CN115736322A

CN115736322A - Atomized base liquid, atomized liquid and method for reducing small-particle-size aerosol particles

Info

Publication number: CN115736322A
Application number: CN202211580500.8A
Authority: CN
Inventors: 邹阳; 邹军; 龙帅; 刘圆缓; 谭玉梅
Original assignee: Shenzhen Zinwi Biotech Co Ltd
Current assignee: Shenzhen Zinwi Biotech Co Ltd
Priority date: 2022-12-09
Filing date: 2022-12-09
Publication date: 2023-03-07
Also published as: WO2024119535A1

Abstract

The application provides the field of electronic cigarettes, and particularly relates to an atomized base liquid, an atomized liquid and a method for reducing aerosol small-particle-size particles, wherein the atomized base liquid comprises 1 and one or more combinations of propylene glycol, glycerol, water and ethanol, and is characterized by further comprising 1, 3-dihydroxyacetone, wherein the mass fraction of the 1, 3-dihydroxyacetone is 5-50%. The atomized particles of the electronic smoke sol containing the atomized base liquid are concentrated in two particle size ranges; aerosols of smaller particle size range can be rapidly satisfied by the smoker, with a reduced amount of aerosol of smaller particle size, reducing the impact on alveoli. The aerosol with large particle size range can bring better mouthfeel to the smokers.

Description

Atomized base liquid, atomized liquid and method for reducing aerosol small-particle-size particles

Technical Field

The application relates to the field of electronic cigarettes, in particular to an atomized base liquid, an atomized liquid and a method for reducing aerosol small-particle-size particles.

Background

At present, the existing electronic cigarettes are more and more popular in the market, but aerosols with different particles in the electronic cigarettes have different settlement rates in human respiratory tracts.

For aerosols with large particle sizes, they mainly settle in the upper respiratory tract, such as the nose, pharynx, larynx; the aerosol particles with large particle size have more remarkable influence on sensory quality than the aerosol with small particles, and the sensory quality of smoke can be obviously changed by adjusting the particle size distribution of the aerosol, thereby bringing different sensory experiences to cigarette smokers.

For small particle size aerosols, they settle primarily in the lower respiratory tract, such as the trachea, bronchi and alveoli; the aerosol deposition part with small particle size is easier to absorb and quickly satisfies, the demand of smokers can be quickly improved by adjusting the particle size distribution of the aerosol, and excessive smoking caused by slow feedback of brains is avoided.

When the particle size in the electronic cigarette is too large and is in a large particle size range, the electronic cigarette can give a smoker a relatively obvious sensory experience, but cannot be quickly smoked; when the particle size is too large in the small particle size range, not only the sensory experience is not obvious, but also if the particle size is too small, a large amount of the particles enter alveoli, and the lung is adversely affected.

The field lacks an electronic atomized liquid which can meet the requirements of taste, can be quickly absorbed and cannot cause too much aerosol to enter alveoli to have great influence on the lung.

Disclosure of Invention

In order to solve the technical problems, the invention provides a substance 1, 3-dihydroxyacetone with the function of regulating and reducing aerosol particles of an electronic cigarette aerosol. 1, 3-dihydroxyacetone is a naturally occurring ketose, also has the characteristics of harmlessness, safety, biodegradability, promotion of brain development, prevention of heart disease and the like, and is widely applied to the fields of food, medicine, cosmetics, health products, feed and the like. 1, 3-dihydroxyacetone is rarely reported as a component of an electronic cigarette, and the prior art does not suggest the effect that 1, 3-dihydroxyacetone can reduce particles with small particle size, and does not suggest the effect on the aspects of improving taste and the like in the field of electronic cigarettes.

When the substance is contained, the concentration of atomized particles of the electronic smoke sol, which are less than 0.1 micron, is greatly reduced, particularly the concentration of particles with the particle diameter of 0.01-0.03 micron is reduced to the maximum extent, so that the particle number of deposited alveoli is greatly reduced; in some embodiments of the invention, the particle size is primarily concentrated in two size ranges; the aerosol with small particle size range can quickly satisfy the requirement of a smoker, the aerosol with smaller particle size is reduced, and the influence on alveoli is reduced. The aerosol with the large particle size range can bring better mouthfeel to smokers.

Specifically, the invention provides an electronic atomization base liquid, which comprises one or more of propylene glycol, glycerol, water and ethanol, and also comprises 1, 3-dihydroxyacetone, wherein the mass fraction of the 1, 3-dihydroxyacetone is 5-50%.

In some embodiments, the combination of one or more of propylene glycol, glycerol, water, ethanol comprises the following protocols:

i: propylene glycol; ii: glycerol; iii: water; iv: ethanol; v: propylene glycol, glycerol; vi: propylene glycol, water; vii: glycerol and water; viii: propylene glycol, ethanol; ix: glycerol, ethanol; x: propylene glycol, glycerol and water; xi: propylene glycol, glycerol, ethanol; or xii: propylene glycol, glycerol, water and ethanol.

In some embodiments, the mass fraction of 1, 3-dihydroxyacetone is 10% to 40%; optionally, the mass fraction of the 1, 3-dihydroxyacetone is 15-35%.

In some embodiments, the propylene glycol is present in a mass fraction of 0% to 50%; the glycerol accounts for 0-50% by mass; the mass fraction of the water is 0-50%; the mass fraction of the ethanol is 0-50%; optionally, the propylene glycol is 0-30% by mass; the glycerol accounts for 30-50% of the mass fraction; the mass fraction of the water is 0-20%; the mass fraction of the ethanol is 0-20%.

When the substance is contained, the particle concentration of atomized particles of the electronic smoke sol, which is less than 0.1 micron, is greatly reduced, particularly the particle concentration of the particle diameter of 0.01-0.03 micron is reduced to the greatest extent, and the particle number of the deposited alveoli is greatly reduced.

On the other hand, the invention also provides electronic atomized liquid which comprises the electronic atomized base liquid.

In some embodiments, the electronically atomized liquid further includes nicotine or nicotine salt, and the final concentration of nicotine in the electronically atomized liquid is 0-20% by mass; optionally, the final concentration mass fraction of nicotine in the electronic atomized liquid is 1% -10%.

In some embodiments, the nicotine salt is a combination of one or more of nicotine malonate, nicotine citrate, nicotine 2-ethylbutyrate, nicotine acetate, nicotine adipate, nicotine benzoate, nicotine butyrate, nicotine cinnamate, nicotine cycloheptane-carboxylate, nicotine fumarate, nicotine glycolate, nicotine hexanoate, nicotine lactate, nicotine levulinate, nicotine malate, nicotine myristate, nicotine octanoate, nicotine oxalate, nicotine propionate, nicotine pyruvate, nicotine succinate, and nicotine undecanoate; optionally, the nicotine salt is one or more of benzoic acid nicotine salt, levulinic acid nicotine salt and lactic acid nicotine salt.

In some embodiments, the electronically atomized liquid further comprises a flavor substance, wherein the flavor substance is one or more of a sweetener, a cooling agent, an acidulant, an essence or a tobacco extract, and the mass fraction of the flavor substance is 0.5-30%.

In some embodiments, the sweetener is 0-10% by mass; the mass fraction of the sour agent is 0-5%; the mass fraction of the cooling agent is 0-10%; the mass fraction of the essence is 0-20%; the mass fraction of the tobacco extract is 0-10%.

In some embodiments, the e-fume sol particle size is predominantly concentrated in the range greater than 0.03 microns; in some embodiments, the e-gas sol particle size is primarily in two size ranges; the aerosol with small particle size range can quickly satisfy the requirement of a smoker, the aerosol with smaller particle size is reduced, and the influence on alveoli is reduced. The aerosol with large particle size range can bring better mouthfeel to the smokers.

The invention also provides a method for reducing aerosol small-particle-size particles, which comprises the following steps:

adding 1, 3-dihydroxyacetone with the final solution mass fraction of 5-50% into the electronic atomization liquid, and stirring and dissolving to obtain a first solution;

the first solution is injected into an electronic atomizer.

Detailed description of the invention

For purposes of the following detailed description, it is to be understood that the application may assume various alternative variations and step sequences, except where expressly specified to the contrary. Moreover, other than in any operating examples, or where otherwise indicated, all numbers expressing, for example, quantities of ingredients used in the specification and claims are to be understood as being modified in all instances by the term "about". Accordingly, unless indicated to the contrary, the numerical parameters set forth in the following specification and attached claims are approximations that may vary depending upon the desired properties to be obtained by the present application. At the very least, and not as an attempt to limit the application of the doctrine of equivalents to the scope of the claims, each numerical parameter should at least be construed in light of the number of reported significant digits and by applying ordinary rounding techniques.

An embodiment of the present invention provides an atomized base liquid, which includes one or more combinations of propylene glycol, glycerol, water, and ethanol, and further includes 1, 3-dihydroxyacetone, wherein the mass fraction of the 1, 3-dihydroxyacetone is 5-50%.

When the substance is contained, the concentration of atomized particles of the electronic smoke sol, which are less than 0.1 micron, is greatly reduced, particularly the concentration of particles with the particle diameter of 0.01-0.03 micron is reduced to the maximum extent, and the number of particles deposited in alveoli is greatly reduced. In some embodiments, the particle sizes are primarily concentrated in two size ranges; aerosols of smaller particle size range can be rapidly satisfied by the smoker, with a reduced amount of aerosol of smaller particle size, reducing the impact on alveoli. The aerosol with the large particle size range can bring better mouthfeel to smokers.

In some embodiments, the combination of one or more of propylene glycol, glycerol, water, ethanol comprises the following:

i: propylene glycol; ii: glycerol; iii: water; iv: ethanol; v: propylene glycol, glycerol; vi: propylene glycol, water;

vii: glycerol and water; viii: propylene glycol, ethanol; ix: glycerol, ethanol; x: propylene glycol, glycerol and water; xi: propylene glycol, glycerol, ethanol; or xii: propylene glycol, glycerol, water and ethanol.

In some embodiments, the electrospray base fluid comprises propylene glycol and 5-50% by weight of 1, 3-dihydroxyacetone. In some embodiments, the base liquid comprises propylene glycol and 10-40% by weight of 1, 3-dihydroxyacetone. In some embodiments, the electrospray base fluid comprises propylene glycol and 15-35% by weight of 1, 3-dihydroxyacetone.

In some embodiments, the electrospray base fluid comprises glycerol and 5-50% by weight of 1, 3-dihydroxyacetone. In some embodiments, the base liquid comprises glycerol and 10-40% by weight of 1, 3-dihydroxyacetone. In some embodiments, the base liquid comprises glycerol and 15-35% by weight of 1, 3-dihydroxyacetone.

In some embodiments, the electrospray base includes water and 5-50% by weight of 1, 3-dihydroxyacetone. In some embodiments, the electrospray base includes water and 10-40% by weight of 1, 3-dihydroxyacetone. In some embodiments, the electrospray base includes water and 15-35% by weight of 1, 3-dihydroxyacetone.

In some embodiments, the electrospray base fluid comprises ethanol and 5-50% by weight of 1, 3-dihydroxyacetone. In some embodiments, the base liquid for electronic atomization comprises ethanol and 10-40% by mass of 1, 3-dihydroxyacetone. In some embodiments, the base liquid for electronic atomization comprises ethanol and 15-35% by mass of 1, 3-dihydroxyacetone.

In some embodiments, the base liquid comprises propylene glycol, glycerol, and 5-50% by weight of 1, 3-dihydroxyacetone. In some embodiments, the electrospray base fluid comprises propylene glycol, glycerol, and 10-40% by weight of 1, 3-dihydroxyacetone. In some embodiments, the base liquid comprises propylene glycol, glycerol, and 15-35% by weight of 1, 3-dihydroxyacetone.

In some embodiments, the base liquid comprises propylene glycol, glycerol, water, and 5-50% by weight of 1, 3-dihydroxyacetone. In some embodiments, the base liquid comprises propylene glycol, glycerol, water, and 10-40% by weight of 1, 3-dihydroxyacetone. In some embodiments, the base liquid comprises propylene glycol, glycerol, water, and 15-35% by weight of 1, 3-dihydroxyacetone.

In some embodiments, the base liquid comprises propylene glycol, glycerol, water, ethanol, and 5-50% by weight of 1, 3-dihydroxyacetone. In some embodiments, the base liquid comprises propylene glycol, glycerol, water, ethanol, and 10-40% by weight of 1, 3-dihydroxyacetone. In some embodiments, the base liquid comprises propylene glycol, glycerol, water, ethanol, and 15-35% by weight of 1, 3-dihydroxyacetone.

In some embodiments, the 1, 3-dihydroxyacetone is present in a mass fraction of 10 to 40%. In still other embodiments, the 1, 3-dihydroxyacetone is present in an amount of 15 to 35 weight percent. In still other embodiments, the mass fraction of 1, 3-dihydroxyacetone is 15%, 25%, 35%.

In some embodiments, the propylene glycol is present in an amount of 0 to 50% by weight. In still other embodiments, the propylene glycol is present in an amount of 0-30% by weight. In still other embodiments, the propylene glycol is present in an amount of 5-20% by weight. In still other embodiments, the propylene glycol is present in an amount of 10-15% by weight. In still other embodiments, the propylene glycol is present in a mass fraction of 10%, 15%.

In some embodiments, the glycerol is present at 0% to 50% by mass. In yet other embodiments, the glycerol is present in an amount of 30% to 50% by weight. In still other embodiments, the glycerol is present in an amount of 35-45% by weight. In yet other embodiments, the glycerol is present at 40% by weight.

In some embodiments, the water is present in an amount of 0-50% by mass. In still other embodiments, the water is present in an amount of 0-20% by mass.

In some embodiments, the ethanol has a mass fraction of 0-50%. In still other embodiments, the ethanol comprises from 0 to 20% by mass. In still other embodiments, the ethanol is present in an amount of 5-15% by weight. In still other embodiments, the ethanol comprises 5% to 10% by mass.

In some embodiments, the present invention also provides an electronically atomized liquid comprising an electronically atomized base liquid as described herein.

In some embodiments, the electronically atomized liquid further includes nicotine or nicotine salt, and the final concentration of nicotine in the electronically atomized liquid is 0-20% by mass; optionally, the final concentration mass fraction of nicotine in the electronic atomized liquid is 1% -10%; optionally, the final concentration of nicotine in the electronic atomized liquid is 1-5% by mass.

In some embodiments, the nicotine salt: the nicotine salt is nicotine malonate, nicotine citrate, nicotine 2-ethylbutyrate, nicotine acetate, nicotine adipate, nicotine benzoate, nicotine butyrate, nicotine cinnamate, nicotine cycloheptane-carboxylate, nicotine fumarate, nicotine glycolate, nicotine hexanoate, nicotine lactate, nicotine levulinate, nicotine malate, nicotine myristate, nicotine octanoate, nicotine oxalate, nicotine propionate, nicotine pyruvate, nicotine succinate, and nicotine undecanoate

In some embodiments, the nicotine salt: benzoic acid nicotine salt, acetopropionic acid nicotine salt and lactic acid nicotine salt.

In some embodiments, the electronic atomization liquid further comprises a flavor substance, wherein the flavor substance is one or more of a sweetening agent, a cooling agent, an acidity agent, an essence or a tobacco extract, and the mass fraction of the flavor substance is 0.5-30%.

In some embodiments, the sweetener is present in an amount of 0 to 10% by weight; the mass fraction of the sour agent is 0-5%; the mass fraction of the cooling agent is 0-10%; the mass fraction of the essence is 0-20%; the mass fraction of the tobacco extract is 0-10%.

In some embodiments, the mass fraction of sweetener in the electronically aerosolized liquid is between 0% and 10%. In still other embodiments, the mass fraction of sweetener in the electronically aerosolized liquid is between 0% and 5%. In still other embodiments, the mass fraction of sweetener in the electronically aerosolized liquid is between 0% and 0.1%.

The sweeteners include, but are not limited to, xylitol, maltose, stevioside, rhamnose, trehalose, erythritol, lactose, galactose, stevioside, licorice, disodium glycyrrhizinate, tripotassium and trisodium glycyrrhizinate, saccharin, acesulfame potassium, advantame, neotame, aspartame, neohesperidin dihydrocarvone, neohesperidin dihydrochalcone, sucralose.

In some embodiments, the mass fraction of the sour agent in the electronically aerosolized liquid is 0-5%. In still other embodiments, the mass fraction of the sour agent in the electronically aerosolized liquid is 0-1%. In still other embodiments, the mass fraction of the sour agent in the electronically aerosolized liquid is 0-0.1%.

The sour agents include, but are not limited to, acetic acid, propionic acid.

In some embodiments, the cooling agent is present in the electronically atomized liquid in an amount of 0 to 10% by mass. In still other embodiments, the cooling agent is present in the electronically atomized liquid in an amount of 0 to 5% by weight. In still other embodiments, the cooling agent is present in the electronically atomized liquid in an amount of 0 to 0.05% by weight.

Such cooling agents include, but are not limited to, menthol, menthone, isomenthone, l-menthyl lactate, WS-23 (N, 2, 3-trimethyl-2-isopropylbutanamide), WS-3 (N-ethyl-p-menthyl-3-carboxamide), WS-5 (N- (ethoxycarbonylmethyl) -p-alkane-3-carboxamide), WS-12 (N- (4-methoxyphenyl) -p-menthyl-3-carboxamide).

In some embodiments, the electronic atomization liquid comprises 0-20% by mass of the essence. In some embodiments, the essence is present in the electronic atomized liquid in an amount of 0 to 10% by mass.

The essence includes, but is not limited to, fruit-flavored essence, flower-flavored essence, tea-flavored essence, milk-flavored essence, and tobacco-flavored essence.

In some embodiments, the mass fraction of tobacco extract in the electronically aerosolized liquid is 0-10%. In still other embodiments, the mass fraction of tobacco extract in the electronically aerosolized liquid is between 0% and 5%.

The tobacco extract is a herbal extract with tobacco flavor, which is obtained by extracting tobacco as a raw material.

the first solution is injected into an electronic atomizer.

adding one or more of nicotine or nicotine salt and flavor substances into an electronic atomization base solution containing 5-50% of 1, 3-dihydroxyacetone in percentage by mass of a final solution, and stirring for dissolving to obtain a first solution;

the first solution is injected into an electronic atomizer.

In the present invention, a numerical range is expressed by "n-m", i.e., a range of numbers n to m, and in some embodiments the range "n-m" includes n, m, and all numbers between n and m. In other embodiments, the range "n-m" includes m and all numbers between n and m; the range "n-m" in some embodiments includes n and all numbers between n and m; in some embodiments the range "n-m" includes all numbers between n and m.

In the description herein, references to the description of the term "one embodiment," "some embodiments," "an example," "a specific example," or "some examples," etc., mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above are not necessarily intended to refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples. Moreover, various embodiments or examples and features of various embodiments or examples described in this specification can be combined and combined by one skilled in the art without being mutually inconsistent.

The articles "a," "an," and "the" as used herein are intended to include "at least one" or "one or more" unless otherwise indicated or clearly contradicted by context. Thus, as used herein, the articles refer to articles of one or more than one (i.e., at least one) object. For example, "a component" refers to one or more components, i.e., there may be more than one component contemplated for use or use in embodiments of the described embodiments.

Drawings

FIG. 1: aerosol particle size test results for example 1

FIG. 2 is a schematic diagram: aerosol particle size test results for example 2

FIG. 3: aerosol particle size test results for example 3

FIG. 4 is a schematic view of: aerosol particle size test results of example 4

FIG. 5: aerosol particle size test results for example 5

FIG. 6: aerosol particle size test results for comparative example 1

FIG. 7: aerosol particle size test results for comparative example 2

FIG. 8: aerosol particle size test results for comparative example 3

FIG. 9: aerosol particle size test results for comparative example 4

FIG. 10: aerosol particle size measurement test results for comparative example 5

FIG. 11: particle size measurement results for 1, 2-propanediol, a single solvent, and 1, 2-propanediol containing 1, 3-dihydroxyacetone (15%)

FIG. 12: external view of a smoking machine used in the present invention

Detailed Description

In order to more clearly illustrate the aspects of the present application, reference is made to the following specific examples. Exemplary embodiments of the present disclosure will be described in more detail below with reference to the accompanying drawings. While exemplary embodiments of the present disclosure are shown in the drawings, it should be understood that the present disclosure may be embodied in various forms and should not be limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the disclosure to those skilled in the art.

Preparation examples:

example 1

Weighing 0.4g of tobacco extract, 0.7g of nicotine benzoate, 8g of glycerol, 7.9g of propylene glycol and 3g of 1, 3-dihydroxyacetone (102 monomer), placing the tobacco extract, the nicotine benzoate, the glycerol, the propylene glycol and the 1, 3-dihydroxyacetone in a sample bottle (the mass fraction of the 1, 3-dihydroxyacetone is 15%), shaking up for 10 minutes to obtain electronic atomization liquid, respectively injecting the electronic atomization liquid into 3 disposable cotton-core smoking sets, and then evaluating the sensory quality of the tobacco tar and testing the particle size of smoke aerosol. The aerosol particle size measurement results are shown in figure 1.

Example 2

Weighing 0.4g and 0.7g of nicotine benzoate, 8g of glycerol, 5.9g of propylene glycol and 5g of 102 monomers (1, 3-dihydroxyacetone) of the tobacco extract, placing the tobacco extract and the propylene glycol in a sample bottle (the mass fraction of the 1, 3-dihydroxyacetone is 25%), shaking the mixture evenly for 10 minutes to obtain electronic atomized liquid, respectively injecting the electronic atomized liquid into 3 disposable cotton-core smoking sets, and then carrying out sensory quality evaluation on tobacco tar and particle size test on smoke aerosol. The aerosol particle size measurement results are shown in figure 2.

Example 3

Weighing 0.4g and 0.7g of nicotine benzoate, 8g of glycerol, 3.9g of propylene glycol and 7g of 102 monomers of the tobacco extract, placing the materials in a sample bottle (the mass fraction of 1, 3-dihydroxyacetone is 35%), shaking uniformly for 10 minutes to obtain electronic atomized liquid, respectively injecting the electronic atomized liquid into 3 disposable cotton-core smoking sets, and then carrying out sensory quality evaluation on tobacco tar and particle size test on smoke aerosol. The aerosol particle size measurement results are shown in figure 3.

Example 4

Weighing 0.4g of tobacco extract, 2g of water, 0.7g of nicotine benzoate, 8g of glycerol, 5.9g of propylene glycol and 3g of 102 monomers, placing the materials in a sample bottle (the mass fraction of 1, 3-dihydroxyacetone is 15%), shaking for 10 minutes to obtain electronic atomization liquid, respectively injecting the electronic atomization liquid into 3 disposable cotton core smoking sets, and then carrying out sensory quality evaluation on tobacco tar and particle size test on smoke aerosol. The aerosol particle size measurement results are shown in figure 4.

Example 5

Weighing 0.4g of tobacco extract, 2g of water, 2g of 95% ethanol, 0.7g of nicotine benzoate, 8g of glycerol, 3.9g of propylene glycol and 3g of 102 monomers, placing the materials in a sample bottle (the mass fraction of 1, 3-dihydroxyacetone is 22.9%), shaking for 10 minutes to obtain electronic atomized liquid, respectively injecting the electronic atomized liquid into 3 disposable cotton core smoking sets, and then carrying out sensory quality evaluation on the tobacco tar and particle size test on the smoke aerosol. The aerosol particle size measurement results are shown in figure 5.

Example 6

Weighing 0.4g of tobacco extract, 0.7g of nicotine benzoate, 17.9g of propylene glycol and 1g of 102 monomers in a sample bottle (the mass fraction of 1, 3-dihydroxyacetone is 5%), shaking up for 10 minutes to obtain electronic atomized liquid, respectively injecting the electronic atomized liquid into 3 disposable cotton core smoking sets, and then carrying out sensory quality evaluation on tobacco tar and particle size test on smoke aerosol.

Example 7

Weighing 0.4g and 0.7g of nicotine benzoate, 8.9g of propylene glycol and 10g of 102 monomers of the tobacco extract, placing the materials in a sample bottle (the mass fraction of 1, 3-dihydroxyacetone is 50%), shaking up for 10 minutes to obtain electronic atomized liquid, respectively injecting the electronic atomized liquid into 3 disposable cotton core smoking sets, and then carrying out sensory quality evaluation on tobacco tar and particle size test on smoke aerosol.

Example 8

Weighing 0.4g of tobacco extract, 0.7g of nicotine benzoate, 16.9g of water and 2g of 102 monomers, placing the mixture in a sample bottle (the mass fraction of 1, 3-dihydroxyacetone is 10%), shaking up for 10 minutes to obtain electronic atomized liquid, respectively injecting the electronic atomized liquid into 3 disposable cotton core smoking sets, and then carrying out sensory quality evaluation on tobacco tar and particle size test on smoke aerosol.

Example 9

Weighing 0.4g of tobacco extract, 0.7g of nicotine benzoate, 9.9g of ethanol and 9g of 102 monomers in a sample bottle (the mass fraction of 1, 3-dihydroxyacetone is 45%), shaking up for 10 minutes to obtain electronic atomized liquid, respectively injecting the electronic atomized liquid into 3 disposable cotton core smoking sets, and then carrying out sensory quality evaluation on tobacco tar and particle size test on smoke aerosol.

Example 10

Weighing 0.4g and 0.7g of nicotine benzoate, 17.4g of ethanol and 1.5g of 102 monomers of the tobacco extract, placing the materials in a sample bottle (the mass fraction of 1, 3-dihydroxyacetone is 7.5%), shaking up for 10 minutes to obtain electronic atomized liquid, respectively injecting the electronic atomized liquid into 3 disposable cotton-core smoking sets, and then carrying out sensory quality evaluation on tobacco tar and particle size test on smoke aerosol.

Example 11

Weighing 0.4g of tobacco extract, 0.7g of nicotine benzoate, 5g of water, 12.9g of glycerol and 1g of 102 monomers, placing the components in a sample bottle (the mass fraction of 1, 3-dihydroxyacetone is 5%), shaking up for 10 minutes to obtain electronic atomized liquid, respectively injecting the electronic atomized liquid into 3 disposable cotton core smoking sets, and then carrying out sensory quality evaluation on tobacco tar and particle size test on smoke aerosol.

Preparation of comparative example:

comparative example 1

Weighing 0.4g of tobacco extract, 0.7g of nicotine benzoate, 8g of glycerol and 10.9g of propylene glycol, placing the tobacco extract in a sample bottle, shaking for 10 minutes to obtain electronic atomized liquid, respectively injecting the electronic atomized liquid into 3 disposable cotton core smoking sets, and then evaluating the sensory quality of tobacco tar and testing the particle size of smoke aerosol. The aerosol particle size measurement results are shown in figure 6.

Comparative example 2

Weighing 0.4g of tobacco extract, 2g of water, 0.7g of nicotine benzoate, 8g of glycerol and 8.9g of propylene glycol, placing the tobacco extract, the water, the nicotine benzoate, the glycerol and the propylene glycol into a sample bottle, shaking uniformly for 10 minutes to obtain electronic atomized liquid, respectively injecting the electronic atomized liquid into 3 disposable cotton-core smoking sets, and then carrying out sensory quality evaluation on tobacco tar and particle size test on smoke aerosol, wherein the particle size test result of the aerosol is shown in figure 7.

Comparative example 3

Weighing 2g,8g of water glycerol and 10g of propylene glycol, placing the materials in a sample bottle, shaking the materials evenly for 10 minutes to obtain electronic atomized liquid, respectively injecting the electronic atomized liquid into 3 disposable cotton core smoking sets, and then carrying out sensory quality evaluation on the tobacco tar and particle size test on the smoke aerosol. The aerosol particle size measurement results are shown in figure 8.

Comparative example 4

Weighing 0.4g of tobacco extract, 2g of water, 2g of 95% ethanol, 0.7g of nicotine benzoate, 8g of glycerol and 6.9g of propylene glycol, placing the mixture in a sample bottle, shaking uniformly for 10 minutes, injecting 3 cigarettes into a disposable cotton core smoking set, and then carrying out sensory quality evaluation and smoke aerosol particle size test on the cigarettes. Aerosol particle size test results: the aerosol particle size measurement results are shown in figure 9.

Comparative example 5

Weighing 2g of water, 2g of 95% ethanol, 8g of glycerol and 8g of propylene glycol, placing the mixture in a sample bottle, shaking up for 10 minutes, injecting tobacco tar into a disposable cotton core smoking set, injecting 3 tobacco tar, and then carrying out sensory quality evaluation on the tobacco tar and particle size test on the aerosol of the smoke. Aerosol particle size test results. The aerosol particle size measurement results are shown in figure 10.

Particle size testing experiment

The method comprises the following steps: the smoking machine performs smoking, and the particle size meter performs aerosol particle size testing.

A smoking machine: the flying herbal FH-Y1216 type smoke extractor stops smoking for 5, and has the smoking capacity of 55 ml and square waves.

Particle size analyzer: german PALAS DEMC2000 model scanning electromigration rate particle size analyzer, scanning range is 10-1200nm, and dilution is 10000 times. As in fig. 12.

As shown in FIGS. 1 to 10, it can be seen that the addition of 1, 3-dihydroxyacetone according to the present invention to various solvents can reduce the particle size of small-particle size aerosols and make the distribution of the aerosols in the middle particle size more concentrated.

In order to further confirm the effect of reducing the particles of aerosol with small particle size and concentrating the distribution of the aerosol in the middle particle size in the electronic cigarette atomized liquid of the 1, 3-dihydroxyacetone. The invention also carried out a verification experiment:

particle size studies were conducted on 1, 2-propanediol as the single solvent, and 1, 2-propanediol containing 1, 3-dihydroxyacetone (15%). The results are shown in FIG. 11. The peak 1# is 1, 2-propylene glycol (particle size range 0.01-0.1 micron) which is a single solvent, and the peak 2# is 1, 2-propylene glycol (particle size range 0.03-0.3 micron) containing 1, 3-dihydroxyacetone (15%), so that the 1, 3-dihydroxyacetone can obviously reduce the particles of aerosol with small particle size and make the distribution of the aerosol in the middle particle size more concentrated.

Meanwhile, the invention also verifies that the particle size changes of the examples 7, 8, 9, 10 and 11 are compared with the corresponding examples without adding 102 monomers, and the examples with adding 102 monomers have the same particle size change trend, namely the particle size ion concentration of less than 0.03 microns is reduced compared with the corresponding examples without adding.

The invention also sets a verification experiment, in the examples 1-11, 0.2% of the original total mass fraction of the sweetening agent (neotame) and 0.5% of the cooling agent (WS-23) are respectively added, compared with the comparative example in the examples 1-11, 0.2% of the original total mass fraction of the sweetening agent (neotame) and 0.5% of the cooling agent (WS-23) are respectively added, but the particle size of the monomer 102 is not added, the example with the monomer 102 is compared with the corresponding comparative example without the addition, the particle size has the same trend of change, namely the ion concentration of the particle size smaller than 0.03 micrometer is reduced.

Taste test experiment

The method comprises the following steps:

the electronic cigarette liquid samples in the above examples and the electronic cigarette liquid samples in the comparative examples were added to an electronic cigarette device, the power was 6.5W, the electronic cigarette liquid was smoked by a large-cycle smoking method in a blind evaluation manner, and 20 persons were used to form professional sensory quality evaluation groups for sensory evaluation, and the sensory evaluation criteria were as described in table 1 below, and mainly included the following evaluation indexes, aroma concentration, irritation (offensive odor), smoke amount, aftertaste, throat hit sensation, smoke humidity, harmony, and satisfaction. The maximum score of each evaluation index is 10, each evaluation index is divided into scoring units by 0.5, and the other indexes are forward scores except that irritation (miscellaneous gas) is reverse scores. The test results are shown in Table 2.

The meaning of 8 index evaluations is:

aroma concentration: the thickness of the nasal cavity and the oral cavity to the whole smoke sense;

irritation: the smoke after the atomization of the electronic cigarette smoke liquid has the sensory feelings of irritation, such as granular feelings, acupuncture feelings, miscellaneous gas and the like, in the oral cavity, the throat and the nasal cavity;

amount of smoke: the total amount of aerosol formed after the electronic cigarette liquid is atomized and the visual smoke amount after the electronic cigarette liquid is sensed and exhaled through the oral cavity;

aftertaste: taste continuity in the oral cavity after the atomized liquid of the electronic cigarette is sucked;

throat hit feeling: physical sensory intensity of smoke impact on the throat after aerosol is inhaled;

humidity of the smoke: the dryness and wetness of the aerosol particle droplet molecules sensed by the oral cavity and the nasal cavity;

coordination: the mixing uniformity and the coordination degree of the aroma after the electronic cigarette liquid is atomized;

the feeling of short-time brain excitation caused by the absorption and reaction of nicotine by the lung in the same number of mouths can be symptoms such as numbness and dizziness of the head.

TABLE 1 sensory quality evaluation criteria

TABLE 2 sensory test results

As can be seen from Table 2, the electronic cigarette related to the embodiment of the invention has the characteristics of obvious cigarette fragrance, harmonious smoke, rich and full smoke, moderate stimulation, clean oral cavity, fresh sweet feeling at the tail end of the smoke, full smoke, lasting and fine smoke and the like compared with a comparative example. Therefore, the 1, 3-dihydroxyacetone which has the function of coordinating the mouthfeel of the electronic cigarette can be reasonably obtained. The aerosol with the large particle size range can bring better mouthfeel to smokers.

As can be seen by combining the attached drawings, the 1, 3-dihydroxyacetone is added to improve the particle size distribution of the aerosol, reduce the small-particle size aerosol, reduce the influence on alveoli and improve the safety of the electronic cigarette.

The specific embodiments are only for explaining the present application and are not limiting to the present application, and those skilled in the art can make modifications to the embodiments without inventive contribution as required after reading the present specification, but all the embodiments are protected by patent law within the scope of the claims of the present application.

Claims

1. The electronic atomization base solution comprises one or more of propylene glycol, glycerol, water and ethanol, and is characterized by also comprising 1, 3-dihydroxyacetone, wherein the mass fraction of the 1, 3-dihydroxyacetone is 5% -50%.

2. The electronically atomized base fluid of claim 1, wherein the combination of one or more of propylene glycol, glycerol, water, and ethanol comprises the following:

3. The electronically atomized base fluid of any one of claims 1 to 2, wherein the 1, 3-dihydroxyacetone has a mass fraction of 10% to 40%; optionally, the mass fraction of the 1, 3-dihydroxyacetone is 15-35%.

4. The electronically atomized base fluid of any one of claims 1 to 2, wherein the propylene glycol is present in an amount of from 0% to 50% by weight; the glycerol accounts for 0-50% by mass; the mass fraction of the water is 0-50%; the mass fraction of the ethanol is 0-50%; optionally, the propylene glycol is 0-30% by mass; the glycerol accounts for 30-50% by mass; the mass fraction of the water is 0-20%;

the mass fraction of the ethanol is 0-20%.

5. An electronically atomized liquid comprising the electronically atomized base liquid of any one of claims 1 to 4.

6. The electronic atomization liquid of claim 5, which further comprises nicotine or nicotine salt, wherein the final concentration of nicotine in the electronic atomization liquid is 0-20% by mass; optionally, the final concentration mass fraction of nicotine in the electronic atomized liquid is 1% -10%.

7. The electronically atomized liquid of claim 6, wherein the nicotine salt is one or more of a combination of nicotine malonate, nicotine citrate, nicotine 2-ethylbutyrate, nicotine acetate, nicotine adipate, nicotine benzoate, nicotine butyrate, nicotine cinnamate, nicotine cycloheptane-carboxylate, nicotine fumarate, nicotine glycolate, nicotine hexanoate, nicotine lactate, nicotine levulinate, nicotine malate, nicotine myristate, nicotine octanoate, nicotine oxalate, nicotine propionate, nicotine pyruvate, nicotine succinate and nicotine undecanoate; optionally, the nicotine salt is one or more of benzoic acid nicotine salt, levulinic acid nicotine salt and lactic acid nicotine salt.

8. The electronically atomized liquid of claim 5, further comprising a flavor, wherein the flavor is one or more of a sweetener, a cooling agent, an acidulant, an essence or a tobacco extract, and the mass fraction of the flavor is 0.5-30%.

9. The electronically atomized liquid of claim 8, wherein the sweetener is present in an amount of 0 to 10% by weight; the mass fraction of the sour agent is 0-5%; the mass fraction of the cooling agent is 0-10%; the mass fraction of the essence is 0-20%; the mass fraction of the tobacco extract is 0-10%.

10. A method for reducing small particle size particles in an aerosol, comprising the steps of:

the first solution is injected into an electronic atomizer.