CN115804833A - 一种万古霉素凝胶剂及其制备方法 - Google Patents
一种万古霉素凝胶剂及其制备方法 Download PDFInfo
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- CN115804833A CN115804833A CN202111089853.3A CN202111089853A CN115804833A CN 115804833 A CN115804833 A CN 115804833A CN 202111089853 A CN202111089853 A CN 202111089853A CN 115804833 A CN115804833 A CN 115804833A
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- vancomycin
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- chitosan
- gelatin
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- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- Gastroenterology & Hepatology (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
时间 | 溶液B(%) | 溶液C(%) |
0 | 100 | 0 |
12 | 100 | 0 |
20 | 0 | 100 |
23 | 100 | 0 |
32 | 100 | 0 |
F2-1 | F2-2 | F2-3 | F2-4 | |
组分 | 百分比%(w/w) | 百分比%(w/w) | 百分比%(w/w) | 百分比%(w/w) |
万古霉素 | 5 | 5 | 5 | 5 |
异丙醇 | 40 | 0 | 0 | 0 |
乙酸 | 0 | 1 | 0 | 0 |
柠檬酸 | 0 | 0 | 1 | 0 |
L-苹果酸 | 0 | 0 | 0 | 1 |
水 | 55 | 94 | 94 | 94 |
共 | 100 | 100 | 100 | 100 |
F3-1 | F3-2 | F3-3 | |
组分 | 百分比%(w/w) | 百分比%(w/w) | 百分比%(w/w) |
万古霉素 | 5 | 5 | 5 |
丙二醇 | 40 | 40 | 40 |
壳聚糖 | 0.5 | 0 | 0.5 |
明胶 | 0 | 0.5 | 0.5 |
乙酸 | 1 | 1 | 1 |
水 | 53.5 | 53.5 | 53 |
共 | 100 | 100 | 100 |
F4-1 | F4-2 | F4-3 | |
组分 | 百分比%(w/w) | 百分比%(w/w) | 百分比%(w/w) |
万古霉素 | 5 | 5 | 5 |
丙二醇 | 40 | 40 | 40 |
壳聚糖 | 0.5 | 0 | 0.5 |
明胶 | 0 | 0.5 | 0.5 |
乳酸 | 1 | 1 | 1 |
水 | 53.5 | 53.5 | 53 |
共 | 100 | 100 | 100 |
F5-1 | F5-2 | F5-3 | |
组分 | 百分比%(w/w) | 百分比%(w/w) | 百分比%(w/w) |
万古霉素 | 0.5 | 0.5 | 3 |
丙二醇 | 40 | 40 | 40 |
壳聚糖 | 0.5 | 0 | 0.5 |
明胶 | 0 | 0.5 | 0.5 |
乙酸 | 1 | 1 | 1 |
水 | 53.5 | 53.5 | 53.5 |
共 | 100 | 100 | 100 |
组成 | 对比处方 |
盐酸万古霉素 | 5g |
聚乙二醇400 | 1.8mL |
N-乙酰-D-丙氨酸 | 1.36g |
L-赖氨酸盐酸盐 | 1.26g |
盐酸或氢氧化钠 | 调节pH至4.5 to 5.5 |
共 | 100ml溶液 |
Claims (10)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202111089853.3A CN115804833A (zh) | 2021-09-14 | 2021-09-14 | 一种万古霉素凝胶剂及其制备方法 |
PCT/CN2022/100192 WO2023040397A1 (zh) | 2021-09-14 | 2022-06-21 | 一种万古霉素凝胶剂及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202111089853.3A CN115804833A (zh) | 2021-09-14 | 2021-09-14 | 一种万古霉素凝胶剂及其制备方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN115804833A true CN115804833A (zh) | 2023-03-17 |
Family
ID=85482181
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202111089853.3A Pending CN115804833A (zh) | 2021-09-14 | 2021-09-14 | 一种万古霉素凝胶剂及其制备方法 |
Country Status (2)
Country | Link |
---|---|
CN (1) | CN115804833A (zh) |
WO (1) | WO2023040397A1 (zh) |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2001274420A1 (en) * | 2000-07-11 | 2002-01-21 | Micio Pharma Chemical Ag | Anhydrous pharmaceutical composition of vancomycin for topical use |
JP2008050298A (ja) * | 2006-08-24 | 2008-03-06 | Neige Corporation:Kk | 皮膚貼付用外用ゲル組成物 |
EP2055309A1 (en) * | 2007-10-31 | 2009-05-06 | Pharmatex Italia Srl | Vancomycin and Teicoplanin anhydrous formulations for topical use |
US9248159B2 (en) * | 2008-10-14 | 2016-02-02 | Robert Stanley Berman | MRSA bactericidal topical gel |
-
2021
- 2021-09-14 CN CN202111089853.3A patent/CN115804833A/zh active Pending
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2022
- 2022-06-21 WO PCT/CN2022/100192 patent/WO2023040397A1/zh active Application Filing
Also Published As
Publication number | Publication date |
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WO2023040397A1 (zh) | 2023-03-23 |
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Effective date of registration: 20240118 Address after: 571127 Guilin Ocean Economic Development Zone, Meilan District, Haikou City, Hainan Province Applicant after: HAINAN POLY PHARM. Co.,Ltd. Applicant after: ZHEJIANG POLY PHARMACEUTICAL Co.,Ltd. Address before: 571127 Guilin Ocean Economic Development Zone, Meilan District, Haikou City, Hainan Province Applicant before: HAINAN POLY PHARM. Co.,Ltd. Applicant before: ZHEJIANG POLY PHARMACEUTICAL Co.,Ltd. Applicant before: Anhui Puli Pharmaceutical Co.,Ltd. |