CN115887573A - Traditional Chinese medicine composition for slowing down aging and improving brain function deterioration and preparation method thereof - Google Patents
Traditional Chinese medicine composition for slowing down aging and improving brain function deterioration and preparation method thereof Download PDFInfo
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Classifications
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for slowing down aging and improving brain function degradation and a preparation method thereof.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for slowing down aging and improving brain function deterioration and a preparation method thereof.
Background
Brain function deterioration becomes a key public health problem of population aging, mainly manifested as adaptive neural plasticity, impaired resilience, abnormal activity of neuronal networks, sensory perception decline, cognitive hypofunction, learning, memory loss, personality change and the like, and is the most common neurodegenerative disease. Age, excessive exercise, smoking, alcohol consumption, obesity, and dietary patterns are all potential factors that contribute to the deterioration of brain function, and brain damage and emotional trauma from early and middle-aged years increase the risk of disease in later years. At present, the treatment medicines on the market comprise cholinesterase inhibitors, nerve soothing and brain nourishing liquid and the like, but the health damage to a human body cannot be estimated due to the defects of large toxic and side effects, incapability of being taken for a long time and the like.
Disclosure of Invention
The invention aims to solve the technical problem of providing a traditional Chinese medicine composition for delaying senility and improving brain function degeneration and a preparation method thereof, so that the medicine effect is improved, the senility is effectively delayed, and the brain function degeneration is improved.
The invention relates to a traditional Chinese medicine composition for slowing down aging and improving brain function deterioration, which comprises, by weight, 25-35 parts of prepared rhizome of rehmannia, 10-20 parts of ginseng, 25-35 parts of cistanche, 8-12 parts of Chinese yam, 8-12 parts of rhizoma acori graminei, 10-20 parts of radix paeoniae alba, 10-20 parts of radix asparagi, 8-12 parts of bighead atractylodes rhizome, 8-12 parts of schisandra chinensis and 3-7 parts of honey-fried licorice root.
Preferably, the traditional Chinese medicine composition comprises, by weight, 30 parts of prepared rehmannia root, 15 parts of ginseng, 30 parts of cistanche, 10 parts of Chinese yam, 10 parts of grassleaf sweelflag rhizome, 15 parts of white paeony root, 15 parts of asparagus, 10 parts of largehead atractylodes rhizome, 10 parts of Chinese magnoliavine fruit and 5 parts of honey-fried licorice root.
The invention provides a preparation method of a traditional Chinese medicine composition for slowing down aging and improving brain function deterioration, which comprises the steps of extracting rhizoma acori graminei water; extracting fructus Schisandrae with water; alcohol extract of ginseng, asparagus and atractylodes; rhizoma Acori Graminei residue, water extractive solution of radix Ginseng, radix asparagi residue, and mixture of radix rehmanniae Preparata, cistanchis herba, rhizoma Dioscoreae, radix Paeoniae alba, and radix Glycyrrhizae Preparata; volatile oil clathrate of rhizoma Acori Graminei; mixing to obtain the Chinese medicinal composition for delaying aging and improving brain function deterioration.
Preferably, the rhizoma acori graminei water extract is prepared by pulverizing rhizoma acori graminei, mixing with water, heating and distilling to obtain the rhizoma acori graminei water extract and the rhizoma acori graminei dregs.
Preferably, the preparation method of the schisandra chinensis water extract comprises the steps of crushing schisandra chinensis, mixing with water, carrying out ultrasonic treatment, and extracting to obtain the schisandra chinensis water extract.
Preferably, the alcohol extract of ginseng, asparagus fern and white atractylodes rhizome is prepared by mixing ginseng, asparagus fern and white atractylodes rhizome, adding ethanol for reflux extraction at least once, filtering, and combining the filtrates to obtain the alcohol extract of ginseng, asparagus fern and white atractylodes rhizome.
Preferably, the preparation method of the water extract of the mixture of the grass-leaved sweetflag rhizome dregs, the alcohol-extracted ginseng and asparagus dregs and the mixture of the rehmannia glutinosa, the cistanche, the yam, the white paeony root and the honey-fried licorice root comprises the steps of combining the grass-leaved sweetflag rhizome dregs, the alcohol-extracted ginseng and asparagus dregs, the rehmannia glutinosa, the cistanche, the yam, the white paeony root and the honey-fried licorice root, adding water for reflux extraction at least once, filtering, and combining the filtrate to obtain the water extract of the mixture of the grass-leaved sweetflag rhizome dregs, the alcohol-extracted ginseng and asparagus dregs, the rehmannia glutinosa, the cistanche, the yam, the white paeony root and the honey-fried licorice root.
Preferably, after mixing, concentrating under reduced pressure and drying, the traditional Chinese medicine composition for slowing aging and improving brain function deterioration is obtained.
The invention has the beneficial effects that the invention adopts the prepared rhizome of rehmannia as the monarch drug and the cistanche salsa, the yam, the ginseng and the white atractylodes rhizome as the ministerial drugs; rhizoma Acori Graminei, radix Paeoniae alba, radix asparagi, and fructus Schisandrae chinensis as adjuvant drugs; compared with other traditional Chinese medicines for delaying senility and improving brain function deterioration, the prepared liquorice root is used as a messenger medicine, so that the ministerial medicine and the adjuvant medicine are mainly changed, the medicine effect of the traditional Chinese medicine composition is effectively improved, the senility is effectively delayed, and the brain function deterioration is improved.
Detailed Description
Example 1
A Chinese medicinal composition for delaying aging and improving brain function deterioration comprises radix rehmanniae Preparata 30g, ginseng radix 15g, cistanchis herba 30g, rhizoma Dioscoreae 10g, rhizoma Acori Graminei 10g, radix Paeoniae alba 15g, radix asparagi 15g, atractylodis rhizoma 10g, fructus Schisandrae 10g, and radix Glycyrrhizae Preparata 5g.
The preparation method comprises the following steps of,
pulverizing rhizoma Acori Graminei into coarse powder, adding 10 times of distilled water, extracting for 6 hr by heating and distilling, collecting volatile oil and residue, and filtering medicinal liquid; preparing the volatile oil into an inclusion compound by using an inclusion agent;
taking a prescription amount of schisandra chinensis, drying and then grinding into coarse powder, adding 10 times of distilled water, carrying out ultrasonic treatment for 30min, collecting medicine residues, and filtering medicine liquid for later use;
taking ginseng, asparagus cochinchinensis and bighead atractylodes rhizome according to the prescription amount, carrying out reflux extraction twice by using 70% ethanol, wherein the amount of the ginseng, the asparagus cochinchinensis and the bighead atractylodes rhizome is 8 times that of the ginseng, the asparagus cochinchinensis and the bighead atractylodes rhizome, extracting for 1.0 hour, and filtering; extracting for 0.5 hr for the second time in an amount of 6 times, filtering, mixing the filtrates, recovering ethanol until no alcohol smell is produced, and filtering the medicinal liquid;
mixing rhizoma Acori Graminei residue after volatile oil extraction, ginseng radix after alcohol extraction, radix asparagi residue with radix rehmanniae Preparata, cistanchis herba, rhizoma Dioscoreae, radix Paeoniae alba, and radix Glycyrrhizae Preparata mixture, soaking for 1h, adding water, reflux-extracting for 2 times, adding 10 times of water for the first time, decocting for 2.0 hr, filtering, adding 8 times of water for the second time, decocting for 1.0 hr, filtering, mixing filtrates, and filtering; mixing the above 4 times of medicinal liquids, mixing the medicinal liquids with the clathrate, and concentrating under reduced pressure to dry.
Comparative example 1
Prepared rhizome of rehmannia 30g, ginseng 10g, broomrape 15g, chinese yam 15g, grassleaf sweelflag rhizome 15g, root of herbaceous peony 15g, asparagus root 10g, white atractylodes rhizome 15g, schisandra fruit 10g, honey-fried licorice root 5g.
The preparation method is the same as example 1.
Comparative example 2
30g of prepared rhizome of rehmannia, 15g of ginseng, 20g of polygala root, 10g of Chinese yam, 10g of grassleaf sweelflag rhizome, 15g of white paeony root, 15g of dwarf lilyturf tuber, 10g of tuckahoe, 10g of Chinese magnoliavine fruit and 5g of honey-fried licorice root.
The preparation method comprises the following steps of,
pulverizing rhizoma Acori Graminei into coarse powder, adding 10 times of distilled water, extracting for 6 hr by heating and distilling, collecting volatile oil and residue, and filtering medicinal liquid; preparing the volatile oil into an inclusion compound by using an inclusion agent;
oven drying fructus Schisandrae chinensis, pulverizing into coarse powder, adding 10 times of distilled water, performing ultrasonic treatment for 30min, collecting residue, and filtering medicinal liquid;
taking ginseng, dwarf lilyturf tuber and tuckahoe according to the prescription amount, carrying out reflux extraction twice by using 70 percent ethanol, wherein the amount of the ginseng, the dwarf lilyturf tuber and the tuckahoe is 8 times that of the ginseng, the dwarf lilyturf tuber and the tuckahoe for the first time, extracting for 1.0 hour, and filtering; extracting for 0.5 hr for the second time in an amount of 6 times, filtering, mixing the filtrates, recovering ethanol until no alcohol smell exists, and filtering the medicinal liquid;
mixing rhizoma Acori Graminei residue after volatile oil extraction, ginseng radix after ethanol extraction, radix Ophiopogonis residue, radix rehmanniae Preparata, cortex et radix Polygalae, rhizoma Dioscoreae, radix Paeoniae alba, and radix Glycyrrhizae Preparata mixture, soaking for 1 hr, adding water, reflux-extracting for 2 times, adding 10 times of water for the first time, decocting for 2.0 hr, filtering, adding 8 times of water for the second time, decocting for 1.0 hr, filtering, mixing filtrates, and filtering; mixing the above 4 times of medicinal liquids, mixing the medicinal liquids with the clathrate, and concentrating under reduced pressure to dry.
Comparative example 3
A Chinese medicinal composition comprises radix rehmanniae Preparata 30g, ginseng radix 15g, cistanchis herba 30g, rhizoma Dioscoreae 10g, rhizoma Acori Graminei 10g, radix Paeoniae alba 15g, radix asparagi 15g, atractylodis rhizoma 10g, fructus Schisandrae 10g, and radix Glycyrrhizae Preparata 5g.
The preparation method comprises mixing the above materials, soaking for 1h, adding water, reflux extracting for 2 times, adding 10 times of water for the first time, decocting for 2.0 hr, filtering, adding 8 times of water for the second time, decocting for 1.0 hr, filtering, mixing the filtrates, filtering, and concentrating under reduced pressure to dry.
Experimental example 1
Preparation of aging model: SD rats are taken as research objects, and the model of aging is replicated by adopting subcutaneous injection of D-galactose (400 mg/kg/D) on the back of the rats for 2 months.
The experimental method comprises the following steps: SPF grade, male SD rats, 180-220g,70, purchased from Silikedada laboratory animals Limited, hunan, and raised in animal laboratory centers at the university of traditional Chinese medicine, hunan. The license of the experimental animal is SCXK (Xiang) 2019-0004, after 3 days of adaptive feeding of SD rats, 70 rats are randomly divided into 7 groups according to the weight: blank group, model group, donepezil hydrochloride tablet group, constitution-consolidating, anti-aging and intelligence-benefiting prescription group, comparative examples 1, 2 and 3, 10 in each group. The rats of each group are modeled and simultaneously administrated by gastric gavage, the daily gavage amount of the rats of the donepezil hydrochloride group is 1.5mg/Kg, the root-strengthening, anti-aging and intelligence-improving formula (example 1) is 13.5g/Kg, the comparative examples 1, 2 and 3 are 13.5g/Kg, 13.5g/Kg and 13.5g/Kg, the rats of each group are administrated according to the administration volume of 10mL/Kg, and the rats of the blank group and the model group are administrated by gastric gavage distilled water according to the volume. Gavage was performed once a day, 2 months later, behavioral testing was performed, and material was taken immediately.
Experiments as in tables 1-4 were performed and the effect of the substance content as in tables 5-16 was tested in the experimental rats to obtain experimental results as in tables 1-16.
Compared with a blank group, the incubation period of the model group rats is shortened (P is less than 0.01), the error frequency is increased (P is less than 0.01), and the difference has significance. Compared with the model group, the incubation period of the positive drug and the constitution-consolidating, anti-aging and intelligence-improving square group rats is prolonged, the error frequency is reduced, and the difference has statistical significance (P is less than 0.01 or P is less than 0.05). The results are shown in Table 1. The suggestion shows that the constitution consolidating, aging preventing and intelligence benefiting prescription effectively promotes the recovery of the learning and memory ability of the model rat.
TABLE 1 influence of the formula for consolidating constitution, preventing aging and improving intelligence on the aging model rat diving platform experiment: (
n＝10)
Note: p <0.05, P <0.01, compared to blank; compared to the model group, # P <0.05, # P <0.01.
TABLE 2 influence of the root-strengthening, anti-aging and intelligence-improving formulation on aging model rat shuttle box experiment: (
n＝10)/>
Note: p <0.05, P <0.01, compared to blank; compared to the model group, # P <0.05, # P <0.01.
TABLE 3 influence of the formula for consolidating constitution, preventing aging and improving intelligence on the rat Water maze experiment of aging model: (
n＝10)
Note: p <0.05, P <0.01, compared to blank; compared to the model group, # P <0.05, # P <0.01.
TABLE 4 influence of the formula for consolidating constitution, preventing aging and improving intelligence on the running test of aging model rats: (
n＝10)
Note: p <0.05, P <0.01, compared to blank; compared to the model group, # P <0.05, # P <0.01.
TABLE 5 influence of the recipes for consolidating body resistance, preventing aging and improving intelligence on the antioxidant action of aging model rats: (
n＝10)
Note: p <0.05, P <0.01; compared to the model group, # P <0.05, # P <0.01.
TABLE 6 influence of the formula for consolidating body resistance, preventing aging and improving intelligence on the antioxidant action of aging model rats: (
n＝10)
Note: comparison with blank group<0.05，**P<0.01; comparison with model group, # P<0.05，##P<0.01. TABLE 7 influence of the recipes for consolidating constitution, preventing aging and improving intelligence on the lipofuscin content in brain and liver tissues of aging model rats: (
n＝10)
Note: p <0.05, P <0.01; compared to the model group, # P <0.05, # P <0.01.
TABLE 8 Foundation-consolidating, anti-aging and intelligence-promotingEffect of recipe on stress status in aging model rats: (
n＝10)
Note: p <0.05, P <0.01, compared to blank; compared to the model group, # P <0.05, # P <0.01.
TABLE 9 influence of the recipes for consolidating constitution, preventing aging and improving intelligence on the stress status of aging model rats: (
n＝10)/>
Note: p <0.05, P <0.01; compared to the model group, # P <0.05, # P <0.01.
TABLE 10 influence of the recipes for consolidating constitution, preventing aging and improving intelligence on the immune function of aging model rats: (
n＝10)
Note: p <0.05, P <0.01, compared to blank; compared to the model group, # P <0.05, # P <0.01.
TABLE 11 influence of the recipes for consolidating body constitution, preventing aging and improving intelligence on the TNF-alpha, IL-1 beta, IL-6 content in hippocampal tissue of aging model rat: (
n＝10)
Note: p <0.05, P <0.01, compared to blank; compared to the model group, # P <0.05, # P <0.01.
TABLE 12 influence of the recipes for consolidating body constitution, preventing aging and improving intelligence on serum TNF-alpha and IL-1 beta of aging model rats: (
n＝10)
Note: p <0.05, P <0.01, compared to blank; compared to the model group, # P <0.05, # P <0.01.
TABLE 13 influence of the recipes for consolidating constitution, preventing aging and improving intelligence on aging model rat NOS and VEGF: (
n＝10)
Note: comparison with blank group<0.05，**P<0.01; comparison with model group, # P<0.05，##P<0.01. TABLE 14 influence of the root-consolidating, anti-aging and nootropic recipe on the BDNF and NGF contents in aging model rats: (
n＝10)
Note: p <0.05, P <0.01, compared to blank; compared to the model group, # P <0.05, # P <0.01.
TABLE 15 influence of the formula for consolidating body resistance, preventing aging and improving intelligence on ATP content in aging model rat: (
n＝10)
Note: comparison with blank group<0.05，**P<0.01; comparison with model group, # P<0.05，##P<0.01. TABLE 16 influence of the recipes for consolidating constitution, preventing aging and improving intelligence on the content of AchE and cerebroprotein in aging model rats: (
n＝10)/>
Note: p <0.05, P <0.01, compared to blank; compared to the model group, # P <0.05, # P <0.01.
In conclusion, compared with comparative examples 1-3, the constitution-consolidating, anti-aging and intelligence-benefiting prescription can obviously improve the brain function degradation, and the diving platform experiment and the water maze experiment show that the prescription can effectively promote the recovery of the spatial memory and the learning ability of a model rat; the shuttle box experiment shows that the learning ability of the rats with brain function degradation for avoiding harmful stimulation can be improved; running experiments show that the compound preparation can effectively improve the motor ability of rats; the antioxidant ability experiment shows that the compound can improve the SOD activity level in the serum of a model rat and has antioxidant effect; the anti-aging capability experiment shows that the composition can effectively reduce the content of model rat aging markers, relieve oxidative stress injury and increase the quality of immune organs; anti-inflammatory ability experiments show that the compound can reduce the content of proinflammatory cytokines in serum and hippocampus, relieve inflammation and improve cognitive dysfunction; the anti-dementia capability experiment shows that the composition can reduce the content of NOS, VEGF, BDNF and NGF in serum, increase the content of ATP, achE and brain protein in brain tissues and improve learning and memory dysfunction.
Those of ordinary skill in the art will understand that: the discussion of any embodiment above is meant to be exemplary only, and is not intended to imply that the scope of the application is limited to these examples; features from the above embodiments, or from different embodiments, may also be combined, steps may be implemented in any order, and there are many other variations of the different aspects of one or more embodiments in this application, as described above, which are not provided in detail for the sake of brevity.
It is intended that the one or more embodiments of the present application cover all such alternatives, modifications, and variations as fall within the broad scope of the present application. Therefore, any omissions, modifications, substitutions, improvements, and the like that may be made without departing from the spirit and principles of one or more embodiments of the present application are intended to be included within the scope of the present application.
Claims (8)
1. A traditional Chinese medicine composition for slowing down aging and improving brain function deterioration is characterized by comprising, by weight, 25-35 parts of rehmannia glutinosa, 10-20 parts of ginseng, 25-35 parts of cistanche, 8-12 parts of Chinese yam, 8-12 parts of rhizoma acori graminei, 10-20 parts of radix paeoniae alba, 10-20 parts of radix asparagi, 8-12 parts of rhizoma atractylodis macrocephalae, 8-12 parts of schisandra chinensis and 3-7 parts of radix glycyrrhizae preparata.
2. The traditional Chinese medicine composition for slowing down aging and improving brain function deterioration as claimed in claim 1, which is characterized by comprising 30 parts by weight of prepared rhizome of rehmannia, 15 parts by weight of ginseng, 30 parts by weight of cistanche, 10 parts by weight of Chinese yam, 10 parts by weight of rhizoma acori graminei, 15 parts by weight of radix paeoniae alba, 15 parts by weight of radix asparagi, 10 parts by weight of rhizoma atractylodis macrocephalae, 10 parts by weight of schisandra chinensis and 5 parts by weight of honey-fried licorice root.
3. A method for preparing the Chinese medicinal composition for slowing down aging and improving brain function deterioration according to claim 1 or 2, which is characterized in that the water extract of rhizoma acori graminei; extracting fructus Schisandrae with water; alcohol extract of ginseng, asparagus and atractylodes; rhizoma acori graminei dregs, ginseng and radix asparagi dregs subjected to alcohol extraction, and water extract of a mixture of radix rehmanniae preparata, herba cistanche, chinese yam, radix paeoniae alba and radix glycyrrhizae preparata; volatile oil clathrate of rhizoma Acori Graminei; mixing to obtain the Chinese medicinal composition for delaying aging and improving brain function deterioration.
4. The preparation method according to claim 3, wherein the aqueous extract of Acorus gramineus Soland is prepared by pulverizing Acorus gramineus Soland, mixing with water, heating and distilling to obtain an aqueous extract of Acorus gramineus Soland and Acorus gramineus Soland residue.
5. The preparation method according to claim 3, wherein the water extract of Schisandra chinensis is prepared by pulverizing Schisandra chinensis, mixing with water, subjecting to ultrasonic treatment, and extracting to obtain the water extract of Schisandra chinensis.
6. The preparation method according to claim 3, wherein the alcohol extract of ginseng, asparagus cochinchinensis and atractylodes macrocephala is prepared by mixing ginseng, asparagus cochinchinensis and atractylodes macrocephala, adding ethanol for reflux extraction at least once, filtering, and combining filtrates to obtain the alcohol extract of ginseng, asparagus cochinchinensis and atractylodes macrocephala.
7. The preparation method according to claim 3, wherein the water extract of the mixture of the grass-leaved sweetflag rhizome dregs, the alcohol-extracted ginseng and asparagus dregs, and the prepared rhizome of rehmannia, the cistanche, the yam, the white peony root and the prepared licorice root is prepared by mixing the grass-leaved sweetflag rhizome dregs, the alcohol-extracted ginseng and asparagus dregs, the prepared rhizome of rehmannia, the cistanche, the yam, the white peony root and the prepared licorice root, adding water for reflux extraction at least once, filtering, and mixing the filtrates to obtain the water extract of the mixture of the grass-leaved sweetflag rhizome dregs, the alcohol-extracted ginseng and asparagus dregs, the prepared rhizome of rehmannia, the cistanche, the yam, the white peony root and the prepared licorice root.
8. The preparation method according to claim 3, wherein the traditional Chinese medicine composition for slowing aging and improving brain function deterioration is obtained by mixing, concentrating under reduced pressure and drying.
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| CN109925402A (en) * | 2019-01-29 | 2019-06-25 | 北京中研同仁堂医药研发有限公司 | A kind of Chinese medicine composition and the preparation method and application thereof |
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