CN105998854A - Medicine for treating diabetic nephropathy and preparation method - Google Patents

Medicine for treating diabetic nephropathy and preparation method Download PDF

Info

Publication number
CN105998854A
CN105998854A CN201610587385.5A CN201610587385A CN105998854A CN 105998854 A CN105998854 A CN 105998854A CN 201610587385 A CN201610587385 A CN 201610587385A CN 105998854 A CN105998854 A CN 105998854A
Authority
CN
China
Prior art keywords
parts
herba
medicine
rhizoma
saururi
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201610587385.5A
Other languages
Chinese (zh)
Inventor
刘咏梅
张小丽
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201610587385.5A priority Critical patent/CN105998854A/en
Publication of CN105998854A publication Critical patent/CN105998854A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/19—Acanthaceae (Acanthus family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/716—Clematis (leather flower)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/78—Saururaceae (Lizard's-tail family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/898—Orchidaceae (Orchid family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a medicine for treating diabetic nephropathy and a preparation method, and belongs to the field of traditional Chinese medicines. The effective composition of the medicine comprises the following raw materials: Herba Kalimeridis, Rhizoma Saururi, Rhizoma seu herba Asystasiellae Chinensis, Radix Oplopanacis Elati, Herba Calystegiae Japonicae, Herba Peristrophis Roxburghianae, Radix Astragali, Herba Melicae Scabrosae, Melica scabrosa Trin., Resina persicae, Exocarpium Citrulli, Herba Medicaginis, Cephalanthera ereota (Thunb.) Blume., Rhizoma Polliae Japonicae, Folium ulmi pumilae and Caulis Clematidis Armandii. The selected medicinal materials of the medicine are compatible suitably, supplement with one another, and have effects of invigorating Qi and nourishing blood, nourishing the kidney and replenishing essence, tonifying the liver and kidney and the like; the various medicinal materials are combined, the efficacy can directly reach a diseased region; the medicine has the advantages of fast curative effect, high cure rate, zero toxic and side effects, safety and convenience on treatment of symptoms such as paratrichosis, alopecia universalis, severe epilation during hair combing or hair washing, hair loss and hypotrichosis which are caused by the diabetic nephropathy, is low in price and easy to prepare, and is worthy of being widely popularized and used clinically.

Description

A kind of medicine for treating diabetic nephropathy and preparation method
Art
The present invention relates to the field of Chinese medicines, particularly relate to a kind of medicine for treating diabetic nephropathy and preparation method.
Background technology
Diabetic nephropathy (DN) is clinical common and multiple diabetic complication.Be complication that diabetes are the most serious it One, diabetic nephropathy is the microvascular complication that diabetes are main, refers mainly to diabetic glomerulosclerosis, a kind of with blood vessel Infringement is main Glomerular lesions.
Much the most asymptomatic, blood pressure can be normal or higher.Its incidence rate extends along with the course of disease of diabetes and increases.Glycosuria Sick kidney volume in early days increases, and glomerular filtration rate increases, and filters state in height, engenders that space protein urine or trace are white later Albuminuria, along with the prolongation of the course of disease occurs continuing albuminuria, edema, hypertension, glomerular filtration rate reduction, and then renal function is not Entirely, uremia, be one of main cause of death of diabetes.
Diabetic nephropathy can cause glomerular sclerosis, thus causes uremia.For diabetic nephropathy patient, typically hold Being susceptible to suffer from a kind of nephropathy is " glomerulosclerosis ", if the glomerule of patient hardens phenomenon, refuse then has no way of draining, Ultimately result in diabetic urine toxication.Diabetic nephropathy can cause cystitis, pyelitis.Diabetes patient, especially controls bad Patient, owing to the phagocytosis of antibacterial is gone down by leukocyte, to antibacterial invade resistance poor, be therefore susceptible to bladder Scorching.If antibacterial is extended up by bladder, or with blood circulation to kidney, is all likely to result in the bacterial infection of kidney, most common Be exactly pyelitis, this is for repetitious acute inflammation, if antibacterial is not eradicated, it is possible to be changed into chronic Inflammation, produces corrosiveness at leisure to the function of kidney and bladder.Diabetic nephropathy can cause inertia of bladder, thus causes bladder Scorching.Inertia of bladder, is the problem of common puzzlement diabetic nephropathy patients undergoing, generally extends during obtaining diabetes, especially glycosuria The patient that sick control is bad, due to the obstacle of local nerve so that the action of muscles controlling bladder contraction is malfunctioning.Inertia of bladder, Often making urine cannot get rid of totally, and produce urine and store, antibacterial then easily breeds in the urine be reserving at bladder, with Cause causes cystitis.
Control diabetic nephropathy at present and mainly have western medicine, western medicine instant effect, but the secondary work of long-term taking Western medicine With bigger.To this end, we are badly in need of developing a kind of medicine to help patient to break away from the misery that diabetic nephropathy brings.
Summary of the invention
The invention provides a kind of medicine for treating diabetic nephropathy and preparation method；Medical material selected by medicine of the present invention Compatibility is suitable, bring out the best in each other, and has the effects such as benefiting qi and nourishing blood, Zishen fill fine, liver and kidney tonifying, and all medicines drug effect that is harmonious can be gone directly pathological changes Position, for treatment diabetic nephropathy cause paratrichosis, alopecia universalis, comb one's hair or wash hair time alopecia increase, chaeta come off, The symptoms such as oligotrichosis have instant effect, cure rate is high, have no side effect, the advantage of safe ready, and low price, easily make Standby, wide popularization and application on clinic.
For achieving the above object, technical scheme is implemented as follows:
A kind of medicine for treating diabetic nephropathy, makes raw material composition and the parts by weight of described effective ingredient For:
Make described effective ingredient raw material composition and parts by weight be:
Make described effective ingredient raw material composition and parts by weight be:
Make described effective ingredient raw material composition and parts by weight be:
The preparation method of a kind of medicine for treating diabetic nephropathy, comprises the following steps that:
(1) Herba Kalimeridis and Rhizoma seu herba Asystasiellae Chinensis are smash juice, filter, stay juice standby；
(2) by Rhizoma Saururi (Herba Saururi), Radix Oplopanacis Elati, Herba Calystegiae Japonicae, Herba Peristrophis Roxburghianae, Herba Melicae Scabrosae, Melica scabrosa Trin., Resina persicae, Exocarpium Citrulli, Cephalanthera ereota (Thunb.) Blume., Folium Bambusae Lotus, Folium ulmi pumilae and Caulis Clematidis Armandii are put in container, are firstly added 10-15 times amount distilled water immersion after 4-5 hour, and heated and boiled 3-4 is little Time, extract；Second time adds 8-10 times amount distilled water heated and boiled 2-3 hour, extracts；Third time adds the heating of 6-8 times amount distilled water Boil 1-2 hour, extract；United extraction liquid, filters, obtains filtrate standby；
(3) Herba Medicaginis is dried grind into powder, obtained the fine powder of 180 mesh, standby；
(4) Radix Astragali is run through, cut sheet, be dried, grind into powder, obtained the fine powder of 160 mesh, standby；
(5) juice, filtrate and the fine powder mixing that step (1)-step (4) prepares, makes tablet, is described for controlling Treat the medicine of diabetic nephropathy.
The property of medicine of Chinese medicine used by the present invention is as follows:
Herba Kalimeridis: acrid in the mouth, cool in nature；Return lung, liver, stomach, large intestine channel.Cooling blood for hemostasis, clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling.Main haematemesis, nosebleed Blood, dysentery, metrorrhagia, wound hemorrhage, jaundice, edema, stranguria with turbid discharge, flu, cough, pharyngalgia sore throat, hemorrhoid, carbuncle, erysipelas, children's's infantile malnutrition Long-pending." Traditional Chinese Medicine in Sichuan will " carries: " help digestion long-pending glutted and breast knot flatulence, dehumidifying heat, and diuresis is brought down a fever, and cough-relieving is coughed, removing toxic substances, controls Serpentis Wound.”
Rhizoma Saururi (Herba Saururi): bitter in the mouth, pungent, cold in nature；Return lung, spleen, stomach, large intestine channel.Clearing away heat and promoting diuresis, removing toxic substances and promoting subsidence of swelling.Main pyretic stranguria, stranguria with blood, Edema, tinea pedis, jaundice, dysentery, leukorrhagia, carbuncle sore tumefacting virus, eczema, venom." south of the Five Ridges gather medicinal herbs record " carries: " control stranguria with turbid discharge, diuresis, Disappear pyretic toxicity.”
Rhizoma seu herba Asystasiellae Chinensis: bitter in the mouth, light, cool in nature；Return lung meridian.Removing stasis to stop bleeding, reunion of fractured tendons and bones, inducing diuresis to remove edema, heat-clearing and toxic substances removing.Master tells Blood, has blood in stool, traumatic hemorrhage, traumatic injury congestive edema, sprain fracture, and rheumatism limb swells, and ascites, skin infection festers, furuncle and phyma, laryngopharynx swelling and pain." Zhejiang Conventional medical herbs among the people " carry: " heat-clearing and toxic substances removing, promoting blood circulation and hemostasis.Controlling traumatic hemorrhage, sprain, furuncle and phyma, ulcer of the lower limb, ascites, lung is tied Core.”
Radix Oplopanacis Elati: sweet in the mouth, micro-hardship, warm in nature.QI invigorating is supporing yang, cough-relieving dredging collateral.Main deficiency of vital energy and physically weak, spiritlessness and weakness, aversion to cold and cold limbs, Sexual impotence, void coughs chronic cough, anemofrigid-damp arthralgia, diabetes, hypertension." Jilin Chinese herbal medicine " carries: " antipyretic, antitussive.”
Herba Calystegiae Japonicae: sweet in the mouth, cold in nature；Return spleen, stomach, large intestine, small intestine meridian.Removing heat from the liver, YIN nourishing, diuresis.Main excessive rising of liver-YANG, head Dizzy, dizzy, dysuria." Luchuan book on Chinese herbal medicine " carries: " diuresis, removing toxic substances, antiinflammatory.Control children's's skin impetigo, dysentery.”
Herba Peristrophis Roxburghianae: sweet in the mouth, light, cool in nature.Clearing away lung-heat to relieve cough, dissipating blood stasis stops blooding.For hemoptysis of pulmonary tuberculosis, pneumonia, diabetes, external Control traumatic injury to swell and ache." conventional Chinese herbal medicine color atlas " carries: " clearing away lung-heat, cough-relieving.Control cough with copious phlegm, internal injury hemoptysis.”
The Radix Astragali: warm in nature, sweet in the mouth.Invigorating QI to consolidate the body surface resistance, expelling pus and toxin by strengthening QI, diuresis granulation promoting.Weak for the deficiency of vital energy, chronic diarrhea proctoptosis, spontaneous perspiration, Edema, sub-official prolapses, chronic nephritis proteinuria, diabetes, the long disunion of the open sore part.Modern medicine study confirms, Radix Astragali grinds End adds feedstuff and feeds 3 to rat, has the effect preventing Jishengshenqiwan.
Herba Melicae Scabrosae: bitter in the mouth, cold in nature.Heat-clearing and toxic substances removing, cooling blood for hemostasis, dampness removing.Main calentura excessive thirst, spits blood, epistaxis, hemoptysis, urine Blood, metrorrhagia, jaundice, edema, stranguria with turbid discharge leukorrhagia, dysentery, children's's infantile malnutrition with fever, furuncle carbuncle." soft science in China medicinal plants " carries: " relieving stranguria by diuresis, heat clearing away.Control urinary tract infection, oedema due to nephritis, cat fever, icterohepatitis, diabetes.”
Melica scabrosa Trin.: sweet in the mouth, cool in nature.Inducing diuresis for treating stranguria syndrome, heat clearing away jaundice eliminating.Main urinary tract infection, oedema due to nephritis, cold, fever, jaundice Type hepatitis, diabetes.
Resina persicae: sweet in the mouth, hardship, property is put down；Return large intestine, bladder warp.And blood, treating stranguria, dysentery relieving.Main stranguria caused by urinary stone, stranguria with blood, dysentery, stomachache, Diabetes, chyluria." herbal classic is met former " carries: " peach tree gluing, making body fluid flow freely, can control stranguria with blood, stranguria caused by urinary stone.Variola is black to be fallen into, and invincible cream is used It.”
Exocarpium Citrulli: sweet in the mouth, cool in nature；GUIXIN, stomach, bladder warp.Heat clearing away, quenches one's thirst, diuresis.Main summer-heat excessive thirst, oliguria, water Swollen, aphtha of the mouth and tongue." modern Practical Chinese medicinal " carries: " for diuretic.Control nephritis edema, diabetes, jaundice.And can alcoholic intoxication.”
Herba Medicaginis: bitter in the mouth, property is put down；Return spleen, stomach, kidney channel.Clear taste, clearing away damp-heat, inducing diuresis to remove edema.Main urinary stone, vesical calculus, Edema, stranguria, quench one's thirst." modern Practical Chinese medicinal " carries: " control uric acid vesical calculus.”
Cephalanthera ereota (Thunb.) Blume.: sweet in the mouth, light, cool in nature；Return kidney, bladder warp.Clearing away heat and promoting diuresis.Main high heat, thirsty, dysuria." Xinhua's book on Chinese herbal medicine Outline " carry: " herb: have the function of clearing away heat and promoting diuresis.For hyperpyrexia, xerostomia, urinary obstruction.”
Rhizoma Polliae Japonicae: mildly bitter flavor, cool in nature.Clearing away heat and promoting diuresis, removing toxic substances and promoting subsidence of swelling.Main yellowish or reddish urine, pyretic stranguria, furuncle carbuncle furuncle and phyma, snakeworm stings Wound." Hunan medicine will " carries: " rhizome: support kidney, tonifying YIN.”
Folium ulmi pumilae: sweet in the mouth, property is put down.Clearing away heat and promoting diuresis, calms the nerves, expelling phlegm for arresting cough.Main edema, dysuria, stranguria caused by urinary stone, turbid urine, insomnia, Summer-heat is stranded vexed, and abundant expectoration is coughed, wine (looking into skin) nose." Treatise on Dietetic Therapy " carries: " diuresis, main stranguria caused by urinary stone.”
Caulis Clematidis Armandii: hardship lightly seasoned, micro-, cold in nature；GUIXIN, small intestinal, bladder warp.Clearing away heat and promoting diuresis, stimulating milk secretion of stimulating the menstrual flow.The main damp and hot difficulty in urination, Edema, stranguria, the aphtha of the mouth and tongue of flaming up of heart-fire, damp and hot arthralgia pain, articular instability, married woman's amenorrhea, galactostasis." Traditional Chinese Medicine in Sichuan will " Carry: " diuretic, heat clearing away, promoting blood circulation.Control nephropathy edema, acute nephritis dysuria, the damp and hot difficulty in urination, gonorrhea, women's amenorrhea and breast Close.”
The present invention compared with prior art, has the advantages that
Selected by medicine of the present invention, medical material compatibility is suitable, bring out the best in each other, and has benefiting qi and nourishing blood, Zishen fill fine, liver and kidney tonifying etc. Effect, all medicines drug effect that is harmonious can go directly diseased region, paratrichosis, alopecia universalis that treatment diabetic nephropathy is caused, comb one's hair or During hair washing, alopecia increases, chaeta comes off, the symptom such as oligotrichosis has instant effect, cure rate is high, have no side effect, safety Advantage, and low price easily, easily prepares, wide popularization and application on clinic.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
The raw material of effective ingredient of the present invention forms and weight is:
The processing step of process for preparing medicine of the present invention is:
(1) Herba Kalimeridis and Rhizoma seu herba Asystasiellae Chinensis are smash juice, filter, stay juice standby；
(2) by Rhizoma Saururi (Herba Saururi), Radix Oplopanacis Elati, Herba Calystegiae Japonicae, Herba Peristrophis Roxburghianae, Herba Melicae Scabrosae, Melica scabrosa Trin., Resina persicae, Exocarpium Citrulli, Cephalanthera ereota (Thunb.) Blume., Folium Bambusae Lotus, Folium ulmi pumilae and Caulis Clematidis Armandii are put in container, are firstly added 10-15 times amount distilled water immersion after 4-5 hour, and heated and boiled 3-4 is little Time, extract；Second time adds 8-10 times amount distilled water heated and boiled 2-3 hour, extracts；Third time adds the heating of 6-8 times amount distilled water Boil 1-2 hour, extract；United extraction liquid, filters, obtains filtrate standby；
(3) Herba Medicaginis is dried grind into powder, obtained the fine powder of 180 mesh, standby；
(4) Radix Astragali is run through, cut sheet, be dried, grind into powder, obtained the fine powder of 160 mesh, standby；
(5) juice, filtrate and the fine powder mixing that step (1)-step (4) prepares, makes tablet, is described for controlling Treat the medicine of diabetic nephropathy.
Usage and dosage: oral, every day 2 times, each 2,15 days is a course for the treatment of, can fully recover 2 to 4 courses for the treatment of, the state of an illness is tight Severe one is followed the doctor's advice the meal with wine amount of adding.
Embodiment 2
The raw material of effective ingredient of the present invention forms and weight is:
The process for preparing medicine processing step of the present embodiment and usage and dosage are same as in Example 1.
Embodiment 3
The raw material of effective ingredient of the present invention forms and weight is:
The process for preparing medicine processing step of the present embodiment and usage and dosage are same as in Example 1.
Embodiment 4
The raw material of effective ingredient of the present invention forms and weight is:
The process for preparing medicine processing step of the present embodiment and usage and dosage are same as in Example 1.
Clinical data:
1, case selection:
Selecting the diabetic nephropathy patient 280 example clinical observation that my institute or outer court make a definite diagnosis, patient is randomly divided into two groups, treatment Organize 140 examples, age 25-70 year, wherein male 70 example, women 70 example, 43.2 years old mean age, course of disease 1-10；Matched group 140 Example, wherein male 70 example, women 70 example, age 25-70 year, 41.6 years old mean age, course of disease 1-10.The disease of two groups of cases Journey, degrees of symptoms are basically identical, without significant difference, have comparability.
2, medicament selection:
Treatment group patient takes medicine of the present invention, every day 2 times, each 2, warm water delivery service in half an hour after meal, 15 days Being a course for the treatment of, take 2 to 4 courses for the treatment of continuously and can fully recover, the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
Matched group takes sugar fall Shenkang granule, and by specification use, the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
3, efficacy determination:
(1) cure: the lower part of the body is lossless or hypohidrosis, cylinderuria, yang-deficiency constitution, neonate albuminuria, carbohydrate tolerance reduction, ketone The transference cures such as urine, nail growth are slow, the rising of excessive thirst polydipsia, blood glucose, ketoacidosis, physical recovery is normal.
(2) effective: above-mentioned symptom has been alleviated.
(3) invalid: disease is unchanged.
4, result:
Taking in the treatment group of medicine of the present invention, cure 102 examples, effective 35 examples, invalid 3 examples, cure rate is 72.9%, always Effective percentage 97.9%.
Curing 40 examples, effective 45 examples, invalid 55 examples in matched group, cure rate is 28.6%, total effective rate 60.7%.
Result above shows, treatment group cure rate and total effective rate are apparently higher than matched group.
Model case is illustrated:
1, Ma, man, 66 years old, retired worker, people from Zhoushan, Guangdong.Patient was decreased obviously because of polydipsia, polyphagia body weight before 10 years, Go local hospital inspection find diabetes, after always oral drugs control blood glucose.Owing to patient keeps on a diet the most well, institute With poor blood glucose control.Before 2 years, starting the puffiness of the eyes occur, nocturia number of times increases, the most to our hospital, checks and is diagnosed as sugar The sick nephropathy of urine.After taking 2 courses for the treatment of of medicine of the present invention, health is clearly better；Continue to take 2 courses for the treatment of of medicine of the present invention, Physical recovery is normal, recovery from illness, follows up a case by regular visits to, does not recurs.
2, grandson, man, 60 years old, peasant, people from Taishan, Zhejiang.There is facial area and edema of pair of lower extremities in patient before half a year, urine is often Rule check, urine protein (+-++) is the most poor with diet, complexion is not good enough, the dizzy symptom such as weak.Control at local hospital After treatment, blood glucose tends to be steady, but edema has no improvement.After patient under the advice of relatives, to our hospital.Take this 2 courses for the treatment of of invention medicine, above-mentioned symptom takes a turn for the better；Continuing to take 3 courses for the treatment of of medicine of the present invention, physical recovery is normal, recovery from illness, with Visit, do not recur.
3, slowly certain, female, 45 years old, housewife, people from Cangzhou, Hebei.Patient suffers from diabetes more than 8, treats in locality, does not has Take a turn for the better；Before 1 year, occurred that retinal hemorrhage, vision are severely impacted.Introduce by friend and come my institute's treatment.When coming institute, suffer from Person's cardinal symptom is: body sleepiness power, is afraid of cold, poor binocular vision, edema of pair of lower extremities, and numbness of hands and feet, slightly activity are i.e. nervous, breast Vexed.Taking 2 courses for the treatment of of medicine of the present invention, above-mentioned symptom takes a turn for the better；After continuing to take 2 courses for the treatment of of medicine of the present invention, above-mentioned disease Shape disappears, recovery from illness, follows up a case by regular visits to, does not recurs.
4, certain is discriminated, female, 39 years old, Aquatic product company personnel, Nanping, Fujian people.There is anasarca, nauseating, appetite difference etc. in patient Symptom, to our hospital.It is diagnosed as according to medical history and procuratorial work: diabetic nephropathy, renal insufficiency, diabetic retinopathy. Taking 3 courses for the treatment of of medicine of the present invention, above-mentioned symptom takes a turn for the better；After continuing to take 2 courses for the treatment of of medicine of the present invention, above-mentioned symptom disappears Losing, physical recovery is normal, and recovery from illness is followed up a case by regular visits to, do not recurred.
5, leaf, man, 30 years old, accounting, people from Baicheng, Jilin.Patient existed because of the symptom such as Nausea and vomiting, abdominal discomfort before 2 years Diabetes are made a definite diagnosis in local hospital inspection, after start that blurred vision, edema occur, companion blood pressure increase, up to 210/150mmHg. Have urine examined routine: PRO3+, BLD-, urine protein 3+--4+, accepts the Drug therapys such as blood sugar lowering, blood pressure lowering, blood fat reducing, diuresis, and effect is failed to understand Aobvious.The most to our hospital.Taking 2 courses for the treatment of of medicine of the present invention, above-mentioned symptom takes a turn for the better；Continue to take medicine of the present invention 2 After the course for the treatment of, above-mentioned symptom disappears, and recovery from illness is followed up a case by regular visits to, do not recurred.
6, Xue, man, 25 years old, supermarket deliveryman, Baoshan, Yunnan people.There is diabetic nephropathy before 2 years in patient, sent out before 1 year Existing decreased renal function, before half a year, edema aggravation, hypourocrinia, deep pulse stringy and thready pulse, give up light white.The most to our hospital.Take this After 2 courses for the treatment of of invention medicine, above-mentioned symptom takes a turn for the better；After continuing to take 2 courses for the treatment of of medicine of the present invention, above-mentioned symptom disappears, recovery from illness, Follow up a case by regular visits to, do not recur.

Claims (5)

1. the medicine being used for treating diabetic nephropathy, it is characterised in that: make the raw material composition of described effective ingredient And parts by weight are:
Herba Kalimeridis 55-85 part Rhizoma Saururi (Herba Saururi) 50-78 part Rhizoma seu herba Asystasiellae Chinensis 47-75 part Radix Oplopanacis Elati 47-75 part
Herba Calystegiae Japonicae 40-68 part Herba Peristrophis Roxburghianae 40-68 part Radix Astragali 38-66 part Herba Melicae Scabrosae 35-62 part
Melica scabrosa Trin. 35-62 part Resina persicae 33-60 part Exocarpium Citrulli 33-60 part Herba Medicaginis 25-45 part
Cephalanthera ereota (Thunb.) Blume. 25-45 part Rhizoma Polliae Japonicae 20-40 part Folium ulmi pumilae 12-32 part Caulis Clematidis Armandii 10-26 part.
A kind of medicine for treating diabetic nephropathy the most according to claim 1, it is characterised in that: make described medicine The raw material of effective ingredient forms and parts by weight are:
76 parts of Rhizoma Saururi (Herba Saururi)s of Herba Kalimeridis, 65 parts of Radix Oplopanacis Elati of 70 parts of Rhizoma seu herba Asystasiellae Chinensiss 65 parts
60 parts of Herba Peristrophis Roxburghianaes of Herba Calystegiae Japonicae, 56 parts of Herba Melicae Scabrosaes of 60 parts of Radixs Astragali 53 parts
53 parts of Resina persicaes of Melica scabrosa Trin., 51 portions of Herba Medicaginiss of 51 parts of Exocarpium Citrullis 38 parts
38 parts of Rhizoma Polliae Japonicaes of Cephalanthera ereota (Thunb.) Blume., 27 portions of Caulis Clematidis Armandiis of 35 parts of Folium ulmi pumilaves 22 parts.
A kind of medicine for treating diabetic nephropathy the most according to claim 1, it is characterised in that: make described medicine The raw material of effective ingredient forms and parts by weight are:
69 parts of Rhizoma Saururi (Herba Saururi)s of Herba Kalimeridis, 59 parts of Radix Oplopanacis Elati of 62 parts of Rhizoma seu herba Asystasiellae Chinensiss 59 parts
52 parts of Herba Peristrophis Roxburghianaes of Herba Calystegiae Japonicae, 50 parts of Herba Melicae Scabrosaes of 52 parts of Radixs Astragali 47 parts
47 parts of Resina persicaes of Melica scabrosa Trin., 45 portions of Herba Medicaginiss of 45 parts of Exocarpium Citrullis 34 parts
34 parts of Rhizoma Polliae Japonicaes of Cephalanthera ereota (Thunb.) Blume., 22 portions of Caulis Clematidis Armandiis of 30 parts of Folium ulmi pumilaves 18 parts.
A kind of medicine for treating diabetic nephropathy the most according to claim 1, it is characterised in that: make described medicine The raw material of effective ingredient forms and parts by weight are:
62 parts of Rhizoma Saururi (Herba Saururi)s of Herba Kalimeridis, 53 parts of Radix Oplopanacis Elati of 56 parts of Rhizoma seu herba Asystasiellae Chinensiss 53 parts
46 parts of Herba Peristrophis Roxburghianaes of Herba Calystegiae Japonicae, 44 parts of Herba Melicae Scabrosaes of 46 parts of Radixs Astragali 41 parts
41 parts of Resina persicaes of Melica scabrosa Trin., 39 portions of Herba Medicaginiss of 39 parts of Exocarpium Citrullis 29 parts
29 parts of Rhizoma Polliae Japonicaes of Cephalanthera ereota (Thunb.) Blume., 17 portions of Caulis Clematidis Armandiis of 25 parts of Folium ulmi pumilaves 14 parts.
5. a preparation method for the medicine for treating diabetic nephropathy as described in any one of claim 1-4, its feature It is: comprise the following steps that:
(1) Herba Kalimeridis and Rhizoma seu herba Asystasiellae Chinensis are smash juice, filter, stay juice standby；
(2) by Rhizoma Saururi (Herba Saururi), Radix Oplopanacis Elati, Herba Calystegiae Japonicae, Herba Peristrophis Roxburghianae, Herba Melicae Scabrosae, Melica scabrosa Trin., Resina persicae, Exocarpium Citrulli, Cephalanthera ereota (Thunb.) Blume., Rhizoma Polliae Japonicae, elm Leaf and Caulis Clematidis Armandii are put in container, are firstly added 10-15 times amount distilled water immersion after 4-5 hour, and heated and boiled 3-4 hour carries Take；Second time adds 8-10 times amount distilled water heated and boiled 2-3 hour, extracts；Third time adds 6-8 times amount distilled water heated and boiled 1- 2 hours, extract；United extraction liquid, filters, obtains filtrate standby；
(3) Herba Medicaginis is dried grind into powder, obtained the fine powder of 180 mesh, standby；
(4) Radix Astragali is run through, cut sheet, be dried, grind into powder, obtained the fine powder of 160 mesh, standby；
(5) juice, filtrate and the fine powder mixing that step (1)-step (4) prepares, makes tablet, is described for treating sugar The medicine of the sick nephropathy of urine.
CN201610587385.5A 2016-07-24 2016-07-24 Medicine for treating diabetic nephropathy and preparation method Pending CN105998854A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610587385.5A CN105998854A (en) 2016-07-24 2016-07-24 Medicine for treating diabetic nephropathy and preparation method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610587385.5A CN105998854A (en) 2016-07-24 2016-07-24 Medicine for treating diabetic nephropathy and preparation method

Publications (1)

Publication Number Publication Date
CN105998854A true CN105998854A (en) 2016-10-12

Family

ID=57117427

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201610587385.5A Pending CN105998854A (en) 2016-07-24 2016-07-24 Medicine for treating diabetic nephropathy and preparation method

Country Status (1)

Country Link
CN (1) CN105998854A (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102485261A (en) * 2010-12-03 2012-06-06 吉林吉春制药有限公司 Medicine for treating diabetes and preparation method thereof
CN103566118A (en) * 2013-11-30 2014-02-12 张晓莉 Medicine for treating chronic nephritis and preparation method
CN104971102A (en) * 2014-04-03 2015-10-14 成都中医药大学附属医院 Drug composition for treating diabetic nephropathy, preparation method and uses thereof
CN105641331A (en) * 2016-02-13 2016-06-08 成都富豪斯生物科技有限公司 Pill medicine for treating diabetic nephropathy and preparation method of pills

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102485261A (en) * 2010-12-03 2012-06-06 吉林吉春制药有限公司 Medicine for treating diabetes and preparation method thereof
CN103566118A (en) * 2013-11-30 2014-02-12 张晓莉 Medicine for treating chronic nephritis and preparation method
CN104971102A (en) * 2014-04-03 2015-10-14 成都中医药大学附属医院 Drug composition for treating diabetic nephropathy, preparation method and uses thereof
CN105641331A (en) * 2016-02-13 2016-06-08 成都富豪斯生物科技有限公司 Pill medicine for treating diabetic nephropathy and preparation method of pills

Similar Documents

Publication Publication Date Title
CN103961553A (en) Medicine for treating side effects of anesthetics and preparation method of medicine
CN107913370A (en) A kind of medicine and preparation method of therapy of combing traditional Chinese and Western medicine alcoholic liver disease
CN103961587A (en) Traditional Chinese medicinal preparation for treating radiographic contrast nephropathy and preparation method thereof
CN103893613B (en) A kind of medicine treating oral ulcer and preparation method
CN105616805A (en) Traditional Chinese medicine preparation used for mastitis nursing and preparation method
CN104800504A (en) Traditional Chinese medicine preparation for treating nephritis and preparation method
CN103877457B (en) Chinese medicinal preparation for treating renal calculus and preparation method thereof
CN105596867A (en) Medicine for treating hydronephrosis and preparation method
CN104623217A (en) Traditional Chinese medicine preparation for treating asthma and preparation method thereof
CN104147277A (en) Traditional Chinese medicinal preparation for treating myasthenia gravis and preparation method
CN105998854A (en) Medicine for treating diabetic nephropathy and preparation method
CN104258206A (en) Traditional Chinese medicine preparation for treating acute glomerulonephritis
CN103721028B (en) One treats anginal medicine and preparation method
CN103961586B (en) A kind of medicine treating vulvitis and preparation method
CN103877557B (en) A kind of Chinese medicine ointment and preparation method for the treatment of tinea unguium
CN103893612B (en) A kind of medicine and preparation method for the treatment of chronic cervicitis
CN105999200A (en) Traditional Chinese medicine preparation for treating uremia and preparation method thereof
CN105617197A (en) Traditional Chinese medicine composition for treating chronic renal failure of dogs as well as preparation method and application of traditional Chinese medicine composition
CN105055802A (en) Medicine for treating cholecystitis and preparation method thereof
CN104258147A (en) Traditional Chinese medicine preparation for treating breast liposarcoma and preparation method of traditional Chinese medicine preparation
CN103877304A (en) Drug for treating gall-stone and preparation method thereof
CN105031148A (en) Medicine for treating undifferentiated spondy loarthropathy and method for preparing medicine
CN104644973B (en) A kind of Chinese medicine preparation and preparation method for the treatment of rheumatic heart disease
CN104547450A (en) Traditional Chinese medicine preparation for treating hyperplasia of mammary glands and preparation method thereof
CN104474353A (en) Medicine for treating myasthenia gravis and preparation method of medicine

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20161012