CN115844895B - 依米立酮化合物在制备用于治疗中枢神经系统癌症的药物中的用途 - Google Patents

依米立酮化合物在制备用于治疗中枢神经系统癌症的药物中的用途

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Publication number
CN115844895B
CN115844895B CN202211658374.3A CN202211658374A CN115844895B CN 115844895 B CN115844895 B CN 115844895B CN 202211658374 A CN202211658374 A CN 202211658374A CN 115844895 B CN115844895 B CN 115844895B
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cancer
compound
therapeutic agent
treatment
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CN115844895A (zh
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J·E·艾伦
M·斯托格努
V·V·普拉布
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Oncoceutics Inc
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Oncoceutics Inc
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Priority claimed from PCT/US2016/015817 external-priority patent/WO2016123571A1/en
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CN202211658374.3A 2016-01-29 2017-01-30 依米立酮化合物在制备用于治疗中枢神经系统癌症的药物中的用途 Active CN115844895B (zh)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
PCT/US2016/015817 WO2016123571A1 (en) 2015-01-30 2016-01-29 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo [1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one, analogs and salts thereof and their use in therapy
USPCT/US2016/015817 2016-01-29
US201662308325P 2016-03-15 2016-03-15
US62/308,325 2016-03-15
US201662425403P 2016-11-22 2016-11-22
US62/425,403 2016-11-22
PCT/US2017/015608 WO2017132661A2 (en) 2016-01-29 2017-01-30 G protein-coupled receptor (gpcr) modulation by imipridones
CN201780015327.8A CN109311980B (zh) 2016-01-29 2017-01-30 通过依米立酮（imipridones）进行的g蛋白偶联受体（gpcr）调制

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CN201780015327.8A Division CN109311980B (zh) 2016-01-29 2017-01-30 通过依米立酮（imipridones）进行的g蛋白偶联受体（gpcr）调制

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CN115844895A CN115844895A (zh) 2023-03-28
CN115844895B true CN115844895B (zh) 2025-10-17

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CN201780015327.8A Active CN109311980B (zh) 2016-01-29 2017-01-30 通过依米立酮（imipridones）进行的g蛋白偶联受体（gpcr）调制

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US (2) US11116771B2 (enExample)
EP (2) EP4524567A3 (enExample)
JP (2) JP7030701B2 (enExample)
KR (2) KR20250065717A (enExample)
CN (2) CN115844895B (enExample)
AU (2) AU2017211423B2 (enExample)
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BR112018015590A2 (pt) * 2016-01-29 2019-10-01 Oncoceutics Inc modulação de receptor acoplado à proteína g (gpcr) por imipridonas
US10172862B2 (en) * 2017-01-30 2019-01-08 Oncoceutics, Inc. Imipridones for gliomas
EP3682035B1 (en) * 2017-09-15 2025-02-05 The Regents of the University of California Detecting somatic single nucleotide variants from cell-free nucleic acid with application to minimal residual disease monitoring
WO2019067709A1 (en) * 2017-09-27 2019-04-04 The Regents Of The University Of California GPCR IN FIBROBLASTS ASSOCIATED WITH CANCER
WO2019152733A1 (en) 2018-01-31 2019-08-08 Mayo Foundation For Medical Education And Research Methods of treating fibrotic pathologies
CA3096448A1 (en) * 2018-04-09 2019-10-17 Orgenesis Inc. Bioxomes particles, redoxomes, method and composition
CN109157656B (zh) * 2018-10-15 2021-08-27 重庆医科大学附属永川医院 一种双靶标肿瘤疫苗及其制备方法和应用
JP2022520997A (ja) * 2019-02-22 2022-04-04 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム イミプリドンを使用する方法
KR20220041847A (ko) 2019-07-30 2022-04-01 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 섬유성 병리를 치료하기 위한 화합물 및 방법
KR102403686B1 (ko) 2020-05-15 2022-05-31 뉴로핏 주식회사 뇌자극 위치 제공장치 및 방법
WO2022029459A1 (en) 2020-08-06 2022-02-10 Eötvös Loránd Tudományegyetem Synthesis of novel imipridone derivatives and their evaluation for their anticancer activity
CN112402439A (zh) * 2020-11-18 2021-02-26 西安组织工程与再生医学研究所 miR-325核酸类似物在制备改善肝胶原沉积相关产品中的应用
US11648248B1 (en) 2022-01-12 2023-05-16 King Abdulaziz University Potent antimicrobial compounds with a pyridazine nucleus
CN119384515A (zh) * 2022-08-03 2025-01-28 施显东 基于drd1和/或drd5的精神状态定量测定方法及其应用
CN115531378B (zh) * 2022-10-19 2023-10-13 中国医学科学院医药生物技术研究所 Pht427作为ndm-1与kpc-2双重抑制剂的应用
WO2024157207A1 (en) * 2023-01-25 2024-08-02 Gpcr Therapeutics, Inc. Gpcr inhibitors and uses thereof
WO2024218275A1 (en) * 2023-04-20 2024-10-24 Institut Gustave Roussy Liquid and solid compositions of imipridone derivatives
CN116731136B (zh) * 2023-08-04 2023-12-05 齐鲁工业大学(山东省科学院) H3k23a组蛋白点突变在提高酿酒酵母乙酸耐受性及木糖发酵性能中的应用

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