MX2022006214A - Composiciones y métodos para desreprimir genes diana del factor de transcripción silenciador de re1. - Google Patents
Composiciones y métodos para desreprimir genes diana del factor de transcripción silenciador de re1.Info
- Publication number
- MX2022006214A MX2022006214A MX2022006214A MX2022006214A MX2022006214A MX 2022006214 A MX2022006214 A MX 2022006214A MX 2022006214 A MX2022006214 A MX 2022006214A MX 2022006214 A MX2022006214 A MX 2022006214A MX 2022006214 A MX2022006214 A MX 2022006214A
- Authority
- MX
- Mexico
- Prior art keywords
- seq
- derepressing
- compositions
- methods
- transcription factor
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
- C12Y301/03016—Phosphoprotein phosphatase (3.1.3.16), i.e. calcineurin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/06—Fusion polypeptide containing a localisation/targetting motif containing a lysosomal/endosomal localisation signal
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- General Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La invención se proporciona compuestos, composiciones y métodos para desreprimir genes diana del factor de transcripción silenciador de RE1 (REST). En particular, se describe un péptido que tiene la secuencia TEDLEPPEPPLPKEN (SEQ. ID NO: 1) y EDLEPPEPPLPK (SEQ. ID NO: 15), o las secuencias inversas compuestas de los D-aminoácidos (retroinvertidos, RI) nekplppeppeldet (SEQ ID NO: 16) y kplppeppelde (SEQ ID NO: 17), para inhibir la actividad de REST. Los péptidos son útiles para tratar, prevenir o mejorar padecimientos tales como traumatismo craneoencefálico, epilepsia, demencia, enfermedad de Huntington (HD), dolor crónico, cáncer cerebral (incluido el glioblastoma multiforme), cáncer pancreático, diabetes y lesión del nervio periférico.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962939149P | 2019-11-22 | 2019-11-22 | |
US202063086248P | 2020-10-01 | 2020-10-01 | |
PCT/US2020/061632 WO2021102345A1 (en) | 2019-11-22 | 2020-11-20 | Compositions and methods for derepressing re1 silencing transcription factor target genes |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022006214A true MX2022006214A (es) | 2022-06-22 |
Family
ID=75981713
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022006214A MX2022006214A (es) | 2019-11-22 | 2020-11-20 | Composiciones y métodos para desreprimir genes diana del factor de transcripción silenciador de re1. |
Country Status (11)
Country | Link |
---|---|
US (1) | US20230059411A1 (es) |
EP (1) | EP4061833A4 (es) |
JP (1) | JP2023503920A (es) |
KR (1) | KR20220104008A (es) |
CN (1) | CN115023434A (es) |
AU (1) | AU2020386637A1 (es) |
BR (1) | BR112022009898A2 (es) |
CA (1) | CA3162241A1 (es) |
IL (1) | IL293165A (es) |
MX (1) | MX2022006214A (es) |
WO (1) | WO2021102345A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN115887655A (zh) * | 2021-09-30 | 2023-04-04 | 中国科学院脑科学与智能技术卓越创新中心 | 直接转分化治疗神经系统疾病 |
CN114377000A (zh) * | 2021-12-24 | 2022-04-22 | 中山大学孙逸仙纪念医院 | 普瑞巴林在制备用于预防或治疗放射性脑损伤药物中的应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2019A (en) | 1841-03-29 | goedes | ||
WO2010129023A2 (en) * | 2009-04-28 | 2010-11-11 | President And Fellows Of Harvard College | Supercharged proteins for cell penetration |
US20120070419A1 (en) * | 2010-03-25 | 2012-03-22 | International Stem Cell Corporation | Method of altering the differentiative state of a cell and compositions thereof |
US20150299698A1 (en) | 2012-11-01 | 2015-10-22 | The Regents Of The University Of California | Methods for engineering non-neuronal cells into neurons and using newly engineered neurons to treat neurodegenerative diseases |
WO2016019315A2 (en) | 2014-08-01 | 2016-02-04 | Oregon Health & Science University | Methods and compositions useful in manipulating the stability of re1 silencing transcription factor |
-
2020
- 2020-11-20 EP EP20890436.7A patent/EP4061833A4/en active Pending
- 2020-11-20 IL IL293165A patent/IL293165A/en unknown
- 2020-11-20 JP JP2022529775A patent/JP2023503920A/ja active Pending
- 2020-11-20 KR KR1020227020940A patent/KR20220104008A/ko active Search and Examination
- 2020-11-20 US US17/778,738 patent/US20230059411A1/en active Pending
- 2020-11-20 MX MX2022006214A patent/MX2022006214A/es unknown
- 2020-11-20 CN CN202080089156.5A patent/CN115023434A/zh active Pending
- 2020-11-20 AU AU2020386637A patent/AU2020386637A1/en active Pending
- 2020-11-20 WO PCT/US2020/061632 patent/WO2021102345A1/en active Search and Examination
- 2020-11-20 CA CA3162241A patent/CA3162241A1/en active Pending
- 2020-11-20 BR BR112022009898A patent/BR112022009898A2/pt unknown
Also Published As
Publication number | Publication date |
---|---|
US20230059411A1 (en) | 2023-02-23 |
BR112022009898A2 (pt) | 2022-09-06 |
JP2023503920A (ja) | 2023-02-01 |
KR20220104008A (ko) | 2022-07-25 |
EP4061833A1 (en) | 2022-09-28 |
IL293165A (en) | 2022-07-01 |
CA3162241A1 (en) | 2021-05-14 |
AU2020386637A1 (en) | 2022-06-16 |
WO2021102345A1 (en) | 2021-05-27 |
EP4061833A4 (en) | 2023-09-06 |
CN115023434A (zh) | 2022-09-06 |
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