CN115843898A - Compound with bowel relaxing function and preparation method thereof - Google Patents
Compound with bowel relaxing function and preparation method thereof Download PDFInfo
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Abstract
The invention relates to the technical field of health-care food, and particularly discloses a compound with the effect of relaxing bowel and a preparation method thereof.
Description
Technical Field
The application relates to the technical field of health-care food, and particularly discloses a compound with an effect of relaxing bowel and a preparation method thereof.
Background
In the process of continuous development of social economy, the life rhythm of people is gradually accelerated along with the step of economic development, and the pressure from work and life is continuously increased. In today's social setting, long term overload of living and working stress causes around 70% of the world's population to suffer from gastrointestinal disorders to varying degrees. Among them, constipation, the most common functional gastrointestinal tract disease in clinical practice, is a common problem which troubles people in modern labor. Is also the inducing factor of a plurality of high lethal diseases such as acute cardiovascular and cerebrovascular diseases, dementia, colorectal cancer and the like, and the prevalence rate is as high as 27 percent.
Meanwhile, with the research of modern medicine and combination with the tea drinking habit since ancient times, the tea drink is found to be suitable for drinking, can effectively reduce fat and weight, resist oxidation, reduce high blood pressure, high blood fat, high blood sugar, high blood fat, radiation, mutation and virus, detoxify, optimize the drinking water quality, and simultaneously has various health care effects of conditioning gastrointestinal tracts, improving metabolism and the like.
Meanwhile, xylo-oligosaccharide is a naturally-occurring five-carbon sugar alcohol, and has the functions of reducing blood sugar, preventing decayed teeth, improving liver functions, relaxing bowel and the like.
In the existing physiological conditioning process, tea drinks and other substances are combined to condition the body of a user together so as to achieve the effects of reducing fat and losing weight, expelling toxin and detoxifying, but how to distribute and combine tea and xylo-oligosaccharide systematically is not involved, and the function of relaxing bowel by compounding tea and xylo-oligosaccharide in a specific way is not achieved.
Therefore, the inventor provides a compound with the effect of relaxing bowel and a preparation method thereof so as to solve the problems.
Disclosure of Invention
The invention aims to solve the problem that the traditional tea and xylo-oligosaccharide compound does not have a systematic compound method and a definite compound means.
In order to achieve the purpose, the basic scheme of the invention provides a compound with the effect of relaxing bowel, which is prepared from tea, xylo-oligosaccharide, semen cassiae, fructus cannabis, semen trichosanthis and semen boitae serving as raw materials in parts by weight: 100-300 parts of tea, 20-60 parts of xylo-oligosaccharide, 5-15 parts of semen cassiae, 5-15 parts of fructus cannabis, 5-15 parts of semen trichosanthis and 5-15 parts of semen boitae.
Further, the raw materials in parts by weight are as follows: 200 parts of tea, 40 parts of xylo-oligosaccharide, 10 parts of cassia seed, 10 parts of fructus cannabis, 10 parts of snakegourd seed and 10 parts of platycladi seed.
Further, the tea leaves are Yaan Tibetan tea.
The basic scheme of the invention also provides a preparation method of the compound with the function of relaxing bowel, which comprises the following steps:
step A001: weighing raw materials;
step A002: selecting and cleaning the weighed Yaan Tibetan tea leaves, then airing and baking to obtain baked Yaan Tibetan tea leaves, wherein the baking temperature is 245-255 ℃;
step A003: grinding roasted Yaan Tibetan tea into powder and sieving with a 100-400 mesh sieve to obtain Yaan Tibetan tea powder, respectively grinding semen Cassiae, fructus Cannabis, semen Trichosanthis and semen Platycladi into powder and sieving with a 50-70 mesh sieve to obtain semen Cassiae powder, fructus Cannabis powder, semen Trichosanthis powder and semen Platycladi powder;
step A004: mixing Yaan Tibetan tea powder, xylo-oligosaccharide, semen cassiae powder, fructus cannabis powder, semen trichosanthis powder and semen boitae powder to obtain a compound of Yaan Tibetan tea, xylo-oligosaccharide, semen cassiae, fructus cannabis, semen trichosanthis and semen boitae, and bagging the compound in tea bags in batches.
Further, in the step a002, the cleaning, airing and baking of the yaan Tibetan tea leaves weighed comprise the following steps:
step S001: the weighed Yaan Tibetan tea leaves are soaked by water spraying, and when the Yaan Tibetan tea leaves are completely wet and completely unfolded, the unfolded Yaan Tibetan tea leaves are obtained;
step S002: soaking completely unfolded Yaan Tibetan tea in barley enzyme cleaning solution with enzyme activity concentration of 0.13-0.26 u/ml for 1-4 hr, and maintaining the temperature of barley enzyme cleaning solution at 2-4 deg.C;
step S003: and spreading the soaked Yaan Tibetan tea leaves on a drainable device for draining, spraying and cleaning with clear water, and gradually performing the steps of dewatering, drying in the air and baking after cleaning to obtain the baked Yaan Tibetan tea leaves.
Furthermore, each liter of barley enzyme cleaning solution is also added with 55-58g of vitamin C, 12-13g of cysteine and 60-65g of reductive glutathione.
Further, in step a003, the roasted yaan zang tea leaves were pulverized and sieved through a 100-mesh sieve.
Further, in step a004, after the bagged compound is obtained, when the bagged compound is soaked, the bagged compound needs to be soaked in water with a PH value of 6.8-7.3, and the soaking temperature is 80-85 ℃.
Further, the soaking time is not less than 10min.
Further, in step A004, the prepared bagged complete compound should be stored in a space with a temperature of 20-30 ℃ and a humidity of 40-60%.
The principle and effect of this basic scheme lie in:
1. according to the invention, by providing a systematic preparation method of the compound of tea, xylo-oligosaccharide, cassia seed, fructus cannabis, semen trichosanthis and semen platycladi, combining a certain amount of tea, xylo-oligosaccharide, cassia seed, fructus cannabis, semen trichosanthis and semen platycladi with tea, xylo-oligosaccharide, cassia seed, fructus cannabis, semen trichosanthis and semen platycladi, a certain effect of relaxing bowel can be achieved when the compound is used for soaking and drinking every time, the stability of the effect of relaxing bowel after drinking the compound is ensured, and the problem that the traditional compound of tea and xylo-oligosaccharide does not have a systematic compounding method and a clear compounding means is solved.
2. On the basis of the provided basic scheme, yaan Tibetan tea can be selected to prepare the compound, rich nutrient substances and dietary fibers contained in the tea can reduce the reabsorption amount of bile acid, change the digestion rate of food and the secretion amount of digestive secretions, promote the acceleration of gastrointestinal peristalsis, promote the emptying of intestinal tracts, reduce the reabsorption of waste and toxin by intestinal walls and excrete stubborn stool; the xylo-oligosaccharide can promote the nutrient elements in the tea leaves to be better absorbed and utilized in intestinal tracts, the xylo-oligosaccharide and the tea leaves achieve the effect of promoting absorption synergistically, and the xylo-oligosaccharide and the tea leaves can be matched with cassia seeds, fructus cannabis, semen trichosanthis and semen boitae in traditional Chinese medicines to better improve the environment in the intestinal tracts and achieve the effect of relaxing bowel.
3. When the Yaan Tibetan tea complex is prepared, the Yaan Tibetan tea needs to be selected, cleaned, aired and baked when the Yaan Tibetan tea complex is prepared, and the Yaan Tibetan tea complex is not polluted when the Yaan Tibetan tea complex is prepared.
4. When the Yaan Tibetan tea is cleaned, the barley enzyme cleaning solution with the enzyme activity concentration of 0.13u/ml-0.26u/ml is selected for cleaning, so that harmful substances can be effectively removed.
5. When the compound is soaked, the compound is soaked in water with the pH value of 6.8-7.3 and the temperature of 80-85 ℃ optimally, so that the beneficial substances in the Yaan Tibetan tea, the xylo-oligosaccharide, the cassia seed, the fructus cannabis, the semen trichosanthis and the semen boitae can be effectively extracted.
Detailed Description
To further illustrate the technical means and effects of the present invention adopted to achieve the predetermined objects, the embodiments, structures, features and effects according to the present invention are described in detail as follows.
A compound with the effect of relaxing bowel and a preparation method thereof are disclosed, wherein the embodiment is as follows:
the raw materials are selected first, in this embodiment, ya' an tibet tea is selected for the tea leaves, but in other embodiments, other kinds of tea leaves can be selected, including but not limited to black tea, green tea, or camellia chrysantha tea.
In this embodiment, after 200 parts of yaan Tibetan tea, 40 parts of xylo-oligosaccharide, 10 parts of cassia seed, 10 parts of fructus cannabis, 10 parts of semen trichosanthis and 10 parts of semen boitae are carried out according to the following parts by weight, a compound of yaan Tibetan tea, xylo-oligosaccharide, cassia seed, fructus cannabis, semen trichosanthis and semen boitae is prepared, and a preparation flow of the compound is as follows:
step A001: weighing raw materials;
step A002: selecting and cleaning the weighed Yaan Tibetan tea leaves, then airing and baking to obtain baked Yaan Tibetan tea leaves, wherein the baking temperature is 245-255 ℃;
step A003: grinding roasted Yaan Tibetan tea into powder and sieving with a 100-400 mesh sieve to obtain Yaan Tibetan tea powder, respectively grinding semen Cassiae, fructus Cannabis, semen Trichosanthis and semen Platycladi into powder and sieving with a 50-70 mesh sieve to obtain semen Cassiae powder, fructus Cannabis powder, semen Trichosanthis powder and semen Platycladi powder;
step A004: mixing Yaan Tibetan tea powder, xylo-oligosaccharide, semen cassiae powder, fructus cannabis powder, semen trichosanthis powder and semen boitae powder to obtain a compound of Yaan Tibetan tea, xylo-oligosaccharide, semen cassiae, fructus cannabis, semen trichosanthis and semen boitae, and bagging the compound in tea bags in batches.
In this embodiment, when step a002 is performed, the cleaning, airing and baking process of the yaan tibet tea leaves can be performed as follows:
step S001: spraying water to soak the weighed Yaan Tibetan tea leaves, and obtaining stretched Yaan Tibetan tea leaves after the Yaan Tibetan tea leaves are completely wet and completely stretched;
step S002: soaking completely unfolded Yaan Tibetan tea in barley enzyme cleaning solution with enzyme activity concentration of 0.13-0.26 u/ml for 1-4 hr, and maintaining the temperature of the barley enzyme cleaning solution at 2-4 deg.C;
step S003: and spreading the soaked Yaan Tibetan tea leaves on a drainable device for draining, spraying and cleaning with clear water, and gradually performing the steps of dewatering, drying in the air and baking after cleaning to obtain the baked Yaan Tibetan tea leaves.
Wherein, in the step S002, the barley enzyme cleaning solution for soaking the extended outer wall of the tea leaves of Yaan Tibetan tea can be directly selected from the barley enzyme cleaning solution with the concentration of 0.13u/ml, and the barley enzyme cleaning solution is soaked and cleaned for 2 hours, and the temperature of the barley enzyme cleaning solution is kept between 2 ℃ and 4 ℃.
In this example, 55g of vitamin C, 12g of cysteine and 60g of reduced glutathione were also added to each liter of barley enzyme cleaning solution used for the soaked yaan tibet tea leaves.
In this example, step a003 was performed, and the yaan zang tea leaves ground into powder were sieved with a 100-mesh sieve to obtain yaan zang tea powder, and step a004 was performed.
In this embodiment, after the formulation and preparation of the compound are completed and the bag is filled, the compound can be directly added into water for soaking to obtain a compound solution of the compound.
When soaking, water with pH value of 6.8-7.3 is preferably used, and soaking temperature is preferably 80-85 deg.C.
In this embodiment, it is preferable to store the prepared formulation in a space having a temperature of 20 to 30 ℃ and a humidity of 40 to 60%.
In the embodiment, the compound prepared by the method is also subjected to an experiment for relaxing bowel, and the experimental object is a healthy male Wister rat commonly used in the existing experiment.
The apparatus used in the experiment comprises a constant temperature illumination incubator provided by east-connected electronic development limited company in Harbin; an ultra clean bench provided by Suzhou Antai air technologies, inc.; DHG-9245A electric heating constant temperature blast drying oven provided by Shanghai Qixin scientific instruments, inc.; BCD-236YH cabinet refrigerator provided by Qingdao Haier company; a constant-temperature water bath provided by an oriental electrical instrument factory in the city of Yuyao; an electronic universal oven provided by Zhongxing Weijie instruments Inc. and an electronic balance provided by Yuyao Ojingmi weight verification equipment Inc.
In this experiment, 50 rats of SPF grade and body mass of 128-135 g, provided by Woodson biology, inc., were selected.
In the initial stage of experiment preparation, folium sennae and loperamide hydrochloride provided by medical general in Yaan city are purchased; purchasing charcoal powder and sodium carboxymethylcellulose provided by WAKE experimental equipment GmbH of Yaan city; yaan Tibetan tea, xylo-oligosaccharide, cassia seed, fructus cannabis, semen trichosanthis and semen boitae are purchased from the market.
And the Yaan Tibetan tea, the xylo-oligosaccharide, the cassia seed, the fructus cannabis, the snakegourd seed and the platycladi seed are subjected to preparation of the compound according to the method provided by the embodiment. Then preparing the immersion liquid of Yaan Tibetan tea, xylo-oligosaccharide, cassia seed, fructus cannabis, snakegourd seed and platycladi seed. And preparing folium sennae extractive solution, and setting control group. And finally preparing carbon powder liquid and rolipram hydrochloride liquid.
After the preparation of the compound decoction, the control group and the test solution is finished, the establishment of a rat constipation model is carried out. The rat constipation models that were successfully modeled were then grouped and tested, fed and subjected to a rat bowel movement experiment.
During the experiment, the water intake, feed intake, body mass increment, the number of feces grains in the last 24h and fresh feces mass m of each group of rats during the molding period of 3d and the gastric lavage test sample period of 7d are recorded respectively f (g) And dry mass m of feces d (g) (the collected fresh feces is dried at 105 ℃ until the constant mass is the dry feces mass), and the moisture content of the rat feces is calculated according to the formula (1):
then, small intestine charcoal dust propulsion experiments were performed:
during the experiment, after the test sample is subjected to gavage for 7d, all rats are fasted for 24h without water prohibition, each rat is gavaged with 1.0mL of carbon powder solution, the rat is killed after 25min by removing the neck, the mesentery is separated by opening the abdominal cavity, the small intestine tube with the upper end from the pylorus to the lower end of the ileocecal part is cut and taken, the small intestine tube is placed on a tray, the small intestine is slightly pulled to be in a straight line, and the total length of the small intestine tube is measured to be the total length l of the small intestine 2 (cm), a charcoal powder advancing length l from pylorus to charcoal powder front edge 1 (cm). The carbon dust advancing rate was calculated according to the formula (2).
Intestinal colony detection is then performed and detection data is collected.
In the experiment, the experimental data are all expressed by x +/-s, the significance analysis is carried out by adopting SPSS19.0, and the difference is significant when P is less than 0.05.
The following are the display of the experimental data and the analysis of the data after the experiment is finished:
firstly, in the establishment stage of a constipation model of a rat, the indexes of the rat during modeling are compared as shown in the following table:
note: * Significant difference (P < 0.05) compared to normal control group; * Very significant difference compared to normal control group (P < 0.01).
The water intake, feed intake, body mass increment, fecal grain number and fecal water content of rats in the constipation model group are all obviously lower than those of the normal control group (P is less than 0.05). The results show that the rat constipation model is successfully established by gastric lavage of loperamide hydrochloride to the rat.
The influence of the compound of Yaan Tibetan tea, xylo-oligosaccharide, cassia seed, fructus cannabis, trichosanthes seed and platycladi seed on the conventional index of a constipation rat can be shown by the influence (x +/-s, n = 4) of a tested sample on the body mass increment, the 24h excrement particle number and the excrement water content of the constipation rat:
note: significant difference compared to the model control group (P < 0.05); #, the difference was very significant (P < 0.01) compared to the model control group; delta. Compared to the positive control group, the difference was significant (P < 0.05); delta. The difference was very significant compared to the positive control group (P < 0.01).
From the above table, it can be seen that: after the tested samples are filled in the stomach for 7 days, compared with a model control group, the body mass increment of rats in each tested sample group is increased to different degrees, wherein the body mass increment of a compound high-dose group is most obvious (P is less than 0.01), and has no obvious difference (P is more than 0.05) with a positive control group and a normal control group, which indicates that the compound of Yaan Tibetan tea, xylo-oligosaccharide, cassia seed, fructus cannabis, semen trichosanthis and semen boitae has no adverse effect on the growth and development of the rats and can promote the growth and development of the rats.
Except for the compound low-dose group, the number of 24h excrement grains of rats in other groups is remarkably higher than that of a model control group (P is less than 0.01), the effect of the compound of Yaan Tibetan tea, xylo-oligosaccharide, cassia seed, fructus cannabis, snakegourd seed and platycladi seed is in a dose-dependent relationship, the effect of the compound is better than that of the control group, and the number of the excrement grains can be recovered to be close to that of the normal control group; the influence of the Yaan Tibetan tea, xylo-oligosaccharide, cassia seed, fructus cannabis, semen trichosanthis and semen boitae on the moisture content of the feces of the constipation rats is in a dose-dependent relationship, and compared with a model control group, the moisture content of the feces of the rats in a compound high-dose group is remarkably improved (P is less than 0.01) and is close to that of a normal control group.
The results show that the compound of Yaan Tibetan tea, xylo-oligosaccharide, cassia seed, fructus cannabis, snakegourd seed and platycladi seed can promote the growth and development of constipation rats, obviously improve the number of particles and the water content of excrement of the constipation rats, have the effect of relaxing bowel, and achieve or be superior to the treatment effect of positive medicaments.
The results show that the compound of Yaan Tibetan tea, xylo-oligosaccharide, cassia seed, fructus cannabis, semen trichosanthis and semen boitae with proper dosage can inhibit the proliferation of harmful flora in intestinal tracts of rats with constipation to promote the growth of beneficial flora, and has the effect of conditioning intestinal microenvironment.
And based on the results, the compound achieves the above effects probably because the rich nutrients and dietary fibers contained in the tea can reduce the reabsorption amount of bile acid, change the digestion rate of food and the secretion amount of digestive secretions, promote the gastrointestinal peristalsis to be accelerated, promote the emptying of intestinal tracts, reduce the reabsorption of waste and toxin by the intestinal walls and excrete stubborn stool; the xylo-oligosaccharide can promote the nutrient elements in the tea leaves to be better absorbed and utilized in intestinal tracts, the xylo-oligosaccharide and the tea leaves achieve the effect of promoting absorption synergistically, and the xylo-oligosaccharide and the tea leaves can be matched with cassia seeds, fructus cannabis, semen trichosanthis and semen boitae in traditional Chinese medicines to better improve the environment in the intestinal tracts and achieve the effect of relaxing bowel.
The invention also provides an embodiment two, which is different from the embodiment one only in that: the tea leaves in the raw materials are selected from green tea, and the raw materials are different in weight ratio, in the embodiment, the raw materials are weighed according to the following weight parts: 100 parts of green tea, 20 parts of xylo-oligosaccharide, 5 parts of cassia seed, 5 parts of fructus cannabis, 5 parts of semen trichosanthis and 5 parts of semen boitae. In this example, the preparation of the formulation was the same as described in example one.
Wherein, for green tea, only simple water washing is needed, and then airing and baking are carried out.
Through experimental statistical analysis, the compound prepared by using the green tea as the raw material also has the function of relaxing bowel.
The invention also provides a third embodiment, and the difference between the third embodiment and the second embodiment is only that: the tea leaves in the raw materials are selected from black tea, and the weight ratio of the raw materials is the same as that in the example. In this example, the preparation method of the compound is the same as that described in example two.
Through experimental statistical analysis, the compound prepared by using the black tea as the raw material also has the function of relaxing bowel.
Although the present invention has been described with reference to the preferred embodiments, it will be understood by those skilled in the art that various changes may be made and equivalents may be substituted for elements thereof without departing from the scope of the present invention.
Claims (10)
1. A compound with the effect of relaxing bowel is characterized in that: the tea is prepared from tea, xylo-oligosaccharide, cassia seed, fructus cannabis, semen trichosanthis and semen boitae serving as raw materials in parts by weight: 100-300 parts of tea, 20-60 parts of xylo-oligosaccharide, 5-15 parts of cassia seed, 5-15 parts of fructus cannabis, 5-15 parts of snakegourd seed and 5-15 parts of platycladi seed.
2. The compound with the effect of relaxing bowel according to claim 1, wherein the raw materials in parts by weight are as follows: 200 parts of tea, 40 parts of xylo-oligosaccharide, 10 parts of cassia seed, 10 parts of fructus cannabis, 10 parts of semen trichosanthis and 10 parts of semen boitae.
3. The compound with the effect of relaxing bowel according to any one of claims 1 or 2, wherein the tea leaves are Yaan Tibetan tea.
4. A method for preparing the compound with the effect of relaxing bowel according to claim 3, which is characterized by comprising the following steps: the method comprises the following steps:
step A001: weighing raw materials;
step A002: selecting and cleaning the weighed Yaan Tibetan tea leaves, then airing and baking to obtain baked Yaan Tibetan tea leaves, wherein the baking temperature is 245-255 ℃;
step A003: grinding the roasted Yaan Tibetan tea leaves into powder and sieving the powder by a sieve of 100-400 meshes to obtain Yaan Tibetan tea powder, respectively grinding the cassia seeds, the fructus cannabis, the semen trichosanthis and the semen boitae into powder and sieving the powder by a sieve of 50-70 meshes to respectively obtain the cassia seed powder, the fructus cannabis powder, the semen trichosanthis powder and the semen boitae powder;
step A004: mixing Yaan Tibetan tea powder, xylo-oligosaccharide, semen cassiae powder, fructus cannabis powder, semen trichosanthis powder and semen boitae powder to obtain a compound of Yaan Tibetan tea, xylo-oligosaccharide, semen cassiae, fructus cannabis, semen trichosanthis and semen boitae, and bagging the compound in tea bags in batches.
5. The preparation method of the compound with the effect of relaxing bowel according to claim 4, wherein in the step A002, the steps of washing, airing and baking the weighed Yaan Tibetan tea leaves comprise the following steps:
step S001: spraying water to soak the weighed Yaan Tibetan tea leaves, and obtaining stretched Yaan Tibetan tea leaves after the Yaan Tibetan tea leaves are completely wet and completely stretched;
step S002: soaking completely unfolded Yaan Tibetan tea in barley enzyme cleaning solution with enzyme activity concentration of 0.13-0.26 u/ml for 1-4 hr, and maintaining the temperature of barley enzyme cleaning solution at 2-4 deg.C;
step S003: and spreading the soaked Yaan Tibetan tea leaves on a drainable device for draining, spraying and cleaning with clear water, and gradually performing the steps of dewatering, drying in the air and baking after cleaning to obtain the baked Yaan Tibetan tea leaves.
6. The method for preparing a compound with bowel relaxing effect according to claim 5, wherein 55-58g of vitamin C, 12-13g of cysteine and 60-65g of reduced glutathione are further added to each liter of barley enzyme cleaning solution.
7. The compound with the effect of relaxing bowel according to claim 4, wherein in the step A003, the roasted Yaan Tibetan tea leaves are sieved by a 100-mesh sieve after being crushed.
8. The method for preparing the compound preparation with effect of relieving constipation according to claim 4, wherein after the bagged compound is obtained in step A004, the bagged compound is soaked in water with pH value of 6.8-7.3 at 80-85 ℃.
9. The method for preparing a compound with bowel relaxing effect according to claim 8, wherein the soaking time is not less than 10min.
10. The method for preparing a compound with bowel relaxing effect according to one of claims 4 to 9, wherein in step a004, the prepared bagged compound is stored at a temperature of 20-30 ℃ and a humidity of 40-60%.
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