CN115836983A - Skin-moistening and nail-protecting composition containing modified chitosan and preparation method thereof - Google Patents
Skin-moistening and nail-protecting composition containing modified chitosan and preparation method thereof Download PDFInfo
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- CN115836983A CN115836983A CN202310164671.0A CN202310164671A CN115836983A CN 115836983 A CN115836983 A CN 115836983A CN 202310164671 A CN202310164671 A CN 202310164671A CN 115836983 A CN115836983 A CN 115836983A
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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Abstract
The invention relates to a skin-moistening and nail-protecting composition containing modified chitosan and a preparation method thereof, wherein the skin-moistening and nail-protecting composition comprises the following components in parts by weight: 3-15 parts of peptide, 0.15-0.75 part of zinc element, 0.2-0.6 part of propolis powder, 0.05-0.3 part of tremella extract, 0.3-0.5 part of modified chitosan and 0.1-0.3 part of mannitol; the modified chitosan is obtained by the grafting reaction of chitosan and isonicotinic acid. The isonicotinic acid grafted chitosan has good water solubility, can improve the viscosity of a composition solution, prolong the release time of an active ingredient, and simultaneously can generate a good synergistic effect with components such as mannitol and the like, so that the active ingredient is uniformly distributed in the solution, the stability of a product is enhanced, and the full absorption of the active ingredient is promoted, thereby realizing good skin moistening, beautifying and nail protection effects.
Description
Technical Field
The invention relates to the technical field of health-care food, in particular to a skin-moistening and nail-protecting composition containing modified chitosan and a preparation method thereof.
Background
With the aging and the influence of environmental factors, such as ultraviolet irradiation, active oxygen radicals in human body increase, and the active oxygen can induce the peroxidation of unsaturated fatty acid (RH) in body lipids to generate lipid peroxidation free radicals. For example, malondialdehyde, a product of peroxidation of unsaturated lipids, plays an important role in the aging process of the human body. Lipid peroxidation also has a great impact on human health, and the liver is extremely vulnerable to lipid peroxide attack to cause liver disease.
The most obvious external manifestation is that the collagen of the human body tends to be lost, so that the skin loses moisture and luster, and the elasticity is deteriorated and roughened. The nails also decrease in gloss and begin to become brittle. Research has shown that the fibroblast productivity decreases from 25 years old, the loss of collagen, an organ of human body, which resists skin aging, increases, and the production and supply speed is not as high as that of human body.
Meanwhile, nowadays, in order to pursue diversification of beauty, nail beauty has become a general fashion trend. However, nails are mainly composed of keratin, and frequent use of various chemical agents for nail beautification can damage nails, cause phenomena such as nail breakage and nail brittleness, and the nails which should be pink can also be dark yellow. However, the existing research and the products on the market have little research on oral nail-care preparations, and more research focuses on nail polish. The product is generally prepared by taking essential oil as a main raw material and adding auxiliary agents such as phthalate, formaldehyde and the like and mixing, has a certain isolation effect, but the nail repair force is weakened after long-term use, and the effect is not durable.
In order to keep skin and nails young, external beauty products and medicines become choices of many people, but all the products are difficult to solve fundamentally. The theory of traditional Chinese medicine has been studied early, and the lung governs the skin and hair, and the liver governs the tendons. The stability of skin and nails is closely related to the balance of human viscera and diet, and the oral nutritional cosmetic can be used for regulating from inside to outside, and has better effect compared with the external cosmetic which is used alone, but the prior oral composition product is lacked, and has larger market blank.
In view of the above, there is a need to develop a new technical solution to provide a health product with good skin moistening and nail protection functions, so as to solve the problems in the prior art.
Disclosure of Invention
Based on the above, the invention develops the skin-moistening and nail-protecting composition containing the modified chitosan, which contains various active ingredients, and the modified chitosan is added, so that the composition has good skin-moistening, beautifying and nail-protecting effects, simultaneously has good stability and lasting effect, overcomes the defects in the existing products, and has good application prospect.
The invention aims to provide a skin-moistening and nail-protecting composition containing modified chitosan, which comprises the following components in parts by weight:
3-15 parts of peptide
0.15 to 0.75 portion of zinc element
0.2-0.6 part of propolis powder
0.05-0.3 parts of tremella extract
0.3-0.5 part of modified chitosan
0.1-0.3 part of mannitol;
wherein the content of the first and second substances,
the tremella extract comprises tremella polysaccharide;
the modified chitosan is obtained by the grafting reaction of chitosan and isonicotinic acid.
The propolis powder is a natural antioxidant, and can significantly improve the activity of superoxide dismutase (SOD) in a human body due to the fact that the propolis powder contains abundant flavonoid, terpene compounds and the like with antioxidant effect. According to the research at home and abroad, the propolis can inhibit the expression of downstream signal molecules NF-kBp65 and p53 and the level of ROS by reducing the activity of PC-PLC and the expression of TLR4 and inhibit the release of NO, thereby exerting the anti-inflammatory effect. In addition, the flavone in propolis can reduce the activity of serum alanine Aminotransferase (ALT) and aspartate Aminotransferase (AST), thereby improving the levels of SOD and GSH-Px in liver tissue, reducing the content of MDA, and protecting liver.
The tremella polysaccharide is similar to plant-derived hyaluronic acid substances, and the active center a- (1-3) -mannan can be combined with moisturizing factors such as amino acid in the skin, so that the barrier function of the skin is improved. In a mouse test, the tremella polysaccharide can obviously reduce the lipofuscin content of the myocardial tissue of a mouse and increase the activity of superoxide dismutase of the brain and the liver tissue. Meanwhile, the content of the P-450 of the liver serving as an example cell can be increased by promoting the synthesis of nucleic acid and protein.
Further, the preparation method of the modified chitosan comprises the following steps:
s1, dissolving chitosan in a solvent, adding isonicotinic acid and an activating agent, and stirring for reaction to obtain a crude product;
and S2, dialyzing the crude product, and freeze-drying to obtain the modified chitosan.
The isonicotinic acid grafted chitosan has better water solubility, and after the component is dissolved in water, the viscosity and the adsorption capacity of a product can be enhanced, so that active substances in the composition can be adsorbed in the solution for a long time, the action time of the product is prolonged, and the functions of long-acting skin moistening and nail protection are realized. Surprisingly, the modified chitosan has better compatibility with mannitol, tremella polysaccharide and other components, so that the active ingredients can stably exist in the composition, the phenomena of component aggregation and precipitation are effectively avoided, a good synergistic effect can be generated among various components, the absorption of the active ingredients is promoted, and the effects of inhibiting and eliminating free radicals and improving and repairing skin and nail injuries are achieved.
Further, in the step S1, the mass ratio of the chitosan to the isonicotinic acid is 1 (0.5-2).
Further, the activating agent is selected from one or more of EDC and NHS.
Further, in step S1, the chitosan has a molecular weight of 50-100 kDa and a degree of deacetylation of 80-95%.
Further, the peptide is selected from one or more of palmitoyl tripeptide, tetrapeptide, carnosine, collagen peptide, elastin peptide, antibacterial peptide, glutathione, wood frog polypeptide, soybean polypeptide, walnut polypeptide, wheat germ active peptide, fish polypeptide, scallop polypeptide, ascidian polypeptide, sea anemone polypeptide and seaweed polypeptide.
Further, the peptides are collagen peptides and scallop polypeptides.
The fish collagen peptide belongs to type I collagen, has the molecular weight of 30X 104Da, the fiber length of 280nm and the diameter of 1.5nm, is a slender needle-shaped rigid body, and forms a spiral structure by 3 alpha-peptide chains with the molecular weight of about 10X 104Da. Contains a large amount of hydrophilic groups, so that the skin moisturizing cream has a good moisturizing effect and can achieve the purpose of keeping the skin moist. It contains no cell and histocompatibility collagen, and does not induce antibody and immune response. And has very strong permeability to skin, and can rapidly supplement collagen lost by skin. The collagen is synthesized by fibroblasts under the catalysis of relevant growth factors and enzymes, is secreted to the outside of cells through exocytosis, and then forms collagen fibers under the action of extracellular enzymes, thereby achieving various skin-care and beauty-care effects.
The scallop polypeptide refers to water-soluble marine polypeptide extracted from viscera of chlamys farreri. Research reports that ultraviolet radiation damage generates superoxide anions to cause oxidative decomposition of cell membranes and enzyme protein sulfhydryl, so that cell damage is caused, and skin and nails are aged prematurely. The scallop polypeptide can effectively remove superoxide anions and hydroxyl free radicals in the skin, inhibit lipid peroxidation, increase the average thickness of fibroblasts and epidermis in skin tissues, and further delay skin aging.
Further, the collagen peptide is 3-10 parts by weight, and the scallop polypeptide is 0.05-0.5 part by weight.
Further, the content of the tremella polysaccharide is 0.1-0.2 part.
Further, the zinc element is selected from one or more of zinc sulfate, zinc glutamate, zinc acetate, zinc lactate, zinc gluconate, zinc glycinate and zinc-rich yeast.
Further, the zinc element is zinc-rich yeast.
Zinc in the zinc-rich yeast is an essential element for human body, and the lack of the element can cause the nail to have symptoms of uneven and easy to break, and the skin to be rough. In vivo, zinc has the effects of stabilizing SOD enzyme structure, scavenging free radicals, and protecting biological membrane.
It is another object of the present invention to provide a method for preparing the above skin and nail care composition containing modified chitosan, comprising the steps of: and sequentially adding the peptide, the zinc element, the propolis powder, the tremella extract and the mannitol into water, uniformly stirring, adding the modified chitosan, and stirring for 20-40 min to obtain the skin-moistening and nail-protecting composition containing the modified chitosan.
The invention has the following beneficial effects:
the skin-moistening and nail-protecting composition containing the modified chitosan adopts the isonicotinic acid grafted chitosan as an additive, the component has better water solubility, the viscosity of a solution of the composition can be improved, the release time of the active component is prolonged, and meanwhile, the active component and mannitol and other components can generate a good synergistic effect, so that the active component is uniformly distributed in the solution, the stability of the product is enhanced, and the full absorption of the active component is promoted, thereby realizing good skin-moistening, beautifying and nail-protecting effects.
Detailed Description
In order to more clearly illustrate the technical solution of the present invention, the following examples are given. The starting materials, reactions and work-up procedures which are given in the examples are, unless otherwise stated, those which are customary on the market and are known to the person skilled in the art.
The words "preferred", "preferably", "more preferred", and the like, in the context of this invention, refer to embodiments of the invention that may, in some instances, provide certain benefits. However, other embodiments may be preferred, under the same or other circumstances. Furthermore, the recitation of one or more preferred embodiments does not imply that other embodiments are not useful, and is not intended to exclude other embodiments from the scope of the invention.
It is to be understood that except in any operating examples, or where otherwise indicated, all numbers expressing, for example, quantities of ingredients used in the specification and claims are to be understood as being modified in all instances by the term "about". Accordingly, unless indicated to the contrary, the numerical parameters set forth in the following specification and attached claims are approximations that may vary depending upon the desired properties to be obtained by the present invention.
The chitosan in the embodiment of the invention is purchased from Qingdao Honghai biotechnology limited, and has the molecular weight of 100 kDa, the deacetylation degree of 91.0 percent and the viscosity of 45 mPa.s.
The collagen peptides in the examples of the present invention were purchased from Roselo, france.
The scallop polypeptide in the embodiment of the invention is purchased from Xian Weizhen Biotech Co.
The zinc-rich yeast in the examples of the present invention was purchased from Angel Yeast Ltd.
The propolis powder in the embodiment of the invention is purchased from Henan Fumei Biotechnology Limited, and the total flavone content is 14.0%.
The tremella polysaccharide in the embodiment of the invention is purchased from Shaanxi femto-Mi Biotech limited.
The preparation method of the modified chitosan in the embodiment of the invention comprises the following steps:
s1. Chitosan was dissolved in 2% acetic acid solution, then isonicotinic acid (chitosan: isonicotinic acid =1, m/m) and an activating agent (edc.hcl: NHS =1.3, 0.26, n/n) were added, and a crude product was obtained after stirring reaction for 6 h;
and S2, carrying out distilled water dialysis and freeze drying on the crude product to obtain the modified chitosan.
In the examples of the present invention, "parts" means parts by mass.
The components and the corresponding parts by weight of the skin and nail care compositions containing modified chitosan of examples 1-3 are shown in table 1.
Table 1 examples 1-3 skin and nail care compositions containing modified chitosan
The process for preparing the skin and nail care compositions of examples 1-3 containing modified chitosan includes the steps of: sequentially adding collagen peptide, scallop polypeptide, zinc-rich yeast, propolis powder, tremella polysaccharide and mannitol into water according to the mass parts, uniformly stirring, adding modified chitosan, and stirring for 30 min to obtain the skin-moistening and nail-protecting composition containing the modified chitosan.
A comparative example thereof was set based on example 1. The ingredients of the comparative examples are shown in table 2.
TABLE 2 skin-moistening and nail-protecting compositions of comparative examples 1-3, the constituents and their parts by mass
Comparative examples 1-3 differ from example 1 in that: the modified chitosan, tremella polysaccharide and mannitol component are replaced or deleted correspondingly, and other components and preparation methods are the same as those in example 1.
Test example 1
Skin moisturizing and nail protection ability test
The test method comprises the following steps:
60 female volunteers of 25-30 years old who are healthy and have no skin diseases are selected and divided into 6 groups of 10 persons, the skin-moistening and nail-protecting compositions prepared in examples 1-3 and comparative examples 1-3 are respectively tried on each group, and the volunteers take 20 mL of the skin-moistening and nail-protecting composition orally every day for 1 month. The water content of the skin in the forehead area of the face was measured at 0 d, 15 d, and 30 d using a skin water and oil content tester (precision instruments, SD-g7, shanghai) and the average value of each time period was calculated for each group. Meanwhile, counting whether the depression and fracture conditions of the nails of the volunteers before and after the test are obviously improved or not.
The test results are shown in table 3.
Table 3 results of performance testing
As can be seen from table 3, the skin-moisturizing and nail-protecting compositions prepared in examples 1 to 3 of the present invention, because of containing the modified chitosan and mannitol, can effectively stabilize and adsorb active ingredients, and generate a good synergistic effect among various components, and promote the dissolution and absorption of peptides, polysaccharides, zinc elements, and other ingredients, thereby further improving the skin-moisturizing ability, effectively increasing the moisture content of skin, and improving the health condition of nails. However, the active ingredients of comparative examples 1 to 3, which employ unmodified chitosan, hyaluronic acid instead of tremella polysaccharide, and no mannitol added, are difficult to be absorbed and utilized sufficiently, and the same effect cannot be achieved, and the test results are significantly lower than those of the examples.
Test example 2
Stability test
The skin and nail care compositions prepared in examples 1 to 3 and comparative examples 1 to 3 were subjected to a stability test by the following specific test method:
high-temperature stability: 100 ml of each of the skin-moistening and nail-protecting compositions are put into a transparent container and sealed, and the transparent container is placed in an environment with the temperature of 40 +/-1 ℃ for 1 month at constant temperature, and then the appearance of the transparent container is observed.
Low-temperature stability: 100 ml of each of the skin-moistening and nail-protecting compositions are put into a transparent container and sealed, and the transparent container is placed in an environment with the temperature of 0 +/-2 ℃ for 1 month at constant temperature, and then the appearance of the transparent container is observed.
The test results are shown in table 4:
TABLE 4 stability testing of examples 1-3 and comparative examples 1-3
According to the table 4, the high and low temperature stability of the modified chitosan, the tremella polysaccharide and the mannitol in the embodiments 1 to 3 is good, the aggregation, the turbidity and the precipitation are not generated, and the stability is obviously superior to that of the comparative examples 1 to 3, so that the modified chitosan, the tremella polysaccharide and the mannitol added in the invention can form a good synergistic effect, and the composition has an effect of improving the stability of the composition.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein.
Furthermore, it should be understood that although the present specification describes embodiments, not every embodiment includes only a single embodiment, and such description is for clarity purposes only, and it is to be understood that all embodiments may be combined as appropriate by one of ordinary skill in the art to form other embodiments as will be apparent to those of skill in the art from the description herein.
Claims (10)
1. The skin-moistening and nail-protecting composition containing the modified chitosan is characterized by comprising the following components in parts by weight:
3-15 parts of peptide
0.15 to 0.75 portion of zinc element
0.2-0.6 part of propolis powder
0.05-0.3 parts of tremella extract
0.3-0.5 part of modified chitosan
0.1-0.3 part of mannitol;
wherein the content of the first and second substances,
the tremella extract comprises tremella polysaccharide;
the preparation method of the modified chitosan comprises the following steps:
s1, dissolving chitosan in a solvent, adding isonicotinic acid and an activating agent, and stirring for reaction to obtain a crude product;
and S2, dialyzing the crude product, and freeze-drying to obtain the modified chitosan.
2. The skin and nail care composition containing modified chitosan according to claim 1, wherein the mass ratio of chitosan to isonicotinic acid in step S1 is 1 (0.5-2).
3. The skin and nail care composition comprising a modified chitosan according to claim 2, wherein said activator is selected from one or more of EDC and NHS.
4. The skin and nail composition comprising modified chitosan according to claim 1, wherein in step S1, the molecular weight of said chitosan is 50-100 kDa.
5. The skin and nail care composition containing modified chitosan according to claim 1, wherein said peptide is selected from one or more of palmitoyl tripeptide, tetrapeptide, carnosine, collagen peptide, elastin peptide, antibacterial peptide, glutathione, wood frog polypeptide, soybean polypeptide, walnut polypeptide, wheat germ active peptide, fish polypeptide, scallop polypeptide, ascidian polypeptide, sea anemone polypeptide, and seaweed polypeptide.
6. The skin caring and nail protecting composition containing modified chitosan according to claim 5, wherein the peptides are collagen peptides and scallop polypeptides.
7. The skin-moistening and nail-protecting composition containing modified chitosan according to claim 6, wherein the collagen peptide is 3-10 parts by weight, and the scallop polypeptide is 0.05-0.5 part by weight.
8. The skin-moistening and nail-protecting composition containing modified chitosan according to claim 1, wherein the content of tremella polysaccharide is 0.1-0.2 parts.
9. The skin and nail care composition containing modified chitosan according to claim 1, wherein said zinc element is selected from one or more of zinc sulfate, zinc glutamate, zinc acetate, zinc lactate, zinc gluconate, zinc glycinate and zinc-rich yeast.
10. A process for the preparation of a modified chitosan-containing skin and nail composition according to any of claims 1 to 9, comprising the steps of: and sequentially adding the peptide, the zinc element, the propolis powder, the tremella extract and the mannitol into water, uniformly stirring, adding the modified chitosan, and stirring for 20-40 min to obtain the skin-moistening and nail-protecting composition containing the modified chitosan.
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| CN113769150A (en) * | 2021-10-22 | 2021-12-10 | 广东海洋大学 | Composite material with rapid blood coagulation effect and preparation method thereof |
| CN115381733A (en) * | 2022-09-22 | 2022-11-25 | 深圳市回春堂健康管理服务有限公司 | Anti-aging composition for promoting collagen effect and application thereof |
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- 2023-02-26 CN CN202310164671.0A patent/CN115836983B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107320382A (en) * | 2017-07-31 | 2017-11-07 | 上海中翊日化有限公司 | A kind of composition containing dried tremella extract and the application in personal care articles |
| CN109125299A (en) * | 2018-10-16 | 2019-01-04 | 罗永城 | A kind of medicament and preparation method thereof promoting wound healing |
| CN112315881A (en) * | 2020-11-17 | 2021-02-05 | 姚佃文 | Collagen peptide mask liquid and preparation method thereof |
| CN112401244A (en) * | 2020-12-11 | 2021-02-26 | 多糖博士生物科技(广州)有限公司 | Composition of medium molecular weight tremella polysaccharide and collagen peptide and application thereof |
| CN113769150A (en) * | 2021-10-22 | 2021-12-10 | 广东海洋大学 | Composite material with rapid blood coagulation effect and preparation method thereof |
| CN115381733A (en) * | 2022-09-22 | 2022-11-25 | 深圳市回春堂健康管理服务有限公司 | Anti-aging composition for promoting collagen effect and application thereof |
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