CN115887655B - 直接转分化治疗神经系统疾病 - Google Patents
直接转分化治疗神经系统疾病 Download PDFInfo
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- CN115887655B CN115887655B CN202111158620.4A CN202111158620A CN115887655B CN 115887655 B CN115887655 B CN 115887655B CN 202111158620 A CN202111158620 A CN 202111158620A CN 115887655 B CN115887655 B CN 115887655B
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Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111158620.4A CN115887655B (zh) | 2021-09-30 | 2021-09-30 | 直接转分化治疗神经系统疾病 |
| CN202510816959.0A CN120754249A (zh) | 2021-09-30 | 2021-09-30 | 直接转分化治疗神经系统疾病 |
| CN202280063875.9A CN118201623A (zh) | 2021-09-30 | 2022-09-30 | 直接转分化治疗神经系统疾病 |
| EP22875183.0A EP4410296A4 (en) | 2021-09-30 | 2022-09-30 | DIRECT TRANSDIFFERENTIATION FOR THE TREATMENT OF NEUROLOGICAL DISEASES |
| PCT/CN2022/123409 WO2023051802A1 (zh) | 2021-09-30 | 2022-09-30 | 直接转分化治疗神经系统疾病 |
| KR1020247013258A KR20240082366A (ko) | 2021-09-30 | 2022-09-30 | 신경계 질환 치료를 위한 직접 전환분화 |
| AU2022357103A AU2022357103A1 (en) | 2021-09-30 | 2022-09-30 | Direct transdifferentiation for treatment of neurological disease |
| US18/697,216 US20250115650A1 (en) | 2021-09-30 | 2022-09-30 | Direct transdifferentiation for treatment of neurological disease |
| CA3233534A CA3233534A1 (en) | 2021-09-30 | 2022-09-30 | Direct transdifferentiation for treatment of neurological disease |
| JP2024519557A JP2024534667A (ja) | 2021-09-30 | 2022-09-30 | 神経系疾患の直接分化転換治療 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111158620.4A CN115887655B (zh) | 2021-09-30 | 2021-09-30 | 直接转分化治疗神经系统疾病 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202510816959.0A Division CN120754249A (zh) | 2021-09-30 | 2021-09-30 | 直接转分化治疗神经系统疾病 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN115887655A CN115887655A (zh) | 2023-04-04 |
| CN115887655B true CN115887655B (zh) | 2025-06-17 |
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Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111158620.4A Active CN115887655B (zh) | 2021-09-30 | 2021-09-30 | 直接转分化治疗神经系统疾病 |
| CN202510816959.0A Pending CN120754249A (zh) | 2021-09-30 | 2021-09-30 | 直接转分化治疗神经系统疾病 |
| CN202280063875.9A Pending CN118201623A (zh) | 2021-09-30 | 2022-09-30 | 直接转分化治疗神经系统疾病 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202510816959.0A Pending CN120754249A (zh) | 2021-09-30 | 2021-09-30 | 直接转分化治疗神经系统疾病 |
| CN202280063875.9A Pending CN118201623A (zh) | 2021-09-30 | 2022-09-30 | 直接转分化治疗神经系统疾病 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20250115650A1 (enExample) |
| EP (1) | EP4410296A4 (enExample) |
| JP (1) | JP2024534667A (enExample) |
| KR (1) | KR20240082366A (enExample) |
| CN (3) | CN115887655B (enExample) |
| AU (1) | AU2022357103A1 (enExample) |
| CA (1) | CA3233534A1 (enExample) |
| WO (1) | WO2023051802A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024199511A1 (zh) * | 2023-03-30 | 2024-10-03 | 上海鲸奇生物科技有限公司 | 治疗神经系统疾病的表达载体和组合物 |
| WO2025173411A1 (ja) * | 2024-02-14 | 2025-08-21 | 国立大学法人筑波大学 | 網膜神経節細胞分化誘導用キット、医薬組成物及び緑内障モデル |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112566640A (zh) * | 2018-06-18 | 2021-03-26 | 罗切斯特大学 | 治疗精神分裂症和其他神经精神病症的方法 |
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|---|---|---|---|---|
| FR2774698B1 (fr) * | 1998-02-12 | 2002-03-01 | Rhone Poulenc Rorer Sa | Utilisation d'elements de regulation negative pour l'expression neurospecifique de transgenes |
| ITVA20060041A1 (it) * | 2006-07-05 | 2008-01-06 | Dialectica Srl | Uso di composti derivati amminotiazolici, di loro composizioni farmaceutiche, nel trattamento di malattie caratterizzate dalla anormale repressione della trascrizione genica, particolarmente il morbo di huntington |
| WO2009058014A2 (en) * | 2007-11-02 | 2009-05-07 | Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patientenzorg | Polypeptides involved in neuronal regeneration-associated gene expression |
| JP5850321B2 (ja) * | 2010-02-10 | 2016-02-03 | 公立大学法人横浜市立大学 | 神経選択的転写抑制因子NRSFに特異的に結合するmSin3Bに結合する化合物の利用 |
| WO2014071157A1 (en) * | 2012-11-01 | 2014-05-08 | The Regents Of The University Of California | Methods for engineering non-neuronal cells into neurons and using newly engineered neurons to treat neurodegenerative diseases |
| WO2016019315A2 (en) * | 2014-08-01 | 2016-02-04 | Oregon Health & Science University | Methods and compositions useful in manipulating the stability of re1 silencing transcription factor |
| EP3622057A1 (en) * | 2017-05-12 | 2020-03-18 | New York Stem Cell Foundation, Inc. | Systems |
| CA3096691A1 (en) * | 2018-04-11 | 2019-10-17 | The Regents Of The University Of California | Reprogramming of non-neuronal cells into neurons and methods and compositions to treat neurodegenerative diseases and disorders |
| MX2022006214A (es) * | 2019-11-22 | 2022-06-22 | Alcamena Stem Cell Therapeutics Llc | Composiciones y métodos para desreprimir genes diana del factor de transcripción silenciador de re1. |
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2021
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| CN112566640A (zh) * | 2018-06-18 | 2021-03-26 | 罗切斯特大学 | 治疗精神分裂症和其他神经精神病症的方法 |
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| M Shimojo et al..Role of zinc finger domains of the transcription factor neuron-restrictive silencer factor/repressor element-1 silencing transcription factor in DNA binding and nuclear localization.《J Biol Chem》.2001,第276卷(第16期),13121-6. * |
| REST, a master transcriptional regulator in neurodegenerative disease;Jee-Yeon Hwang et al.;《Curr Opin Neurobiol》;20180130;第48卷;193-200 * |
| Role of zinc finger domains of the transcription factor neuron-restrictive silencer factor/repressor element-1 silencing transcription factor in DNA binding and nuclear localization;M Shimojo et al.;《J Biol Chem》;20010420;第276卷(第16期);13121-6 * |
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| CN118201623A (zh) | 2024-06-14 |
| KR20240082366A (ko) | 2024-06-10 |
| CN115887655A (zh) | 2023-04-04 |
| US20250115650A1 (en) | 2025-04-10 |
| EP4410296A1 (en) | 2024-08-07 |
| CA3233534A1 (en) | 2023-04-06 |
| CN120754249A (zh) | 2025-10-10 |
| WO2023051802A1 (zh) | 2023-04-06 |
| JP2024534667A (ja) | 2024-09-20 |
| EP4410296A4 (en) | 2025-10-15 |
| AU2022357103A1 (en) | 2024-05-02 |
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