CN101716269B - Traditional Chinese medicine composition for treating hyperpiesia - Google Patents
Traditional Chinese medicine composition for treating hyperpiesia Download PDFInfo
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- CN101716269B CN101716269B CN2008101576516A CN200810157651A CN101716269B CN 101716269 B CN101716269 B CN 101716269B CN 2008101576516 A CN2008101576516 A CN 2008101576516A CN 200810157651 A CN200810157651 A CN 200810157651A CN 101716269 B CN101716269 B CN 101716269B
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Abstract
The invention discloses a traditional Chinese medicine composition for treating hyperpiesia, prepared by extracting traditional Chinese medicines of uncaria, radix scrophulariae, hoantchy roots and rhizoma cyperi as raw materials with ethanol into pharmaceutically acceptable preparation forms, such as tablets, particle preparations, and the like. The medicament has the efficacy of clearing liver and benefiting qi, mainly treats hyperpiesia, illness irritability, insomnia, dizziness, weariness, hypodynamia, bitter taste and pulse, and the like differentiated as liver-fire qi deficiency in traditional Chinese medical science. Proved by efficacy tests, the invention has remarkable hypotensive action without toxic and side effect.
Description
Technical field:
The present invention relates to the hyperpietic Chinese medicine composition of a kind of treatment, being specifically related to a kind of is the Chinese patent medicine of feedstock production with the Chinese herbal medicine, the invention still further relates to the method for preparing of this medicine.
Background technology:
Hypertension is one of modal cardiovascular disease; Closely related with coronary heart disease, cerebrovascular disease etc.; The sickness rate of coronary artery disease in hypertension patients according to investigations, has the people of 62.9%-93.6% to suffer from hypertension apparently higher than non-Hypertensive Population in the patients with coronary heart disease.The whole nation has accounted for 34% of total death toll because of the death toll of cardiovascular and cerebrovascular disease.Die from apoplexy at untreated hypertension philtrum 70-80%, 11%-15% dies from coronary heart disease.5%-10% dies from renal failure.Therefore hypertension is called " the noiseless killer " of human health.
Hypertension can be divided into constitutional and Secondary cases two big classes, and the former is called essential hypertension and also claims hypertension; The latter is called the secondary hypertension disease, also is called the symptom hypertension.Hypertension is main with nervous functions such as headache, dizziness imbalance shape disease in early days, and the later stage then shows as the symptom due to the heart, brain, the renal insufficiency.In motherland's traditional medicine, hypertension belongs to " headache ", " wind syndrome of head ", " dizzy ", " liver-wind " categories such as " liver-yang ".Its cause of disease is mainly imbalance between YIN and YANG in the human body, deficiency of kidney yin, and excessive rising of liver-YANG, obstinate disease, deficiency of YIN affecting YANG causes deficiency of both YIN and YANG and falls ill.Clinical common pattern of syndrome has: accumulate type, obstruction of collaterals by blood stasis type in the anti-high type of yang-excess type, the deficiency of YIN, deficiency of yang type, deficiency of both YIN and YANG type, expectorant are turbid.Be that principle is aided with Drug therapy mainly for the treatment of hypertension clinically at present with rule of life, reasonable diet, physical training; The Drug therapy of hypertension is main with Western medicine such as diuretic, vasodilation, calcium channel blocker, adrenergic receptor blocker, sympathetic inhibitor and relevant Chinese medicine Drug therapy mainly; But the clinical drug curative effect of treating essential hypertension at present clinically is often not obvious, and most of drug side effect is obvious.
Chinese medicine composition of the present invention is to the essential hypertension pathogenesis due to the liver-fire deficiency of vital energy, and the legislation prescription, derive from for many years through proved recipe,, the supplementing QI and nourishing YIN strongly fragrant in order to air to open of writing out a prescription is rule of treatment.With the Ramulus Uncariae Cum Uncis is monarch, gets the effect of its heat clearing away suppressing the hyperactive liver; Minister is got the Radix Astragali with invigorating the spleen and replenishing QI with the Radix Scrophulariae nourishing YIN and clearing away heat; Assistant is with Rhizoma Cyperi promoting the circulation of QI dissipating depression of QI.The merit that four Chinese medicine is played the liver heat removing QI invigorating altogether for the side.Its decoct is obvious through the clinical application for many years curative effect.We have developed the profound blood pressure lowering granule of hook according to the physicochemical property that hyperpietic etiology and pathogenesis and the profound blood pressure lowering granule of hook Chinese medicine are formed, have absorb fast, bioavailability is high, curative effect is obvious and the characteristics of easy processing.It will have comparatively vast market prospect, will bring good social benefit and economic interests.
Summary of the invention:
The object of the present invention is to provide a kind of is that raw material can effectively be treated the essential hypertension medicine with the Chinese herbal medicine, and this medicine has no side effect, taking convenience, and short treating period, evident in efficacy.
Another object of the present invention is to provide the method for preparing of this medicine.
Provided by the inventionly being used to treat hyperpietic Chinese medicine composition, is the preparation of being processed by the following weight proportion raw material:
Ramulus Uncariae Cum Uncis 900-1500 weight portion Radix Scrophulariaes 200-800 weight portions
The Radix Astragali 300-900 weight portion Rhizoma Cyperis 100-600 weight portions
The above-mentioned medicine that is used to treat hypertension is passable, can process said multiple dosage form on the pharmaceutics, like tablet, hard capsule, soft capsule, pill, powder, syrup, mixture, drop pill, granule, oral liquid.
The above-mentioned method for preparing that is used to treat the medicine of hypertension may further comprise the steps:
(1) Ramulus Uncariae Cum Uncis adds 5～8 times of amount 65%～95% ethanol, reflux, extract, 2～5 times, and each 1～3 hour, filter, merging filtrate, decompression recycling ethanol, subsequent use;
(2) Rhizoma Cyperi adds 6～10 times of water gagings, soaks 2～5 hours, extracts volatile oil with vapor distillation, and the aqueous solution after distillation device is in addition collected, and is subsequent use; Volatile oil is with 6 times of amount β-cyclodextrin, 30 ℃～50 ℃ following enclose 1～2 hour;
(3) medicinal residues and Radix Scrophulariae, the Radix Astragali add 6～10 times of amount 65%～95% alcohol reflux 2～5 times, and each 1～3 hour, filter, merging filtrate, decompression recycling ethanol, subsequent use; Medicinal residues add 6～10 times of water gagings decoctions 1～3 time after the alcohol extraction, each 1 hour, filter merging filtrate.
(4) aqueous solution and each alcohol extract after the above-mentioned distillation of merging, being concentrated into relative density is the clear paste of 1.28～1.30 (60 ℃ of surveys), drying under reduced pressure gets dry extract, is ground into fine powder, adds Benexate Hydrochloride, adds an amount of protein sugar and dextrin, mix homogeneously.
(5) above-mentioned fine powder is added suitable adjuvant, process suitable dosage form, promptly get.
Medicine of the present invention has the effect of liver heat removing QI invigorating, cures mainly essential hypertension, and disease is seen irritated irritability, dizzy, the fatigue and asthenia of insomnia, bitter taste rapid pulse etc.Chinese medical discrimination is the liver-fire deficiency of vital energy.Show to have the effect that significantly brings high blood pressure down through the test of pesticide effectiveness, have no side effect.
Below in conjunction with embodiment and pharmacodynamics test the present invention is described further.
Embodiment 1
(1) hook taking rattan 1300g adds 6 times of amount 75% ethanol, reflux, extract, 2 times, and each 1 hour, filter, merging filtrate, decompression recycling ethanol, subsequent use;
(2) Rhizoma Cyperi 300g adds 6 times of water gagings, soaks 3 hours, extracts volatile oil with vapor distillation, and the aqueous solution after distillation device is in addition collected, and is subsequent use; Volatile oil is with 6 times of amount β-cyclodextrin, 30 ℃ of following enclose 1 hour;
(3) medicinal residues and Radix Scrophulariae 520g, Radix Astragali 630g add 8 times of amount 75% alcohol reflux 2 times, and each 1 hour, filter, merging filtrate, decompression recycling ethanol, subsequent use; Medicinal residues add 6 times of water gagings decoctions 2 times after the alcohol extraction, each 1 hour, filter merging filtrate.
(4) aqueous solution and each alcohol extract after the above-mentioned distillation of merging, being concentrated into relative density is the clear paste of 1.28～1.30 (60 ℃ of surveys), drying under reduced pressure gets dry extract, is ground into fine powder, adds Benexate Hydrochloride, adds an amount of protein sugar and dextrin, mix homogeneously.
(5) with above-mentioned fine powder with 80% ethanol moistening, the system soft material is crossed 14 mesh sieves, 40 ℃ of oven dry, granulate is processed 1000g, packing promptly gets granule of the present invention.
Embodiment 2
(1) hook taking rattan 1350g adds 6 times of amount 75% ethanol, reflux, extract, 2 times, and each 1 hour, filter, merging filtrate, decompression recycling ethanol, subsequent use;
(2) Rhizoma Cyperi 280g adds 8 times of water gagings, soaks 2 hours, extracts volatile oil with vapor distillation, and the aqueous solution after distillation device is in addition collected, and is subsequent use; Volatile oil is with 6 times of amount β-cyclodextrin, 40 ℃ of following enclose 1 hour;
(3) medicinal residues and Radix Scrophulariae 540g, Radix Astragali 650g add 8 times of amount 75% alcohol reflux 2 times, and each 1 hour, filter, merging filtrate, decompression recycling ethanol, subsequent use; Medicinal residues add 8 times of water gagings decoctions 2 times after the alcohol extraction, each 1 hour, filter merging filtrate.
(4) aqueous solution and each alcohol extract after the above-mentioned distillation of merging, being concentrated into relative density is the clear paste of 1.28～1.30 (60 ℃ of surveys), drying under reduced pressure gets dry extract, is ground into fine powder, adds Benexate Hydrochloride, adds an amount of protein sugar and dextrin, mix homogeneously.
(5) above-mentioned fine powder is added 8% starch and 2% sodium stearate mix homogeneously, filled capsules is processed 1000, promptly gets capsule of the present invention.
Above embodiment has been merely the present invention has been further described, and scope of the present invention does not receive the limitation of the embodiment that lifts.
The hyperpietic Chinese medicine composition of a kind of treatment provided by the invention, for proving the effect of its treatment hypertension, the inventor uses the granule for preparing by the method that provides in the foregoing description to carry out pharmacodynamics test, and result of study is following:
(1) granule of the present invention can obviously reduce the blood pressure and the heart rate of spontaneous hypertensive rat (SHR) and two kidneys, one folder type Hypertensive Rats; Generally the 1w blood pressure begins to descend after administration; The blood pressure lowering amplitude of two kinds of rats is respectively 26.2% and 26.3% approximately, and heavy dose can also delay the rise of blood pressure after the drug withdrawal.
(2) granule high dose of the present invention is all accelerated the little VPV of mice significantly, in, low dosage presents certain function trend.The microcirculation disturbance that causes improves significantly; Show on little VPV and the fluidised form; Compare with the blank group; Little VPV when high, middle dosage can obviously resist microcirculation disturbance slows down, and high, medium and low dosage all can obviously accelerate little circulatory disorders and recover the normal required time, explains that granule of the present invention has the effect of blood circulation promoting and blood stasis dispelling, microcirculation improvement.
(3) granule of the present invention has tangible reduction effect to whole blood contrast viscosity (high, medium and low shear rate), and " gluing " improved significantly.Erythrocyte aggregation index increases reflection " dense ", this is presented certain function trend.Plasma viscosity increases reflection and " coagulates ", this is presented certain function trend.Point out granule blood stasis of the present invention-change sticking, dense, that coagulate to have some improvement, further specify the effect of its blood circulation promoting and blood stasis dispelling.
(4) the high, medium and low dosage difference of granule of the present invention can be extremely significantly and is suppressed the synthetic of the interior PGE2 of rat inflammation tissue significantly, and high, medium and low dosage and blank group have utmost point significance and significant difference more respectively; Point out through statistical procedures: its effect of high dosage intensity is suitable with diclofenac.
Claims (4)
1. treat hyperpietic Chinese medicine composition for one kind, it is characterized in that it is the medicament of being processed by the following weight proportion raw material:
Ramulus Uncariae Cum Uncis 900-1500 weight portion Radix Scrophulariae 200-800 weight portion
Radix Astragali 300-900 weight portion Rhizoma Cyperi 100-600 weight portion
2. the hyperpietic Chinese medicine composition of treatment according to claim 1 is characterized in that described medicament is a said dosage form on any pharmaceutics.
3. the hyperpietic Chinese medicine composition of a kind of treatment according to claim 2 is characterized in that described medicament is tablet, hard capsule, soft capsule, pill, powder, syrup, mixture, drop pill, granule, oral liquid formulations.
4. the method for preparing of the hyperpietic Chinese medicine composition of treatment according to claim 3 may further comprise the steps:
(1) Ramulus Uncariae Cum Uncis adds 5～8 times of amount 65%～95% ethanol, reflux, extract, 2～5 times, and each 1～3 hour, filter, merging filtrate, decompression recycling ethanol, subsequent use;
(2) Rhizoma Cyperi adds 6～10 times of water gagings, soaks 2～5 hours, extracts volatile oil with vapor distillation, and the aqueous solution after distillation device is in addition collected, and is subsequent use; Volatile oil is with 6 times of amount beta-schardinger dextrin-s, 30 ℃～50 ℃ following enclose 1～2 hour;
(3) medicinal residues and Radix Scrophulariae, the Radix Astragali add 6～10 times of amount 65%～95% alcohol reflux 2～5 times, and each 1～3 hour, filter, merging filtrate, decompression recycling ethanol, subsequent use; Medicinal residues add 6～10 times of water gagings decoctions 1～3 time after the alcohol extraction, each 1 hour, filter merging filtrate.
(4) aqueous solution and each alcohol extract after the above-mentioned distillation of merging, being concentrated into relative density is the clear paste of 1.28～1.30 (60 ℃ of surveys), drying under reduced pressure gets dry extract, is ground into fine powder, adds Benexate Hydrochloride, adds an amount of protein sugar and dextrin, mix homogeneously.
(5) above-mentioned fine powder is added suitable adjuvant, process suitable dosage form, promptly get.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2008101576516A CN101716269B (en) | 2008-10-09 | 2008-10-09 | Traditional Chinese medicine composition for treating hyperpiesia |
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| CN101716269B true CN101716269B (en) | 2012-02-15 |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106074910A (en) * | 2016-08-12 | 2016-11-09 | 广西中医药大学附属瑞康医院 | A kind of Anti-hypertension Chinese medicine formulation preparation method |
| CN109700915A (en) * | 2019-03-13 | 2019-05-03 | 贵州克艾康医药开发有限公司 | It is a kind of to treat hypertension compound Chinese herb capsule and preparation method |
| CN114010699B (en) * | 2021-12-22 | 2023-04-28 | 山东中医药大学 | Traditional Chinese medicine composition for treating hypertension and preparation method thereof |
| CN114767790A (en) * | 2022-03-24 | 2022-07-22 | 中国中医科学院广安门医院 | Traditional Chinese medicine composition for treating hypertension and traditional Chinese medicine preparation and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101195001A (en) * | 2007-12-03 | 2008-06-11 | 门连社 | Chinese medicine prescription for treating hypertension, hypercholesterolemia and hyperglycemia |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101195001A (en) * | 2007-12-03 | 2008-06-11 | 门连社 | Chinese medicine prescription for treating hypertension, hypercholesterolemia and hyperglycemia |
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