CN115813998A - Winter-stored vigor-consolidating nourishing preparation and preparation method thereof - Google Patents

Winter-stored vigor-consolidating nourishing preparation and preparation method thereof Download PDF

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CN115813998A
CN115813998A CN202111090948.7A CN202111090948A CN115813998A CN 115813998 A CN115813998 A CN 115813998A CN 202111090948 A CN202111090948 A CN 202111090948A CN 115813998 A CN115813998 A CN 115813998A
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radix
preparation
nourishing
parts
concentrated solution
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王登之
舒庆艳
方令豪
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Rilein Beijing Institute Of Biochemistry
Zhongkerui Rhine Beijing Biotechnology Co ltd
Ruilin Beijing Biotechnology Co ltd
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Rilein Beijing Institute Of Biochemistry
Zhongkerui Rhine Beijing Biotechnology Co ltd
Ruilin Beijing Biotechnology Co ltd
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    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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Abstract

A nourishing preparation for warming and invigorating qi and blood, nourishing bones and muscles, and strengthening body resistance is prepared from radix Codonopsis, radix rehmanniae Preparata, poria, atractylodis rhizoma (baked), superfine micropowder of Burdock, achyranthis radix, fructus Lycii, colla Plastri Testudinis, and decoction concentrate of cortex Cinnamomi, rhizoma Ligustici Chuanxiong, glycyrrhrizae radix, radix astragali, radix Angelicae sinensis, and radix Paeoniae alba as main raw materials, and is scientifically mixed with colla Corii Asini solution containing fructus Jujubae, rhizoma Zingiberis recens, herba Thymi, and flos Magnoliae, and then concentrated into concentrated solution, which can be added into novel preparation to prepare into nourishing preparation such as Mel ointment, oral liquid, soft candy, cake, etc., and has good recuperating effect on dizziness, listlessness, short breath, cardiopalmus, cold limbs, weakness of feet and knees, and menoxenia caused by deficiency of both qi and blood. The invention not only is the novelty of the medicine combination and the preparation method, but also particularly the invention technical product is proved to have excellent effect on the prevention and treatment of sub-health of the traditional Chinese medicine by the evaluation and scientific detection of relevant professional institutions.

Description

Winter-stored tonic preparation for consolidating constitution and its preparation method
[ technical field ] A method for producing a semiconductor device
The invention relates to a winter-storage essence-consolidating tonic preparation for warming and invigorating qi and blood, nourishing bones and muscles and strengthening the essence and a preparation method thereof, belonging to the field of biological medicine.
[ background of the invention ]
The traditional Chinese medicine of China is boldly and profound. The traditional Chinese medicine ointment nourishing preparation is further provided with profound health preserving philosophy and wisdom, under the guidance of the overall view and syndrome differentiation theory of traditional Chinese medicine, a treatment method is established according to different clinical symptoms of people, time and places, a prescription is developed and added or subtracted according to symptoms, the prescription is established, the traditional Chinese medicines which are prepared into the prescription are decocted under general conditions, dregs are removed, juice is obtained, and the decoction is evaporated and concentrated and then added with honey, crystal sugar or animal glue such as donkey-hide gelatin, tortoise-plastron glue and the like to prepare a semi-fluid oral preparation. The nourishing preparation in the paste formula has the characteristics of medicines for treating diseases, and has the functions of tonifying deficiency, strengthening body resistance, protecting health and preserving health. The cream-type nourishing preparation can be used for: chronic diseases such as atrophic gastritis, cold hands and feet, coronary heart disease, old and chronic bronchitis, or chronic diseases with general weakness, or constitution strengthening; patients in the convalescent stage of the disease; the middle-aged and the elderly and sub-healthy people with reduced immunity and insufficient energy; the nourishing preparation in the form of paste has the advantages of being suitable for four seasons, high in medicine concentration, stable in medicine effect, convenient to take for a long time and the like, and is popular and sought by more and more people.
The cream and formula nourishing preparation technology is far from the source of the development history of traditional Chinese medicines, and roughly goes through three stages, a systematic technology is gradually formed from the beginning of the war country to the Jin Tangsong yuan stage of Han, the Mingqing enters the complete maturity stage, and the cream and formula nourishing preparation technology enters the new development stage nearly at present, the research and clinical application of the cream and formula nourishing preparation technology are rapidly developed, and rich medical achievements are obtained.
The 'prescription for fifty-two diseases' written in the beginning of the first four centuries or the end of the first three centuries in the state of war is the oldest medical prescription in China, wherein the 'prescription prepared by boiling glue with water, boiling ginseng and rice, sip with sip and finally no food' is the earliest oral paste prescription nourishing preparation in the literature; the technical method for preparing the paste by decocting and decocting is recorded for the first time in Shen nong Ben Cao Jing (Shen nong's herbal) about written in Qin Han period, and a foundation is laid for preparing modern paste; the tonic preparation of the ointment formula in Suzuo Tang Yaowang Suzuo Qianjin Chi Fang has the characteristics of decoction in water, residue removal, juice extraction, concentration and oral administration; the early oral paste is also called as decoction, all the medicines with higher decoction viscosity, such as honey, maltose, nourishing medicine juice, jujube paste, animal fat, skin and bone, etc. can be called as decoction, and the aconitum chinese decoction and the pig paste hair decoction in the last year of east Han, zhang Zhongjing (golden lack of essence) are earlier oral paste prescription nourishing preparations; the 'plaster' is named for the first time in Wuwei Han dynasty medical notes of eastern Han period, such as Bai Bing Gao Yao Fang and Qian jin Gao Yao Fang, the prescription and the taking method of the nourishing preparation of the paste prescription are completely recorded, and the Nanchao, ceramic Hongyan and Shen nong Ben Cao Jing Ji Zhu are stated: for diseases, it is suitable to take pills, powder, decoction, wine and decoction, or take the source of disease as the source of ear-making. "it is explicitly indicated that the paste is decocted into the oral preparation; particularly, the rehmannia root decoction for nourishing stomach yin and clearing deficiency heat in the ' Beiji Qianjin key prescription ' is adopted, and the ' ancient and modern decoction prescriptions 6 recorded in the roll of Tangwang cover ' Wai Tai Mi Yao Fang ' firstly improves the medical science of the nourishing cream prescription to a new height for nourishing and strengthening to dispel deficiency and impairment and overstrain injury, namely before and after the Tang Dynasty, the medical science of the nourishing cream prescription basically forms a dialectical thought combining the nourishing and the treatment.
The systematic scientific construction is completed by entering the medicine of nourishing preparations of the Mingqing paste formula. The names and preparation methods of the nourishing preparations in the paste formula are basically fixed, and the nourishing preparations in the paste formula are increasingly widely applied clinically. Motherwort paste in Ming, li Shizhen (compendium of materia Medica), ginseng paste in Gong Tingxian (god of longevity and Baoyuan), tuckahoe paste and other paste prescription nourishing preparations are used up to now, sun Yikui (red water and Xuanzhu) is a nourishing paste for treating consumptive disease, which is a representative prescription of traditional Chinese medicine paste prescription nourishing preparations, and the modern customized paste prescription nourishing preparations are made up in the first river; in the Qing Dynasty, the nourishing preparation of the paste prescription becomes a common means for clinical treatment of diseases, namely the ' Peizshi empty paste ' in She Shi medical record true record of Qing-Ye Tianshi, the ' Yulinggao ' in Wang Shixiong ' along with the resting diet spectrum, the wind flourishing from the Shangqing Gong to the folk using the nourishing preparation of the paste prescription for regulation and nourishing, such as ' Qingtai hospital prescription ' and ' Cixi Guangxi medical prescription ' together accept 30 nourishing preparations of various oral paste prescriptions, wherein the nourishing preparation of the paste prescription can be extracted all the year round as long as the disease is favorable, is not limited to winter, such as the paste for regulating the middle-jiao and clearing heat and resolving dampness, the paste for strengthening Yuan Yiyin in July, the paste for clearing heat and regulating the spleen and removing dampness in September, and meanwhile, the nourishing preparation of the paste prescription should be applied according to syndrome differentiation and is not restricted to tonifying; the kidney life school of the south of the Yangtze river integrates the concepts of ' nourishing yin in autumn and winter ', ' storing essence in kidney ', ' storing essence in spring without disease and warm ' and the like in the Huangdi's inner classic into the Mingmen theory, and the thought of ' tonifying in winter ' is deeply exerted, so that the plaster nourishing formula is created.
The medical science of the tonic preparation of the paste and prescription class is leaping forward to the modern scientific and technological achievements, and in 1939 Qin Bawei, the grand universe of the paste and prescription class, systematically arranges some basic concepts, points and principles in the treatment of the tonic preparation of the paste and prescription class for the first time, and summarizes the clinical experience of the tonic preparation of the paste and prescription class for treating diseases into a book in the form of a medical plan, which still follows the basic principle of the tonic preparation of the paste and prescription class for treating diseases up to now; 58 nourishing preparations of the ointment prescriptions, which are compiled by the Chinese medicine research institute and Shenyang pharmaceutical institute in 1962 from national Chinese patent medicine prescription Collection, are more in number than any one of the previous prescriptions. In 1989, the number of tonic preparations in the paste prescription, which is compiled by Chinese medicinal materials corporation and Chinese patent medicine information center of the national medicine administration, is increased to 152, wherein the tonic preparations in the paste prescription are traditional ones, such as two-instrument paste, guilu Erxian paste, etc., and are also changed from other formulations, such as Shiquan Dabu Tang to Shiquan Dabu paste, and Shenludan to Jinying Gorgon paste, etc. In particular, yan Xin and Hu Dongpei in 2004, the Chinese ointment prescription, 2011 Wu Yingen, the Chinese ointment prescription therapeutics, 2014 Wang Qingguang, and the Chinese ointment nourishing preparation medicine is promoted to a new theory and technology.
The invention is inherited and innovated according to 'Shiquan san' which comes from the book 2 of 'applicable prescription for signaling', so as to 'tonify deficiency, nourish honor Wei Sanjiao, five zang-organs and six fu-organs'. Tracing the source of the disease, the four monarch drugs decoction is combined with the four drugs decoction and is added with the astragalus and the cinnamon; the earlier Yao Wan from Zhang Zhongjing (golden Kui Yao L ü e) contains most of the components of the recipe (only astragalus root is absent). The recipe carried by the prescription from Taiping Huimin He Ji Ju Fang is more famous as 'Shiquan Da Bu Tang', which is used for treating deficiency of men and women, five strains and seven injuries, and no diet; deficiency and impairment due to chronic diseases, tidal fever, attack of qi on bone and spine, spasm and pain, nocturnal emission, sallow complexion, weakness of feet and knees, poor breath after all diseases, worry, anxiety, impairment of blood and qi, dyspnea, cough, fullness in middle energizer, weakness of spleen and kidney, and vexation of five hearts, thereby determining the role of the formula as the main prescription for tonifying qi and blood. Since then, the clinical application of the recipe continues to develop by doctors of all ages, for example, according to the fact that the recipe 2 from Wai Ke Jian (Ex surgical Performance) has the effect of tonifying qi and blood, the recipe is applied to the syndrome of ulcer with deficiency of both qi and blood, which can not form pus for a long time, or can not form pus and can not heal after ulceration. The book 8 in Jiyinjiao gang mu refers to the recipe for treating various diseases before and after pregnancy, and the book 2 and 9 in Jiyinwei Xuan Zhu, yuan Xie and Xiao, which are used to treat herpes, syncope and epilepsy, gradually expand the scope of application of the recipe to those with syndrome of deficiency of both qi and blood in various families, including the interior, the exterior, the women and the children.
The Shiquan Dabu Tang is originally a boiled powder, is changed into pills or paste by doctors of later generations, is respectively named as Shiquan Dabu pills (see 'measles complete book) and Shiquan Dabu paste (see' Chinese medicinal prescription and prescription book), and is prepared into dosage forms such as oral liquid and the like at present, so that the Shiquan Dabu Tang is more convenient for long-term administration.
The modern pharmacological research shows that the medicine composition related to the 'Shiquandabu decoction' has obvious effects of tonifying qi and blood and enhancing the immunity of organisms. The combination with the novel soft extract preparation is convenient for long-term taking, and has very wide market application prospect.
[ Prior art documents ]
[ patent document ]
[ patent document 1 ] application publication no: CN200410060978.3
[ patent document 2 ] application publication no: CN202110251958.8
[ patent document 3] application publication no: CN202110188542.6
[ patent document 4 ] application publication No.: CN202110062569.0
[ patent document 5 ] application publication no: CN201711486318.5
[ patent document 6] application publication no: CN202011426129.0
[ patent document 7] application publication no: CN201710778573.0
[ patent document 8] application publication number: CN201610709953.4
[ patent document 9] application publication no: CN202011297420.2
[ patent document 10] application publication No.: CN93105616.0
[ non-patent literature ]
[ non-patent document 1 ] Zhang Ruiping, chen Wenming, left Asia Jack, yang Lei, wen Min; retrospective study of the use of the ointment formula in Chinese medicine in nearly 6 years at the first subsidiary hospital of the university of traditional Chinese medicine in Hunan; the Chinese medicine is reported; 18 th year 2019.
[ Nonpatent document 2 ] Lin Jiwei, wang Dongcai, wu Haibin, and the like; the traditional Chinese medicine ointment formula has original source flow and modern development conditions; chinese patent medicine; 2018, (11).2554-2556.
[ Nonpatent document 3] Yang Bing, tang Dongxin, long Fengxi, and the like; exploring the historical source and development characteristics of the cream formula; asia Pacific traditional medicine, 2016, (8), 4-6.doi:10.11954/ytctyy.201608002.
[ Nonpatent document 4 ] Wang Wenjuan; talking about the history of Chinese ointment formula; chinese patent medicine 2009, (1) Aconitum carmichaeli 1-Aconitum carmichaeli 2.
[ Nonpatent document 5 ] Li Jushuang; the formula literature before Tang dynasty and the characteristics thereof; journal of traditional Chinese medicine literature, 2008, (1), 16-18.
[ non-patent document 6] Zhou Xin, weng Chaoming, han Li, and the like; preliminary analysis of application conditions of ointment prescriptions in China; chinese medicine journal, 2011, (7) 101-103.
[ non-patent document 7] Linhong, shen Minhe, ruan Shanming, etc.; the ancient book ointment prescription treats the disease; gansu TCM, 2011, (6) 5-7.
[ non-patent document 8] Zhang Monian; clinical research on qi-tonifying and nerve-soothing paste for treating qi-blood deficiency type chronic fatigue syndrome; guangzhou university of traditional Chinese medicine, 2018.
[ non-patent document 9] Xu Hanming; the pharmaceutical research of the modified Guilu Erxian plaster; guangzhou university of traditional Chinese medicine 2014.57.
[ non-patent document 10] Huang Zhuowei, huang Wenxuan; research and clinical application of the ten-full-nourishing Shang Yaoli are in the near situation; traditional Chinese medicine information; stage 2, 1992.
[ summary of the invention ]
[ problem to be solved by the invention ]
In 2007, the Chinese medical society issues "sub-health TCM clinical guidelines" to point out: sub-health refers to a state of the human body between healthy and diseased. A person in a sub-health state cannot meet the health standard, and is manifested by symptoms of reduced vitality and reduced function and adaptability within a certain period of time, but does not meet the clinical or sub-clinical diagnosis standard of diseases related to modern medicine.
Sub-health is manifested in various clinical symptoms, and can be manifested in body aspects as fatigue, weakness, muscle and joint pain, dizziness, headache, palpitation, chest distress, sleep disorder, inappetence, abdominal discomfort, loose stool, constipation, sexual hypofunction, aversion to cold and heat, cold, dry eyes and the like. Psychological aspects may be manifested by depressed mood, dysphoria, irritability, fear, timidity, memory loss, inability to concentrate, lack of energy, slow response, etc. The social interaction can show that the corresponding social roles cannot be well born, the work and the study are difficult, the interpersonal relationship and the family relationship cannot be processed normally, the normal social interaction is difficult, and the like.
According to relevant research and analysis, the white-collar sub-health proportion of the mainstream cities in China is as high as 76%, the white-collar in a strain state is close to six-component, and the proportion of healthy people is less than 3% in a true sense. The health-related population of China is only 15% of the total population, while 15% of people are in disease states and the remaining 70% are in "sub-health" states. If a huge sub-healthy population in China is allowed to naturally develop without social intervention, the population will have more and more adverse effects on social economy and people's life. On the one hand, the quality of life of people will gradually decline; on the other hand, sub-health gradually develops into various chronic diseases, so that the medical cost of the society is rapidly increased, and the coming of an aging society is covered.
The modern Chinese medicine provides a brand-new and effective new idea for manual intervention of sub-health by the profound 'preventive treatment' wisdom of the traditional Chinese medicine. Just as in Huangdi's classic on the day: "is you no longer treating diseases and no diseases for eriodictyor, is a last-part medicine for fuwei diseases, is a second-part medicine for fuwei diseases, such as going through the well with extreme thirst and casting with great fight? From this, it can be seen that the traditional Chinese medicine has an important method for systematically treating the disease without the rain, the silk and the muzzle before the disease is prevented.
Today we further elucidate sub-health from the traditional chinese medicine theory: the main pathogenesis is the disharmony between heart and kidney, dysfunction of spleen in transport and transportation, and disorder of qi activity. Treating the diseases of heart and kidney, regulating qi, strengthening spleen, soothing liver, benefiting gallbladder and reaching triple energizer. Chinese ointment based tonic preparations should have unique technical advantages in this respect.
[ MEANS FOR SOLVING PROBLEMS ] to solve the problems
A plurality of methods and technologies for treating diseases by traditional Chinese medicine are important means for manual intervention of sub-health, and Chinese ointment formula nourishing preparation medicine is the first priority. The life and health science and technology field is not two choices of the inventor for creating a plurality of novel cream nourishing preparations with stable and obvious drug effect, safety, greenness and good compliance of edible people.
From a large amount of literature, the wisdom of Chinese ointment prescription nourishing preparation medicine provides brand-new solution ideas and methods for people. Chinese traditional medicine and pharmacology are gathering profound philosophy wisdom and thousands of years of health preserving concept and practical experience of Chinese national folk, is a treasure of ancient science in China, and is a key (one of) for opening a Chinese civilization treasure house. By combining with modern science and technology, better invention and technical products can be obtained.
[ technical characteristics, novelty, and Effect of the invention ]
The invention relates to a winter storage nourishing preparation for warming and invigorating qi and blood, nourishing bones and muscles and strengthening the body resistance and a preparation method thereof, which takes superfine micropowder of codonopsis pilosula, rehmannia root, tuckahoe, largehead atractylodes rhizome (baked), burdock, achyranthes root, medlar and tortoise plastron glue, and decoction concentrated solution of cinnamon, szechuan lovage rhizome, liquorice, astragalus root, szechuan lovage rhizome, angelica, white paeony root and radix morindae as main raw materials, scientifically matched with red date, ginger and thyme to extract and separate, then added into donkey-hide gelatin solution, and finally added into a novel preparation to prepare the nourishing preparation, and the preparation is a novel pharmaceutical composition and preparation with better nourishing efficacy for dizziness, fatigue, short breath, palpitation, cold limbs, weakness of feet and knees, irregular menstruation and the like caused by deficiency of both qi and blood.
The invention is based on the technology and method of the traditional Chinese medicine and the 'Chinese ointment medicine' and the classic famous prescription 'Shiquandabu decoction', and is inherited and innovated by combining the pharmaceutical industry technologies of modern novel drug delivery systems and the like.
The 'ten-full nourishing soup' is from the 'Taiping Huimin He Ji Ju Fang' issued by the nation in the first department of China in Song Dynasty, and is prepared by combining a basic qi-tonifying prescription, 'four-monarch-seed soup', with a basic blood-tonifying prescription, 'four-ingredient soup', and then adding qi-tonifying astragalus root and yang-tonifying cinnamon.
The prescription of the SHIQUANDABU decoction comprises Ginseng radix, cortex Cinnamomi (without rough skin and fire), rhizoma Ligustici Chuanxiong, rehmanniae radix (with wine and steamed and baked), poria (baked), atractylodis rhizoma (baked), glycyrrhrizae radix (baked), radix astragali (without radix Rhapontici), rhizoma Ligustici Chuanxiong, radix Angelicae sinensis (with radix Rhapontici and with radix Paeoniae alba). The preparation method comprises processing the first ten materials into coarse powder, adding rhizoma Zingiberis recens and fructus Jujubae, and decocting with water to seven minutes to obtain decoction.
The functions are mainly used for treating deficiency of men and women, five strains and seven injuries, no diet, deficiency and impairment due to long-term illness, tidal fever, qi attacking bone and spine, spasm and pain, nocturnal emission, sallow complexion, foot and knee weakness, all qi after illness is not as old, worry, anxiety, injury, bleeding, asthma, cough, fullness in middle-jiao, spleen and kidney qi weakness, five hearts and vexation, and all the symptoms are treated. The medicine has the property of Wen Bure, which has the effects of tonifying, nourishing qi and cultivating spirit, activating spleen to quench thirst, regulating vital qi and exorcising evil, warming spleen and kidney, and the effect cannot be mentioned.
In the formula, the Chinese traditional medicine and the prepared rehmannia root are matched, wherein the Chinese traditional medicine can tonify primordial qi greatly, and the prepared rehmannia root can nourish blood with thick taste, and can tonify both qi and blood; the bighead atractylodes rhizome and the poria cocos tonify spleen and excrete dampness, and assist the ginseng to tonify qi and tonify spleen; radix astragali helps radix Ginseng to nourish lung and spleen; the angelica and the white peony root nourish blood and regulate nutrient, and help the prepared rehmannia root to tonify yin and blood; the rhizoma ligustici wallichii is used for activating blood and qi to make the tonifying without stagnation; cinnamon warms the kidney to dispel cold and helps vigor; the application method comprises adding rhizoma Zingiberis recens and fructus Jujubae as guiding drugs to regulate spleen and stomach. The whole formula has the effects of tonifying qi and blood, nourishing heart and soothing nerves.
The medicine composition comprises radix codonopsitis, prepared rehmannia root, tuckahoe, largehead atractylodes rhizome (baked), burdock, medlar, achyranthes root, tortoise-plastron glue, cinnamon, szechuan lovage rhizome, astragalus, angelica, white peony root and liquorice, and is matched with red date, ginger, thyme, donkey-hide gelatin and Chinese globeflower, and then refined brown sugar honey is added, wherein the radix codonopsitis and the astragalus root are in a nature and taste sweet bottle and enter lung and spleen channels to benefit middle-jiao and qi, and are monarch medicines together with the angelica to nourish yin and enrich blood, and four special medicines are used for essence, benefit qi and enrich blood; the medlar, the achyranthes root, the burdock and the radix morindae officinalis mainly enter liver and kidney and tonify essence and strengthen tendons, and are ministerial drugs; the tuckahoe, the atractylodes and the tortoise-plastron glue assist in tonifying qi and spleen, and the cinnamon warms the kidney to dispel cold and supports primordial qi, which are adjuvant drugs; ligusticum wallichii is used for clearing and activating the channels and collaterals, and radix paeoniae alba is used for dredging blood vessels, and is used as a guiding drug; and ginger, red date and honey are added to regulate the intestines and stomach. The whole formula has the effects of warming and invigorating qi and blood, tonifying yang and strengthening the defense, and nourishing heart and soothing the nerves.
Therefore, the medicinal composition has excellent prescription for nourishing five internal organs by monarch, minister, assistant and guide and has great technical advantages compared with the traditional formula.
2. Compared with the conventional decoction, pill and nourishing preparation prepared by the conventional method, the nourishing preparation has higher nutritive value and absorbability, and better eating and mouthfeel compliance due to the innovative preparation process.
Firstly, meat medicinal materials are used as medicines by using whole herbs through an ultrafine micro powder technology, so that nutritional ingredients are not lost, and the taste can be kept fine and smooth;
secondly, after the fine forging technology, the cellulosic medicinal materials are decocted by water, and the active ingredients can be basically and completely released;
thirdly, the medicinal ingredients are dissolved and carried by the red dates, the ginger, the thyme, the donkey-hide gelatin and the manglietia and further fused with refined honey and other substances, so that the medicine property is more balanced, and the medicine taste is more mellow.
The invention is compared with the conventional dosage form
Pill preparation Decoction preparation Traditional ointment The invention
Whether the whole herb is used as medicine Is that Whether or not Is rarely used Most of the total weight of the product
Whether or not to be ultra-fine micro powder Is free of Is free of Is free of Is that
Taste of food In general terms Is bitter in taste In general Jia
Absorbability In general In general In general Good taste
Nutritive value In general In general In general Good taste
Fourthly, if the honey paste is prepared, the innovation of the process prescription completely avoids the phenomenon of 'sand return (separation of sugar and water)' caused by unstable refined honey dosage of the traditional soft extract and the problem of poor palatability of the traditional soft extract due to overhigh viscosity. The relevant index controls are as follows:
Figure BSA0000252659350000071
( Note: because the sugar content of the product is low, the product is more suitable for people with high blood sugar. )
Therefore, the preparation method is unique and novel, and has great technical advantages compared with the traditional preparation process.
[ detailed technical solution ]
1. The medicine combination is as follows: the winter-stored peiyuan-solid-foundation nourishing preparation consists of the following three parts in percentage by mass:
radix codonopsitis, prepared rehmannia root, tuckahoe, largehead atractylodes rhizome (baked), burdock, medlar, twotooth achyranthes root and tortoise-plastron glue superfine powder: 1-65%;
decocting cortex Cinnamomi, rhizoma Ligustici Chuanxiong, radix astragali, radix Angelicae sinensis, radix Paeoniae alba, and Glycyrrhrizae radix with water to extract effective components: 1 to 55 percent;
red date, ginger, thyme, donkey-hide gelatin and manglietia water decoction: 5 to 25 percent;
2. the preparation process comprises the following steps:
firstly, cleaning codonopsis pilosula, prepared rehmannia root, poria cocos, bighead atractylodes rhizome (baked), burdock, medlar, achyranthes and tortoise-plastron glue, dehydrating and drying at low temperature, and sieving by using a superfine grinder to obtain micron-sized powder F for later use; secondly, cleaning cinnamon, ligusticum wallichii, astragalus mongholicus, angelica sinensis, white peony and liquorice, drying, forging, soaking in multiple times of purified water for 4-24 hours, heating, cooking and extracting for 6-12 hours conventionally, collecting concentrated solution, and filtering, separating and purifying the concentrated solution to obtain stock solution A; thirdly, softening and dissolving the donkey-hide gelatin by warm water, mixing and adding the fine powder of the thyme and the woodlotus with the red dates, the ginger and the ginger, decocting for 1-8 hours, and filtering to obtain a stock solution B; fourthly, heating the stock solution B, then adding the stock solution A, adding the F under the condition of stirring, and then decocting and concentrating to obtain a medicinal composition concentrated solution; fifthly, performing quality inspection on the obtained concentrated solution according to relevant quality indexes, and finally filling the qualified concentrated solution into a stainless steel tank to obtain the product; sixthly, adding the concentrated solution into semi-finished products such as honey paste, honey pills, oral liquid, soft sweets, biscuits and cakes according to different novel preparations, and then obtaining the winter-storage and essence-consolidating nourishing preparation by a subsequent simple processing technology.
[ detailed description ] embodiments
Example 1:
prescription (mass ratio):
8 parts of codonopsis pilosula, 12 parts of prepared rehmannia root, 8 parts of poria cocos, 8 parts of bighead atractylodes rhizome (baked), 4 parts of burdock, 5 parts of medlar, 3 parts of achyranthes root and 2 parts of tortoise-plastron glue;
3 parts of cinnamon, 6 parts of ligusticum wallichii, 12 parts of astragalus mongholicus, 18 parts of angelica sinensis, 12 parts of white peony root and 6 parts of liquorice, and 8 times of water is added to extract a concentrate: 40 parts are obtained;
adding 3 times of water into 5 parts of red dates, 3 parts of ginger, 1 part of thyme, 2 parts of donkey-hide gelatin and 0.5 part of manglietia to obtain a decoction concentrated solution: 15 parts of (1);
3 parts of brown sugar and 7 parts of honey, and refining to obtain refined honey: 10 parts.
The preparation method comprises the following steps:
firstly, pulverizing cleaned and freeze-dried radix codonopsitis, prepared rehmannia root, tuckahoe, largehead atractylodes rhizome (baked), burdock, medlar, achyranthes and tortoise-plastron glue by a superfine pulverizer and sieving to obtain micron-sized powder F;
secondly, cleaning cinnamon, ligusticum wallichii, astragalus mongholicus, angelica sinensis, white peony roots and liquorice, drying, then forging and crushing by using a forging machine, and adding 8 times of purified water to soak for 4 hours; decocting at 100 deg.C for about 8 hr, and filtering to obtain concentrated solution A;
thirdly, adding 3 times of water into red dates, ginger, thyme, donkey-hide gelatin and manglietia, heating to 100 ℃, decocting for 4 hours, and filtering to obtain a concentrated solution B;
fourthly, adding honey into a honey refining pot, heating, controlling the temperature to be not more than 95 ℃, and slowly adding brown sugar until the brown sugar is completely melted to obtain refined honey C;
fifthly, heating the stock solution B, then adding the stock solution A, adding the F under the condition of stirring, decocting and concentrating, adding the refined honey C to a fixed amount, and further grinding by a colloid mill;
and sixthly, performing quality inspection on the obtained paste according to relevant quality indexes, and finally filling the qualified paste into a bottle with quality control.
Example 2:
prescription (mass ratio):
8 parts of codonopsis pilosula, 12 parts of prepared rehmannia root, 8 parts of poria cocos, 8 parts of bighead atractylodes rhizome (baked), 4 parts of burdock, 8 parts of medlar, 4 parts of achyranthes root and 3 parts of tortoise-plastron glue;
3 parts of cinnamon, 6 parts of ligusticum wallichii, 12 parts of astragalus, 18 parts of angelica, 12 parts of white peony root and 6 parts of liquorice, and 7 times of water is added to extract a concentrate: 35 parts are obtained;
adding 4 parts of red date, 3 parts of ginger, 1 part of thyme, 3 parts of donkey-hide gelatin and 0.4 part of manglietia with 4 times of water to obtain a decoction concentrated solution: 13 parts of (1);
200 parts of carrageenan, 1000 parts of starch syrup, 1200 parts of white sugar, 200 parts of citric acid and a proper amount of spice.
The preparation method comprises the following steps:
firstly, pulverizing cleaned and freeze-dried radix codonopsitis, prepared rehmannia root, tuckahoe, largehead atractylodes rhizome (baked), burdock, medlar, achyranthes and tortoise-plastron glue by a superfine pulverizer and sieving to obtain micron-sized powder F;
secondly, cleaning cinnamon, ligusticum wallichii, astragalus mongholicus, angelica sinensis, white peony roots and liquorice, drying, then forging and crushing by using a forging machine, and adding 7 times of purified water to soak for 7 hours; decocting at 105 deg.C for about 7 hr, and filtering to obtain concentrated solution A;
thirdly, adding 4 times of water into red dates, ginger, thyme, donkey-hide gelatin and manglietia, heating to 100 ℃, decocting for 5 hours, and filtering to obtain concentrated solution B;
fourthly, firstly, 1000 parts of starch syrup, 1200 parts of white sugar, 200 parts of lemon and 400 parts of water are stirred into syrup, the syrup is slowly heated to the constant temperature of 60 ℃, and then 1000 parts of carrageenan melted by warm water are added into the syrup under the stirring condition; then, continuously and slowly heating, controlling the temperature not to exceed 110 ℃ for sugar cooking, and cooling to the normal temperature after about 15 minutes to obtain the soft candy cake C;
fifthly, heating the stock solution B, adding the stock solution A, adding the stock solution F under the condition of stirring, decocting and concentrating, adding the soft candy cake C to blend to a fixed amount, and further performing injection molding, demolding, dehumidifying and drying to obtain the winter-storage Baoyuan solid nourishing soft candy;
and sixthly, performing quality inspection on the obtained soft sweets according to relevant quality indexes, and finally performing internal wrapping and external wrapping after the soft sweets are qualified.
Example 3:
prescription (mass ratio):
8 parts of codonopsis pilosula, 12 parts of prepared rehmannia root, 8 parts of poria cocos, 8 parts of bighead atractylodes rhizome (baked), 5 parts of burdock, 8 parts of medlar, 4 parts of achyranthes root and 2 parts of tortoise-plastron glue;
3 parts of cinnamon, 6 parts of ligusticum wallichii, 12 parts of astragalus mongholicus, 18 parts of angelica sinensis, 12 parts of white peony root and 6 parts of liquorice, and 9 times of water is added to extract a concentrate: 40 parts are obtained;
adding 3 times of water into 2 parts of red dates, 2 parts of ginger, 1 part of thyme, 4 parts of donkey-hide gelatin and 0.6 part of manglietia to obtain a decoction concentrated solution: 15 parts of (1);
200 parts of starch, 10 parts of syrup, 5 parts of edible vegetable oil, 80 parts of (red, green) bean powder, 10 parts of eggs and 10 parts of honey.
The preparation method comprises the following steps:
firstly, pulverizing cleaned and freeze-dried radix codonopsitis, prepared rehmannia root, tuckahoe, largehead atractylodes rhizome (baked), burdock, medlar, achyranthes and tortoise-plastron glue by a superfine pulverizer and sieving to obtain micron-sized powder F;
secondly, cleaning cinnamon, ligusticum wallichii, astragalus mongholicus, angelica sinensis, white peony roots and liquorice, drying, then forging and crushing by using a forging machine, and adding 9 times of purified water to soak for 3 hours; decocting at 105 deg.C for about 9 hr, and filtering to obtain concentrated solution A;
thirdly, adding 3 times of water into red dates, ginger, thyme, donkey-hide gelatin and manglietia, heating to 100 ℃, decocting for 4 hours, and filtering to obtain a concentrated solution B;
fourthly, adding the bean powder into a stirring tank, slowly adding the honey until the bean powder is completely fused to obtain honey bean powder C;
fifthly, heating the stock solution B, then adding the stock solution A, adding the F under the condition of stirring, decocting and concentrating, adding the honey bean flour C to a certain amount, and further kneading and stirring to obtain a stuffing material D;
sixthly, adding 200 parts of starch, 10 parts of syrup, 5 parts of edible vegetable oil and 10 parts of eggs into a stirring cylinder, and gradually adding clean water, stirring and kneading to prepare a leather G;
seventhly, injecting the wrapper G and the stuffing D into a cake forming machine, performing injection molding, baking and cooling;
and eighthly, performing quality inspection on the obtained nourishing cakes according to related quality indexes, and finally packaging the cakes inside and outside after the cakes are qualified.

Claims (6)

1. A nourishing paste for warming and invigorating qi and blood, nourishing bone and muscle, and strengthening body resistance is prepared from radix Codonopsis, radix rehmanniae Preparata, poria, atractylodis rhizoma (baked), superfine micropowder of Burdock, achyranthis radix, fructus Lycii, colla Plastri Testudinis, and decoction concentrate of cortex Cinnamomi, rhizoma Ligustici Chuanxiong, glycyrrhrizae radix, radix astragali, radix Angelicae sinensis, and radix Paeoniae alba, and is scientifically mixed with colla Corii Asini solution containing fructus Jujubae, rhizoma Zingiberis recens, herba Thymi, and flos Magnoliae, and then concentrated into concentrated solution.
2. The preparation of claim 1, wherein the preparation is prepared from the following raw materials:
honey paste
Oral liquid
Instant granule
Tablet formulation
Honeyed pill
Candy
Soft sweet
Biscuit
A cake product is provided.
3. The preparation method is characterized in that codonopsis pilosula, prepared rehmannia root, poria cocos, bighead atractylodes rhizome (baked), burdock, radix achyranthis bidentatae, medlar and tortoise-plastron glue superfine powder and decoction concentrated solution of cinnamon, ligusticum wallichii, liquorice, astragalus mongholicus, angelica sinensis and white paeony root are taken as main raw materials, are scientifically matched with donkey-hide glue solution mixed with red dates, ginger and thyme, and then are concentrated into concentrated solution, and finally can be added into a novel preparation to prepare the winter-storage banking-up-basis-strengthening nourishing preparation of claim 1: the medicine composition comprises the following components in percentage by weight:
radix codonopsitis, prepared rehmannia root, tuckahoe, largehead atractylodes rhizome (baked), burdock, medlar, twotooth achyranthes root and tortoise-plastron glue superfine powder: 1-65%;
decocting cortex Cinnamomi, rhizoma Ligustici Chuanxiong, radix astragali, radix Angelicae sinensis, radix Paeoniae alba, and Glycyrrhrizae radix with water to extract effective components: 1 to 55 percent;
red date, ginger, thyme, donkey-hide gelatin and manglietia water decoction: 5 to 25 percent.
4. The preparation method or process of the winter-storage Baoyuan Guben nourishing paste as claimed in claim 1 is as follows: firstly, cleaning codonopsis pilosula, prepared rehmannia root, poria cocos, bighead atractylodes rhizome (baked), burdock, medlar, achyranthes and tortoise-plastron glue, dehydrating and drying at low temperature, and sieving by using a superfine grinder to obtain micron-sized powder F for later use; secondly, cleaning cinnamon, ligusticum wallichii, astragalus mongholicus, angelica sinensis, white peony and liquorice, drying, forging, soaking in multiple times of purified water for 4-24 hours, heating, cooking and extracting for 6-12 hours conventionally, collecting concentrated solution, and filtering, separating and purifying the concentrated solution to obtain stock solution A; thirdly, softening and dissolving the donkey-hide gelatin with warm water, mixing and adding the red date, ginger, thyme fine powder, decocting for 1-8 hours, and filtering to obtain a stock solution B; fourthly, heating the stock solution B, then adding the stock solution A, adding the F under the condition of stirring, and then decocting and concentrating to obtain a concentrated solution; and fifthly, performing quality inspection on the obtained concentrated solution according to relevant quality indexes, and finally filling the qualified concentrated solution into a stainless steel tank.
5. The process for preparing the composition as claimed in claim 3, wherein the raw materials include radix Codonopsis, radix rehmanniae Preparata, poria, atractylodis rhizoma (baked), burdock, fructus Lycii, achyranthis radix, and colla Plastri Testudinis, and the composition is prepared by washing radix Codonopsis, radix rehmanniae Preparata, poria, atractylodis rhizoma (baked), burdock, fructus Lycii, achyranthis radix, and colla Plastri Testudinis, dehydrating at low temperature, drying, and sieving with superfine pulverizer to obtain micrometer powder.
6. The method of claim 3, wherein the extract is prepared by cleaning cortex Cinnamomi, rhizoma Chuanxiong, radix astragali, radix Angelicae sinensis, radix Paeoniae alba, and radix Glycyrrhizae, drying, grinding, soaking in purified water for 4-24 hours, extracting by heating and steaming for 6-12 hours, collecting the concentrated solution, filtering, separating, and purifying to obtain the stock solution. The forging is coarse particles of the traditional Chinese medicinal materials processed by a special non-standard equipment forging crusher.
CN202111090948.7A 2021-09-17 2021-09-17 Winter-stored vigor-consolidating nourishing preparation and preparation method thereof Pending CN115813998A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106138439A (en) * 2016-08-31 2016-11-23 张彦 A kind of blood tonic
CN109010619A (en) * 2018-09-26 2018-12-18 杭州方回春堂集团有限公司 Ginseng donkey-hide gelatin paste and preparation method thereof and method of quality control

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106138439A (en) * 2016-08-31 2016-11-23 张彦 A kind of blood tonic
CN109010619A (en) * 2018-09-26 2018-12-18 杭州方回春堂集团有限公司 Ginseng donkey-hide gelatin paste and preparation method thereof and method of quality control

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
龚昕芳: "响应面法优化中药膏方(十全大补膏)制备工艺", 中国药师, vol. 19, no. 03, pages 456 - 460 *

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