CN115886145A - Hair removal ball tablet for cats and preparation method thereof - Google Patents

Abstract

The invention relates to the field of pet nutritional health products, in particular to a hair removal ball tablet for cats and a preparation method thereof. The hair-melting pill for cats is prepared from plantain seed husk powder, compound mineral elements, compound vitamins, compound amino acids, sodium carboxymethyl cellulose, magnesium stearate, goat milk powder and microcrystalline cellulose according to a specific proportion. The components are organically combined, so that the gastrointestinal peristalsis is enhanced, the discharge of the cat on the agglomerated hair balls in the stomach is enhanced, and the hair balls are discharged gently without damaging the intestines and stomach; the composition has the effects of coordinating intestines and stomach, greatly improving constipation and vomiting of the cat and helping to recover gastrointestinal inflammation; provides comprehensive nutrients, nourishes hair follicles, promotes hair growth, strengthens hair quality, prevents non-seasonal hair loss and depilation, and prevents the occurrence of hair bulb disease from the source. The product of the invention has good palatability, convenient administration, stable property and long shelf life.

Description

Hair removal ball tablet for cats and preparation method thereof

Technical Field

The invention relates to the field of pet nutritional health products, in particular to a hair removal ball tablet for cats and a preparation method thereof.

Background

Cats love cleanly and like licking their own hair. However, the cat's tongue has many barbs, which can sweep the cleaned hair and other dirt into the stomach during repeated licking. This behavior is more frequent in spring and autumn and during non-seasonal, pathological hair removal. In addition, the cat raising places are messy and bad, and silky objects and hairy objects are easy to cause the cats to be sucked into the mouth and then accumulated in the stomach. The cat does not have the capability of digesting the hair, one part of the hair can be discharged along with the excrement, the other part of the hair can be left in the stomach to be gradually enlarged, and when the hair is accumulated to a certain degree, the hair bulb in the stomach can be spit out through vomiting. When the cat can not spit the hair bulbs in the stomach regularly and can not discharge the hair bulbs along with the excrement, the hair bulbs in the stomach and intestine become bigger, and the health of the cat is affected finally, and serious gastrointestinal diseases are induced. When the cats have pompon disease, the cats need to be fed with the product for removing pompon regularly to assist the cats in discharging the pompon in the body.

Patent CN201710758121.6 discloses a pet hair-melting paste and a preparation method thereof, wherein the pet hair-melting paste is prepared from sucrose, glycerol, vitamins, lecithin, starch, oat seedling cellulose, a flavoring agent and magnesium sulfate heptahydrate according to a specific proportion. The hair-removing cream contains sucrose, and is easy to make cat fat after long-term administration, and excessive sugar supply can cause burden to cat's body, and can cause endocrine disturbance and even depilation in severe cases. In addition, glycerol has the effect of relaxing bowel, and has the effect of catharsis when the dosage is large. The long-term taking of the hair-dissolving ointment containing glycerin is easy to cause the loss of fat-soluble vitamins. Patent CN201810641184.8 discloses a fur-removing paste for cats, which is composed of edible white oil, fish oil, wheat straw powder, soluble dietary fiber, beeswax, chicken liver extract, food additives and the like. Patent 202110889644.0 discloses a hair-removing cream for cats, which comprises collagen, sodium carboxymethylcellulose, bone glue, chicken liver powder, chicken meat powder, edible oil, fructooligosaccharide, hydrolyzed fish protein powder, maltitol, saccharomyces cerevisiae extract, glycerol, barley seedling powder, vitamin nano-liposome, protein chelated minerals, potassium iodide, taurine and water. The components of the hair-melting ointment, such as edible white oil, beeswax and edible oil, can lubricate the intestinal tract and facilitate the discharge of hair bulbs, but have irritation to the intestinal tract, and the long-term use of the hair-melting ointment can cause the loss of fat-soluble vitamins and is not beneficial to the health of the cats. In addition, the feeding amount of the hair melting paste is not easy to control, the hair melting paste cannot be used up once after being unsealed, bacteria are easy to pollute and breed, and the hair melting paste is easy to decay and deteriorate particularly in high-temperature seasons.

Disclosure of Invention

The invention aims to provide a hair ball removing tablet for cats, which is rich in plant dietary fibers, is beneficial to expelling hair balls in vivo by cats and relieving hair ball diseases, and is mild and non-irritant. Meanwhile, the hair conditioner can comprehensively supplement nutrients such as vitamins, amino acids, minerals and the like necessary for the hair growth of the cats, strengthen hair quality by nourishing hair follicles, prevent non-seasonal and pathological unhairing and hair falling of the cats, and prevent the occurrence of hair bulb disease from the source.

In order to achieve the purpose, the invention provides the following technical scheme:

the fur removing sheet for cats comprises the following raw materials in percentage by weight: 15-35% of plantain seed husk powder, 0.1-1% of compound mineral elements, 0.05-0.5% of compound vitamins, 1-5% of compound amino acids, 1-5% of sodium carboxymethylcellulose, 1-5% of magnesium stearate, 5-10% of goat milk powder and 40-80% of microcrystalline cellulose.

Further, the compound mineral elements comprise zinc methionine, manganese methionine, iron glycine, copper glycine and selenium yeast. The weight percentage of the zinc methionine in the hair melting ball sheet is 0.04 to 0.40 percent, the weight percentage of manganese methionine is 0.01 to 0.10 percent, the weight percentage of iron glycinate is 0.04 to 0.40 percent, the weight percentage of copper glycinate is 0.01 to 0.10 percent, and the weight percentage of selenium yeast is 0.0004 to 0.0040 percent.

Further, the compound vitamins comprise vitamin A, vitamin D3, vitamin E, vitamin C and vitamin B2. The weight percentage of the vitamin A in the hair ball melting sheet is 0.007 to 0.075 percent, the vitamin D3 is 0.0007 to 0.0075 percent, the vitamin E is 0.025 to 0.250 percent, the vitamin C is 0.015 to 0.150 percent, and the vitamin B2 is 0.005 to 0.050 percent.

Further, the compound amino acid is taurine and cystine. The weight percentage of the taurine in the hair melting ball sheet is 0.1 to 1.0 percent, and the weight percentage of the cystine is 0.1 to 1.0 percent.

The preparation method of the fur ball tablet for cats provided by the invention comprises the following steps:

1) Sieving all the raw material components with a 60-mesh sieve for later use;

2) Weighing the formula amount of Plantago ovata forsk husk powder, compound mineral elements, compound vitamins, compound amino acids and microcrystalline cellulose, and sequentially adding into a wet granulation mixer according to an equivalent incremental method for 4min to obtain primary powder;

3) Weighing the sodium carboxymethylcellulose according to the prescription amount, adding purified water, and uniformly stirring to prepare the adhesive;

4) Adding the adhesive in the step 3 into the primary powder prepared in the step 2 while stirring to prepare a soft material;

5) Drying the soft material at 90 + -5 deg.C for 30min, sieving with 14 mesh sieve, and granulating to obtain dry granule;

6) Adding the granules, magnesium stearate and goat milk powder into a total mixing machine, and mixing for 15min;

7) And (5) tabletting the semi-finished product prepared in the step (5) to obtain the pilling.

Compared with the prior art, the invention has the following beneficial effects:

the Plantago ovata forsk shell powder is rich in dietary fiber, and the ratio of soluble dietary fiber to insoluble dietary fiber is as high as 7. Can quickly absorb water in the stomach to form a transparent pasty substance, can promote hairs to gather from the stomach to the intestinal tract, is mild and does not hurt the stomach. In addition, the pasty substance can improve the lubricating condition of feces and intestinal wall, maintain the moisture and softness of feces, and the gel mass can stimulate the intestinal wall to produce reflex contraction effect, so as to accelerate the evacuation speed of intestinal tract, and accelerate the discharge of hair bulb in vivo. In addition, the plantain seed husk powder can greatly relieve constipation symptoms of cats caused by pompon disease and is beneficial to the recovery of intestinal health.

Vitamin A, vitamin C, vitamin D3, vitamin E, vitamin B2, cystine, methionine, taurine, glycine, zinc, manganese, iron, copper and selenium are nutrients necessary for the growth of the hair of the cat, the components are organically combined and scientifically proportioned, the symptoms of poor hair growth, easiness in hair shedding and hair loss and the like caused by nutrient deficiency of the cat can be effectively improved, and the hair bulb disease is prevented from being generated from the source. The cat health-care product can be used for preventing and treating the pompon disease, maintaining the intestinal health and enhancing the immunity of the organism by regular use, thereby improving the health degree of the cat.

The goat milk powder is rich in nutrition, easy to digest, good in palatability due to compatibility with ferric glycinate, selenium yeast and the like, and capable of being eaten by pets without refusing.

Compared with the existing hair paste product, the product of the invention: (1) the palatability is good, and no phagostimulant is contained; (2) the hair bulb is discharged mildly, so that the hair bulb has no stimulation to gastrointestinal tracts; (3) The drug administration is more convenient and accurate, and the feeding can be reasonably carried out according to the weight of the cat; (4) The nutrition is more comprehensive, and the pompon disease can be more effectively prevented and treated; and (5) the quality is more stable, and the shelf life is longer.

Detailed Description

The present invention will be described in further detail with reference to specific examples, but the present invention should not be construed as being limited thereto. Modifications or substitutions to methods, procedures, or conditions of the invention may be made without departing from the spirit and scope of the invention. The experimental methods and reagents of the formulations not specified in the examples were carried out according to the conventional conditions in the art.

The raw materials of the invention are all commercial products.

Example 1

A fur ball dissolving tablet for cats comprises the following components in percentage by weight:

plantago ovata seed husk powder 15%, zinc methionine 0.04%, manganese methionine 0.01%, ferric glycinate 0.04%, copper glycinate 0.01%, selenium yeast 0.0004%, vitamin A0.007%, vitamin D3.0007%, vitamin E0.025%, vitamin C0.015%, vitamin B2.005%, taurine 0.1%, cystine 0.1%, microcrystalline cellulose 77.65%, sodium hydroxymethyl cellulose 1%, goat milk powder 5%, and magnesium stearate 1%.

The preparation method comprises the following steps:

1) Sieving all the raw material components with a 60-mesh sieve for later use;

2) Weighing formula amounts of Plantago ovata forsk seed husk powder, zinc methionine, manganese methionine, iron glycine, copper glycine, selenium yeast, vitamin A, vitamin D3, vitamin E, vitamin C, vitamin B2, taurine, cystine and microcrystalline cellulose, and sequentially adding into a wet granulation mixer according to an equivalent incremental method for mixing for 4min to obtain primary powder;

3) Weighing the sodium carboxymethylcellulose according to the prescription amount, adding purified water, and uniformly stirring to prepare the adhesive;

4) Adding the adhesive in the step 3 into the primary powder prepared in the step 2 while stirring to prepare a soft material;

5) Drying the soft material at 90 + -5 deg.C for 30min, sieving with 14 mesh sieve, and granulating to obtain dry granule;

6) Adding the sized particles, the magnesium stearate and the goat milk powder into a total mixing machine, and mixing for 15min;

7) And (5) tabletting the semi-finished product prepared in the step (5) to obtain the pilling.

Example 2

A fur ball dissolving tablet for cats comprises the following components in percentage by weight:

20% of plantain seed husk powder, 0.1% of zinc methionine, 0.03% of manganese methionine, 0.1% of ferric glycinate, 0.03% of copper glycinate, 0.001% of yeast selenium, 0.02% of vitamin A, 0.002% of vitamin D, 0.025% of vitamin E, 0.03% of vitamin C, 0.01% of vitamin B2, 0.3% of taurine, 0.3% of cystine, 69% of microcrystalline cellulose, 2% of sodium carboxymethylcellulose, 6% of goat milk powder and 2% of magnesium stearate.

The preparation method comprises the following steps:

1) Sieving all the raw material components with a 60-mesh sieve for later use;

2) Weighing formula amounts of Plantago ovata forsk seed husk powder, zinc methionine, manganese methionine, iron glycine, copper glycine, selenium yeast, vitamin A, vitamin D3, vitamin E, vitamin C, vitamin B2, taurine, cystine and microcrystalline cellulose, and sequentially adding into a wet granulation mixer according to an equivalent incremental method for mixing for 4min to obtain primary powder;

3) Weighing the sodium carboxymethylcellulose according to the prescription amount, adding purified water, and uniformly stirring to prepare the adhesive;

4) Adding the adhesive in the step 3 into the primary powder prepared in the step 2 while stirring to prepare a soft material;

5) Drying the soft material at 90 + -5 deg.C for 30min, sieving with 14 mesh sieve, and granulating to obtain dry granule;

6) Adding the granules, magnesium stearate and goat milk powder into a total mixing machine, and mixing for 15min;

7) And (5) tabletting the semi-finished product prepared in the step (5) to obtain the pilling.

Example 3

A fur ball dissolving tablet for cats comprises the following components in percentage by weight:

25% of plantain seed husk powder, 0.2% of zinc methionine, 0.05% of manganese methionine, 0.2% of ferric glycinate, 0.05% of copper glycinate, 0.002% of yeast selenium, 0.04% of vitamin A, 0.0035% of vitamin D3, 0.15% of vitamin E, 0.05% of vitamin C, 0.02% of vitamin B2, 0.5% of taurine, 0.5% of cystine, 60.23% of microcrystalline cellulose, 3% of sodium hydroxymethyl cellulose, 7% of goat milk powder and 3% of magnesium stearate.

The preparation method comprises the following steps:

1) Sieving all the raw material components with a 60-mesh sieve for later use;

2) Weighing formula amounts of Plantago ovata forsk seed husk powder, zinc methionine, manganese methionine, iron glycine, copper glycine, selenium yeast, vitamin A, vitamin D3, vitamin E, vitamin C, vitamin B2, taurine, cystine and microcrystalline cellulose, and sequentially adding into a wet granulation mixer according to an equivalent incremental method for mixing for 4min to obtain primary powder;

3) Weighing a prescribed amount of sodium carboxymethylcellulose, adding purified water, and uniformly stirring to prepare an adhesive;

4) Adding the adhesive in the step 3 into the primary powder prepared in the step 2 while stirring to prepare a soft material;

5) Drying the soft material at 90 + -5 deg.C for 30min, sieving with 14 mesh sieve, and granulating to obtain dry granule;

6) Adding the granules, magnesium stearate and goat milk powder into a total mixing machine, and mixing for 15min;

7) And (5) tabletting the semi-finished product prepared in the step (5) to obtain the pilling.

Example 4

A fur ball dissolving tablet for cats comprises the following components in percentage by weight:

30% of psyllium husk powder, 0.3% of zinc methionine, 0.08% of manganese methionine, 0.3% of ferric glycinate, 0.08% of copper glycinate, 0.003% of selenium yeast, 0.06% of vitamin A, 0.005% of vitamin D, 0.2% of vitamin E, 0.1% of vitamin C, 0.03% of vitamin B2, 0.7% of taurine, 0.7% of cystine, 51.44% of microcrystalline cellulose, 4% of sodium carboxymethylcellulose, 8% of goat milk powder and 4% of magnesium stearate.

The preparation method comprises the following steps:

1) Sieving all the raw material components with a 60-mesh sieve for later use;

2) Weighing formula amounts of Plantago ovata forsk seed husk powder, zinc methionine, manganese methionine, iron glycine, copper glycine, selenium yeast, vitamin A, vitamin D3, vitamin E, vitamin C, vitamin B2, taurine, cystine and microcrystalline cellulose, and sequentially adding into a wet granulation mixer according to an equivalent incremental method for mixing for 4min to obtain primary powder;

3) Weighing the sodium carboxymethylcellulose according to the prescription amount, adding purified water, and uniformly stirring to prepare the adhesive;

4) Adding the adhesive in the step 3 into the primary powder prepared in the step 2 while stirring to prepare a soft material;

5) Drying the soft material at 90 + -5 deg.C for 30min, sieving with 14 mesh sieve, and granulating to obtain dry granule;

6) Adding the granules, magnesium stearate and goat milk powder into a total mixing machine, and mixing for 15min;

7) And (5) tabletting the semi-finished product prepared in the step (5) to obtain the pilling.

Example 5

A fur ball dissolving tablet for cats comprises the following components in percentage by weight:

35% of plantain seed husk powder, 0.4% of zinc methionine, 0.1% of manganese methionine, 0.4% of ferric glycinate, 0.1% of copper glycinate, 0.004% of selenium yeast, 0.075% of vitamin A, 0.0075% of vitamin D3, 0.25% of vitamin E, 0.15% of vitamin C, 0.05% of vitamin B2, 1% of taurine, 1% of cystine, 41.46% of microcrystalline cellulose, 5% of sodium hydroxymethyl cellulose, 10% of milk powder and 5% of magnesium stearate.

The preparation method comprises the following steps:

1) Sieving all the raw material components with a 60-mesh sieve for later use;

2) Weighing formula amounts of Plantago ovata forsk seed husk powder, zinc methionine, manganese methionine, iron glycine, copper glycine, selenium yeast, vitamin A, vitamin D3, vitamin E, vitamin C, vitamin B2, taurine, cystine and microcrystalline cellulose, and sequentially adding into a wet granulation mixer according to an equivalent incremental method for mixing for 4min to obtain primary powder;

3) Weighing a prescribed amount of sodium carboxymethylcellulose, adding purified water, and uniformly stirring to prepare an adhesive;

4) Adding the adhesive in the step 3 into the primary powder prepared in the step 2 while stirring to prepare a soft material;

5) Drying the soft material at 90 + -5 deg.C for 30min, sieving with 14 mesh sieve, and granulating to obtain dry granule;

6) Adding the granules, magnesium stearate and goat milk powder into a total mixing machine, and mixing for 15min;

7) And (5) tabletting the semi-finished product prepared in the step (5) to obtain the pilling.

Test example 1 quality index examination

(I) test materials

The hair ball melting tablets of examples 1 to 5 were packed in high density polyethylene bottles for oral solid pharmaceutical use.

Test method and index

The investigation indexes include properties, smell, smoothness, friability and disintegration time limit. The friability testing method was carried out according to the specification of "0923 tablet friability test method" in the first appendix of the 2020 edition of the "Chinese veterinary pharmacopoeia". The disintegration time limit is determined according to 0921 disintegration time limit inspection method in the appendix of the first part of the 2020 edition of the Chinese veterinary pharmacopoeia.

Examination results

The results of quality index investigation of the fuzz ball tablets of each example group are shown in table 1. The results in table 1 show that the pills prepared by the method have good appearance, the friability and the disintegration time meet the requirements, and the smell is appropriate, which indicates that the preparation process of the pills is good.

TABLE 1 survey of quality index of hair ball tablet

Test example 2 evaluation of therapeutic Effect

1. Test materials

The hair melting ball tablets of examples 1 to 5 were prepared from commercially available hair melting paste as a comparative example.

Test method

2.1 Test animal

180 Chinese countryside cats diagnosed with the hair bulb disease are grouped according to the principle that the weight and the sex proportion are similar, and the number of the groups is 6, and each group contains 30 cats. Indoor cage culture is adopted, basic cats are fed regularly three times a day in the morning, in the middle and at night, and water is freely drunk.

Frequency of feeding

The feed is fed for 2 weeks 1 time a day.

Clinical observations

The sick cat was observed every day for mental state, appetite, whether or not retching and defecation were caused, and for softness and hardness of stool and whether or not there was hair in the stool.

Index for evaluating therapeutic effect

2.4.1 Cure rate

The pompon disease is completely relieved, the mental state and the appetite are recovered to be normal, the defecation is not abnormal, the constipation is avoided, and the excrement is normal.

High efficiency

The trichomadesis is partially relieved, the mental state and the appetite are increased, and the excrement can be discharged, but the excrement is hard and has scattered hair or hair balls. Vomiting can be observed, which can highlight some hair balls with mucus on the surface.

Inefficiency of

Pompon symptoms were not alleviated, mental status was poor, there was no appetite, constipation, no defecation for many days, abdominal distension, and a marked pain response in the affected cats.

Test results

The therapeutic effect of the hair ball melting pieces of each example group and the hair melting cream of the comparative example on the hair ball disease is shown in table 2. As can be seen from the data in the table, the hairball melting tablets of the example groups are continuously fed for 2 weeks, the cure rate of the hairball cat disease is 66.7 to 76.7 percent, the effective rate is 86.7 to 96.7 percent, and the hairball melting tablets are obviously higher than the hairball melting tablets of the comparative example. The results show that the components of the formula of the hair ball melting tablet supplement each other, and the ideal hair ball melting effect can be achieved.

TABLE 2 evaluation results of therapeutic effects of the respective groups

In light of the foregoing description of the preferred embodiment of the present invention, many modifications and variations will be apparent to those skilled in the art without departing from the spirit and scope of the invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention. The technical scope of the present invention is not limited to the content of the specification, and must be determined according to the scope of the claims.

Claims (8)

1. The hair removal pill for cats and the preparation method thereof are characterized in that the pill comprises the following raw materials by weight percent: 15-35% of plantain seed husk powder, 0.1-1% of compound mineral elements, 0.05-0.5% of compound vitamins, 1-5% of compound amino acids, 1-5% of sodium carboxymethylcellulose, 1-5% of magnesium stearate, 5-10% of goat milk powder and 40-80% of microcrystalline cellulose.

2. A wool ball melting tablet for cats according to claim 1, wherein the complex mineral elements comprise zinc methionine, manganese methionine, iron glycine, copper glycine, selenium yeast.

3. The wool ball melting sheet for cats, according to the claim 2, is characterized in that, the content of zinc methionine in the wool ball melting sheet is 0.04 to 0.40 percent, the content of manganese methionine is 0.01 to 0.10 percent, the content of iron glycinate is 0.04 to 0.40 percent, the content of copper glycinate is 0.01 to 0.10 percent, and the content of selenium yeast is 0.0004 to 0.0040 percent.

4. The wool ball melting sheet for cats according to claim 1, wherein the vitamin complex comprises vitamin A, vitamin D3, vitamin E, vitamin C, and vitamin B2.

5. The hair ball melting sheet for cats according to claim 4, wherein the content of vitamin A in the hair ball melting sheet is 0.007 to 0.075%, the content of vitamin D3 is 0.0007 to 0.0075%, the content of vitamin E is 0.025 to 0.250%, the content of vitamin C is 0.015 to 0.150%, and the content of vitamin B2 is 0.005 to 0.050% by weight.

6. The cat hair ball melting tablet as claimed in claim 1, wherein the compound amino acid is taurine and cystine.

7. The wool ball melting sheet for cats according to claim 6, wherein the content of taurine in the wool ball melting sheet is 0.1 to 1.0% and the content of cystine is 0.1 to 1.0% by weight percentage.

8. A process for the preparation of a cat chemosphere tablet according to any one of claims 1 to 8, comprising the steps of:

1) Sieving all the raw material components with a 60-mesh sieve for later use;

2) Weighing the formula amount of Plantago ovata forsk husk powder, compound mineral elements, compound vitamins, compound amino acids and microcrystalline cellulose, and sequentially adding into a wet granulation mixer according to an equivalent incremental method for 4min to obtain primary powder;

3) Weighing the sodium carboxymethylcellulose according to the prescription amount, adding purified water, and uniformly stirring to prepare the adhesive;

4) Adding the adhesive in the step 3 into the primary powder prepared in the step 2 while stirring to prepare a soft material;

5) Drying the soft material at 90 + -5 deg.C for 30min, sieving with 14 mesh sieve, and granulating to obtain dry granule;

6) Adding the granules, magnesium stearate and goat milk powder into a total mixing machine, and mixing for 15min to obtain semi-finished product;

7) And (4) tabletting the semi-finished product prepared in the step (6) to obtain the pilling.