CN115836983B - Skin-moistening and skin-care composition containing modified chitosan and preparation method thereof - Google Patents
Skin-moistening and skin-care composition containing modified chitosan and preparation method thereof Download PDFInfo
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- CN115836983B CN115836983B CN202310164671.0A CN202310164671A CN115836983B CN 115836983 B CN115836983 B CN 115836983B CN 202310164671 A CN202310164671 A CN 202310164671A CN 115836983 B CN115836983 B CN 115836983B
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Abstract
The invention relates to a skin-moistening and skin-care composition containing modified chitosan and a preparation method thereof, wherein the skin-moistening and skin-care composition comprises the following components in parts by mass: 3-15 parts of peptide, 0.15-0.75 part of zinc element, 0.2-0.6 part of propolis powder, 0.05-0.3 part of tremella extract, 0.3-0.5 part of modified chitosan and 0.1-0.3 part of mannitol; the modified chitosan is obtained by grafting reaction of chitosan and isonicotinic acid. The isonicotinic acid grafted chitosan has good water solubility, can improve the viscosity of a composition solution, prolongs the release time of active ingredients, can generate good synergistic effect with mannitol and other ingredients, ensures that the active ingredients are uniformly distributed in the solution, enhances the stability of a product, and promotes the full absorption of the active ingredients, thereby realizing good effects of moisturizing, beautifying and protecting the skin.
Description
Technical Field
The invention relates to the technical field of health-care foods, in particular to a skin-moistening and nail-care composition containing modified chitosan and a preparation method thereof.
Background
With the aging and the influence of environmental factors such as ultraviolet irradiation, active oxygen free radicals in human body are increased, and the active oxygen can induce the peroxidation of unsaturated fatty acid (RH) in lipid in human body to generate lipid peroxidation free radicals. For example, malondialdehyde, a product of peroxidation of unsaturated lipids, plays an important role in the aging process of the human body. Lipid peroxidation also has a great influence on human health, and liver is extremely vulnerable to lipid peroxide to cause liver diseases.
The most obvious appearance is that the collagen of the human body is in a loss trend, so that the skin loses moisture and luster, and the elasticity is poor and becomes rough. Nail gloss also decreases and begins to become brittle. Studies have shown that the capacity of fibroblasts decreases from 25 years old and that the rate of loss of collagen, the sharp tool against skin aging, in humans begins to increase, with less rapid supply.
Meanwhile, in order to pursue diversity of beauty, the female has become a popular fashion trend. However, nails are mainly composed of keratin, and various chemical reagents are frequently used for nail beautification, so that the nails are damaged, nail breakage, nail fragility and other phenomena are caused, and the nails which are required to be pink are dark yellow. The existing research and market products have little research on oral nail polish preparations and focus more on nail polish. The product is generally prepared by mixing essential oil serving as a main raw material and auxiliary agents such as phthalic acid ester, formaldehyde and the like, and has a certain isolation effect, but the nail repairing force is weakened after long-term use, and the effect is not durable.
In order to keep the skin, nails and the like youthful, the external beauty skin care product and the doctor make many choices, but the problems are difficult to solve fundamentally. The theory of traditional Chinese medicine has been studied for a long time, and lung governs fur and liver governs tendons. The stability of skin and nails has close relation with the balance of viscera and diet of human body, and the skin and nails can be regulated from inside to outside through the oral nutrition beautifying agent, so that the skin and nails have better effect compared with the external beautifying product which is singly used, but the related oral composition product is lacking at present, and a large market blank exists.
In view of the foregoing, there is a need to develop a new technical solution to provide a health care product with good skin care and nail care functions, so as to solve the problems in the prior art.
Disclosure of Invention
Based on the above, the invention develops the skin-moistening and nail-care composition containing the modified chitosan, which contains various active ingredients, and the modified chitosan is added, so that the composition has good skin-moistening, beautifying and nail-care effects, and meanwhile, has good stability and lasting effect, overcomes the defects in the existing products, and has good application prospect.
The invention aims at providing a skin-moistening and nail-care composition containing modified chitosan, which comprises the following components in parts by weight:
peptide 3-15 parts
0.15-0.75 part of zinc element
0.2-0.6 part of propolis powder
0.05-0.3 part of tremella extract
0.3 to 0.5 part of modified chitosan
Mannitol 0.1-0.3 weight portions;
wherein, the liquid crystal display device comprises a liquid crystal display device,
the tremella extract comprises tremella polysaccharide;
the modified chitosan is obtained by grafting reaction of chitosan and isonicotinic acid.
Propolis powder is a natural antioxidant, and contains flavonoid compounds, terpene compounds and the like with rich antioxidant effect, so that the activity of superoxide dismutase (SOD) in a human body can be obviously improved. According to domestic and foreign researches, the propolis can inhibit the expression of downstream signal molecules NF-KBp65 and p53 and the level of ROS and inhibit the release of NO by reducing the activity of PC-PLC and the expression of TLR4, thereby playing an anti-inflammatory role. In addition, the flavone in the propolis can reduce the activity of serum glutamic pyruvic transaminase (ALT) and glutamic pyruvic transaminase (AST), thereby improving the level of SOD and GSH-Px in liver tissues, reducing the content of MDA and protecting liver.
The tremella polysaccharide is similar to plant-derived hyaluronic acid substances, and the active center a- (1-3) -manna can be combined with moisturizing factors such as amino acid in skin, and the like, so that the barrier function of the skin is improved. In the test of mice, tremella polysaccharide can obviously reduce lipofuscin content of myocardial tissues of mice and increase superoxide dismutase activity of brain and liver tissues. Meanwhile, the content of P-450 in liver cells, for example, can be increased by promoting the synthesis of nucleic acid and protein.
Further, the preparation method of the modified chitosan comprises the following steps:
s1, dissolving chitosan in a solvent, then adding isonicotinic acid and an activating agent, and stirring for reaction to obtain a crude product;
s2, dialyzing and freeze-drying the crude product to obtain the modified chitosan.
The isonicotinic acid grafted chitosan has better water solubility, and after the isonicotinic acid grafted chitosan is dissolved in water, the viscosity and the adsorption capacity of the product can be enhanced, so that active substances in the composition are adsorbed in the solution for a long time, the acting time of the product is prolonged, and the functions of long-acting skin moisturizing and nail care are realized. Surprisingly, the modified chitosan has better compatibility with mannitol, tremella polysaccharide and other components, so that the active components can be stably existing in the composition, the aggregation and precipitation phenomena of the components are effectively avoided, and a good synergistic effect can be generated among various components to promote the absorption of the active components, thereby realizing the effects of inhibiting and removing free radicals, and improving and repairing skin and nail injuries.
Further, in the step S1, the mass ratio of the chitosan to the isonicotinic acid is 1 (0.5-2).
Further, the activator is selected from one or more of EDC and NHS.
Further, in the step S1, the molecular weight of the chitosan is 50-100 kDa, and the deacetylation degree is 80-95%.
Further, the peptide is selected from one or more of palmitoyl tripeptide, tetrapeptide, carnosine, collagen peptide, elastin peptide, antibacterial peptide, glutathione, wood frog polypeptide, soybean polypeptide, walnut polypeptide, wheat germ active peptide, fish polypeptide, scallop polypeptide, sea squirt polypeptide, sea anemone polypeptide, and seaweed polypeptide.
Further, the peptide is collagen peptide and scallop polypeptide.
The fish collagen peptide belongs to type I collagen, has a molecular weight of 30 x 104Da, a fiber length of 280nm and a diameter of 1.5nm, is an elongated needle-shaped rigid body, and forms a spiral structure by 3 alpha-peptide chains with a molecular weight of about 10 x 104 Da. Contains a large amount of hydrophilic groups, so that the moisturizing agent has good moisturizing effect and can achieve the aim of keeping skin moist. Does not contain cell and tissue compatible collagen, and does not induce antibody and immune response. And the skin-penetrating agent has very strong permeability to skin, and can rapidly supplement collagen lost by the skin. The collagen is synthesized by fibroblast under the catalysis of relevant growth factors and enzymes, secreted out of the cell by exocytosis, and formed into collagen fiber under the action of extracellular enzymes, so as to achieve various skin care and beauty effects.
The scallop polypeptide is water-soluble marine polypeptide extracted from viscera of Chlamys farreri. It is reported that ultraviolet radiation damage is caused by oxidative decomposition of cell membrane and enzyme protein hydrosulfide group caused by superoxide anion, and causes cell damage, so that skin and nails are aged prematurely. The scallop polypeptide can effectively remove superoxide anions and hydroxyl radicals in skin, inhibit lipid peroxidation, and increase the average thickness of fibroblasts and epidermis in skin tissues, thereby delaying skin aging.
Further, the weight portion of the collagen peptide is 3-10, and the weight portion of the scallop polypeptide is 0.05-0.5.
Further, the content of the tremella polysaccharide is 0.1-0.2 part.
Further, the zinc element is selected from one or more of zinc sulfate, zinc glutamate, zinc acetate, zinc lactate, zinc gluconate, zinc glycinate and zinc-enriched yeast.
Further, the zinc element is zinc-rich yeast.
Zinc in zinc-rich yeast is an essential element for human body, and when the element is lacking, the nail is provided with symptoms of uneven pits and easy breakage, and the skin is roughened. Zinc has effects of stabilizing SOD enzyme structure, scavenging free radicals, and protecting biological membrane.
Another object of the present invention is to provide a method for preparing the above-mentioned skin care and nail care composition containing modified chitosan, comprising the steps of: sequentially adding peptide, zinc element, propolis powder, tremella extract and mannitol into water, uniformly stirring, adding modified chitosan, and stirring for 20-40 min to obtain the skin-moistening and nail-care composition containing the modified chitosan.
The invention has the following beneficial effects:
the skin-moistening and nail-care composition containing the modified chitosan adopts isonicotinic acid grafted chitosan as an additive, has better water solubility, can promote the viscosity of a composition solution, prolongs the release time of active ingredients, can generate good synergistic effect with mannitol and other ingredients, ensures that the active ingredients are uniformly distributed in the solution, enhances the stability of a product, promotes the full absorption of the active ingredients, and realizes good skin-moistening, beautifying and nail-care effects, so that the skin-moistening and nail-care composition has wide application environment and good application prospect, and has great economic value and market potential.
Detailed Description
In order to more clearly illustrate the technical solution of the present invention, the following examples are set forth. The starting materials, reactions and workup procedures used in the examples are those commonly practiced in the market and known to those skilled in the art unless otherwise indicated.
The words "preferred," "more preferred," and the like in the present disclosure refer to embodiments of the present disclosure that may provide certain benefits in some instances. However, other embodiments may be preferred under the same or other circumstances. Furthermore, the recitation of one or more preferred embodiments does not imply that other embodiments are not useful, nor is it intended to exclude other embodiments from the scope of the invention.
It should be understood that, except in any operating examples, or where otherwise indicated, quantities or all numbers expressing, for example, quantities of ingredients used in the specification and claims are to be understood as being modified in all instances by the term "about". Accordingly, unless indicated to the contrary, the numerical parameters set forth in the following specification and attached claims are approximations that may vary depending upon the desired properties to be obtained by the present invention.
The chitosan in the embodiment of the invention is purchased from Qingdao Hongsha biotechnology Co., ltd, and has the molecular weight of 100 kDa, the deacetylation degree of 91.0% and the viscosity of 45 mPa.s.
Collagen peptides in the examples of the present invention were purchased from french Luo Sailuo.
The scallop polypeptide in the embodiment of the invention is purchased from the Sichuan treasures biotechnology Co.
The zinc-rich yeasts of the present embodiments are purchased from Angel Yeast Co.
The propolis powder in the embodiment of the invention is purchased from Henan Fumei biotechnology Co., ltd, and the total flavone content is 14.0%.
The tremella polysaccharide in the embodiment of the invention is purchased from Shaanxi femto biotechnology Co.
The preparation method of the modified chitosan in the embodiment of the invention comprises the following steps:
s1, dissolving chitosan in 2% acetic acid solution, adding isonicotinic acid (chitosan: isonicotinic acid=1:1, m/m) and an activator (EDC.HCl: NHS=1.3:0.26, n/n), and stirring to react for 6 h to obtain a crude product;
s2, performing distilled water dialysis and freeze drying on the crude product to obtain the modified chitosan.
In the embodiment of the invention, "parts" refer to parts by weight.
The respective components and the corresponding parts by weight of the skin care and nail care compositions of examples 1-3 containing the modified chitosan are shown in Table 1.
Table 1 examples 1-3 skin-caring and nail-protecting compositions containing modified chitosan
The method for preparing the skin care and nail care composition containing the modified chitosan of the examples 1-3 comprises the following steps: according to the parts by weight, the collagen peptide, the scallop polypeptide, the zinc-rich yeast, the propolis powder, the tremella polysaccharide and the mannitol are sequentially added into water, the modified chitosan is added after uniform stirring, and the skin-moistening and nail-care composition containing the modified chitosan is obtained after stirring for 30 min.
Its comparative example was set based on example 1. The ingredients of the comparative examples are shown in Table 2.
Table 2 the skin care and nail care compositions of comparative examples 1 to 3 comprise the components in parts by weight
Comparative examples 1 to 3 differ from example 1 in that: the modified chitosan, tremella polysaccharide and mannitol components are correspondingly replaced or deleted, and other components and preparation methods are the same as those of the example 1.
Test example 1
Skin moisturizing and nail care capability test
The testing method comprises the following steps:
60 healthy, skin disease-free female volunteers of 25 to 30 years were selected and divided into 6 groups of 10 persons each, each group being tested with the skin care and nail care compositions prepared in examples 1 to 3 and comparative examples 1 to 3, and the volunteers were orally administered 20 mL daily for 1 month. The skin moisture content of the forehead area of the face was measured using a skin moisture oil content tester (Shanghai precision instruments factory SD-g 7) at 0 d, 15 d, 30 d, and the average value of each time period was calculated for each group. And meanwhile, the situation of the pits and the cracks of the nails of the volunteers before and after the test is counted, so that the situation of whether the volunteers have obvious improvement is counted.
The test results are shown in Table 3.
TABLE 3 Performance test results
According to Table 3, it can be seen that the skin care and nail care compositions prepared in examples 1-3 of the present invention contain the modified chitosan and mannitol, which can effectively stabilize and adsorb active ingredients, and a good synergistic effect is generated among various components, so that dissolution and absorption of ingredients such as peptides, polysaccharides, zinc elements, etc. are promoted, and thus the skin care capability is further improved, the moisture content of the skin is effectively increased, and the health condition of nails is improved. The active ingredients of comparative examples 1 to 3, which were not modified chitosan, hyaluronic acid instead of tremella polysaccharide and mannitol, were not fully absorbed and utilized, and the same effects could not be achieved, and the test results were significantly lower than those of examples.
Test example 2
Stability test
The skin care nail compositions prepared in examples 1-3 and comparative examples 1-3 were tested for stability by the following procedure:
high temperature stability: taking 100 ml parts of each skin-moistening and nail-care composition, placing into a transparent container, sealing, placing into an environment of 40+/-1 ℃, standing at constant temperature for 1 month, and observing the appearance.
Low temperature stability: taking 100 ml parts of each skin-moistening and nail-care composition, placing into a transparent container, sealing, placing into an environment of 0+/-2 ℃, standing at constant temperature for 1 month, and observing the appearance.
The test results are shown in table 4:
TABLE 4 stability test of examples 1-3 and comparative examples 1-3
According to Table 4, the high-low temperature stability of the invention examples 1-3 is good, and aggregation, turbidity and precipitation are not generated, which is obviously better than that of the comparative examples 1-3, thus showing that the modified chitosan, tremella polysaccharide and mannitol added by the invention can form good synergistic effect, and the stability of the composition is improved.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential characteristics thereof. The present embodiments are, therefore, to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein.
Furthermore, it should be understood that although the present disclosure describes embodiments, not every embodiment is provided with a separate embodiment, and that this description is provided for clarity only, and that the disclosure is not limited to the embodiments described in detail below, and that the embodiments described in the examples may be combined as appropriate to form other embodiments that will be apparent to those skilled in the art.
Claims (4)
1. The skin-moistening and nail-care composition containing the modified chitosan is characterized by comprising the following components in parts by weight:
peptide 3-15 parts
0.15-0.75 part of zinc element
0.2-0.6 part of propolis powder
0.1-0.3 part of tremella extract
0.3 to 0.5 part of modified chitosan
Mannitol 0.1-0.3 weight portions;
wherein, the liquid crystal display device comprises a liquid crystal display device,
the tremella extract is tremella polysaccharide;
the peptide is collagen peptide and scallop polypeptide;
the zinc element is one or more selected from zinc sulfate, zinc glutamate, zinc acetate, zinc lactate, zinc gluconate, zinc glycinate and zinc-enriched yeast;
the preparation method of the modified chitosan comprises the following steps:
s1, dissolving chitosan in a solvent, then adding isonicotinic acid and an activating agent, and stirring for reaction to obtain a crude product;
s2, dialyzing and freeze-drying the crude product to obtain the modified chitosan;
in the step S1, the mass ratio of the chitosan to the isonicotinic acid is 1 (0.5-2), and the molecular weight of the chitosan is 50-100 kDa; the activator is selected from one or more of EDC and NHS.
2. The skin-care and nail-care composition containing modified chitosan according to claim 1, wherein the collagen peptide is 3-10 parts by mass and the scallop polypeptide is 0.05-0.5 parts by mass.
3. The skin care and nail care composition containing modified chitosan according to claim 1, wherein the content of the tremella polysaccharide is 0.1-0.2 parts.
4. A method for preparing the skin care and nail care composition containing modified chitosan according to any one of claims 1 to 3, comprising the steps of: sequentially adding peptide, zinc element, propolis powder, tremella extract and mannitol into water, uniformly stirring, adding modified chitosan, and stirring for 20-40 min to obtain the skin-moistening and nail-care composition containing the modified chitosan.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112315881A (en) * | 2020-11-17 | 2021-02-05 | 姚佃文 | Collagen peptide mask liquid and preparation method thereof |
| CN112401244A (en) * | 2020-12-11 | 2021-02-26 | 多糖博士生物科技(广州)有限公司 | Composition of medium molecular weight tremella polysaccharide and collagen peptide and application thereof |
| CN115381733A (en) * | 2022-09-22 | 2022-11-25 | 深圳市回春堂健康管理服务有限公司 | Anti-aging composition for promoting collagen effect and application thereof |
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| CN107320382B (en) * | 2017-07-31 | 2018-06-22 | 上海中翊日化有限公司 | A kind of composition containing dried tremella extract and the application in personal care articles |
| CN109125299A (en) * | 2018-10-16 | 2019-01-04 | 罗永城 | A kind of medicament and preparation method thereof promoting wound healing |
| CN113769150B (en) * | 2021-10-22 | 2022-05-17 | 广东海洋大学 | Composite material with rapid blood coagulation effect and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112315881A (en) * | 2020-11-17 | 2021-02-05 | 姚佃文 | Collagen peptide mask liquid and preparation method thereof |
| CN112401244A (en) * | 2020-12-11 | 2021-02-26 | 多糖博士生物科技(广州)有限公司 | Composition of medium molecular weight tremella polysaccharide and collagen peptide and application thereof |
| CN115381733A (en) * | 2022-09-22 | 2022-11-25 | 深圳市回春堂健康管理服务有限公司 | Anti-aging composition for promoting collagen effect and application thereof |
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