010571764A CN102485261B CN 102485261 B CN102485261 B CN 102485261B CN 201010571764 A CN201010571764 A CN 201010571764A CN 102485261 B CN102485261 B CN 102485261B
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Abstract
The invention relates to a medicine for treating diabetes and specifically to a Chinese patent medicine prepared from Chinese herbal medicines and a preparation method thereof. The medicine is prepared from the following bulk drugs by weight: 130 to 180 g of ginseng, 425 to 475 g of radix astragali, 730 to 780 g of cortex lycii, 275 to 325 g of root of kudzu vine, 275 to 325 g of anemarrhena, 275 to 325 g of Chinese yam, 350 to 400 g of trichosanthes root, 220 to 270 g of Chinese magnoliavine, 125 to 175 g of chicken's gizzard membrane and 260 to 310 g of corn silk. The preparation method comprises the following steps: weighing the bulk drugs according to a weight ratio, carrying out micro grinding, ethanol reflux extraction, water decoction and filtration on the bulk drugs, merging soup, carrying out condensation, uniform mixing, drying and ultramicro grinding on the merged soup so as to obtain main drug submicron powder and uniformly mixing the submicron powder with accessories so as to prepare dispersing tablets or slow release pellets.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of diabetes, the Chinese patent medicine that the Chinese herbal medicine of specifically take is prepared as raw material.The invention still further relates to the preparation method of this medicine.
Background technology
Diabetes be one group due to insulin secretion and (or) effect defect cause, take that chronic blood glucose increases the metabolic disease as feature.Various complication due to it have become that patient is disabled, the one of the main reasons of premature death.The death toll causing at developed country's diabetic complication is after cardiovascular and cerebrovascular disease, cancer, to be listed as the 3rd.Up to now, diabetes remain a kind of disease that is difficult to one-time cure, and except patient controls with diet and exercise therapy, oral antidiabetic drug is occupied very consequence in the treatment of diabetes, and approximately 70% diabetics needs the treatment of long-term taking antidiabetic drug.
Diabetics there will be metabolism of blood glucose and metabolism disorder of blood lipid mostly, and due to the glycolysis of liver, the approach such as the synthetic and raw fat effect of glycogen are difficult for starting, and are obstructed in blood glucose outlet.New oral hypoglycemic constantly goes on the market, and for clinical treatment provides condition, also to rational use of drug, brings certain difficulty.Reasonable selection orally-taken blood sugar reducing medicine, significant for prevention and minimizing adverse effect.Therefore, develop a kind of toxic and side effects little, convenient oral, the Chinese medicine novel form hypoglycemic medicine that bioavailability is high, very urgent, very important in order to treat the complication of the diabetes such as diabetes and pedopathy, nephropathy, oculopathy, encephalopathy, heart disease.
Summary of the invention
One of the object of the invention is to provide a kind ofly can treat the medicine of diabetes significantly, stably; Guarantee that this medicine also has definite, controlled therapeutical effect to treatment diabetes and complication thereof.
Two of the object of the invention is to provide a kind of novel form for the treatment of diabetes medicament--the preparation method of dispersible tablet, the preparation technology of this dosage form selects novel disintegrating agent and diluent to prepare and absorb Chinese medicine (rapid release) preparation fast, bioavailability is high with reference to the design philosophy of rapidly disintegrating formulation, and the Chinese medicine research of Zhe Jiangdui China and exploitation produce significant impact.
Three of the object of the invention is to provide a kind of novel form for the treatment of diabetes medicament--the preparation method of slow-release micro-pill, the preparation technology of this dosage form is simple, for raising Chinese Herbs, raising bioavailability, release, stablize, promote new drug development and promote the modernization of Chinese medicine to there is immeasurable effect, there is good scientific research and application prospect.
The object of the present invention is achieved like this, and medicine of the present invention is to be made by the crude drug of following weight proportion:
Radix Ginseng 130-180g, Radix Astragali 425-475g, Cortex Lycii 730-780g,
Radix Puerariae 275-325g, Rhizoma Anemarrhenae 275-325g, Rhizoma Dioscoreae 275-325g,
Radix Trichosanthis 350-400g, Fructus Schisandrae Chinensis 220-270g, Endothelium Corneum Gigeriae Galli 125-175g,
Stigma Maydis 260-310g.
1. the method for, the medicine of said ratio being made to dispersible tablet is: ginseng submicron powder is broken; Radix Puerariae, Fructus Schisandrae Chinensis add 75% alcohol reflux three times, and each 1.5 hours, merge extractive liquid,, filtered, and medicinal liquid is standby; The Radix Astragali, Cortex Lycii, the Rhizoma Anemarrhenae, Rhizoma Dioscoreae, Radix Trichosanthis, Endothelium Corneum Gigeriae Galli and Stigma Maydis decoct with water three times, and each 1.5 hours, merge decoction liquor, filter; Merge with above-mentioned medicinal liquid, be concentrated into relative density 1.35-1.37(60 ℃) clear paste, add ginseng submicron powder, mix, dry, micronizing, obtain principal agent superfine powder, mix with calcium sulfate, with 10% PVP K30 aqueous solution, make binding agent, granulate, dry, add crospolyvinylpyrrolidone, tween 80, micropowder silica gel, mix, make dispersible tablet, obtain.
2. the preparation method of, the medicine of said ratio being made to slow-release micro-pill is: Radix Ginseng powder is broken into fine powder; Radix Puerariae, Fructus Schisandrae Chinensis add 75% alcohol reflux three times, and each 1.5 hours, merge extractive liquid,, filtered; The Radix Astragali, Cortex Lycii, the Rhizoma Anemarrhenae, Rhizoma Dioscoreae, Radix Trichosanthis, Endothelium Corneum Gigeriae Galli and Stigma Maydis decoct with water three times, each 1.5 hours, merge decoction liquor; Merge with said extracted liquid, be concentrated into relative density 1.35-1.37(60 ℃) clear paste, add Radix Ginseng fine powder, winner's ointment powder, adds microcrystalline Cellulose, mixes, and adds adhesive soft material processed, makes micropill, wraps slow release film-coat, obtains.
Dispersible tablet adjuvant is equipped with calcium sulfate 30-50%(filler), crospolyvinylpyrrolidone 4-8%(disintegrating agent), 10% PVP K30 aqueous solution 2-6%(adhesive), tween 80 0.2-0.6%(surfactant), micropowder silica gel 2-6%(lubricant); Micropill adjuvant is equipped with microcrystalline Cellulose 20%-40%.
Wherein the interpolation quantity of adjuvant be the weight of principal agent superfine powder/principal agent cream powder of obtaining be basis.
Described dispersible tablet, every heavy 0.6g, 12 of every plates, every box 2 plates; Instructions of taking: every day 3 times, each 2-4 sheet.
Described slow-release micro-pill, 0.2g*12 grain/0.125*24 grain; Instructions of taking: every day 3 times, each 4/8.
Medicine of the present invention has the following advantages and good effect:
1, medicine of the present invention can effectively reduce blood glucose, regulates the electrolyte disturbance of health, recovers function, improve complication, liver and kidney tonifying, slakes thirst and help produce saliva, for the treatment of non-insulin-dependent diabetes mellitus (type Ⅱdiabetes mellitus), be mainly manifested in and emphasize equilibrium between yin and yang, integrally-regulated, thus reach recovery pancreatic function, play dual regulation, both blood sugar lowering, can prevent hypoglycemia again.
2, herbal mixture dispersible tablet formulation of the present invention can significantly strengthen its blood sugar reducing function, and reduces its consumption and toxic and side effects, in treatment diabetes, can effectively reduce the generation of its complication.
3, herbal mixture sustained-release pellet preparation of the present invention, can be steady, lasting release medicine, and when improving bioavailability, slowly release more can alleviate toxic and side effects and the zest to human body.
clinical data
Physical data: this group patient is the 10 routine diabeticss that hospital receives treatment, without matched group.
Treatment group patient's 10 examples, wherein man, each 5 examples of female.Maximum 75 years old age, minimal ages 37 years old, 54.5 years old mean age, the elder of the course of disease 13 years, the shortest person half a year.
Diagnostic criteria: adopt blood sample, urine sample analyzer is measured, the diabetes diagnosis newest standards of formulating with reference to country: 1, have classical symptom, fasting glucose >=7.0 mmol/l or post-prandial glycemia >=11.1 mmol/l; 2, there is no classical symptom, only fasting glucose >=7.0 mmol/l or post-prandial glycemia >=11.1 mmol/l should repeat once again, still reach above value person, can be diagnosed as diabetes; 3, there is no classical symptom, only fasting glucose >=7.0 mmol/l or post-prandial glycemia >=11.1 mmol/l carbohydrate tolerance are tested 2 hours blood glucose >=11.1 mmol/l persons, can be diagnosed as diabetes.
Treatment standard: a kind of hypoglycemic medicine is oral, one month is a course for the treatment of, and check blood glucose and urine sugar level should decline, and continues to take rear blood glucose and urine sugar level and should reach the national arm's length standard of formulating.
Clinic control: euglycemia, the urine sugar level that after taking medicine, blood glucose and urine sugar level return to national regulation is decided to be effective, after taking medicine, blood glucose and urine sugar level decline and are decided to be improvement, after taking medicine the index of blood glucose and glucose in urine without change, be decided to be invalid.
The therapeutic outcome of this group clinical case: obvious effective rate 93%, takes a turn for the better 7%, clinical total effective rate 100%.
clinical case
Case 1 patient's Records of the Historian, man, 49 years old, live young road, Kuancheng District, Changchun, Jilin, ill 5 years, facial area and edema of pair of lower extremities, routine urianlysis: urine protein (++～+++) is simultaneously poor with diet, and complexion is not good enough, the dizzy symptom such as weak.Local doctor informs and should not use sulphanylureas and biguanide antidiabetic medicament again, in order to avoid make impaired renal function.Therefore start to take medicine of the present invention in August, 06, the two weeks of taking medicine, edema phenomenon disappears.Take medicine a course for the treatment of (one month), polydipsia, polyuria, the transference cure of eating more, body weight increases 5kg.Result of laboratory test: blood glucose 7.5 mmol/L, glucose in urine (+-).Continue to take medicine two months, result: blood glucose is down to 5.0 mmol/L, glucose in urine (-), drug withdrawal, keeps on a diet.
Case 2 patient Wang Nan, female, 55 years old, live near Ya Tai street, Changchun, Jilin, ill 11 years, routine urianlysis: urine protein (+++), three-many-one-little, simultaneously with retinal hemorrhage, the dizzy symptom such as weak.Start to take medicine of the present invention in February, 09, takes medicine 10 days, and amount of drinking water reduces, and voided volume reduces.Take medicine a course for the treatment of (one month), retinal hemorrhage phenomenon disappears.Result of laboratory test: blood glucose 7.0 mmol/L, glucose in urine (+-).Continue to take medicine two months, result: blood glucose is down to 5.2 mmol/L, glucose in urine (-), suspends drug withdrawal, diet control.
Case 3 patient Wang Shanshan, female, 42 years old, live near the Jilin University of Changchun, Jilin, in June, 2010, doctor was diagnosed as type Ⅱdiabetes mellitus, blood glucose: 6.2 mmol/L, glucose in urine: (+-), subjective symptoms: xerostomia, polydipsia, night frequent micturition, polyphagia, easily starve, do not take medicine always, by diet control, but blood glucose is still higher, and clinical symptoms loses.Within 2010, JIUYUE starts to take medicine of the present invention on 25th, serve on 20 days, and subjective symptoms all disappears, and through chemical examination blood glucose 5.6 mmol/L, glucose in urine (-), serve on after one month, by diet control, had reached clinical recovery.
Case 4 patient Li Qiangs, man, 69 years old, live Dehui City, Jilin Province, conscious polydipsia at the beginning of 2006, appetite increases, hunger, frequent micturition.In JIUYUE, 2006 inspection: blood glucose 9.3 mmol/L, glucose in urine (+-), through glucose tolerance test, be diagnosed as type Ⅱdiabetes mellitus.Diet control before this, clinical symptoms is without obvious change.On January 21st, 2009 starts to take medicine of the present invention, and after the course for the treatment of, subjective symptoms all disappears, through chemical examination blood glucose 6.0 mmol/L, glucose in urine (-), the clinical recovery from illness standard that reaches.
The high hypo of case 5 patient, man, 75 years old, lives Jilin, Jilin Province, suffer from diabetes 13 years, once took multiple Chinese and Western hypoglycemic medicine, it is unstable that some Western medicine are taken rear blood glucose, fluctuated, often occur hypoglycemia, informal dress is large with Western medicine side effect, has Drug resistance, takes some Chinese medicine hypoglycemic effects not good.Chemically examine blood glucose 12.3 mmol/L in February, 2000, glucose in urine (+++), takes 2 of the medicines of the present invention blood glucose course for the treatment of and is down to 5.8 mmol/L, and glucose in urine (-), reaches arm's length standard, and doctor's advice is strictly kept on a diet.
Case 6 patient Zhang Nan, female, 37 years old, live near Chongqing road, Changchun City, suffer from diabetes half a year, occurred before this serious xerostomia, happiness drink, frequent micturition, after take Chinese medicine decoction one month, cause stomachache, cut out Chinese medicine latter two month, chemical examination blood glucose reaches 8.5 mmol/L, and three-many-one-little symptom increases the weight of.Now take a course for the treatment of of medicine of the present invention, chemical examination blood glucose reaches normal level, three-many-one-little transference cure, and the after treatment in month that continues to take medicine, doctor's advice is careful in one's diet.
Case 7 patient's Liu Lilis, female, 56 years old, live Changchun City, suffer from diabetes medical history 7 years, 2004 ill, at that time assay: blood glucose 8.3 mmol/L, glucose in urine (++), take medicine two weeks of the present invention, blood glucose is down to 5.3 mmol/L, glucose in urine (-), again take two weeks and consolidate curative effect, reach criterion of cure.
Case 8 patient Nan Youhai, man, 59 years old, live near street, Silicon Valley, Changchun City, within 2009, suffer from inspection type Ⅱdiabetes mellitus, blood glucose 9.8 mmol/L, glucose in urine (++), merging neuralgia, body void is weak, skelalgia, starts to take medicine of the present invention after ill, takes continuously 2 courses for the treatment of, conscious various pain disappears, chemical examination blood glucose 5.8 mmol/L of hospital, glucose in urine (-), doctor advised drug withdrawal, dietary adjustments.
9 patients are fragrant the first month of autumn for case, female, 62 years old, live Changchun City, 95 years are ill, through doctor's result of laboratory test: and blood glucose 11.5 mmol/L, glucose in urine (++), take for many years Western medicine always, after take again Chinese medicine decoction two weeks, under the weather cutting out, after take 3 courses for the treatment of of medicine of the present invention, blood glucose is down to 6.5 mmol/L, after the course for the treatment of of continuing to take medicine, changes dietary adjustments into.
Case 10 patient Cai Yongjiu, man, 41 years old, live Jiutai City, Jilin Province, 2008 the year end assay, blood glucose 8.9 mmol/L, glucose in urine (+-), through glucose tolerance test, is diagnosed as type Ⅱdiabetes mellitus.Start to keep on a diet, do not take medicine, clinical symptoms increases the weight of, and again checks blood glucose 9.5 mmol/L, glucose in urine (++), start to take medicine of the present invention in June, 2009, and after the course for the treatment of, felling ailments oneself disappears, chemical examination blood glucose 5.5 mmol/L, glucose in urine (-), the clinical recovery from illness index that reaches, suggestion is kept on a diet, assisted movement.
The specific embodiment
embodiment 1
Weighting raw materials Radix Ginseng 130g in proportion, Radix Astragali 425g, Cortex Lycii 730g, Radix Puerariae 275g, Rhizoma Anemarrhenae 275g, Rhizoma Dioscoreae 275g, Radix Trichosanthis 350g, Fructus Schisandrae Chinensis 220g, Endothelium Corneum Gigeriae Galli 125g, Stigma Maydis 260g.
Dispersible tablet adjuvant adds quantity take and obtain principal agent superfine powder weight as basis, adds calcium sulfate 30%, crospolyvinylpyrrolidone 4%, 10% PVP K30 aqueous solution 2%, tween 80 0.2%, micropowder silica gel 2%.Micropill adjuvant adds quantity take and obtain principal agent cream grain weight amount as basis, adds microcrystalline Cellulose 20%.
Dispersible tablet processed: above-mentioned ginseng submicron powder is broken; Radix Puerariae, Fructus Schisandrae Chinensis add 75% alcohol reflux three times, and each 1.5 hours, merge extractive liquid,, filtered, and medicinal liquid is standby; The Radix Astragali, Cortex Lycii, the Rhizoma Anemarrhenae, Rhizoma Dioscoreae, Radix Trichosanthis, Endothelium Corneum Gigeriae Galli and Stigma Maydis decoct with water three times, and each 1.5 hours, merge decoction liquor, filter; Merge with above-mentioned medicinal liquid, be concentrated into relative density 1.35(60 ℃) clear paste, add ginseng submicron powder, mix, dry, micronizing, principal agent superfine powder 225g, therefrom precision takes 100g and calcium sulfate 30g mixes, and with 10% PVP K30 aqueous solution 2g, makes binding agent, granulate, dry, add crospolyvinylpyrrolidone 4g, tween 80 0.2g, micropowder silica gel 2g, mix, make dispersible tablet, obtain.Above-mentioned tablet, every heavy 0.6g.
Slow-release micro-pill processed: above-mentioned Radix Ginseng powder is broken into fine powder; Radix Puerariae, Fructus Schisandrae Chinensis add 75% alcohol reflux three times, and each 1.5 hours, merge extractive liquid,, filtered; The Radix Astragali, Cortex Lycii, the Rhizoma Anemarrhenae, Rhizoma Dioscoreae, Radix Trichosanthis, Endothelium Corneum Gigeriae Galli and Stigma Maydis decoct with water three times, each 1.5 hours, merge decoction liquor; Merge with said extracted liquid, be concentrated into relative density 1.35(60 ℃) clear paste, add Radix Ginseng fine powder, the ointment powder 245g of winner, therefrom precision takes 100g and adds microcrystalline Cellulose 20g, mixes, and adds adhesive soft material processed, makes micropill, wraps slow release film-coat, obtains.Above-mentioned micropill, 0.2g*10 grain/0.125*20 grain.
embodiment 2
Weighting raw materials Radix Ginseng 140g in proportion, Radix Astragali 435g, Cortex Lycii 740g, Radix Puerariae 285g, Rhizoma Anemarrhenae 285g, Rhizoma Dioscoreae 285g, Radix Trichosanthis 360g, Fructus Schisandrae Chinensis 230g, Endothelium Corneum Gigeriae Galli 135g, Stigma Maydis 270g.
Dispersible tablet adjuvant adds quantity take and obtain principal agent superfine powder weight as basis, adds calcium sulfate 40%, crospolyvinylpyrrolidone 6%, 10% PVP K30 aqueous solution 4%, tween 80 0.4%, micropowder silica gel 4%; Micropill adjuvant adds quantity take and obtain principal agent cream grain weight amount as basis, adds microcrystalline Cellulose 30%.The method for making of its dispersible tablet and slow-release micro-pill is with embodiment 1.
embodiment 3
Weighting raw materials Radix Ginseng 150g in proportion, Radix Astragali 445g, Cortex Lycii 750g, Radix Puerariae 295g, Rhizoma Anemarrhenae 295g, Rhizoma Dioscoreae 295g, Radix Trichosanthis 370g, Fructus Schisandrae Chinensis 240g, Endothelium Corneum Gigeriae Galli 145g, Stigma Maydis 280g.
Dispersible tablet adjuvant adds quantity take and obtain principal agent superfine powder weight as basis, adds calcium sulfate 50%, crospolyvinylpyrrolidone 8%, 10% PVP K30 aqueous solution 6%, tween 80 0.6%, micropowder silica gel 6%; Micropill adjuvant adds quantity take and obtain principal agent cream grain weight amount as basis, adds microcrystalline Cellulose 40%.The method for making of its dispersible tablet and slow-release micro-pill is with embodiment 1.
embodiment 4
Weighting raw materials Radix Ginseng 160g in proportion, Radix Astragali 455g, Cortex Lycii 760g, Radix Puerariae 305g, Rhizoma Anemarrhenae 305g, Rhizoma Dioscoreae 305g, Radix Trichosanthis 380g, Fructus Schisandrae Chinensis 250g, Endothelium Corneum Gigeriae Galli 155g, Stigma Maydis 290g.
Dispersible tablet adjuvant adds quantity take and obtain principal agent superfine powder weight as basis, adds calcium sulfate 30%, crospolyvinylpyrrolidone 4%, 10% PVP K30 aqueous solution 2%, tween 80 0.2%, micropowder silica gel 2%.Micropill adjuvant adds quantity take and obtain principal agent cream grain weight amount as basis, adds microcrystalline Cellulose 20%.
Dispersible tablet processed: above-mentioned ginseng submicron powder is broken; Radix Puerariae, Fructus Schisandrae Chinensis add 75% alcohol reflux three times, and each 1.5 hours, merge extractive liquid,, filtered, and medicinal liquid is standby; The Radix Astragali, Cortex Lycii, the Rhizoma Anemarrhenae, Rhizoma Dioscoreae, Radix Trichosanthis, Endothelium Corneum Gigeriae Galli and Stigma Maydis decoct with water three times, and each 1.5 hours, merge decoction liquor, filter; Merge with above-mentioned medicinal liquid, be concentrated into relative density 1.37(60 ℃) clear paste, add ginseng submicron powder, mix, dry, micronizing, obtain principal agent superfine powder, mix with calcium sulfate, with 10% PVP K30 aqueous solution, make binding agent, granulate, dry, add crospolyvinylpyrrolidone, tween 80, micropowder silica gel, mix, make dispersible tablet, obtain.Above-mentioned tablet, every heavy 0.6g.
Slow-release micro-pill processed: above-mentioned Radix Ginseng powder is broken into fine powder; Radix Puerariae, Fructus Schisandrae Chinensis add 75% alcohol reflux three times, and each 1.5 hours, merge extractive liquid,, filtered; The Radix Astragali, Cortex Lycii, the Rhizoma Anemarrhenae, Rhizoma Dioscoreae, Radix Trichosanthis, Endothelium Corneum Gigeriae Galli and Stigma Maydis decoct with water three times, each 1.5 hours, merge decoction liquor; Merge with said extracted liquid, be concentrated into relative density 1.37(60 ℃) clear paste, add Radix Ginseng fine powder, winner's ointment powder, adds microcrystalline Cellulose, mixes, and adds adhesive soft material processed, makes micropill, wraps slow release film-coat, obtains.Above-mentioned micropill, 0.2g*10 grain/0.125*20 grain.
embodiment 5
Weighting raw materials Radix Ginseng 170g in proportion, Radix Astragali 465g, Cortex Lycii 770g, Radix Puerariae 315g, Rhizoma Anemarrhenae 315g, Rhizoma Dioscoreae 315g, Radix Trichosanthis 390g, Fructus Schisandrae Chinensis 260g, Endothelium Corneum Gigeriae Galli 165g, Stigma Maydis 300g.
Dispersible tablet adjuvant adds quantity take and obtain principal agent superfine powder weight as basis, adds calcium sulfate 40%, crospolyvinylpyrrolidone 6%, 10% PVP K30 aqueous solution 4%, tween 80 0.4%, micropowder silica gel 4%; Micropill adjuvant adds quantity take and obtain principal agent cream grain weight amount as basis, adds microcrystalline Cellulose 30%.The method for making of its dispersible tablet and slow-release micro-pill is with embodiment 4.
embodiment 6
Weighting raw materials Radix Ginseng 180g in proportion, Radix Astragali 475g, Cortex Lycii 780g, Radix Puerariae 325g, Rhizoma Anemarrhenae 325g, Rhizoma Dioscoreae 325g, Radix Trichosanthis 400g, Fructus Schisandrae Chinensis 270g, Endothelium Corneum Gigeriae Galli 175g, Stigma Maydis 310g.
Dispersible tablet adjuvant adds quantity take and obtain principal agent superfine powder weight as basis, adds calcium sulfate 50%, crospolyvinylpyrrolidone 8%, 10% PVP K30 aqueous solution 6%, tween 80 0.6%, micropowder silica gel 6%; Micropill adjuvant adds quantity take and obtain principal agent cream grain weight amount as basis, adds microcrystalline Cellulose 40%.The method for making of its dispersible tablet and slow-release micro-pill is with embodiment 4.
Claims (1)
1. a dispersible tablet for the treatment of diabetes, is characterized in that: weighting raw materials Radix Ginseng 130g in proportion, Radix Astragali 425g, Cortex Lycii 730g, Radix Puerariae 275g, Rhizoma Anemarrhenae 275g, Rhizoma Dioscoreae 275g, Radix Trichosanthis 350g, Fructus Schisandrae Chinensis 220g, Endothelium Corneum Gigeriae Galli 125g, Stigma Maydis 260g;
Dispersible tablet adjuvant adds quantity take and obtain principal agent superfine powder weight as basis, adds calcium sulfate 30%, crospolyvinylpyrrolidone 4%, 10% PVP K30 aqueous solution 2%, tween 80 0.2%, micropowder silica gel 2%;
Dispersible tablet processed: above-mentioned ginseng submicron powder is broken; Radix Puerariae, Fructus Schisandrae Chinensis add 75% alcohol reflux three times, and each 1.5 hours, merge extractive liquid,, filtered, and medicinal liquid is standby; The Radix Astragali, Cortex Lycii, the Rhizoma Anemarrhenae, Rhizoma Dioscoreae, Radix Trichosanthis, Endothelium Corneum Gigeriae Galli and Stigma Maydis decoct with water three times, and each 1.5 hours, merge decoction liquor, filter; Merge with above-mentioned medicinal liquid, 60 ℃ of clear paste that are concentrated into relative density 1.35, add ginseng submicron powder, mix, dry, micronizing, obtain principal agent superfine powder 225g, therefrom precision takes 100g and calcium sulfate 30g mixes, and 10% PVP K30 aqueous solution 2g makes binding agent, granulates, dry, add crospolyvinylpyrrolidone 4g, tween 80 0.2g, micropowder silica gel 2g, mix, make dispersible tablet.
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| CN105998854A (en) * | 2016-07-24 | 2016-10-12 | 刘咏梅 | Medicine for treating diabetic nephropathy and preparation method |
| CN108498734A (en) * | 2018-07-05 | 2018-09-07 | 程庸堂 | A kind of Chinese prescription for treating diabetes |
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