CN115843299A - 寡核苷酸的合成和相关化合物 - Google Patents

寡核苷酸的合成和相关化合物 Download PDF

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Publication number
CN115843299A
CN115843299A CN202180039628.0A CN202180039628A CN115843299A CN 115843299 A CN115843299 A CN 115843299A CN 202180039628 A CN202180039628 A CN 202180039628A CN 115843299 A CN115843299 A CN 115843299A
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China
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group
compound
formula
optionally substituted
independently selected
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Pending
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CN202180039628.0A
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English (en)
Chinese (zh)
Inventor
钟明宏
Y·金
D·加拉
M·普哈维克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jensen Biopharmaceutical Co ltd
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Jensen Biopharmaceutical Co ltd
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Application filed by Jensen Biopharmaceutical Co ltd filed Critical Jensen Biopharmaceutical Co ltd
Publication of CN115843299A publication Critical patent/CN115843299A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
CN202180039628.0A 2020-03-31 2021-03-30 寡核苷酸的合成和相关化合物 Pending CN115843299A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063003067P 2020-03-31 2020-03-31
US63/003067 2020-03-31
PCT/IB2021/052595 WO2021198883A1 (en) 2020-03-31 2021-03-30 Synthesis of oligonucleotides and related compounds

Publications (1)

Publication Number Publication Date
CN115843299A true CN115843299A (zh) 2023-03-24

Family

ID=75340013

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180039628.0A Pending CN115843299A (zh) 2020-03-31 2021-03-30 寡核苷酸的合成和相关化合物

Country Status (11)

Country Link
US (1) US20240092821A1 (https=)
EP (1) EP4126894A1 (https=)
JP (1) JP2023520201A (https=)
KR (1) KR20220161436A (https=)
CN (1) CN115843299A (https=)
AU (1) AU2021247043A1 (https=)
BR (1) BR112022019752A2 (https=)
CA (1) CA3178892A1 (https=)
IL (1) IL296862A (https=)
MX (1) MX2022012255A (https=)
WO (1) WO2021198883A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4293035A4 (en) 2021-02-12 2025-03-05 Ajinomoto Co., Inc. METHOD FOR THE PRODUCTION OF OLIGONUCLEOTIDES
EP4601656A1 (en) * 2022-10-12 2025-08-20 Pharmorage Pty Limited Modified oligonucleotides
WO2025028656A1 (ja) 2023-08-02 2025-02-06 日東電工株式会社 オリゴヌクレオチドを製造する方法
WO2025235761A1 (en) * 2024-05-09 2025-11-13 Biogen Ma Inc. Reagents and processes for preparing oligonucleotides

Citations (2)

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Publication number Priority date Publication date Assignee Title
JP2000247940A (ja) * 1999-02-26 2000-09-12 Sankyo Co Ltd 新規ベンジルアジド化合物
CN101684136A (zh) * 2008-09-23 2010-03-31 苏州瑞博生物技术有限公司 一种寡核苷酸的制备方法

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WO1992001704A1 (en) 1990-07-26 1992-02-06 Koichi Shudo Oligodeoxyribonucleotides
US6972330B2 (en) * 1996-02-13 2005-12-06 Sirna Therapeutics, Inc. Chemical synthesis of methoxy nucleosides
US5753789A (en) 1996-07-26 1998-05-19 Yale University Oligonucleotides containing L-nucleosides
ES2192672T3 (es) 1996-11-18 2003-10-16 Takeshi Imanishi Nuevos analogos de nucleotidos.
US6770748B2 (en) 1997-03-07 2004-08-03 Takeshi Imanishi Bicyclonucleoside and oligonucleotide analogue
JP3756313B2 (ja) 1997-03-07 2006-03-15 武 今西 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体
US6251666B1 (en) 1997-03-31 2001-06-26 Ribozyme Pharmaceuticals, Inc. Nucleic acid catalysts comprising L-nucleotide analogs
US6794499B2 (en) 1997-09-12 2004-09-21 Exiqon A/S Oligonucleotide analogues
JP4236812B2 (ja) 1997-09-12 2009-03-11 エクシコン エ／エス オリゴヌクレオチド類似体
ES2234563T5 (es) 1999-02-12 2018-01-17 Daiichi Sankyo Company, Limited Nuevos análogos de nucleósidos y oligonucleótidos
US7084125B2 (en) 1999-03-18 2006-08-01 Exiqon A/S Xylo-LNA analogues
US7053207B2 (en) 1999-05-04 2006-05-30 Exiqon A/S L-ribo-LNA analogues
US6525191B1 (en) 1999-05-11 2003-02-25 Kanda S. Ramasamy Conformationally constrained L-nucleosides
JP4151751B2 (ja) 1999-07-22 2008-09-17 第一三共株式会社 新規ビシクロヌクレオシド類縁体
US7569575B2 (en) 2002-05-08 2009-08-04 Santaris Pharma A/S Synthesis of locked nucleic acid derivatives
WO2004041889A2 (en) 2002-11-05 2004-05-21 Isis Pharmaceuticals, Inc. Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
US9284344B2 (en) 2012-05-30 2016-03-15 Hokkaido System Science Co., Ltd. Oligonucleotide synthesis method using highly dispersible liquid-phase support
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WO2017111137A1 (ja) 2015-12-22 2017-06-29 味の素株式会社 オリゴヌクレオチドの製造方法
TW201906855A (zh) 2017-05-02 2019-02-16 日商日產化學工業股份有限公司 寡核苷酸之製造方法

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
JP2000247940A (ja) * 1999-02-26 2000-09-12 Sankyo Co Ltd 新規ベンジルアジド化合物
CN101684136A (zh) * 2008-09-23 2010-03-31 苏州瑞博生物技术有限公司 一种寡核苷酸的制备方法
CN101868473A (zh) * 2008-09-23 2010-10-20 苏州瑞博生物技术有限公司 一种寡核苷酸的制备方法

Non-Patent Citations (3)

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HARRI LÖNNBERG: "Synthesis of oligonucleotides on a soluble support", 《BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY》, vol. 13, 12 July 2017 (2017-07-12), pages 1368 - 1387, XP055798685, DOI: 10.3762/bjoc.13.134 *
TAKESHI WADA ET AL.: "2-(Azidomethyl)benzoyl as a new protecting group in nucleosides", 《TETRAHEDRON LETTERS》, vol. 42, 30 December 2001 (2001-12-30), pages 1069 - 1072, XP085040739, DOI: 10.1016/S0040-4039(00)02183-3 *
赵兴绪编著: "《转基因食品生物技术及其安全评价》", 30 July 2009, 北京：中国轻工业出版社, pages: 69 *

Also Published As

Publication number Publication date
BR112022019752A2 (pt) 2022-11-16
IL296862A (en) 2022-11-01
WO2021198883A1 (en) 2021-10-07
KR20220161436A (ko) 2022-12-06
AU2021247043A1 (en) 2022-10-27
JP2023520201A (ja) 2023-05-16
CA3178892A1 (en) 2021-10-07
US20240092821A1 (en) 2024-03-21
MX2022012255A (es) 2023-01-11
EP4126894A1 (en) 2023-02-08

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