CN115737463B

CN115737463B - Fat-reducing shaping cream and preparation method and application thereof

Info

Publication number: CN115737463B
Application number: CN202211230457.2A
Authority: CN
Inventors: 林佳恩; 周黎贞; 韩志东; 张娇
Original assignee: Quanhou Guangzhou Research Institute Of Biotechnology Co ltd
Current assignee: Quanhou Guangzhou Research Institute Of Biotechnology Co ltd
Priority date: 2022-09-30
Filing date: 2022-09-30
Publication date: 2024-05-14
Anticipated expiration: 2042-09-30
Also published as: CN115737463A

Abstract

The invention belongs to the technical field of cosmetics, and particularly relates to fat-reducing shaping cream and a preparation method and application thereof. The fat-reducing and shaping cream comprises the following components: phase A: deionized water, glycerol, 1, 3-butanediol, a thickener, a preservative and a penetration enhancer; and B phase: emulsifying agent, auxiliary emulsifying agent, cetostearyl alcohol, mineral oil, caprylic/capric triglyceride, isononyl isononanoate and butter fruit; and C phase: polydimethyl siloxane; and D phase: a pH adjuster, deionized water, skin conditioner; e phase: and (5) essence. The invention aims to provide fat-reducing shaping cream and a preparation method and application thereof. The fat-reducing and shaping cream provided by the invention can effectively promote the degradation of in-vivo triglyceride, has obvious fat-reducing and detumescence effects, is applied to slimming products and fat-reducing products, can reduce residual fat of chin when being matched with a V-face hanging film for use, and has the effect of pointedly eliminating residual fat of double chin.

Description

Fat-reducing shaping cream and preparation method and application thereof

Technical Field

The invention belongs to the technical field of cosmetics, and particularly relates to fat-reducing shaping cream and a preparation method and application thereof.

Background

The liposuction molding method is used for performing the liposuction operation on the local fat, and the technology can realize the level of small-wound operation at present and can perform body fat removal in a targeted manner. However, the liposuction molding method has a plurality of defects as well: ① Expensive; ② The recovery time is long; ③ The pain sensation is intense; ④ After the grease is extracted, the local skin presents an uneven appearance and touch sense, and the corresponding part is sensitive; ⑤ Sequela of hard and numb easily occur; ⑥ Once infection occurs after surgery, skin needs to be incised and repaired, and scars which are difficult to repair are left on the surface.

The meal replacement products are various meal replacement products such as ferment jelly, dietary fiber meal replacement powder, weight-reducing beverage, protein powder, protein stick and the like in the market at present, and the low-fat and high-fiber food is used for replacing daily diet to reduce the ingested heat, so that the body fat rate is reduced, and the shaping effect is achieved. However, meal replacement products are not targeted, can be taken for a long time to be effective, are easy to cause trace element loss, and cause hypokalemia and the like.

The body shaping instrument achieves the shaping effect through an A-radio frequency heating technology, a B-medium-low frequency mixing technology or a C-far infrared technology and an air negative pressure technology; but has the problems of high price, effect to be verified in the market, difficult popularization and the like.

The face molding mask type product is usually made of polyamide fiber, polyurethane fiber, artificial fiber and other materials with good elasticity, and is partially made of PU leather, and graphene, far infrared and/or anion micro heat conducting materials are additionally added to the face molding mask type product, so that the face molding mask type product has a heat conducting function and can automatically generate heat when being used by consumers. But it is expensive and has low fat-reducing efficiency.

The slimming cream can repair damaged cells and inhibit fat growth. For example, V-face massage cream and smearing type facial mask are massage cream products, which mainly comprise thickener, emulsifier, humectant, skin conditioner (marine fat-reducing factor) and the like, are used for massaging face and neck, can promote the absorption of effective components through massage, can play roles of improving tension, resisting aging, tendering skin and eliminating edema, and become a hot spot research object in recent years. Chinese patent CN 108078833B discloses a slimming and fat-reducing cream and its preparation method, which comprises the following components: 1 to 2 percent of hydrolyzed red algae extract, 2 to 4.5 percent of caffeine silanol C,0.2 to 0.5 percent of green soy bean seed extract, 1 to 2 percent of radix peucedani extract, 0.05 to 0.15 percent of ginger root oil, 1 to 3 percent of beta-glucan, 15 to 20 percent of grease, 1.5 to 2.5 percent of emulsifying agent, 0.2 to 1.5 percent of emulsifying stabilizer, 12 to 20 percent of polyalcohol, 0.1 to 1 percent of inorganic salt, 0.3 to 1 percent of preservative and the balance of water. Although the invention realizes the shaping effect in a safe and mild mode, the fat-reducing effect is poor due to the single action mechanism, and the skin sensibility after long-term use is unknown.

Therefore, there is a need to develop a safe and side-effect-free external lipid-eliminating plastic cream with obvious lipid-eliminating effect.

Disclosure of Invention

In order to solve the problems in the prior art, the invention aims to provide fat-reducing plastic cream and a preparation method and application thereof. The fat-reducing plastic cream provided by the invention has reasonable proportion of each component, can effectively promote the degradation of triglyceride in a human body, has obvious fat-reducing and swelling-reducing effects, can also improve skin elasticity, is applied to slimming products and fat-reducing products, can reduce residual fat of chin when being matched with a V-face ear-hanging film, and has the effect of pointedly eliminating the residual fat of double chin.

The technical scheme of the invention is as follows:

A fat-reducing shaping cream comprises A phase, B phase, C phase, D phase and E phase, wherein:

the phase A comprises the following components in parts by weight: 40 to 70 parts of deionized water, 2 to 6 parts of glycerol, 1 to 3 parts of 1, 3-butanediol, 0.45 to 1.3 parts of thickening agent, 1 to 1.5 parts of preservative and 1 to 10 parts of penetration enhancer;

the phase B comprises the following components in parts by weight: 1 to 3 parts of emulsifying agent, 0.5 to 2 parts of auxiliary emulsifying agent, 0.5 to 3 parts of cetostearyl alcohol, 1 to 4 parts of mineral oil, 1 to 7 parts of caprylic/capric triglyceride, 1 to 7 parts of isononyl isononanoate and 1 to 7 parts of butter fruit tree fruit fat;

the phase C comprises the following components in parts by weight: 1-3 parts of polydimethylsiloxane;

the phase D comprises the following components in parts by weight: 0.2 to 0.4 part of pH regulator, 2 to 6 parts of deionized water and 1.1 to 6.1 parts of skin conditioner;

the phase E comprises the following components in parts by weight: 0.005-0.01 part of essence.

Further, in the phase A, the thickener is composed of xanthan gum, acrylic acid (ester) type/C10-30 alkanol acrylate cross-linked polymer and hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer according to the weight ratio of 0.5-2: 1 to 3: 3-8.

Further, the preservative consists of p-hydroxyacetophenone and 1, 2-hexanediol according to the weight ratio of 5-7: 5-8 parts.

Further, in the phase D, the skin conditioner is composed of marine lipid-lowering factors and the extract of the Chinese zodiac olibanum seeds according to the weight ratio of 1-6:0.1.

Still further, the fat-reducing and shaping cream consists of an A phase, a B phase, a C phase, a D phase and an E phase, wherein:

The phase A consists of the following components in parts by weight: 58.59 parts of deionized water, 4 parts of glycerol, 2 parts of 1, 3-butanediol, 0.8 part of thickener, 1.2 parts of preservative and 5 parts of penetration enhancer;

the thickener is prepared from xanthan gum, acrylic acid (esters)/C10-30 alkanol acrylate cross-linked polymer and hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer according to the weight ratio of 1:2:5, composing;

still further, the acrylic/C10-30 alkanol acrylate cross-linked polymer is Carbopol Ultrez 20 Polymer; the hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer is SEPINOV ^TM EMT 10.

SEPINOV ^TM EMT 10 is a thickener with very high application flexibility, can be compatible with various types of emulsifying agents and oil, can also be compatible with various special active ingredients, can bring soft but non-sticky skin feel to the product, and is very suitable for massage cream. Besides, the EMT 10 has excellent emulsifying and stabilizing capability, and can effectively play a role in assisting an emulsifying and stabilizing system for the marine lipid-lowering factors of the skin conditioner with high content of oil and oil solubility in the formula.

Further, the preservative consists of p-hydroxyacetophenone and 1, 2-hexanediol according to a weight ratio of 5: 7. The p-hydroxyacetophenone and the 1, 2-hexanediol are corrosion-resistant promoters with broad-spectrum antibacterial activity and good corrosion-resistant effect, can effectively resist bacteria, yeasts and moulds, are mild and low-irritation raw materials, are matched for use, replace the traditional corrosion-resistant agents, can reduce the irritation of a formula, and achieve the mild corrosion-resistant effect. In addition, the p-hydroxyacetophenone also has good antioxidant effect and emulsion stabilizing effect, and can protect the skin conditioner marine lipid-lowering factor in the phase D in the invention to a certain extent.

The phase B consists of the following components in parts by weight: 2 parts of emulsifying agent, 1 part of auxiliary emulsifying agent, 1 part of cetostearyl alcohol, 2 parts of mineral oil, 4 parts of caprylic/capric triglyceride, 4 parts of isononyl isononanoate, and 4 parts of butter fruit tree fruit fat;

The phase C consists of the following components in parts by weight: 2 parts of polydimethylsiloxane;

the phase D consists of the following components in parts by weight: 0.3 part of pH regulator, 4 parts of deionized water and 4.1 parts of skin conditioner;

The skin conditioner is prepared from marine lipid-eliminating factor and extract of Chinese zodiac olibanum seed according to a weight ratio of 4:0.1;

The phase E consists of the following components in parts by weight: 0.01 part of essence.

Further, the permeation enhancer in the phase A is caffeine; the emulsifier in the phase B is a Lubo GlucateTM SS emulsifier in the United states; the auxiliary emulsifier is French Sibirex MONTANOV 202,202 emulsifier; the pH regulator in the phase D is triethanolamine.

The invention also provides application of the fat-reducing plastic cream in preparation of fat-reducing cosmetics.

In addition, the invention also provides a preparation method of the molding cream, which comprises the following steps:

S1: heating deionized water in the phase A, adding other components in the phase A, and homogenizing;

S2: mixing and heating all components of the phase B, and stirring until no particles exist;

s3: adding the B phase component obtained in the step S2 into the A phase component obtained in the step S1, and homogenizing to obtain a mixture 1;

S4: stirring and cooling the mixture 1 obtained in the step S3, adding a C-phase component, homogenizing and stirring to obtain a mixture 2;

s5: and (3) stirring and cooling the mixture 2 obtained in the step (S4), adding D, E phase components, stirring and discharging.

Further, deionized water is heated to 80-85 ℃ in the step S1; in the step S2, heating the components in the phase B to 80-85 ℃; in the step S4, stirring and cooling to 55-65 ℃; and in the step S5, stirring and cooling to 40-45 ℃.

Further, the homogenization speeds in the steps S1, S3 and S4 are 3000-3500 rpm; the homogenization time of the steps S1 and S3 is 4-8 min; the homogenization time in the step S4 is 2-5 min.

Further, the stirring speed in the steps S4 and S5 is 100-120 rpm; the stirring time in the step S4 is 2-5 min; the stirring time in the step S5 is 10-15 min.

The lipid-reducing molding cream provided by the invention has obvious targeted effect on local lipid reduction by reasonably selecting and limiting substances and proportions added by each component, and has clear principle: by adding caffeine, the metabolism of the human body is accelerated, the blood circulation is promoted, edema is removed, the phosphodiesterase activity is inhibited, and the degradation of fatty acid triglyceride is accelerated; meanwhile, the skin conditioning agent which is composed of the marine lipid-lowering factors and the extract of the Chinese zodiac olibanum seeds according to a specific proportion can be used for synergism, and the lipid-lowering effect is effectively improved. The added marine fat-reducing factors induce the expression of white and non-active beige fat cells UCP1 to brown, activate heat generation to increase beta-oxidation of fatty acid and promote the degradation of triglyceride; the added extract of the Chinese zodiac olibanum seed can improve the level of the lipophilic protein, reduce the level of the apocynin protein, prevent fat aggregation and ensure that the fat of small oil drops is easier to degrade than that of large oil drops. The experimental data in the experimental example show that the caffeine and the skin conditioner (the marine fat-reducing factor and the extract of the Chinese zodiac olibanum seed) are mutually synergistic, and are indispensable to be combined according to a specific proportion, so that the waistline size of a subject is effectively reduced, and the waist elasticity of the subject is improved.

Compared with the prior art, the shaping cream and the preparation method and application thereof provided by the invention have the following advantages:

(1) The fat-reducing plastic cream provided by the invention has reasonable proportion of each component, and can effectively promote in-vivo triglyceride degradation, has obvious fat-reducing and swelling-reducing effects through the synergistic effect of the added caffeine and the skin conditioning agent according to a certain proportion, and simultaneously can improve skin elasticity.

(2) The fat-eliminating plastic cream provided by the invention belongs to a non-invasive product, has higher safety compared with methods such as botulinum toxin injection, fat extraction operation and the like, can not produce adverse effects on toxicity, paralysis and drug resistance of human bodies, and does not need risk and pain of pathogenicity and sequela.

(3) The fat-reducing shaping cream provided by the invention has strong operability in use, does not need to go to a beauty parlor, is assisted by instruments and equipment or other people, only needs to be simply smeared and massaged, and can be matched with a V-face hanging film for use in a motion process. And the cost performance is high, the popularity is strong, and the cost required by the liposuction operation is lower than that of buying the shapemachine and the botulinum toxin. Meanwhile, the user only needs to maintain normal diet in the process of using the shaping cream provided by the invention, and does not need to strictly control diet, so that the tedious and bitter of meal replacement products are avoided.

Drawings

FIG. 1 is a graph of subject waistline variation data;

Fig. 2 is a graph of data of changes in lumbar elasticity of a subject.

Detailed Description

The invention is further illustrated by the following description of specific embodiments, which are not intended to be limiting, and various modifications or improvements can be made by those skilled in the art in light of the basic idea of the invention, but are within the scope of the invention as long as they do not depart from the basic idea of the invention.

In the following examples and comparative examples, the reagents not specifically described were conventional reagents, and were purchased from conventional reagent manufacturers and sales companies, and the information of some raw material manufacturers and the like are shown in Table 1:

TABLE 1

EXAMPLES 1-5 fat-reducing and shaping cream of the present invention and preparation method

As shown in Table 2 below, a weight ratio table (in parts by weight) of 5 examples of the fat-reducing and shaping cream of the present invention is shown.

TABLE 2

The preparation method of the fat-reducing and shaping cream of the embodiments 1 to 5 is as follows:

S1: heating deionized water in the phase A to 85 ℃, adding other components in the phase A, and homogenizing at 3500rpm for 5min;

S2: mixing all components in phase B, heating to 85deg.C, and stirring until no particles are present;

S3: adding the B phase component obtained in the step S2 into the A phase component obtained in the step S1, and homogenizing at 3500rpm for 5min to obtain a mixture 1;

s4: stirring and cooling the mixture 1 obtained in the step S3 to 60 ℃, adding the C phase component, homogenizing for 2min at 3500rpm, and stirring for 3min at 110rpm to obtain a mixture 2;

S5: and (3) stirring and cooling the mixture 2 obtained in the step (S4) to 45 ℃, adding D, E phase components, homogenizing at 3500rpm for 2min, stirring at 110rpm for 10min, and discharging.

Comparative examples 1-6 fat-reducing and shaping cream and preparation method thereof

As shown in the following table 3, a weight ratio table (in parts by weight) of 6 comparative examples of the lipid-lowering molding cream of the present invention is listed, wherein the differences between comparative examples 1 to 6 and example 1 are: caffeine was not added in phase a of comparative example 1; no marine lipid-lowering factor was added in phase E of comparative example 2; the extract of the boswellia serrata seed was not added in the E phase of comparative example 3; comparative example 4 caffeine in phase a was replaced with laurocapram in 1 part by weight; comparative example 5 marine lipid-lowering factor in phase D was replaced with ACTIPORI NE 8G, 4 parts by weight; comparative example 6 the weight fraction of marine lipid-lowering factor in phase D was reduced to 0.8 parts and the extract of boswellia serrata seed was increased to 3.3 parts.

The procedure for the preparation of the fat-reducing and shaping creams of comparative examples 1 to 6 is the same as that of examples 1 to 5.

TABLE 3 Table 3

Test example one, performance detection

1. The test method comprises the following steps:

Volunteers were screened, and the volunteers were pertinently recruited to have body fat rates (BMI of 23-30) and were divided into 11 groups of 6 persons each, and fat-reducing plastic creams prepared in examples 1-5 and comparative examples 1-6 of the present invention were used respectively; in order to facilitate the test of fat-reducing effect, a waist with relatively more fat is selected as a tested part, and the value of the change is also conveniently measured.

The using method comprises the following steps: taking 5-8 g of test sample to be smeared on a tested part (the tested part is the waist) once in the morning and evening, and massaging for 5-10min; the test period is two months; three-point positioning determines the test site, reduces errors, and increases the elasticity test of the test site, the instrument being measured (instrument name: cutometer dual MPA, probe specification: a=0-200 b=720-780).

2. The waist circumference variation and waist elasticity variation results of the subject are shown in fig. 1 and 2.

As can be seen from the data of FIG. 1, the waist size of the test person in example 1 is reduced by 4.42cm, the effect is most obvious, and the next is that in example 4, examples 5, 3 and 2, respectively, the effect of the raw material proportioning of example 1 is optimal. Comparative example 1 the waist size of the tester was reduced by 1.05cm, and the effect was also positive, but the effect was not obvious enough, compared with example 1, it was demonstrated that caffeine 50C was an indispensable raw material, and the active ingredient thereof was caffeine, which can promote internal circulation, metabolism, promote the discharge of excessive moisture in the body, detumescence and the like. Comparative example 2, with a waist circumference increased by 0.47cm, comparative example 1, demonstrates that skin conditioning agents (marine lipo-reducing factors) are also indispensable, and the mechanism of action of the raw materials is mainly through inducing the expression of white and inactive beige adipocytes UCP1, and converting them into beige adipocytes with activity, increasing the beta oxidation of fatty acids, and actually burning the fat accumulated in the beige and white adipocytes. The extract of the seed of the Chinese zodiac in comparative example 3 is removed, the formula does not show positive lipid-removing effect, and the raw materials can increase the content of the lipoavidin and reduce the secretion level of the lipocalin, so that the fat at the tested part is prevented from being aggregated into mature adipocytes from small liquid drops, and the small liquid drop fat is generally easier to degrade than the mature adipocytes, and glycerin and fatty acid are released. Thus, the material is directly acting on adipocytes. Comparative example 4 replaced caffeine 50C with laurocapram, which was mainly used as a permeation enhancer, had poor lipid-lowering effect, indicating that caffeine 50C was also not replaceable. The comparative example 5 has positive effect, but the effect is not obvious, the ACTIPORINE G is used for replacing the marine lipid-lowering factor in the skin conditioner, the lipid-lowering effect is greatly reduced, ACTIPORINE G acts on mitochondria, the effect of promoting the lipolysis and the collagen synthesis in fibroblasts is realized, but the lipid-lowering effect is not obvious in comparison. When the ratio of the marine lipid-lowering factor to the extract of the Chinese zodiac olibanum seed in the skin conditioner is changed in comparative example 6, the lipid-lowering effect is obviously weakened compared with that of example 1, which shows that the lipid-lowering effect can be more obvious only when the addition amount of the marine lipid-lowering factor and the extract of the Chinese zodiac olibanum seed is in the range of 1-6:0.1.

As can be seen from FIG. 2, the waist elasticity of the test subject of example 1 was increased most, and the waist circumference decreasing trend was nearly regular for example 4 times. In contrast, in example 1, the waist elasticity of the test person is not as obvious as that of the test example, and it is explained that caffeine 50C and skin conditioner (marine fat-reducing factor and extract of Chinese zodiac olibanum seed) are synergistic and matched with each other in the test example, and the dosage is also a certain amount of the test person, so that the more obvious effect can be achieved.

In conclusion, the formula of the embodiment 1 has obvious fat-reducing effect, has high application value in the aspect of fat elimination of double chin according to the analysis of mechanism and experimental data, can provide a closed and pressure environment in the process of promoting the hydrolysis of triglyceride by being matched with a V-face hanging film, has the effects of promoting the penetration of functional components of a material body, improving fat-reducing effect and simultaneously has a plastic lifting effect, and is a combination with very good market prospect.

The above embodiments are merely illustrative of the principles of the present invention and its effectiveness, and are not intended to limit the invention. Modifications and variations may be made to the above-described embodiments by those skilled in the art without departing from the spirit and scope of the invention. Accordingly, it is intended that all equivalent modifications and variations of the invention be covered by the claims, which are within the ordinary skill of the art, be within the spirit and scope of the present disclosure.

Claims

1. The fat-reducing plastic cream is characterized by comprising an A phase, a B phase, a C phase, a D phase and an E phase, wherein:

The phase A comprises the following components in parts by weight: 40 to 70 parts of deionized water, 2 to 6 parts of glycerol, 1 to 3 parts of 1, 3-butanediol, 0.45 to 1.3 parts of thickening agent, 1 to 1.5 parts of preservative and 1 to 10 parts of permeation promoter;

the phase E comprises the following components in parts by weight: 0.005-0.01 part of essence;

the skin conditioner consists of marine lipid-eliminating factors and a Chinese zodiac olibanum seed extract according to the weight ratio of 1-6:0.1;

The permeation enhancer in the phase A is caffeine; the emulsifier in the phase B is a Lubo GlucateTM SS emulsifier in the United states; the auxiliary emulsifier is French Sibirex MONTANOV 202,202 emulsifier; the pH regulator in the phase D is triethanolamine.

2. The fat-reducing and shaping cream according to claim 1, wherein in phase a, the thickener comprises xanthan gum, acrylic acid (esters)/C10-30 alkanol acrylate cross-linked polymer and hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer in a weight ratio of 0.5-2: 1 to 3: 3-8.

3. The fat-reducing and shaping cream according to claim 1, wherein in phase a, the preservative consists of p-hydroxyacetophenone and 1, 2-hexanediol in a weight ratio of 5-7: 5-8 parts.

4. The lipid-reducing and shaping cream of claim 1, consisting of a phase a, B, C, D, E phases, wherein:

The preservative consists of p-hydroxyacetophenone and 1, 2-hexanediol according to the weight ratio of 5:7, forming;

5. Use of the fat-reducing and shaping cream according to any one of claims 1 to 4 for the preparation of fat-reducing cosmetics.

6. A method for preparing the fat-reducing and shaping cream as set forth in any one of claims 1 to 4, comprising the steps of:

7. The method for preparing the fat-reducing and shaping cream according to claim 6, wherein deionized water is heated to 80-85 ℃ in the step S1; the heating temperature in the step S2 is 80-85 ℃; in the step S4, stirring and cooling to 55-65 ℃; and in the step S5, stirring and cooling to 40-45 ℃.

8. The method for preparing the fat-reducing and shaping cream according to claim 6, wherein the homogenization speed in the steps S1, S3 and S4 is 3000-3500 rpm; the homogenization time of the steps S1 and S3 is 4-8 min; the homogenization time in the step S4 is 2-5 min;

The stirring speed of the steps S4 and S5 is 100-120 rpm; the stirring time in the step S4 is 2-5 min; the stirring time in the step S5 is 10-15min.