CN110150760A - A kind of aerosol generation system - Google Patents

Abstract

Present invention discloses a kind of aerosols to generate system/material, it is characterized in that it includes containing pharmaceutically acceptable nicotine (nicotine) salt and pharmaceutically acceptable aerosol or the composition of smoke creating agent (I) and containing pharmaceutically acceptable alkalinity alkali more stronger than the nicotine (pKa value that its pKa value is greater than the nicotine) and pharmaceutically acceptable aerosol or the composition of smoke creating agent (II) that the aerosol, which generates system/material, above-mentioned composition (I) and (II) are used (/ consumption) person's sucking with aerosolization state or vaporization state or aerosol state or aerosol (aerosol).Aerosol strength foot, physiology satisfaction is good, and larynx sense of choking is low or nothing, and irritation is low or nothing, crosses that larynx is good, and nicotine bioavailability is high, and consumer's use feeling is good.Present invention further teaches one kind can make above-mentioned composition (I) and (II) aerosolization or vaporization or aerosolization or aerosolized device.

Description

A kind of aerosol generation system

Technical field

The present invention relates to a kind of aerosols to generate system, good more specifically to a kind of consumer's use feeling Aerosol generates system.

Background technique

In recent years, with the understanding that harm of smoking is acted on, government organs and different healthy groups and it is other have it is emerging The tissue of interest has carried out many movements and plan to publicize the information of the effect of the adverse health caused by smoking.Moreover, conduct To the understanding of illeffects as a result, there are many plans for being related to attempting to reduce smoking incidence.

The best thing that serious smoker can do is to reduce or preferably even stop completely smoking.But it is real It tests and shows that most smoker has found that this is extremely difficult, because most smoking causes to rely on disease or habituation. WHO has the diagnosis for being known as tobacco dependence in its International Classification of Diseases.It is other, for example, APA,American Psychiatric Association be known as at Addiction nicotine dependence.It is commonly accepted that these difficulties for stopping smoking are since heavy smokers rely on caused by nicotine.

Nicotine is the important material base of tobacco and tobacco product organoleptic quality.Nicotine can act on the nervous centralis of people System causes corresponding physiological reaction, and suitable nicotine intake can be long with arousing brain, raising spirit, elimination pain and increase nervous excitation Phase use can cause habituation.

Application nicotine can bring satisfaction, conventional method be by smoking, such as cigarette of enfleuraging, cigar or pipe cigarette, or Pass through news or chewing tobacco.But because forming a large amount of harmful substances, such as carcinogenic tar product, an oxygen during result of combustion of tobacco Change carbon, aldehyde and hydrogen cyanide, smoking has serious health risks, it is therefore desirable for forming a kind of alternative of comfortable application nicotine Formula can be used for promoting stopping smoking and/or replace smoking.

With the continuous development of global tobacco control campaign, cigarette/nicotine replacement of various relative healths is continued to bring out, wherein It is the most popular with electronic cigarette (electronic cigarette).Electronic cigarette core is electronics tobacco tar (electronic Cigarette liquid), tobacco tar generates fog similar to real smoke flue gas under the action of atomizer, is but free of tar, an oxygen Change the harmful substances such as carbon and is known.

Currently, the main component of tobacco juice for electronic smoke be usually solvent (propylene glycol and glycerine, total content generally 90% with On), nicotine (general content is 0~3%) and fragrance matter (according to different taste, such as tobacco, peppermint, coffee, fruit, add Add different flavor components).Currently, tobacco juice for electronic smoke available on the market sucks the intracavitary sweet sense of deutostoma mostly overweight, tobacco Fragrance is too weak, and strength is insufficient, is not able to satisfy the needs of consumer, seriously constrains the development of electronic cigarette.The main reason is that should Free state nicotine content is very little in tobacco juice.

Nicotine exists in the form of free state and two kinds of reference state in electronic cigarette.Cigarette in Cigarette Impact and tobacco and main flume The content of alkali is related, especially has close relationship with free state nicotine therein.The physiology satisfaction of cigarette smoking is mainly Intake total amount by nicotine and its speed into hematological system determine.1970, the discovery free nicotine such as Armitage compared matter Sub- state nicotine has stronger lipophilicity, it is easier to penetrate mucous membrane of mouth to be absorbed by the body more quickly.It is produced when smoking Physiological stimulation intensity and flue gas strength are related with the content of free nicotine in flue gas, and content is higher, and strength is bigger.

Patent CN201510942417.4 discloses a kind of tobacco juice for electronic smoke containing pH adjusting agent, wraps in the tobacco juice for electronic smoke The pH adjusting agent of 1~10% mass percent is included, the pH value of tobacco juice for electronic smoke is pH7.2~pH8.9.The tobacco juice for electronic smoke is promoted Free state nicotine burst size improves the physiology satisfaction of electronic cigarette to a certain extent.

Patent CN104473322A discloses a kind of tobacco juice for electronic smoke containing nicotine and organic acid, when being aspirated by electronic cigarette Heating process, the organic acid of evaporating volatile or be broken down into free nicotine.To make up the uniformity of nicotine release.

But free state nicotine has strong larynx sense of choking, and suction acrid flavour is peppery, and irritation is big.Free state nicotine content rises, electronics Cigarette tobacco juice crosses larynx variation, and consumer's use feeling is deteriorated, and consumer generates psychology refused to use.

Therefore, a kind of strength foot is needed in reality, physiology satisfaction is good, and larynx sense of choking is low or nothing, and irritation is low or nothing, crosses larynx Good, the good electronic cigarette of consumer's use feeling of property.

Summary of the invention

It is an object of the invention to provide a kind of strength foots, and physiology satisfaction is good, and larynx sense of choking is low or nothing, irritation it is low or Nothing, larynx excessively is good, the good electronic cigarette of consumer's use feeling.

Based on above-mentioned purpose, the present inventor is through research it was unexpectedly observed that the solution and alkalinity of nicotine salt (reference state nicotine) The solution of alkali more stronger than nicotine especially in alveolar, meets to be atomized state in vivo, can generate free state nicotine on the spot, Larynx sense of choking can be significantly reduced or be eliminated, irritation can be significantly reduced or eliminate, larynx, " strength " and physiology was significantly improved and meets Sense, significantly improves the use feeling of consumer；Meanwhile the content of the high free state nicotine of volatility significantly drops in nicotine solution It is low or essentially 0, it is remarkably improved the stability of nicotine and reduces free state nicotine and volatilize from nicotine solution, be conducive to stablize Total nicotine content in nicotine solution.According to above-mentioned discovery, the present invention is completed.

Key property and advantage of the invention:

1) compared with current Nicotine replacement products, this product can preferably deliver or " propulsion " nicotine, preferably offer product Receptor's nicotine of pole acts on, and

2) preferably alleviate addiction to be intended to, and preferably control addiction is intended to, and

3) there are higher total withdrawal rate, less, lower ill-effect, higher nicotine bioavailability (biological utilisation Degree).

(strength foot, physiology satisfaction is good, and larynx sense of choking is low or nothing, and irritation is low or nothing, crosses larynx the present invention relates to a kind of Good, nicotine bioavailability (bioavilability) is high, and consumer's use feeling is good) electronic cigarette (or aerosol generation system/ Material), it is characterised in that the electronic cigarette (or aerosol generates system/material) includes containing pharmaceutically acceptable nicotine (nicotine) salt and pharmaceutically acceptable aerosol or the composition of smoke creating agent (I) and contain pharmaceutically acceptable alkali Property more stronger than nicotine alkali (pKa value that its pKa value is greater than the nicotine) and pharmaceutically acceptable aerosol or smoke creating The composition (II) of agent, (above-mentioned composition (I) and (II) be mutually isolated non-blending together), above-mentioned composition (I) and (II) (through aerosolization or vaporization or aerosolization or it is aerosolized after) with aerosolization state or vaporization state aerosol state or gas it is molten Glue (aerosol) is used (/ consumption) person's sucking (in vivo (especially in lung's (alveolar))), (in use (/ consumption) person's body It is interior to meet (especially in lung's (alveolar)) and (generate free state nicotine)).Above-mentioned electronic cigarette (or aerosol generates system/material Material) it further include that one kind can make above-mentioned composition (I) and (II) aerosolization or vaporization or aerosolization or aerosolized device (kits, device, equipment, unit).

Above-mentioned composition (I) or (II) are (at 25 DEG C of room temperature) solid-state, semisolid or liquefied mixture or solution, above-mentioned When composition (I) or (II) are (at 25 DEG C of room temperature) solid-state, dosage form can be powder agent, granule, tablet (containing blocky agent, different Shape piece), capsule.

The composition of tobacco leaf object (such as pipe tobacco, offal) containing pharmaceutically acceptable nicotine (nicotine) salt can also For the present invention.

Nicotine in the present invention means 3- (1- methyl -2- pyrrolidinyl)-pyridine, including synthesizes nicotine and come from tobacco The nicotine extract of plant or part thereof, such as independent Nicotiana or combinations thereof.

The nicotine salt of the present invention typically refers to the pharmaceutically acceptable salt of nicotine, including its pharmaceutically acceptable nothing Machine hydrochlorate, acylate, the pKa value of above-mentioned acid are lower than nicotine pKa value, and preferably low 0.5, more preferably low 1, most preferably low 2.

Above-mentioned pharmaceutically acceptable following Examples of organic acids is such as:

1), atomicity is the alkane or cycloalkane polybasic carboxylic acid of C2~C7 (preferably C2~C6):

Such as suitable or anti-methylmaleic acid, dihydroxy is suitable or fumaric acid, maleic acid (maleic acid), fumaric acid (fumaroyl, fumaric acid, fumaric acid), galactosaccharic acid, glucosaccharic acid, itaconic acid (enedioic acid class), malic acid, Muconic acid (muconic acid), oxalic acid, malonic acid, succinic acid (succinic acid), glutaric acid, adipic acid, mesoxalic acid (mesoxalic acid), Oxalacetic acid (oxaloacetic acid, butanone diacid), ketoglutaric acid, hexanone diacid, diethyl malonic acid, citric acid, tartaric acid, the rhizome of Chinese monkshood Acid, citramalic acid (2-Hydroxy-2-methylbutanedioic acid), dihydroxytartaric acid,

2), atomicity is the alkane or cycloalkane monocarboxylic acid of C2~C14 (preferably C2~C6):

Such as acetic acid, propionic acid, isopropyl acid, butyric acid, isobutyric acid, positive valeric acid, isovaleric acid, valproic acid, acid, iso caproic acid, positive heptan Acid, isoamyl acetic acid, lactic acid, acrylic acid, butenoic acid, methacrylate, pivalic acid (trimethylace tonitric), 2,2- dihydromethyl propionic acid, Portugal Grape saccharic acid, D or L-GuA, glycolic, D-ALPHA-Hydroxypropionic acid, Pfansteihl, hydroxybutyric acid (such as α-, β-, γ-type), hydroxyl valeric acid (such as α-, β-, γ-type), hydroxycaproic acid (such as α-, β-, γ-type), dihydroxy valeric acid, two hydroxycaproic acids, three hydroxycaproic acids, octanoic acid, capric acid, lauric acid, Palmitinic acid,

3), the hydrogen on benzene compound molecular structure ring is C1~C7 (more preferable C1~C6) by one or more carboxyl carbon atom numbers Linear chain or branched chain (preferably straight chain is dominant) alkane or the one or more hydroxyl carbon atom numbers of cycloalkyl group, one or more carboxyls are C2~C7 (preferably C2~C6) linear chain or branched chain alkane (preferably straight chain is dominant) hydrocarbon or cycloalkyl group replace and alkane chain in molecular structure Highest carbon atom number is not higher than the carboxylic acid of C7 (preferably C6):

Such as anisic acid (methoxy benzoic acid), atrolactic acid, diphenylglycollic acid, benzoic acid, caffeic acid, o/ or p/ or m- Cresotinic acid, salicylic acid, acetylsalicylic acid, ferulic acid, high hay-scented acid (4-Hydroxy-3-methoxybenzeneacetic Acid), 4 hydroxyisophthalic acid, phenylpropionic acid, p-hydroxybenzoic acid, M-phthalic acid, mandelic acid (mandelic acid), benzene pregnancy Acid, 4,6- dihydroxy -2- methyl benzoic acid (orsellinic acid), phenylacetic acid, protocatechuic acid (3,4- dihydroxy-benzoic acid), isopropylbenzene first Sour (insoluble), gallic acid, 2,5-dihydroxybenzoic acid, 2,5- dihydroxyphenyl acetic acid,

4), the hydrogen on furan compound, pyrylium compound and pyranone compounds molecular structure ring is by one or more carboxyl carbons Atomicity is C1~C7 (more preferable C1~C6) linear chain or branched chain (preferably straight chain is dominant) alkane or cycloalkyl group, one or more The one or more hydroxyl carbon atom numbers of carboxyl be C2~C7 (more preferable C1~C6) linear chain or branched chain (preferably straight chain is dominant) alkane or Cycloalkyl group replace and in molecular structure alkane chain highest carbon atom number be not higher than C7 (preferably C6) carboxylic acid:

Such as dihydrochalcone, 2- furylacrylic acid, furancarboxylic acid, D- galacturonic acid, glucuronic acid, a- pyranone -5- Carboxylic acid,

5), ascorbic acid, dehydroascorbic acid, (6-) deoxidation-L-AA, glucoascorbic acid, different anti-bad Hematic acid,

6), alkane chain highest carbon atom number is not higher than C7 (preferably C6, what more preferable straight chain was dominant) in other molecular structures Organic acid:

Such as angelic acid ((Z) -2- methyl-2-butenoic acid), camphoric acid (diacid), butylmalonic acid, carboxyglutamic acid (carboxyl Glutamic acid, polycarboxylic acid), cinnamic acid, coumaric acid (o/ or p/ or m- hydroxy-cinnamic acid), coumarilic acid (2-benzofurancarboxylic acid, benzene a pair of horses going side by side furan Mutter carboxylic acid), Dan Yiji tartaric acid, glucoheptonic acid, glycolic acid, glycyrrhizic acid, glyoxylic acid hydrate, hydroxyglutamic acid, 1- hydroxyl -2- Naphthoic acid, 3- hydroxyl -2- naphthoic acid, iminodisuccinic acid, heteroauxin, isonicotinic acid, 2-keto-L-gulonic acid, kojic acid, Lactobionic acid, pivalic (trimethylace tonitric, pivalic acid, PivalicAcid, neopentanoic acid), prephenic acid (1- carboxylic -4- carboxylic -2,5- hexamethylene Diene -1- pyruvic acid), reductic acid (1,2- dihydroxy -3- ketone cyclopentene), chinic acid, crotonic acid (crotonic acid), sorbic acid, Edetic acid(EDTA), pentaacetic acid, pimelic acid, clavulanic acid, ribonucleotide, deoxynucleotide, inosinicacid, Alpha-Methyl furans inosinicacid, Adenylic acid (adenylate, AMP), guanylic acid (guanylic acid, GMP), cytidylic acid (cytidine monophosphate, CMP), urine Pyrimidine nucleotide (uridylic acid, UMP), thymidylic acid (thymidylic acid, TMP), inosinic acid (inosinicacid, IMP), Xanthylic acid, tyrosine, tryptophan, cystine, phosphorylated amino acid (such as phosphotyrosine, phosphoserine and phosphoric acid Threonine) and acidic amino acid (such as glutamic acid, aspartic acid),

And the acid salt or ackd salt of above-mentioned multicomponent organic acid 7).

It is preferred for Examples of organic acids malic acid, glycyrrhizic acid, tartaric acid, the grape of the invention that nicotine salt is formed with nicotine Saccharic acid, oxalic acid, galactosaccharic acid, glucosaccharic acid, glutamic acid, aspartic acid, benzoic acid, ascorbic acid, dehydroascorbic acid, (6-) deoxidation-L-AA, glucoascorbic acid, arabo-ascorbic acid.Because they have more good mouthfeel or/ With lower irritation or/and higher stability.

Above-mentioned pharmaceutically acceptable following inorganic acid preferred embodiment is such as:

Hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, pyrosulfuric acid, sulfurous acid, pyrosulfurous acid, thiosulfuric acid, disulfate, biphosphate Salt, bisulfites, benzene sulfonic acid, sulfosalicylic acid.

Volatile organic acids is particularly preferred for the present invention.It can be real for example, formic acid, acetic acid, benzene first with volatile organic acids Acid, phenylacetic acid, octanoic acid, propionic acid, butyric acid, isobutyric acid, methylbutanoic acid, valeric acid, isovaleric acid, methylvaleric acid, caproic acid, isocaproic acid, In most preferably benzoic acid, 2-Methyl Butyric Acid, valeric acid, isovaleric acid, 3 methylvaleric acid, phenylacetic acid, isovaleric acid, octanoic acid.This is because The increase of isoamyl acid content is conducive to fragrance and is unfavorable for the promotion of sugariness；It is advantageous to increase 2-Methyl Butyric Acid, the content of valeric acid In miscellaneous gas and irritating decrease；Phenylacetic acid is conducive to the promotion of concentration；And octanoic acid then plays forward direction for concentration and strength Effect.

The preparation method of many nicotine salts is known, and be can be used.

Table 1 can be used for the present invention and nicotine into the sour example of salt

It can be with the acid of nicotine forming salt	Acid: the molar ratio * of nicotine	It can be with the acid of nicotine forming salt	Acid: the molar ratio * of nicotine
				Formic acid	2∶1	Lauric acid	3∶1
Acetic acid	3∶1	Palmitinic acid	3∶1
				Propionic acid	3∶1	Tartaric acid	2∶1
Butyric acid	3∶1	Citric acid	2∶1
				2-Methyl Butyric Acid	3∶1	Malic acid	2∶1
3 Methylbutanoic acid	3∶1	Oxalic acid	2∶1
				Valeric acid	3∶1	Benzoic acid	1∶1
Gentianic acid	1∶1	Gallic acid	1∶1
				Phenylacetic acid	3∶1	Salicylic acid	1∶1
Phthalic acid	1∶1	Picric acid	2∶1
				Sulfosalicylic acid	1∶1	Tannic acid	1∶5
Pectic acid	1∶3	Alginic acid	1∶2
				Hydrochloric acid	2∶1	Nitric acid	1∶1
Benzene sulfonic acid	1∶1	Pyruvic acid	2∶1
				Glutamic acid	1∶1	Aspartic acid	1∶1
Sulfuric acid	1∶1	Phosphoric acid	1∶3

Illustrate: suggestion when prepared by *

Contain a small amount of or micro free state nicotine in above-mentioned composition (I), the amount of usual free state nicotine is less than upper State 10% of the amount of total nicotine (free state and reference state) in composition (I), preferably less than 5%, more preferably less than 1%, most Goodly less than 0.1%.

The content of nicotine salt is usually 0.001%~25% (wt/wt) in above-mentioned composition (I), but reachable when highest 75% (wt/wt) or higher, preferably 0.01%~10% (wt/wt), more preferably 0.1%~3% (wt/wt), most preferably 0.5%~2.0% (wt/wt).

When above-mentioned composition (I) is solution, pH value is usually 3~6.9, and preferably 4~6.5, more preferably 4~6.0, most Good ground 4.5~5.5.The solution of the nicotine salt lower pH value solution irritation increases.The higher pH value of the solution of nicotine salt should The amount of solution free state nicotine increases, and larynx sense of choking is significantly increased, and irritation also increases.If the pH of the solution of nicotine salt is 6.8, Only about 10% nicotine is free form in solution.When pH is about 8.8, about 90% nicotine is free alkali in solution Form.PH adjusting agent be selected from hydrochloric acid, sulfuric acid, phosphoric acid, citric acid, lactic acid, tartaric acid, malic acid, metatartaric acid, acetic acid, oneself two One or more of acid, fumaric acid, sodium hydroxide, sodium carbonate, sodium bicarbonate, potassium carbonate, sodium citrate, potassium citrate are mixed It closes.

The content of (alkalinity is more stronger than above-mentioned nicotine) alkali above-mentioned in above-mentioned composition (II) is usually 0.001%~25% (wt/wt), up to 75% (wt/wt) or higher but when highest, preferably 0.01%~10% (wt/wt), more preferably 0.1%~ 3% (wt/wt), most preferably 0.5%~2.0% (wt/wt).

When above-mentioned composition (II) is solution, pH value is usually 7.2~12, and preferably 7.5~11, more preferably 8~10, Most preferably 8~9.

For pharmaceutically acceptable alkalinity alkali more stronger than above-mentioned nicotine of the invention, pKa of the pKa value compared with the nicotine Value is high, preferably high by 0.5, more preferably high by 1, most preferably high by 1.5.Since the pKa value of nicotine is 8.02 (at 25 DEG C of temperature), therefore on The pKa value for stating alkali is greater than 8.02 (at 25 DEG C of temperature), is preferably greater than 8.5, even more preferably greater than 9, is most preferably greater than 9.5；It is above-mentioned Alkali is usually less than 10g/kg in the solubility (at 25 DEG C of temperature) in water or ethyl alcohol, is preferably not less than 30g/kg, more preferably Not less than 50g/kg, most preferably it is not less than 100g/kg.

For pharmaceutically acceptable alkalinity more stronger than above-mentioned nicotine alkali preferred embodiment such as urea, deanol of the invention (2- (dimethyl amine) ethyl alcohol, pKa9.03), trometamol (Pehanorm, pKa8.1), ethanol amine (pKa10.81), two Ehtylethanolamine (pKa about 10), diethanol amine (pKa11.09), triethanolamine (pKa11.01), diethanol monoisopropanolamine, two Ethoxy tert-butyl alcohol amine, ethambutol (two butanol of ethylenediamine), isobutyl hydramine, dipropanolamine, tripropanol amine, triisopropanolamine, Diisopropanolamine (DIPA), two butanolamines, three butanolamines, two isobutyl hydramine, three isobutyl hydramine, diamyl hydramine, three amylalcohol amine, diisoamyl alcohol Amine, three isoamyl hydramine, two hydramine, triethanol amine, tromethamine, urethane (urethanes), amido monosaccharide or disaccharide And (such as deoxystreptamine, desosamine (such as 2- desosamine), deoxy-glucose amine are (such as first or ethylization amido monosaccharide or disaccharide 6- deoxidation-d-glucosamine), fucosamine (Fucosamine) and N- second (or first) acyl-fucosamine), galactosamine (such as D- Galactosamine), glucamine (Glucamine), Glucosamine (pKa8.04), meglumine (pKa9.5), Portugal ethamine (pKa About 9), neamine (or N- first (or second) acyl neamine), mycosamine (disaccharide amine), N- first (or second) base -- L- aminoglucose (or N- second (or first) acyl-L- aminoglucose), streptobiosamine, chitobiose (β-Isosorbide-5-Nitrae-disaccharides-gucosamine)), caffeine, pyrrole is trembled Alcohol/pungent (pKa8.96), pyridoxamine (pKa10.5), pyridoxal (pKa8.66), thiamines (pKa9.2), amino acid especially rely ammonia Acid, histidine, spermine acid, the soluble basic salt of amino acid is (such as: lysine, histidine, spermine acid, asparagine, paddy ammonia Acid, glutamine, glycine, isoleucine, leucine, methionine, phenylalanine, serine, threonine, valine, sulphur Base alanine, L-Glycylglycine, ornithine), soluble saccharin salt, glycyrrhizic acid normal salt and its basic salt or basic salt, Dihydrochalcone normal salt and its basic salt or basic salt, creatine salt, soluble carbonic acid (just) salt, basic carbonate (just) salt, carbon Sour hydrogen salt (pKa10.3), percarbonate, soluble sulfurous acid (just) salt, thiosulfuric acid (just) salt, (pKa is about for phosphoric acid (just) salt 13), hydrophosphate (pKa12.67), pyrophosphoric acid (just) salt and its basic salt or basic salt, alkali or alkaline earth metal are soluble Basic salt and their mixture；The salt above-mentioned soluble-salt preferred ammonium salt and formed with alkali or alkaline earth metal ion, more Particular certain cancers, sylvite, calcium salt, magnesium salts, zinc salt, ammonium salt.

For the more preferable example of pharmaceutically acceptable alkalinity alkali more stronger than above-mentioned nicotine such as amido monosaccharide of the invention Or disaccharide and first or ethylization amido monosaccharide or disaccharide (such as deoxystreptamine, desosamine (such as 2- desosamine), deoxy-glucose Amine (such as 6- deoxidation-d-glucosamine), fucosamine (Fucosamine) and N- second (or first) acyl-fucosamine), galactosamine (such as D-galactosamine), glucamine (Glucamine), Glucosamine (pKa8.04), meglumine (pKa9.5), Portugal's second Amine (pKa about 9), neamine (or N- second (or first) acyl neamine), mycosamine (disaccharide amine), N- first (or second) base -- L- glucose Amine (or N- second (or first) acyl-L- aminoglucose), streptobiosamine, chitobiose (β-Isosorbide-5-Nitrae-disaccharides-gucosamine)), pyridoxol/pungent (pKa8.96), pyridoxamine (pKa10.5), pyridoxal (pKa8.66), thiamines (pKa9.2), lysine, histidine, spermine acid, The soluble basic salt of amino acid is (such as: lysine, histidine, spermine acid, asparagine, glutamic acid, glutamine, sweet ammonia Acid, isoleucine, leucine, methionine, phenylalanine, serine, threonine, valine, cysteic acid, N- glycyl Glycine, ornithine), soluble saccharin salt, glycyrrhizic acid normal salt and its basic salt or basic salt, dihydrochalcone normal salt and Its basic salt or basic salt, creatine salt and their mixture；The preferred ammonium salt of above-mentioned soluble-salt and with alkali metal or alkaline earth gold Belong to the salt that ion is formed, the more preferable sodium salt of above-mentioned soluble-salt, sylvite, calcium salt, magnesium salts, zinc salt, ammonium salt.Have for them better Good mouthfeel or/and lower irritation.

Table 2 is preferred for examples of amino acids of the invention

	CAS registration number	PKa value	Water solubility, g/kg
				Arginine Arginine	74-79-3	9.00	182.6a)
Asparagine Aspargine	70-47-3	8.73	25.1
				Glutamic acid Glutamic acid	56-86-0	9.58	8.61a)b)
Glutamine Glutamine	56-85-9	9.00	42
				Glycine Glycine	56-40-6	9.58	250.9
Histidine tidine	71-00-1	9.09	43.5
				Isoleucine Isoleucine	73-32-5	9.60	34.2
Leucine Leucine	61-90-5	9.58	22.0
				Lysine Lysine	56-97-1	9.16	It is easily molten
Methionine Methionine	63-68-3	9.08	56
				Phenylalanine Phenylalanine	63-91-2	9.09	27.9
Serine Serine	56-45-1	9.05	50.2
				Threonine Threonine	72-19-5	8.96	98.1
Valine Valine	72-18-4	9.52	88.5
				Cysteic acid Cysteic acid	13100-82-8	8.70	It is easily molten
L-Glycylglycine N-Glycylglycine	556-50-3	8.10	It is easily molten
				Ornithine Ornithine	70-26-8	8.78	It is easily molten

Above-mentioned data are originated from " Handbook of Chemistry and Physics ", and 85^thedition；Table 7-1 (“20standard amino acids that are the basic constituents of proteins”)and Table 7-2(“Amino acids and related compounds of biochemical importance”).。

Herein, above-mentioned composition (I) and aerosol in (II) or smoke creating agent, which refer to, promotes aerosol to generate Reagent.Aerosol generating agent can be by promoting incipient vaporization and/or gas to condense or be sublimed into inhalable solid and/or liquid Aerosol promotes the generation of aerosol.In some embodiments, aerosol generating agent can improve fragrance (flavour) The delivering in material is generated from aerosol.

Any suitable one or more aerosol generating agents may be embodied in above-mentioned composition of the present invention (I) and (II) In.Suitable aerosol generating agent is selected from pharmaceutically acceptable low boiling point or sublimation point, and (in the present invention, definition is to be often referred to Boiling point or sublimation point are lower than 500 DEG C or 450 DEG C of temperature under 1atm (1 standard atmospheric pressure), preferably, 350 DEG C, more preferably 250 DEG C, But it is not less than 50 DEG C, is preferably not less than 60 DEG C, be more preferably not less than 70 DEG C, is most preferably not less than 80 DEG C, this paper is following herewith, Be not stated otherwise) additive, the example includes but is not limited to: pharmaceutically acceptable following additive: low boiling point or liter China's point sugar, such as 1,3-Dihydroxyacetone, 1,3-Dihydroxyacetone dimer, 2- deoxidation-L-ribose, 2-deoxy-D-ribose 2- Deoxy-D-ribose, arabinose, erythrose, erythrulose, D- xylulose, fructose, ribose, xylose, glucose, sorb Sugar；Low boiling point or sublimation point polyalcohol, such as glycerol, xylitol, D-sorbite, antierythrite；Low boiling point or sublimation point glycol, such as Propylene glycol, butanediol, 1,2- pentanediol, 1,2- hexylene glycol, 1,2- heptandiol, 1,2- ethohexadiol；Low boiling point or sublimation point unitary Alcohol, as atomicity be C2~C14 monohydric alcohol (such as ethyl alcohol, tert-butyl alcohol amylalcohol, laruyl alcohol, Rou Dou guan alcohol), menthol, borneol, Borneol, isoborneol；Low boiling point or sublimation point acid, such as lactic acid, adipic acid, benzoic acid, phenylacetic acid, vanillic acid, salicylic acid, Ah Si Woods, the fatty acid that atomicity is C8-C14 such as lauric acid, Rou Dou guan acid；Low boiling point or sublimation point ether, aldehydes or ketones, such as Ethylene Glycol Ether such as poloxamer (such as poloxamer105,124), polyglycereol, polypropylene glycol, polyethylene glycol (ether), such as diethylene glycol (DEG), three sweet Alcohol, tetraethylene glycol, vanillic aldehyde, ethyl vanillin, camphor；Low boiling point or sublimation point ester, as polyol ester (glycerol atomicity be C1~ The aliphatic ester (such as glycerin diacetate, glycerol triacetate, glycerol monobutyralte) of C8, triethylene glycol diacetate esters), single carboxylic (aliphatic alcohol ester that such as lactic acid atomicity is C1~C6, atomicity are the fatty acid of C1~C18 for acid, dicarboxylic acids or polycarboxylic acid's ester Atomicity is aliphatic alcohol ester (such as myristinate (such as ethyl myristate and isopropyl myristate), the stearic acid of C1~C6 Methyl esters), suberic acid diethylester, dodecanedioic acid dimethyl ester, tetradecanedioic acid dimethyl ester, atomicity be C2~C6 polyacid atom Number is the aliphatic alcohol ester (such as triethyl citrate, diethyl malate, diethyl succinate) of C1~C6, acetic acid laurylene base Ester, Ergol, phenylethyl phenylacetate, ethyl vanillate, propene carbonate)；Water；Or their mixture.

Particularly preferred aerosol generating agent example includes but is not limited to: D-sorbite, xylitol, glycerol, ethyl alcohol, glycerol Aliphatic ester that aliphatic ester that atomicity is C1~C4, propylene glycol atomicity are C1~C4, polyglycereol, polypropylene glycol, atom Aliphatic alcohol ester, propene carbonate and its mixture that the polyacid atomicity that number is C2~C6 is C1~C4, for example, it is ethyl alcohol, sweet Oil, propylene glycol, triethylene glycol, butanediol (1,2- butanediol, 1,3 butylene glycol, 1,4- butanediol), 1,2- pentanediol, 1,2- Hexylene glycol, 1,2- heptandiol, 1,2- ethohexadiol, glycerol triacetate, glycerol oxalic acid formic acid esters, glycerol dioctyl phthalate acetic acid esters, Glycerol oxalic acid propionic ester, glycerin tripropionate, poly- two~six glycerol, poly- two~six propylene glycol and poly- two~six ethylene glycol, three Ethylene acetate, triethyl citrate, diethyl malate, diethyl succinate, propene carbonate or their mixing Object.

When above-mentioned composition (I) and (II) are solution, solvent is usually liquid aerosol generating agent (at 25 DEG C of temperature), Aliphatic ester that such as water, ethyl alcohol, atomicity are C3~C8 in fact aliph polyols, glycerol atomicity are C1~C8, the third two The polyacid atomicity that alcohol atomicity is C1~C8 aliphatic ester, polyglycereol, polypropylene glycol, atomicity are C2~C6 is C1~C4 Aliphatic alcohol ester, propene carbonate and its mixture, such as water, ethyl alcohol, glycerol, propylene glycol, triethylene glycol, butanediol (1,2- Butanediol, 1,3 butylene glycol, 1,4- butanediol), it is 1,2- pentanediol, 1,2- hexylene glycol, 1,2- heptandiol, 1,2- ethohexadiol, sweet Oily triacetate, glycerol dioctyl phthalate acetic acid esters, glycerol oxalic acid propionic ester, glycerin tripropionate, gathers glycerol oxalic acid formic acid esters Two~six glycerol, poly- two~six propylene glycol and polyethylene glycol, triethylene glycol diacetate esters, triethyl citrate, malic acid diethyl Ester, diethyl succinate, propene carbonate or their mixture.It also may include one or more lipids.And it can be with Mixture comprising the above ingredient.

Above-mentioned composition (I) and (II) may include other additives.Other additives can be optionally added to wherein.

Optional additive includes one or more stabilization additives, such as antioxidant, including vitamin E, that is, is given birth to Phenol, the salt of vitamin C, i.e. ascorbic acid and it, sodium pyrosulfite, butylated hydroxytoluene, butylated hydroxyanisol；And anti-corrosion Agent, including parabens, benzalkonium chloride, chlorobutanol, benzylalcohol, β-phenylacetaldehyde alcohol, cetylpyridinium chloride； Gallic acid ester (galate), such as propyl gallate.

Other optional additives include one or more additives selected from the following:

Reinforcing agent (penetration enhancers), such as azone (azone)；Vitamin, such as vitamin C and E；Minerals, such as Fluoride, especially sodium fluoride, sodium monofluorophosphate and stannous fluoride；Deodorant, such as zinc and cyclodextrin；

Propellant, such as be optionally liquefied 1,1,2,2- tetrafluoroethane (HFC-134a) and be optionally liquefied 1,1,1, 2,3,3,3- heptafluoro-propanes (HFC-227)；Thickener (viscosity modifier), such as polysaccharide compound.

Sweetener, including one or more synthesis sweeteners and/or natural sugar, such as it is selected from artificial sweetener, it is such as sugared Essence and its sodium and calcium salt, aspartame, acesulfame and its sylvite, support Martin's polypeptide (thaumatin) and glycyrrhizin；

Polyalcohol such as sorbierite, xylitol, mannitol and glycerol；Monosaccharide, including glucose (also known as dextrose), Fructose (also known as levulose) and galactolipin；

Disaccharide, including sucrose (also known as sucrose (sucrose)), lactose (also known as lactose (milk sugar)) and wheat Bud sugar (also known as maltose (malt sugar))；

The mixture of sugar, including liquid glucose syrup, such as main mixing comprising dextrose, maltose, dextrin and water The starch hydrolysate of object, inverted sugar syrup, such as the sucrose by converting enzymatic conversion comprising dextrose, fructose and water are closed, The syrup of high sugar content, such as molasses, honey and malt extract；With their mixture.

Seasoning and/or aromatic, for example, by the fresh or dry flower of distillation, solvent extraction or cold pressing, bud, leaf, stem, Essential oil obtained from fruit, seed, pericarp, bark or root, as peppermint, spearmint, eucalyptus, Chinese ilex, slender and delicate jasmine (niaouli), In cloves, cardamom, cortex cinnamomi, semen armeniacae amarae, coriander, Carum carvi, ginger, needle juniper, orange, bigarabe, lemon grape fruit, citrus, bergamot, hundred Fragrant, fennel and rosemary oil；

Atural spice or aromatic, including natural origin is in fruit, berry, core, fragrance, peppermint, tobacco, cocoa, coffee Coffee, tea, vanilla, Radix Glycyrrhizae, caramel, taffy, honey, grape wine, Spirit and beer flavoring ingredient essential oil or concentrate Dilution；

The synthesis seasoning being made up of and aromatic: mixing with match for example fruit, berry, core, fragrance, peppermint, Tobacco, cocoa, coffee, tea, vanilla, Radix Glycyrrhizae, caramel, taffy, honey, grape wine, Spirit or beer it is natural flavour mountaineous The mixture of chemical substance including hydrocarbon, alcohol, aldehyde, ester, ketone, ether and oxide；

And their mixture.

Dosage (weight) between above-mentioned composition (I) and (II) is than no limitation, usually 1:100~100:1 (wt/wt), Preferably 1:10~10:1 (wt/wt) is more preferably 1:3~3:1 (wt/wt), is most preferably 1:1.5~1.5:1 (wt/ wt)。

Manufacture the method and application method of above-mentioned composition (I) and (II) (aerosol generation material)

Component in above-mentioned composition (I) and (II) can add in any suitable order, and mix to uniform, i.e., ?.It when above-mentioned composition (I) and (II) are liquid, can be sub-packed in smoke grenade or in the container that volume is bigger, add when using later It adds in smoking set.When above-mentioned composition (I) and (II) are solid-state, mix to uniform laggard Yi Walk be made powder agent, granule or Tablet can be sub-packed in smoke grenade, be added directly in smoking set when can also use later.

Term explanation:

Terminology used in the present invention " low boiling point or sublimation point " is often referred to boiling point or sublimation point under 1atm and is lower than 500 DEG C of temperature Or 450 DEG C, preferably, 350 DEG C, more preferably 250 DEG C, but it is not less than 50 DEG C, preferably it is not less than 60 DEG C, is more preferably not less than 70 DEG C, most preferably it is not less than 80 DEG C.

Terminology used in the present invention " pharmaceutically acceptable " refers to abiology or the undesirable material of other aspects To give the material to (biology) individual, such as people, without causing any excessively undesirable biology such as toxicity in individual Effect, or excessively harmful interaction will not occur with any component in the composition comprising it.

What terminology used in the present invention " additive " referred to that carrier for bioactive ingredients includes one or more can mix each other It closes and without interaction without occurring to reduce carrier for bioactive ingredients stability and/or bioactivity effect and be suitable for Locally or systemically give bioactivity at auxiliary material.

Terminology used in the present invention " about " be index value variation range or can value range in ± 30%, preferably ± In 20%, in ± 10%, in most preferably ± 5%, such as from about 10, then it represents that 7~13, preferably 8~12, more preferably 9~11, most preferably Ground 9.5~10.5.

Terminology used in the present invention "an", which refers to, includes at least one kind, can for it is a kind of, two kinds or more.

Terminology used in the present invention " dissolving in " refers to solubility of the substance in 25 DEG C of temperature of 100ml solvent such as water not Lower than 5g, preferably 10~30g.

Application about treatment, treatment and preparation

Electronic cigarette (or aerosol generates system/material) product of the invention can be used for treating.The treatment can be doctor It controls to be selected from and reduces using tobacco, stops using tobacco, it is other that tobacco, temporary give up is used to use tobacco (temporary Abstinence from abstaining from use of tobacco), Alzheimer's, Crohn's disease, pa Golden Sen Shi disease, the disease or medical indications and body weight control of Tourette's syndrome and ulcerative colitis.

Device

One kind is for (above-mentioned) electronic cigarette (or aerosol generates system/material) aerosolization or vaporization or aerosolization or gas The device (kits, device, equipment, unit) of solation comprising 2 atomization subsystems being independently not communicated with, (point Other aerosolization or vaporization or aerosolization or aerosolized above-mentioned composition (I) and (II) (or two different aerosols generate material Material)), the atomization subsystem respectively include a fluid reservoir/or accommodating chamber (and its constituting parts), a spray chamber (and its constituting parts), The component of the component or generation aerosol of one mist or smoke path (and its constituting parts) or guiding piece 1 and atomizing, on It states fluid reservoir/or accommodating chamber directly to communicate with above-mentioned spray chamber or be connected to by guiding piece 2, above-mentioned mist or smoke path or draw 1 one end of guiding element is communicated with above-mentioned spray chamber, and 2 mists of (mouth) Kong Xiangtong or above-mentioned are inhaled with one respectively for the other end or smog is logical Nearby (definition of " nearby " is to be no less than this with a distance from suction (mouth) hole to lead in suction (mouth) hole for road or 1 other end of guiding piece The 70% of road overall length, preferably 90%, more preferably 95%.Most preferably 99%, in the range of) converge and inhale (mouth) with one jointly later Hole connection or above-mentioned 2 mists or smoke path or 1 other end of guiding piece are converged and are communicated therewith at suction (mouth) hole, on It states between two fluid reservoirs/or accommodating chamber isolation to be not communicated with, above-mentioned two atomization interventricular septum is from being not communicated with, above-mentioned two mist or smoke path Or isolation is not communicated with (but except above-mentioned suction (mouth) hole or " nearby " defined above), above-mentioned two guiding piece 2 interval between guiding piece 1 From being not communicated with.Above-mentioned spray chamber can be hollow continuous cavity, be also possible to discontinuous cavity, for example containing numerous micropores Micropore in material (non-woven fabrics, ceramics, glass, metal, plastics such as containing numerous micropores)；Above-mentioned guiding piece 2 can be Material (non-woven fabrics, ceramics, glass, metal, plastics as contained fine duct) containing fine duct, is also possible to hollow Ingress pipe；The component of above-mentioned atomizing includes heating type (such as resistance heating formula or electromagnetism (oscillation) heating type) or/and vibration The atomizing component of dynamic formula (such as ultrasonic activation formula) or/and compression.It is preferred that electric resistor heating type component, is applying electricity to the component When stream, the resistance in component converts electric energy to the thermal energy that heating aerosol generates material.Heating element can be silk screen, coil Or the form of multiple conducting wires.Heating element may include metal or metal alloy.Metal be electrically and thermally can excellence conductor.Properly Metal include but is not limited to: copper, aluminium, platinum, tungsten, gold, silver and titanium.Suitable metal alloy includes but is not limited to: nichrome And stainless steel.Above-mentioned fluid reservoir/or accommodating chamber can directly be contacted with the liquid storage, can also non-direct contact, such as above-mentioned fluid reservoir/or Accommodating chamber accommodates another container such as smoke grenade for filling the liquid storage.

It further include shell, power supply module, necessary attachment for the device of the invention.Jin mono- Walk may also include smoke grenade, control Component processed, (pneumatic) switch block.Above-mentioned shell is equipped with cigarette holder and venthole, and above-mentioned suction (mouth) hole is located in above-mentioned cigarette holder, Above-mentioned venthole is connected with the air inlet of spray chamber, the venthole of above-mentioned spray chamber and above-mentioned mist or smoke path or guidance Part 1 is connected to.Preferably, multistage (annular) accommodating chamber is provided on above-mentioned pharynx mouth inner wall, when can avoid user's suction cigarette holder It will not be drawn onto tobacco tar, so that smoker has better mouthfeel.Preferably, above-mentioned air inlet and/or venthole are located in atomization chamber Inner port be equipped with protrude from atomization cavity wall hole wall, make atomization chamber condense generate tobacco tar will not be directly from venthole stream It is drawn onto mouth out and by user, so that smoker be made to obtain better mouthfeel, and/or avoids tobacco tar from air inlet, venthole Outflow makes inside electronic cigarette or outer surface is stain.

It is above-mentioned to be used for (above-mentioned) electronic cigarette (or aerosol generates system/material) aerosolization or vaporization or aerosolization or gas The device of solation can be configured to aerosol generation material (above-mentioned composition (I) and (II)) being heated approximately to 50-500 Or 450 DEG C, 100-350 DEG C, 150-350 DEG C, 150-330 DEG C or 180-300 DEG C of temperature.

Such as preferred embodiment example of the invention:

Example 1),

The spray outlet of one independent ultrasonic atomizer or compression atomizing device or net formula atomizer and another it is independent The conduit that the spray outlet of ultrasonic atomizer or compression atomizing device or net formula atomizer is independently not communicated with two respectively is connected, The other end of the conduit is connected with two branch pipes in a threeway, and the other end branch pipe of the threeway and one can cover in nose and mouth On air-suction cover be connected, user can suck mist or cigarette in the air-suction cover by air-suction cover nasal cavity or/and oral cavity Mist.It is not communicated with preferably, one end branch pipe for communicating with the air-suction cover that can be covered on nose and mouth of above-mentioned threeway is spaced intermediate.

Example 2),

One ultrasonic atomizer, compression atomizing device or net formula atomizer include 2 atomization subsystems being independently not communicated in it System, the conduit that the spray outlet of the atomization subsystem is independently not communicated with two respectively are connected, the other end of the conduit and one Two branch pipes in a threeway are connected, and the air-suction cover that the other end branch pipe of the threeway can cover on nose and mouth with one is connected, Or be connected with the air-suction cover that the conduit of one (preferably, spaced intermediate be not communicated with) can cover on nose and mouth with one, user The mist or smog in the air-suction cover can be sucked by air-suction cover nasal cavity or/and oral cavity.Preferably, above-mentioned threeway with can cover It is not communicated in one end branch pipe that the air-suction cover on nose and mouth communicates is spaced intermediate.

Example 3),

The electronic smoking sets combination that 2 each to carry independent atomization system is directly used in oral cavity sucking together, or after combination its Spray outlet is connected to two conduits being independently not communicated with (such as rubber tube, silicone tube) respectively is used for oral cavity sucking or above-mentioned The other end of two conduits being independently not communicated with is connected with two branch pipes in a threeway, the other end branch pipe of the threeway with One conduit that can be used for oral cavity sucking communicates.The outer diameter of above-mentioned conduit is usually 3mm-12mm, preferably 4mm-6mm.Preferably Ground, the tube at one end is big, and one end is small, big outer diameter be 8mm-12mm, outer diameter be 2mm-5mm, small one end be used for mouth.

Example 4), in it include electronic smoking sets of 2 atomization subsystems being independently not communicated with (for above-mentioned electronic cigarette (or aerosol generate system/material) aerosolization or vaporization or aerosolization or aerosolized device (kits, device, Equipment, unit)), such as:

Example 4-1),

A kind of electronic cigarette (tool) is (a kind of for above-mentioned electronic cigarette (or aerosol generates system/material) aerosolization or vapour Change or aerosolization or aerosolized device (kits, device, equipment, unit)) comprising outside a cigarette cavity Shell (4), power supply (2), smoke grenade (3) and tobacco rod attachment, the shell is interior to be sequentially equipped with the power supply by front end to rear end (2), a jettron (7), radio-frequency generator (8), a magnetostrictive vibrator (9) and two not connected appearances spaced intermediate The electromagnetic induction heater (10) of chamber (fluid reservoir/or accommodating chamber) or a jettron (7), power supply (2), high frequency occur The electromagnetism of device (8), a magnetostrictive vibrator (9) and not connected two cavities (fluid reservoir/or accommodating chamber) spaced intermediate Induction heater (10), wherein the radio-frequency generator (8) by conducting wire respectively with the magnetostrictive vibrator (9), electromagnetic induction heater (10) is connected with jettron (7)；

The front end of the shell (4) is provided with a light emitting diode (6), is pneumatically opened with described respectively by conducting wire It closes (7) and power supply (2) is connected；

The rear end of the shell (4) is connected with the smoke grenade (3), is equipped in the smoke grenade (3) spaced intermediate Not connected two cavities (fluid reservoir/or accommodating chamber) (31)；

Mist or smoke path in the electronic cigarette (tobacco rod attachment) is spaced intermediate not connected.(such as Fig. 1-1,3 institutes Show)

Preferably, above-mentioned electronic cigarette further includes a cigarette cap (1), the front end of the light emitting diode (6) is set, it will The light emitting diode (6) covers on the inside.

Preferably, power supply described in above-mentioned electronic cigarette (2) is a rechargeable battery, there is the positive contact point of a charging (21) and cathode contact point (22).

Preferably, magnetostrictive vibrator described in above-mentioned electronic cigarette (9) comprising: a magnetostrictive rod (93), Its both ends is respectively arranged with a permanent magnet (91), and the outside of the magnetostrictive rod (93) and two permanent magnets (91) is arranged with A permanent magnet (91) and the electromagnetic induction heater is arranged in driving coil (92), a vibrating sensor (94) (10) between.(as shown in Figs. 1-2)

Preferably, electromagnetic induction heater described in above-mentioned electronic cigarette (10) comprising: an oscillating plate (101) passes through External screw thread thereon is fixedly connected on the shell (4), and its underpart, which is correspondingly arranged on, spaced intermediate not connected has two The stainless steel tube (104) of cavity (fluid reservoir/or accommodating chamber), (fluid reservoir/holds (104) two cavities of the volume stainless steel tube Receive chamber) it is internal be separately installed with nickel screen silk (103), be provided between the stainless steel tube (104) and the shell (4) Induction coil (102).(as shown in Figs. 1-2)

Preferably, jettron described in above-mentioned electronic cigarette (7) comprising: a upper clamp (71), a lower clamp (74) It is docking together, wherein it is respectively arranged with groove at the docking of the upper clamp (71) and lower clamp (74), it is described The outer rim of a silica gel leather bag (73) is equipped in groove, the silica gel leather bag (73) has a centre bore, and a magnet (72) is mounted on In the centre bore of the silica gel leather bag (73), venthole is provided on the lower clamp (74), the upper clamp (71) is interior It is provided with circuit board, the line for placing the board lead is provided on the outside of the upper clamp (71) and lower clamp (74) Slot.(as shown in Figs 1-4)

Preferably, being provided with air cleft or stomata on silica gel leather bag (73) described in above-mentioned electronic cigarette.

Preferably, being provided with sequentially concatenated human body clutter sensor on circuit board described in above-mentioned electronic cigarette (75), a data processor (76), a master control output circuit (77), an amplification output circuit (78) and an overtemperature and overcurrent mistake Discharge protection circuit (79), wherein the amplification output circuit (78) and overtemperature and overcurrent over-discharge protection circuit (79) and a ultrasound Atomizer is connected (70).(as shown in Figs. 1-5)

Preferably, smoke grenade described in above-mentioned electronic cigarette (3) includes a shell (33), surface is provided with positioning convex platform (35), the bayonet (32) spaced intermediate being not communicated with is sequentially provided in the shell, two tobacco juices spaced intermediate being not communicated with return Chamber (34) and two fluid reservoirs/spaced intermediate being not communicated with or accommodating chamber (31) are flowed, the setting of the shell (33) outer end is useful To avoid the cotton silk screen (36) spaced intermediate being not communicated in tobacco juice sucking user mouthful.(as shown in figures 1 to 6)

Example 4-2),

A kind of electronic cigarette (tool) is (a kind of for above-mentioned electronic cigarette (or aerosol generates system/material) aerosolization or vapour Change or aerosolization or aerosolized device (kits, device, equipment, unit)), it is characterised in that the device includes Outer housing, cigarette holder, necessary attachment and supersonic atomizer；There are two the mist being not communicated with is isolated in above-mentioned outer housing and cigarette holder Vapour or smoke path, one end are communicated with the venthole on above-mentioned cigarette holder, the gas in the other end and above-mentioned supersonic atomizer Mist outlet communicates；The supersonic atomizer, including inner housing (10), power supply (12), liquid storing part (fluid reservoir/or accommodating chamber) (14), reticular component (20) and vibration source (30), the shell (10) is interior to be formed with liquid storing part (fluid reservoir/or accommodating chamber) (14), the liquid storing part (fluid reservoir/or accommodating chamber) (14) (centre) separates not connected, and upper end is equipped with liquid feeding to be opened/closed Mouthful, (for storing liquid) and be equipped with aerosol exit, the aerosol exit and the mist communicated therewith or smoke path be (in Between) isolation it is not connected, the reticular component (20) is embedded at the aerosol exit, the reticular component (20) be with The porous network structure of multiple micropores (21), the vibration source (30) connect with the reticular component (20), the vibration source (30) it is electrically connected with the power supply (12), the vibration source (30) can generate after being powered to be vibrated and drive the reticular component (20) it vibrates to carry out vibratory atomizer to the liquid of the reticular component (20) nearby；The micropore (21) is through described netted Smog after component (20) enables liquid to be atomized is flowed out along micropore 21, the reticular component (20) and the power supply (12) electricity Connection, the reticular component (20) can be generated heat after powered up and carry out heating mist to the liquid of the reticular component (20) nearby Change.(as shown in Fig. 2-1,2)

Preferably, the supersonic atomizer, wherein the vibration source (30) is at least partially disposed at the liquid storing part (14) in, and the end face of one end of the vibration source (30) is connect with the reticular component (20).

Preferably, the supersonic atomizer, wherein the vibration source (30) be located at the power supply (12) with it is described Between liquid storing part (14) and one end of the vibration source (30) is protruded into the liquid storing part (14).

Preferably, the supersonic atomizer, wherein the supersonic atomizer is used for electronic cigarette, the shell (10) partition (18) with the shell (10) tight engagement is equipped in, partition (18) closing forms the liquid storing part (14) Bottom, one end of the vibration source (30) is upward through the partition (18) and protrudes into the liquid storing part (14).

Preferably, the supersonic atomizer, wherein the periphery of the reticular component (20) and liquid storing part (14) Cover lining (24) are equipped between aerosol exit, are sealed between reticular component (20) and shell (10) by cover lining (24), and The periphery of reticular component (20) is abutted with cover lining (24), so that reticular component (20) is able to maintain in vibration in cover lining (24) in.

Preferably, the supersonic atomizer, wherein the longitudinal section of the liquid storing part (14) is in concave shape, the storage The center in liquid portion (fluid reservoir/or accommodating chamber) (14) forms (centre) and two not connected aerosol channels (16), the net is isolated One end of the micropore (21) of shape component (20) is connected to the liquid storing part (14), and the other end and the aerosol channel (16) are even It is logical.

Preferably, the supersonic atomizer, wherein the reticular component (20) is slab construction, the netted structure The micropore (21) of part (20) is formed by floor (23) in the gap after honeycomb arrangement, and the micropore (21) is both ends Aperture is big, median pore radius is small or the micropore (21) is that one end aperture is big, other end aperture is small, wherein when described fine Hole (21) big, other end aperture hour for one end aperture, the big one end in aperture is to be connected to the inside of the liquid storing part (14) Fluid inlet end, the small one end in aperture are aerosol exit end.

Preferably, the supersonic atomizer, wherein the reticular component (20) further includes metal mesh, the metal Net includes two layers, and the top-level metallic net being respectively arranged at the top of reticular component (20) and setting are in reticular component (20) bottom Underlying metal net, the floor (23) are arranged at intervals between underlying metal net and top-level metallic net, and with underlying metal net and The electrical connection of top-level metallic net.

Preferably, the supersonic atomizer, wherein the material of the reticular component (20) is conductive anticorrosion material Material.

Example 4-3),

It is a kind of with lubricating cup Integral electronic cigarette (tool) (it is a kind of for above-mentioned electronic cigarette (or aerosol generate system/ Material) aerosolization or vaporization or aerosolization or it is aerosolized with lubricating cup device (kits, device, equipment, Unit)), including shell (1) and the control assembly (2), battery (3) and the atomizer (4) that are set in shell (1), the control Component (2) is electrically connected with the heating wire (41) of battery (3), atomizer (4) respectively, it is characterised in that: in the shell (1) also Equipped with the lubricating cup (fluid reservoir/or accommodating chamber) (5) for receiving tobacco juice, (fluid reservoir/is accommodated for the atomizer (4) and lubricating cup Chamber) (5) be adjacently positioned, and the lubricating cup (5) is equipped with tobacco juice outlet (51) by the one end of atomizer (4), and the tobacco juice exports (51) Place is packaged with interior material (such as interior non-woven fabrics, ceramics, glass, metal, the plastics for having micropore) preferred non-woven fabrics for having micropore (52), the heating wire (41) of the atomizer (4) is close in described have the material (preferably non-woven fabrics (52)) of micropore to arrange, institute Stating has two not connected cavities spaced intermediate (fluid reservoir/or appearance in atomizer (4) and lubricating cup (fluid reservoir/or accommodating chamber) (5) Receive chamber), the tobacco juice outlet (51) and the mist or smoke path (centre) that communicate therewith are isolated not connected.(as Fig. 3-1 institute Show)

Preferably, the bore of the outlet of tobacco juice described in above-mentioned electronic cigarette (51) is identical as the caliber size of lubricating cup (5).

Preferably, one end of shell described in above-mentioned electronic cigarette (1) is equipped with, (centre has) two is not connected but flue gas can Wherein respectively by duct, and on have the cigarette holder covers (11) of above-mentioned channel openings (i.e. suction nozzle hole), the shell (1) it is another One end is equipped with the light cover (12) with LED light, and the control assembly (2) is fixed in light cover (12), control assembly (2) packet Include control circuit board and control switch.

Preferably, the side of light cover described in above-mentioned electronic cigarette (12) is equipped with the first air inlet (121), the control group The control switch of part (2) is air suction type automatic switch.

Preferably, atomizer described in above-mentioned electronic cigarette (4) includes oil removal silica gel seat (42) and the mutual not phase of (centre) isolation Logical but flue gas can be in the connecting tube (43) wherein passed through respectively, and the oil removal silica gel seat (42) and shell (1) are interference fitted, described One end of connecting tube (43) contradicts on oil removal silica gel seat (42), and the other end of the connecting tube (43) is contradicted to be exported in tobacco juice (51) the interior of end face has on the material (preferably non-woven fabrics (52)) of micropore, sets respectively on two chambers of connecting tube (43) isolation Have a glass fiber rope (44), the heating wire (41) is set around on the glass fiber rope (44), and the oil removal silica gel seat (42) is equipped with Two chambers that two air inlets (or (centre) isolation is not communicated with) (421) are isolated with connecting tube (43) respectively communicate, the stomata (421) It is connected respectively with a suction nozzle hole on the first air inlet (121), cigarette holder cover (11).(as shown in figure 3-1)

Example 4-4),

A kind of electronic cigarette device (/ tool) is (a kind of for above-mentioned electronic cigarette (or aerosol generates system/material) aerosolization Or vaporization or aerosolization or aerosolized device (kits, device, equipment, unit)), which includes The atomization subsystem that (upper and lower) shell, power supply module, necessary attachment and 2 are independently not communicated with；Its lower case (for cuboid, Its) in comprising power supply module, atomization subsystem, two mist or smoke path that are not communicated with, the mist or smoke path is isolated One end is communicated with above-mentioned atomization subsystem, the other end in following upper housings mist or smoke path communicate；Its upper housing is Cigarette holder, (shape be two bevel edges (preferably arc-shaped)) Chang Burr when being connected, Duan Burr with lower case on have two ventholes ( Prismatoid), inside have two the mist or smoke path that are not communicated with is isolated, one end is communicated with above-mentioned venthole, the other end and Mist or smoke path in above-mentioned lower case communicate.Preferably, the rib (/ side) or/and angle quilt of above-mentioned upper housing and lower case Radiused processing.It is extended preferably, its upper housing cigarette holder mouth inhales end to adapt to the needs of suction.Above-mentioned upper housing cigarette holder extends Portion can be not limited to cylindric, flat column, prism-shaped, hammer body shape for natural sciences.

Above-mentioned separate atomising subsystem respectively include a fluid reservoir/or accommodating chamber (and its constituting parts), a spray chamber (and its Constituting parts), a mist or smoke path (and its constituting parts) or guiding piece 1 and the component for playing atomizing, above-mentioned fluid reservoir/or Accommodating chamber is directly communicated with above-mentioned spray chamber or is connected to by guiding piece 2, and above-mentioned mist or smoke path or guiding piece 1 are above-mentioned Mist or smoke path in upper and lower casing are isolated between above-mentioned two fluid reservoir/or accommodating chamber and are not communicated with, between above-mentioned two spray chamber Isolation is not communicated with, and is isolated between above-mentioned two guiding piece 2 and is not communicated with, and not phase is isolated between above-mentioned two mist or smoke path or guiding piece 1 It is logical.

Above-mentioned composition (I) and (II) are individually positioned in two fluid reservoirs/that above-mentioned isolation is not communicated with or accommodating chamber and (or hold Chamber) in or above-mentioned composition (I) and (II) be first preset in the containers such as glass, ceramics, metal respectively, then together with above-mentioned appearance Device is placed on together in two fluid reservoirs/that above-mentioned isolation is not communicated with or accommodating chamber (or cavity).

Preferred technical solution:

(strength foot, physiology satisfaction is good, and larynx sense of choking is low or nothing, and irritation is low or nothing, crosses that larynx is good, and nicotine is raw 1. a kind of Object utilization rate (bioavilability) is high, and consumer's use feeling is good) electronic cigarette (or aerosol generates system/material), Be characterized in that the electronic cigarette (or aerosol generates system/material) include containing pharmaceutically acceptable nicotine (nicotine) salt and Pharmaceutically acceptable aerosol or the composition of smoke creating agent (I) and containing pharmaceutically acceptable alkalinity it is more stronger than the nicotine The alkali pKa value of the nicotine (its pKa value be greater than) and pharmaceutically acceptable aerosol or the composition of smoke creating agent (II), (above-mentioned composition (I) and (II) be mutually isolated non-blending together), above-mentioned composition (I) and (II) (through aerosolization or Vaporization or aerosolization are aerosolized rear) used with aerosolization state or vaporization state or aerosol state or aerosol (aerosol) (/ consumption) person sucking (in vivo (especially in lung's (alveolar))), (in use (/ consumption) person's body (especially lung's (alveolar) It is interior) meet and (generate free state nicotine)).

2. according to the electronic cigarette (or aerosol generates system/material) of technical solution 1, it is characterised in that the composition (I) or (II) is (at 25 DEG C of room temperature) solid-state, semisolid or liquefied mixture or solution.

3. according to the electronic cigarette (or aerosol generates system/material) of technical solution 1, it is characterised in that the composition (I) or (II) is (at 25 DEG C of room temperature) solid-state, and dosage form is powder agent, granule, tablet (containing blocky agent, Special-shaped sheet), capsule Agent.

4. according to the electronic cigarette of technical solution 1 (or aerosol generates system/material), it is characterised in that the electronic cigarette (or Aerosol generates system/material) composition containing the tobacco leaf object containing pharmaceutically acceptable nicotine (nicotine) salt.

5. according to the electronic cigarette of technical solution 1 (or aerosol generates system/material), it is characterised in that the nicotine salt is The pKa value of pharmaceutically acceptable inorganic acid salt or acylate, above-mentioned acid is lower than nicotine pKa value.

6. according to the electronic cigarette (or aerosol generates system/material) of technical solution 5, it is characterised in that the pKa of the acid Value low compared with nicotine pKa value 1.

7. according to the electronic cigarette (or aerosol generates system/material) of technical solution 5, it is characterised in that the pKa of the acid Value low compared with nicotine pKa value 2.

8. according to the electronic cigarette (or aerosol generates system/material) of technical solution 5, it is characterised in that the organic acid choosing From pharmaceutically acceptable following acid: atomicity is the alkane or cycloalkane polybasic carboxylic acid, original of C2~C7 (preferably C2~C6) Subnumber is the alkane of C2~C14 (preferably C2~C6) or the hydrogen on cycloalkane monocarboxylic acid, benzene compound molecular structure ring by one Or more carboxyl carbon atom numbers are C1~C7 (more preferable C1~C6) linear chain or branched chain (preferably straight chain is dominant) alkane or cycloalkane The one or more hydroxyl carbon atom numbers of base, one or more carboxyls are that (preferably straight chain is dominant C2~C7 (preferably C2~C6) linear chain or branched chain alkane ) hydrocarbon or cycloalkyl group replace and alkane chain highest carbon atom number is not higher than carboxylic acid, the furan of C7 (preferably C6) in molecular structure The hydrogen muttered on compound, pyrylium compound and pyranone compounds molecular structure ring is C1~C7 by one or more carboxyl carbon atom numbers (more preferable C1~C6) linear chain or branched chain (preferably straight chain is dominant) alkane or the one or more hydroxyl carbon of cycloalkyl group, one or more carboxyls Atomicity be it is that C2~C7 (more preferable C1~C6) linear chain or branched chain (preferably straight chain is dominant) alkane or cycloalkyl group replace and Alkane chain highest carbon atom number is not higher than carboxylic acid, ascorbic acid, dehydroascorbic acid, (6-) of C7 (preferably C6) in molecular structure Deoxidation-L- ascorbic acid, glucoascorbic acid, arabo-ascorbic acid, alkane chain highest carbon atom number in other molecular structures The acid salt or ackd salt of organic acid and above-mentioned multicomponent organic acid not higher than C7 (preferably C6, what more preferable straight chain was dominant).

9. according to the electronic cigarette (or aerosol generates system/material) of technical solution 5, it is characterised in that the organic acid choosing From suitable or anti-methylmaleic acid, dihydroxy is suitable or fumaric acid, maleic acid (maleic acid), fumaric acid (trans- fourth Enedioic acid, fumaric acid, fumaric acid), galactosaccharic acid, glucosaccharic acid, itaconic acid (enedioic acid class), malic acid, hexadiene two Sour (muconic acid), oxalic acid, malonic acid, succinic acid (succinic acid), glutaric acid, adipic acid, mesoxalic acid (mesoxalic acid), oxalacetic acid (oxaloacetic acid, butanone diacid), ketoglutaric acid, hexanone diacid, diethyl malonic acid, citric acid, tartaric acid, aconitic acid, lemon apple It is sour (2-Hydroxy-2-methylbutanedioic acid), dihydroxytartaric acid, acetic acid, propionic acid, isopropyl acid, butyric acid, different Butyric acid, positive valeric acid, isovaleric acid, valproic acid, acid, iso caproic acid, positive enanthic acid, isoamyl acetic acid, lactic acid, acrylic acid, butenoic acid, isobutene Acid, pivalic acid (trimethylace tonitric), 2,2- dihydromethyl propionic acid, gluconic acid, D or L-GuA, glycolic, D-ALPHA-Hydroxypropionic acid, Pfansteihl, hydroxybutyric acid (such as α-, β-, γ-type), hydroxyl valeric acid (such as α-, β-, γ-type), hydroxycaproic acid (such as α-, β-, γ-type), dihydroxy Valeric acid, two hydroxycaproic acids, three hydroxycaproic acids, octanoic acid, capric acid, lauric acid, palmitinic acid, anisic acid (methoxy benzoic acid), adjacent benzene generation cream Acid, diphenylglycollic acid, benzoic acid, caffeic acid, o/ or p/ or m- cresotinic acid, salicylic acid, acetylsalicylic acid, ferulic acid, height Hay-scented acid (4-Hydroxy-3-methoxybenzeneacetic acid), 4 hydroxyisophthalic acid, phenylpropionic acid, to hydroxyl Benzoic acid, M-phthalic acid, mandelic acid (mandelic acid), mellitic acid, 4,6- dihydroxy -2- methyl benzoic acid (orsellinic acid), benzene Acetic acid, protocatechuic acid (3,4- dihydroxy-benzoic acid), cumic acid (insoluble), gallic acid, 2,5- dihydroxy-benzoic acid, 2, 5- dihydroxyphenyl acetic acid, dihydrochalcone, 2- furylacrylic acid, furancarboxylic acid, D- galacturonic acid, glucuronic acid, a- pyranone- 5- carboxylic acid, ascorbic acid, dehydroascorbic acid, (6-) deoxidation-L-AA, glucoascorbic acid, arabo-ascorbic acid, Angelic acid ((Z) -2- methyl-2-butenoic acid), camphoric acid (diacid), butylmalonic acid, carboxyglutamic acid (carboxyglutamic acid, it is more Carboxylic acid), cinnamic acid, coumaric acid (o/ or p/ or m- hydroxy-cinnamic acid), coumarilic acid (2-benzofurancarboxylic acid, coumarilic acid), Single ethyl tartaric acid, glucoheptonic acid, glycolic acid, glycyrrhizic acid, glyoxylic acid hydrate, hydroxyglutamic acid, 1- hydroxy-2-naphthoic acid, 3- hydroxy-2-naphthoic acid, iminodisuccinic acid, heteroauxin, isonicotinic acid, 2-keto-L-gulonic acid, kojic acid, lactobionic acid, three Methylene diacetate (trimethylace tonitric, pivalic acid, PivalicAcid, neopentanoic acid), prephenic acid (1- carboxylic -4- carboxylic -2,5- cyclohexadiene -1- third Ketone acid), reductic acid (1,2- dihydroxy -3- ketone cyclopentene), chinic acid, crotonic acid (crotonic acid), sorbic acid, edetic acid(EDTA), three Triamine pentaacetic acid, pimelic acid, clavulanic acid, ribonucleotide, deoxynucleotide, inosinicacid, Alpha-Methyl furans inosinicacid, adenosine Acid (adenylate, AMP), guanylic acid (guanylic acid, GMP), cytidylic acid (cytidine monophosphate, CMP), uridylate (uridylic acid, UMP), thymidylic acid (thymidylic acid, TMP), inosinic acid (inosinicacid, IMP), xanthosine Acid, tyrosine, tryptophan, cystine, phosphorylated amino acid (such as phosphotyrosine, phosphoserine and phosphothreonine) and acid The acid salt or ackd salt of acidic amino acid (such as glutamic acid, aspartic acid) and above-mentioned multicomponent organic acid；

Or the inorganic acid be selected from hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, pyrosulfuric acid, sulfurous acid, pyrosulfurous acid, thiosulfuric acid, Disulfate, dihydric phosphate, bisulfites, benzene sulfonic acid, sulfosalicylic acid and above-mentioned multi-element, inorganic acid acid salt or Ackd salt.

10. according to the electronic cigarette (or aerosol generates system/material) of technical solution 5, it is characterised in that the organic acid Selected from volatile organic acids.

11. according to the electronic cigarette (or aerosol generates system/material) of technical solution 5, it is characterised in that the organic acid Selected from malic acid, glycyrrhizic acid, tartaric acid, gluconic acid, oxalic acid, galactosaccharic acid, glucosaccharic acid, glutamic acid, aspartic acid, benzene Formic acid, ascorbic acid, dehydroascorbic acid, (6-) deoxidation-L-AA, glucoascorbic acid, arabo-ascorbic acid, first Acid, acetic acid, phenylacetic acid, octanoic acid, propionic acid, butyric acid, isobutyric acid, methylbutanoic acid, valeric acid, isovaleric acid, methylvaleric acid, caproic acid, dissident Acid.

12. according to the electronic cigarette (or aerosol generates system/material) of technical solution 1, it is characterised in that the composition (I) contain a small amount of or micro free state nicotine in, the amount of free state nicotine is less than total nicotine (trip in above-mentioned composition (I) Amorph and reference state) amount 10%.

13. according to the electronic cigarette (or aerosol generates system/material) of technical solution 1, it is characterised in that the composition (I) contain a small amount of or micro free state nicotine in, the amount of free state nicotine is less than total nicotine (trip in above-mentioned composition (I) Amorph and reference state) amount 1%.

14. according to the electronic cigarette (or aerosol generates system/material) of technical solution 1, it is characterised in that the composition (I) content of nicotine salt is 0.001%~25% (wt/wt) in.

15. according to the electronic cigarette (or aerosol generates system/material) of technical solution 1, it is characterised in that the composition It (I) is solution, pH value is usually 3~6.9.

16. according to the electronic cigarette (or aerosol generates system/material) of technical solution 1, it is characterised in that the composition (II) content of (alkalinity is more stronger than the nicotine) alkali described in is 0.001%~25% (wt/wt).

17. according to the electronic cigarette (or aerosol generates system/material) of technical solution 1, it is characterised in that the composition It (II) is solution, pH value is 7.2~12.

18. according to the electronic cigarette (or aerosol generates system/material) of technical solution 1, it is characterised in that the pKa of the alkali It is worth high by 0.5 compared with the pKa value of nicotine.

19. according to the electronic cigarette (or aerosol generates system/material) of technical solution 1, it is characterised in that the pKa of the alkali It is worth high by 1 compared with the pKa value of nicotine.

20. according to the electronic cigarette (or aerosol generates system/material) of technical solution 1, it is characterised in that the pKa of the alkali It is worth high by 1.5 compared with the pKa value of nicotine.

21. according to the electronic cigarette (or aerosol generates system/material) of technical solution 1, it is characterised in that the alkali is in water Or the solubility (at 25 DEG C of temperature) in ethyl alcohol is not less than 10g/kg.

22. according to the electronic cigarette (or aerosol generates system/material) of technical solution 1, it is characterised in that the alkali is selected from Urea, deanol, trometamol, ethanol amine, diethyl ethylene diamine, diethanol amine, triethanolamine, diethanol monoisopropanolamine, Dihydroxy ethyl tert-butyl alcohol amine, ethambutol (two butanol of ethylenediamine), isobutyl hydramine, dipropanolamine, tripropanol amine, three isopropanols Amine, diisopropanolamine (DIPA), two butanolamines, three butanolamines, two isobutyl hydramine, three isobutyl hydramine are diamyl hydramine, three amylalcohol amine, two different Amylalcohol amine, three isoamyl hydramine, two hydramine, triethanol amine, tromethamine, urethane, amido monosaccharide or disaccharide, first or ethylization Amido monosaccharide or disaccharide, caffeine, pyridoxol/pungent, pyridoxamine, pyridoxal, thiamines, amino acid, the soluble alkali of amino acid Property salt, soluble saccharin salt, glycyrrhizic acid normal salt and its basic salt or basic salt, dihydrochalcone normal salt and its basic salt or alkali Property salt, creatine salt, soluble carbonic acid (just) salt, basic carbonate (just) salt, bicarbonate, percarbonate, soluble sulfurous Sour (just) salt, thiosulfuric acid (just) salt, phosphoric acid (just) salt, hydrophosphate, pyrophosphoric acid (just) salt and its basic salt or basic salt, alkali Metal or alkaline-earth metal soluble alkali salt and their mixture.

23. according to the electronic cigarette (or aerosol generates system/material) of technical solution 22, it is characterised in that the solubility The salt that salt is selected from ammonium salt and is formed with alkali or alkaline earth metal ion.

24. according to the electronic cigarette (or aerosol generates system/material) of technical solution 22, it is characterised in that the solubility Salt is selected from sodium salt, sylvite, calcium salt, magnesium salts, zinc salt, ammonium salt.

25. according to the electronic cigarette (or aerosol generates system/material) of technical solution 1, it is characterised in that the alkali is selected from Deoxy-glucose amine, fucosamine and N- second (or first) acyl-fucosamine), galactosamine, glucamine, Glucosamine, Portugal Methylamine, Portugal's ethamine, neamine (or N- first (or second) acyl neamine), mycosamine, N- first (or second) base -- L- aminoglucose, N- Second (or first) acyl-L- aminoglucose, streptobiosamine, chitobiose, pyridoxol/pungent, pyridoxamine, pyridoxal, thiamines, lysine, group Propylhomoserin, spermine acid, asparagine, glutamic acid, glutamine, glycine, isoleucine, leucine, methionine, phenylpropyl alcohol ammonia Acid, serine, threonine, valine, cysteic acid, L-Glycylglycine, ornithine, the soluble alkalinity of amino acid Salt, soluble saccharin salt, glycyrrhizic acid normal salt and its basic salt or basic salt, dihydrochalcone normal salt and its basic salt or alkalinity Salt, creatine salt and their mixture；It the preferred ammonium salt of above-mentioned soluble-salt and is formed with alkali or alkaline earth metal ion Salt.

26. according to the electronic cigarette (or aerosol generates system/material) of technical solution 1, it is characterised in that the aerosol Or smoke creating agent is selected from pharmaceutically acceptable 1 normal atmosphere pressure boiling point or sublimation point is lower than 500 DEG C of temperature, but is not less than 50 DEG C of additive.

27. according to the electronic cigarette (or aerosol generates system/material) of technical solution 1, it is characterised in that the aerosol Or smoke creating agent is selected from pharmaceutically acceptable 1 normal atmosphere pressure boiling point or sublimation point is lower than 350 DEG C of temperature, but is not less than 60 DEG C of additive.

28. according to the electronic cigarette (or aerosol generates system/material) of technical solution 1, it is characterised in that the aerosol Or smoke creating agent is selected from pharmaceutically acceptable 1 normal atmosphere pressure boiling point or sublimation point is lower than 250 DEG C of temperature, but is not less than 70 DEG C of additive.

29. according to the electronic cigarette (or aerosol generates system/material) of technical solution 1, it is characterised in that the aerosol Or smoke creating agent is selected from pharmaceutically acceptable following additive: low boiling point or sublimation point sugar；Low boiling point or sublimation point are polynary Alcohol；Low boiling point or sublimation point glycol；Low boiling point or sublimation point monohydric alcohol；Low boiling point or sublimation point acid；Low boiling point or sublimation point ether, Aldehydes or ketones；Low boiling point or sublimation point ester；And their mixture；Above-mentioned low boiling point or sublimation point are lower than 450 DEG C of temperature, but not low In 70 DEG C.

30. according to the electronic cigarette (or aerosol generates system/material) of technical solution 1, it is characterised in that the aerosol Or smoke creating agent is selected from C3H6O3, C3H6O3 dimer, 2- deoxidation-L-ribose, 2- deoxidation-D- Ribose 2-Deoxy-D-ribose, arabinose, erythrose, erythrulose, D- xylulose, fructose, ribose, xylose, glucose, Sorbose；Glycerol, xylitol, D-sorbite, antierythrite；Propylene glycol, butanediol, 1,2- pentanediol, 1,2- hexylene glycol, 1,2- Heptandiol, 1,2- ethohexadiol；Atomicity is the monohydric alcohol of C2~C14, menthol, borneol, borneol, isoborneol；Lactic acid, benzene first Acid, phenylacetic acid, vanillic acid, salicylic acid, aspirin, atomicity are the fatty acid of C8-C14；Poloxamer, poly- two~six is sweet Oily, poly- two~six propylene glycol, poly- two~six ethylene glycol, vanillic aldehyde, ethyl vanillin, camphor；Glycerol atomicity is C1~C8's Aliphatic ester, triethylene glycol diacetate esters, lactic acid atomicity are the aliphatic alcohol ester of C1~C6, and atomicity is the fat of C1~C18 Sour atomicity is aliphatic alcohol ester, suberic acid diethylester, the dodecanedioic acid dimethyl ester, tetradecanedioic acid dimethyl ester of C1~C6, former Subnumber is the aliphatic alcohol ester that C2~C6 polyacid atomicity is C1~C6, acetic acid laurylene base ester, Ergol, phenylacetic acid benzene Ethyl ester, ethyl vanillate, propene carbonate；Water；Or their mixture.

31. according to the electronic cigarette (or aerosol generates system/material) of technical solution 1, it is characterised in that the aerosol Or smoke creating agent is selected from glycerol, xylitol, D-sorbite, antierythrite；Propylene glycol, butanediol, 1,2- pentanediol, 1,2- oneself Glycol, 1,2- heptandiol, 1,2- ethohexadiol；Ethyl alcohol, the tert-butyl alcohol, amylalcohol, adipic acid；Poloxamer 105 or 124, poly- two~six Glycerol, poly- two~six propylene glycol, poly- two~six ethylene glycol；Glycerol triacetate, glycerol oxalic acid formic acid esters, glycerol dioctyl phthalate second Acid esters, glycerol oxalic acid propionic ester, glycerin tripropionate, triethylene glycol diacetate esters, triethyl citrate, malic acid diethyl Ester, diethyl succinate, propene carbonate；Water；Or their mixture.

32. a kind of (for according to technical solution 1) electronic cigarette (or aerosol generates system/material) aerosolization or vaporization Or aerosolization or aerosolized device (kits, device, equipment, unit), it is characterised in that the device includes 2 Independently be not communicated with atomization subsystem (, respectively aerosolization or vaporization or aerosolization or the aerosolized composition (I) and (Ⅱ))。

33. a kind of (for according to technical solution 1) electronic cigarette (or aerosol generates system/material) aerosolization or vaporization Or aerosolization or aerosolized device (kits, device, equipment, unit), it is characterised in that the device includes 2 The atomization subsystem being independently not communicated with, the atomization subsystem respectively include a fluid reservoir/or accommodating chamber (and its constituting parts), one Spray chamber (and its constituting parts), a mist or smoke path (and its constituting parts) or guiding piece 1 and the component for playing atomizing, on It states fluid reservoir/or accommodating chamber directly to communicate with above-mentioned spray chamber or be connected to by guiding piece 2, above-mentioned mist or smoke path or draw 1 one end of guiding element is communicated with above-mentioned spray chamber, and 2 mists of (mouth) Kong Xiangtong or above-mentioned are inhaled with one respectively for the other end or smog is logical Nearby (definition of " nearby " is to be no less than this with a distance from suction (mouth) hole to lead in suction (mouth) hole for road or 1 other end of guiding piece The 70% of road overall length, preferably 90%, more preferably 95%.Most preferably 99%, in the range of) converge and inhale (mouth) with one jointly later Hole connection or above-mentioned 2 mists or smoke path or 1 other end of guiding piece are converged and are communicated therewith at suction (mouth) hole, on It states between two fluid reservoirs/or accommodating chamber isolation to be not communicated with, above-mentioned two atomization interventricular septum is from being not communicated with, above-mentioned two mist or smoke path Or isolation is not communicated with (but except above-mentioned suction (mouth) hole or " nearby " defined above), above-mentioned two guiding piece 2 interval between guiding piece 1 From being not communicated with.

34. according to the device of technical solution 33, it is characterised in that the spray chamber is hollow continuous cavity.

35. according to the device of technical solution 33, it is characterised in that the spray chamber is discontinuous cavity.

36. according to the device of technical solution 33, it is characterised in that the spray chamber is in the material containing numerous micropores Micropore.

37. according to the device of technical solution 33, it is characterised in that the spray chamber is non-woven fabrics, pottery containing numerous micropores Porcelain, glass, metal, the micropore in plastics.

38. according to the device of technical solution 33, it is characterised in that the guiding piece 2 is the material containing fine duct.

39. according to the device of technical solution 33, it is characterised in that the guiding piece 2 be the non-woven fabrics containing fine duct, Ceramics, glass, metal, plastics.

40. according to the device of technical solution 33, it is characterised in that the guiding piece 2 is hollow ingress pipe.

41. according to the device of technical solution 33, it is characterised in that the component of described atomizing include heating type or/and The atomizing component of oscillatory type or/and compression.

42. according to the device of technical solution 33, it is characterised in that the component of described atomizing includes resistance heating formula Or the atomizing component of electromagnetism (oscillation) heating type or/and ultrasonic activation formula.

43. according to the device of technical solution 33, it is characterised in that the device further includes shell, power supply module, necessary attached Part.

44. according to the device of technical solution 43, it is characterised in that the device further includes that smoke grenade, control assembly, (pneumatic) open Close component.

45. according to the device of technical solution 43, it is characterised in that the shell is equipped with cigarette holder and venthole, the suction (mouth) hole is located in above-mentioned cigarette holder, and above-mentioned venthole is connected with the air inlet of spray chamber, the venthole of above-mentioned spray chamber and institute It states mist or smoke path or guiding piece 1 is connected to.

46. it is a kind of for according to the electronic cigarette of technical solution 1 (or aerosol generates system/material) aerosolization or vaporization or Aerosolization or aerosolized device (kits, device, equipment, unit), it is characterised in that the device includes a cigarette Shape cavity shell (4), power supply (2), smoke grenade (3) and tobacco rod attachment are sequentially equipped with by front end to rear end in the shell described Power supply (2), a jettron (7), radio-frequency generator (8), a magnetostrictive vibrator (9) and spaced intermediate not connected The electromagnetic induction heater (10) or a jettron (7), power supply (2), height of two cavities (fluid reservoir/or accommodating chamber) Frequency generator (8), a magnetostrictive vibrator (9) and not connected two cavities (fluid reservoir/or accommodating chamber) spaced intermediate Electromagnetic induction heater (10), wherein the radio-frequency generator (8) is vibrated with the magnetostriction respectively by conducting wire Device (9), electromagnetic induction heater (10) are connected with jettron (7)；

The rear end of the shell (4) is connected with the smoke grenade (3), is equipped in the smoke grenade (3) spaced intermediate Not connected two cavities (fluid reservoir/or accommodating chamber) (31)；

Mist or smoke path in the electronic cigarette (tobacco rod attachment) is spaced intermediate not connected.

47. it is a kind of for according to the electronic cigarette of technical solution 1 (or aerosol generates system/material) aerosolization or vaporization or Aerosolization or aerosolized device (kits, device, equipment, unit)), it is characterised in that the device includes shell Body, cigarette holder, necessary attachment and supersonic atomizer；Have in above-mentioned outer housing and cigarette holder two be isolated the mist that is not communicated with or Smoke path, one end are communicated with the venthole on above-mentioned cigarette holder, and the other end goes out with the aerosol in above-mentioned supersonic atomizer Mouth communicates；The supersonic atomizer, including inner housing (10), power supply (12), liquid storing part (fluid reservoir/or accommodating chamber) (14), Reticular component (20) and vibration source (30), the shell (10) is interior to be formed with liquid storing part (fluid reservoir/or accommodating chamber) (14), institute It states liquid storing part (fluid reservoir/or accommodating chamber) (14) (centre) and separates not connected, upper end is equipped with filling opening to be opened/closed, and is equipped with Aerosol exit, the aerosol exit and the mist communicated therewith or smoke path are that not connected, the net is isolated in (centre) Shape component (20) is embedded at the aerosol exit, and the reticular component (20) is the holey with multiple micropores (21) Structure, the vibration source (30) connect with the reticular component (20), and the vibration source (30) is electrically connected with the power supply (12) It connects, the vibration source (30) can generate after being powered to be vibrated and drive the reticular component (20) vibration to the reticular component (20) liquid nearby carries out vibratory atomizer；After the micropore (21) is atomized liquid through the reticular component (20) Smog can be flowed out along micropore 21, and the reticular component (20) is electrically connected with the power supply (12), and the reticular component (20) exists It can generate heat after energization and heating atomization is carried out to the liquid of the reticular component (20) nearby.

48. it is a kind of for according to the electronic cigarette of technical solution 1 (or aerosol generates system/material) aerosolization or vaporization or Aerosolization or the aerosolized device (kits, device, equipment, unit) with lubricating cup), including shell (1) and Control assembly (2), battery (3) and atomizer (4) in shell (1), the control assembly (2) respectively with battery (3), mist Change heating wire (41) electrical connection of device (4), it is characterised in that: the lubricating cup for receiving tobacco juice is additionally provided in the shell (1) (fluid reservoir/or accommodating chamber) (5), the atomizer (4) and lubricating cup (fluid reservoir/or accommodating chamber) (5) are adjacently positioned, the lubricating cup (5) one end by atomizer (4) is equipped with tobacco juice outlet (51), and the interior material for having micropore is packaged at the tobacco juice outlet (51) (52), the heating wire (41) of the atomizer (4) is close in described have the material (52) of micropore to arrange, the atomizer (4) With lubricating cup (fluid reservoir/or accommodating chamber) (5) in have two not connected cavities (fluid reservoir/or accommodating chamber) spaced intermediate, it is described Tobacco juice outlet (51) and the isolation of the mist or smoke path that communicate therewith are not connected.

49. it is a kind of for according to the electronic cigarette of technical solution 1 (or aerosol generates system/material) aerosolization or vaporization or Aerosolization or aerosolized device (kits, device, equipment, unit)), it is characterised in that the device includes upper and lower The atomization subsystem that shell, power supply module, necessary attachment and 2 are independently not communicated with；It include power supply module, mist in its lower case The mist or smoke path that sub-systems, two isolation are not communicated with, the mist or smoke path one end and above-mentioned atomization subsystem Communicate, the other end in following upper housings mist or smoke path communicate；Its upper housing is cigarette holder, the long side Burr and lower case There are two ventholes on the connected side, Duan Burr, inside there are two the mist or smoke path being not communicated with, one end and above-mentioned outlet is isolated Hole communicates, the other end in above-mentioned lower case mist or smoke path communicate.

50. according to the device (kits, device, equipment, unit) of technical solution 49, it is characterised in that described only Vertical atomization subsystem respectively includes a fluid reservoir/or accommodating chamber (and its constituting parts), a spray chamber (and its constituting parts), a mist Or smoke path (and its constituting parts) or guiding piece 1 and the component for playing atomizing, above-mentioned fluid reservoir/or accommodating chamber with it is above-mentioned Spray chamber is directly communicated or is connected to by guiding piece 2, and above-mentioned mist or smoke path or guiding piece 1 are in the upper and lower casing Mist or smoke path, be isolated between above-mentioned two fluid reservoir/or accommodating chamber and be not communicated with, above-mentioned two atomizations interventricular septum from being not communicated with, It is isolated between above-mentioned two guiding piece 2 and is not communicated with, is isolated between above-mentioned two mist or smoke path or guiding piece 1 and is not communicated with.

Detailed description of the invention:

1. Fig. 1-1 is electronic smoking set example 4-1 structural schematic diagram；

2. Fig. 1-2 is electronic smoking set example 4-1 ultrasonic magnetostrictive vibrator and electromagnetic induction heater structural schematic diagram；

3. Fig. 1-3 is electronic smoking set example 4-1 control circuit schematic diagram；

4. Fig. 1-4 is electronic smoking set example 4-1 jettron structural schematic diagram；

5. Fig. 1-5 is electronic smoking set example 4-1 circuit board thematic structure schematic diagram；

6. Fig. 1-6 is electronic smoking set example 4-1 smoke grenade structural schematic diagram.

7. the structural schematic diagram that Fig. 2-1 is electronic smoking set example 4-2 supersonic atomizer；

8. the work flow diagram that Fig. 2-2 is electronic smoking set example 4-2 supersonic atomizer.

9. Fig. 3-1 is electronic smoking set example 4-3 schematic cross-sectional view.

Embodiment

Embodiment 1

Nicotine salting liquid: maleic acid nicotine salt, concentration: 0.08%, solvent: water and butanediol (volume ratio 9:1), pH Value: 6.2, (adding to) total amount: 100ml；

Aqueous slkali: leucine potassium, concentration: 12.5%, solvent: water, (adding to) total amount: 100ml.

Atomising device: the fog of the spray outlet of an independent ultrasonic atomizer and another independent ultrasonic atomizer The conduit being independently not communicated with two respectively is exported to be connected, the other end of the conduit is connected with two branch pipes in a threeway, The air-suction cover that the other end branch pipe of the threeway can cover on nose and mouth with one is connected, and user can pass through the air-suction cover nasal cavity Or/and oral cavity sucks mist or cigarette in the air-suction cover, above-mentioned threeway be connected with the air-suction cover that can be covered on nose and mouth one Branch pipe is spaced intermediate is not communicated at end.Above-mentioned ultrasonic atomizer is Guangdong China ultrasonic atomizer (model: WH-2000), and atomization speed is about 2ml/min。

Embodiment 2

Nicotine salting liquid: galactosaccharic acid nicotine salt, concentration: 1.5%, solvent: water and ethyl alcohol (volume ratio 8:2), pH value: 3.2, (adding to) total amount: 100ml；

Aqueous slkali: fucosamine, concentration: 4.5%, solvent: water and glycerol (volume ratio 8:2), (adding to) total amount: 100ml.

Atomising device: the spray outlet of an independent compression atomizer and another independent compression atomizer The conduit that spray outlet is independently not communicated with two respectively is connected, the other end of the conduit and two branch pipe phases in a threeway Even, the air-suction cover that the other end branch pipe of the threeway can cover on nose and mouth with one is connected, and user can be used by the air-suction cover Nasal cavity or/and oral cavity suck mist or cigarette in the air-suction cover, and above-mentioned threeway is connected with the air-suction cover that can be covered on nose and mouth One end branch pipe spaced intermediate be not communicated with.Above-mentioned ultrasonic atomizer are as follows: fish dive compression atomizer (model: 403H), atomization speed Spend about 0.25ml/min.

Embodiment 3

Nicotine salting liquid: malic acid nicotine salt, concentration: 0.5%, solvent: water and propylene glycol (volume ratio 7:3), pH value: 5.6, (adding to) total amount: 100ml；

Aqueous slkali: ornithine sodium, concentration: 17.5%, solvent: water, (adding to) total amount: 100ml.

Atomising device: the spray outlet of an independent compression atomizer and another independent compression atomizer The conduit that spray outlet is independently not communicated with two respectively is connected, the other end of the conduit and two branch pipe phases in a threeway Even, the air-suction cover that the other end branch pipe of the threeway can cover on nose and mouth with one is connected, and user can be used by the air-suction cover Nasal cavity or/and oral cavity suck mist or cigarette in the air-suction cover, and above-mentioned threeway is connected with the air-suction cover that can be covered on nose and mouth One end branch pipe spaced intermediate be not communicated with.Above-mentioned ultrasonic atomizer are as follows: Omron compression atomizer (model: NE-C25S), mist Change speed about 0.25ml/min.

Embodiment 4

Nicotine salting liquid: oxalic acid nicotine salt, concentration: 0.7%, solvent: water and glycerol (volume ratio 7.5:2.5), pH value: 6.8, (adding to) total amount: 100ml；

Aqueous slkali: sodium propionate water, concentration: 1.5%, solvent: water and propylene glycol (volume ratio 6:4), (adding to) total amount: 100ml。

Atomising device: the spray outlet of an independent compression atomizer and another independent compression atomizer The conduit that spray outlet is independently not communicated with two respectively is connected, the other end of the conduit and two branch pipe phases in a threeway Even, the air-suction cover that the other end branch pipe of the threeway can cover on nose and mouth with one is connected, and user can be used by the air-suction cover Nasal cavity or/and oral cavity suck mist or cigarette in the air-suction cover, and above-mentioned threeway is connected with the air-suction cover that can be covered on nose and mouth One end branch pipe spaced intermediate be not communicated with.Above-mentioned ultrasonic atomizer are as follows: Omron compression atomizer (model: NE-C28), mist Change speed about 0.25ml/min.

Embodiment 5

Nicotine salting liquid: succinic acid (succinic acid) nicotine salt, concentration: 3.5%, solvent: water and glyceryl acetate (volume ratio 9:1), pH value: 5.2, (adding to) total amount: 100ml；

Aqueous slkali: calcium gluconate, concentration: 0.5%, solvent: water and glycerol (volume ratio 7:3), (adding to) total amount: 100ml.

Atomising device: the fog of the spray outlet of an independent net formula atomizer and another independent net formula atomizer The conduit being independently not communicated with two respectively is exported to be connected, the other end of the conduit is connected with two branch pipes in a threeway, The air-suction cover that the other end branch pipe of the threeway can cover on nose and mouth with one is connected, and user can pass through the air-suction cover nasal cavity Or/and oral cavity sucks mist or cigarette in the air-suction cover, above-mentioned threeway be connected with the air-suction cover that can be covered on nose and mouth one Branch pipe is spaced intermediate is not communicated at end.Above-mentioned ultrasonic atomizer is fish dive net formula atomizer (model: M-102 or HL100A), atomization Speed about 0.2ml/min.

Embodiment 6

Nicotine salting liquid: ketoglutaric acid nicotine salt, concentration: 4.5%, solvent: water and polyethylene glycol (volume ratio 8.5: 1.5), pH value: 4.5, (adding to) total amount: 100ml；

Aqueous slkali: sodium pyrophosphate, concentration: 1.5%, solvent: water and butanediol (volume ratio 9.5:0.5), (adding to) total amount: 100ml。

Atomising device: the spray outlet of an independent compression atomizer and another independent compression atomizer The conduit that spray outlet is independently not communicated with two respectively is connected, the other end of the conduit and two branch pipe phases in a threeway Even, the air-suction cover that the other end branch pipe of the threeway can cover on nose and mouth with one is connected, and user can be used by the air-suction cover Nasal cavity or/and oral cavity suck mist or cigarette in the air-suction cover, and above-mentioned threeway is connected with the air-suction cover that can be covered on nose and mouth One end branch pipe spaced intermediate be not communicated with.Above-mentioned ultrasonic atomizer is Philip compression atomizing device (model: CN-B-0103), mist Change speed about 0.2ml/min.

Embodiment 7

Nicotine salting liquid: citric acid nicotine salt, concentration: 1.5%, solvent: water and glycerol triacetate (volume ratio 8.5: 1.5), pH value: 5.3, (adding to) total amount: 10ml；

Aqueous slkali: dibastic sodium phosphate, concentration: 0.8%, solvent: water and propylene glycol (volume ratio 8.5:1.5), (adding to) total amount: 1000ml。

Atomising device: the fog of the spray outlet of an independent net formula atomizer and another independent net formula atomizer The conduit being independently not communicated with two respectively is exported to be connected, the other end of the conduit is connected with two branch pipes in a threeway, The air-suction cover that the other end branch pipe of the threeway can cover on nose and mouth with one is connected, and user can pass through the air-suction cover nasal cavity Or/and oral cavity sucks mist or cigarette in the air-suction cover, above-mentioned threeway be connected with the air-suction cover that can be covered on nose and mouth one Branch pipe is spaced intermediate is not communicated at end.Above-mentioned ultrasonic atomizer is to come Fushi's net formula atomizer (model: mini air 360+), mist Change speed about 0.8ml/min.

Embodiment 8

Nicotine salting liquid: tartaric acid nicotine salt, concentration: 2.5%, solvent: water and propylene glycol, poly- two glycerol (volume ratio 1.5:6.5:2), pH value: 6.5, (adding to) total amount: 100ml；

Aqueous slkali: sodium carbonate, concentration: 1.5%, solvent: water and propylene glycol (volume ratio 1.5:8.5), (adding to) total amount: 100ml。

Atomising device: what the both ends that two identical independent electronic smoking sets are independently not communicated with two respectively differed in size Conduit (such as rubber tube, silicone tube) is connected, and sucks after combination for oral cavity, and biggish one end of above-mentioned conduit is connected to smoking set fog Outlet, lesser one end are sucked for oral cavity, and small end outer diameter is 3mm-4mm.The electronic smoking set is patent of invention The smoking set disclosed in CN201410223508.8 or commercially available electronic smoking set (as evil spirit flute MOTI board, TENSO board, China's gift doorplate, HOPESON board, below herewith).

Embodiment 9

Nicotine salting liquid: acetic acid nicotine salt, concentration: 2.5%, solvent: water and propene carbonate (volume ratio 1.5:8.5), PH value: 5.5, (adding to) total amount: 100ml；

Aqueous slkali: sodium phosphate, concentration: 1.2%, solvent: water and glycerol diethyl propyl propionate (volume ratio 1.5:8.5) (add To) total amount: 100ml.

Atomising device: what the both ends that two identical independent electronic smoking sets are independently not communicated with two respectively differed in size Conduit (such as rubber tube, silicone tube) is connected, and sucks after combination for oral cavity, and biggish one end of above-mentioned conduit is connected to smoking set fog Outlet, lesser one end are sucked for oral cavity, and small end outer diameter is 3mm-4mm.The electronic smoking set is patent of invention The smoking set or commercially available electronic smoking set disclosed in CN201410371441.2.

Embodiment 10

Nicotine salting liquid: butyric acid nicotine salt, concentration: 0.5%, solvent: water and propylene glycol, glycerol triacetate (volume ratio 1.5:6.5:2), pH value: 5.2, (adding to) total amount: 1000ml；

Aqueous slkali: trisodium glycyrrhetinate, concentration: 0.5%, solvent: water and propylene glycol, glycerol (volume ratio 1:7.5:1.5), (adding to) total amount: 10ml.

Atomising device: what the both ends that two identical independent electronic smoking sets are independently not communicated with two respectively differed in size Conduit (such as rubber tube, silicone tube) is connected, and sucks after combination for oral cavity, and biggish one end of above-mentioned conduit is connected to smoking set fog Outlet, lesser one end are sucked for oral cavity, and small end outer diameter is 3mm-4mm.The electronic smoking set is utility model patent The smoking set or commercially available electronic smoking set disclosed in CN201320043282.4.

Embodiment 11

Nicotine salting liquid: lactic acid nicotine salt, concentration: 2.5%, solvent: water and propylene glycol, poly- triglycerin (volume ratio 1:7: 2), pH value: 4.2, (adding to) total amount: 100ml；

Aqueous slkali: saccharin sodium, concentration: 2.5%, solvent: water and propylene glycol (volume ratio 1.5:8.5), (adding to) total amount: 100ml。

Atomising device: what the both ends that two identical independent electronic smoking sets are independently not communicated with two respectively differed in size Conduit (such as rubber tube, silicone tube) is connected, and sucks after combination for oral cavity, and biggish one end of above-mentioned conduit is connected to smoking set fog Outlet, lesser one end are sucked for oral cavity, and small end outer diameter is 3mm-4mm.The electronic smoking set is utility model patent The smoking set or commercially available electronic smoking set disclosed in CN201390000190.6.

Embodiment 12

Nicotine salting liquid: acrylic acid nicotine salt, concentration: 1.5%, solvent: water and propene carbonate (volume ratio 1.5: 8.5), pH value: 6.5, (adding to) total amount: 100ml；

Aqueous slkali: cysteic acid potassium, concentration: 1.5%, solvent: water and propylene glycol (volume ratio 1.5:8.5), (adding to) Total amount: 100ml.

Atomising device: what the both ends that two identical independent electronic smoking sets are independently not communicated with two respectively differed in size Conduit (such as rubber tube, silicone tube) is connected, and sucks after combination for oral cavity, and biggish one end of above-mentioned conduit is connected to smoking set fog Outlet, lesser one end are sucked for oral cavity, and small end outer diameter is 3mm-4mm.The electronic smoking set is utility model patent The smoking set or commercially available electronic smoking set disclosed in CN201390000289.6.

Embodiment 13

Nicotine salting liquid: gluconic acid nicotine salt, concentration: 1.5%, solvent: water and propylene glycol, polyethylene glycol 200 (volume Than 1:8:1), pH value: 5.3, (adding to) total amount: 10ml；

Aqueous slkali: valine ammonium, concentration: 3.5%, solvent: water and propylene glycol (volume ratio 1.5:8.5), (adding to) total amount: 100ml。

Atomising device: what the both ends that two identical independent electronic smoking sets are independently not communicated with two respectively differed in size Conduit (such as rubber tube, silicone tube) is connected, and sucks after combination for oral cavity, and biggish one end of above-mentioned conduit is connected to smoking set fog Outlet, lesser one end are sucked for oral cavity, and small end outer diameter is 3mm-4mm.The electronic smoking set is utility model patent The smoking set or commercially available electronic smoking set disclosed in CN201320734533.3.

Embodiment 14

Nicotine salting liquid: Pfansteihl nicotine salt, concentration: 0.5%, solvent: water and propene carbonate (volume ratio 1.5: 8.5), pH value: 4.2, (adding to) total amount: 100ml；

Aqueous slkali: spermine acid, concentration: 4.5%, solvent: water and propylene glycol, glycerol caprylate (volume ratio 1.5:6.5:2), (adding to) total amount: 100ml.

Atomising device: what the both ends that two identical independent electronic smoking sets are independently not communicated with two respectively differed in size Conduit (such as rubber tube, silicone tube) is connected, and sucks after combination for oral cavity, and biggish one end of above-mentioned conduit is connected to smoking set fog Outlet, lesser one end are sucked for oral cavity, and small end outer diameter is 3mm-4mm.The electronic smoking set is utility model patent The smoking set or commercially available electronic smoking set disclosed in CN201320734377.0.

Embodiment 15

Nicotine salting liquid: Α-hydroxycaproic acid nicotine salt, concentration: 1.5%, solvent: water and propylene glycol, glycerol (volume ratio 1.5: 7.5:1), pH value: 5.2, (adding to) total amount: 100ml；

Aqueous slkali: triethanolamine, concentration: 1.5%, solvent: propylene glycol, (adding to) total amount: 100ml.

Atomising device: what the both ends that two identical independent electronic smoking sets are independently not communicated with two respectively differed in size Conduit (such as rubber tube, silicone tube) is connected, and sucks after combination for oral cavity, and biggish one end of above-mentioned conduit is connected to smoking set fog Outlet, lesser one end are sucked for oral cavity, and small end outer diameter is 3mm-4mm.The electronic smoking set is utility model patent The smoking set or commercially available electronic smoking set disclosed in CN201390000294.7.

Embodiment 16

Nicotine salting liquid: sad nicotine salt, concentration: 4.5%, solvent: water and propylene glycol, poly- six glycerol (volume ratio 1.5: 7.5:1), pH value: 5.6, (adding to) total amount: 100ml；

Aqueous slkali: Sodium Glycinate, concentration: 1.5%, solvent: water and propylene glycol (volume ratio 1.5:8.5), (adding to) total amount: 100ml。

Atomising device: what the both ends that two identical independent electronic smoking sets are independently not communicated with two respectively differed in size Conduit (such as rubber tube, silicone tube) is connected, and sucks after combination for oral cavity, and biggish one end of above-mentioned conduit is connected to smoking set fog Outlet, lesser one end are sucked for oral cavity, and small end outer diameter is 3mm-4mm.The electronic smoking set is utility model patent The smoking set or commercially available electronic smoking set disclosed in CN201390000291.3.

Embodiment 17

Nicotine salting liquid: benzoic acid nicotine salt, concentration: 2.5%, solvent: water and propylene glycol, poly- dipropylene glycol (volume ratio 1.5:7.5:1), pH value: 5.0, (adding to) total amount: 200ml；

Aqueous slkali: lysine, concentration: 1.5%, solvent: water and propylene glycol (volume ratio 1.5:8.5), (adding to) total amount: 100ml。

Atomising device: what the both ends that two identical independent electronic smoking sets are independently not communicated with two respectively differed in size Conduit (such as rubber tube, silicone tube) is connected, and sucks after combination for oral cavity, and biggish one end of above-mentioned conduit is connected to smoking set fog Outlet, lesser one end are sucked for oral cavity, and small end outer diameter is 3mm-4mm.The electronic smoking set is patent of invention The smoking set or commercially available electronic smoking set disclosed in CN201410371441.2.

Embodiment 18

Nicotine salting liquid: nicotine salicylate salt, concentration: 0.5%, solvent: water and propylene glycol (volume ratio 1.5:8.5), pH Value: 6.4, (adding to) total amount: 100ml；

Aqueous slkali: thiamines, concentration: 0.5%, solvent: water and propylene glycol, glyceryl acetate (volume ratio 1.5:6.5:2), (adding to) total amount: 100ml.

Atomising device: what the both ends that two identical independent electronic smoking sets are independently not communicated with two respectively differed in size Conduit (such as rubber tube, silicone tube) is connected, and sucks after combination for oral cavity, and biggish one end of above-mentioned conduit is connected to smoking set fog Outlet, lesser one end are sucked for oral cavity, and small end outer diameter is 3mm-4mm.The electronic smoking set is patent of invention The smoking set or commercially available electronic smoking set disclosed in CN200710121524.6.

Embodiment 19

Nicotine salting liquid: mandelic acid (mandelic acid) nicotine salt, concentration: 3.5%, solvent: water and propylene glycol, polyethylene glycol 300 (volume ratio 1.5:7.5:1), pH value: 5.5, (adding to) total amount: 100ml；

Aqueous slkali: Sodium phenylalaninate, concentration: 1.5%, solvent: water and propylene glycol, glycerol (volume ratio 1.5:6.5:2), (adding to) total amount: 100ml.

Atomising device: what the both ends that two identical independent electronic smoking sets are independently not communicated with two respectively differed in size Conduit (such as rubber tube, silicone tube) is connected, and sucks after combination for oral cavity, and biggish one end of above-mentioned conduit is connected to smoking set fog Outlet, lesser one end are sucked for oral cavity, and small end outer diameter is 3mm-4mm.The electronic smoking set is utility model patent The smoking set or commercially available electronic smoking set disclosed in CN201621239037.0.

Embodiment 20

Nicotine salting liquid: protocatechuic acid (3,4-Dihydroxybenzoic acid) nicotine salt, concentration: 6.5%, solvent: water and the third two Alcohol, diethyl malate (volume ratio 1.5:8.0:0.5), pH value: 5.2, (adding to) total amount: 100ml；

Aqueous slkali: pyridoxamine, concentration: 2.5%, solvent: water and propylene glycol, caproin (volume ratio 1.5:8.0: 0.5) total amount: 100ml, (is added to).

Atomising device: what the both ends that two identical independent electronic smoking sets are independently not communicated with two respectively differed in size Conduit (such as rubber tube, silicone tube) is connected, and sucks after combination for oral cavity, and biggish one end of above-mentioned conduit is connected to smoking set fog Outlet, lesser one end are sucked for oral cavity, and small end outer diameter is 3mm-4mm.The electronic smoking set is utility model patent The smoking set or commercially available electronic smoking set disclosed in CN201720429415.X.

Embodiment 21

Nicotine salting liquid: glucuronic acid nicotine salt, concentration: 5.5%, solvent: water and propylene glycol, diethyl succinate (body Product is than 1.5:8.0:0.5), pH value: 4.5, (adding to) total amount: 100ml；

Aqueous slkali: mycosamine, concentration: 2.5%, solvent: water and propylene glycol, glycerol (volume ratio 1.5:6.5:2) (add To) total amount: 100ml.

Atomising device: device example 4-1 (i.e. device shown in attached drawing 1-1~6) in specification.

Embodiment 22

Nicotine salting liquid: ascorbic acid nicotine salt, concentration: 9.5%, solvent: water and propene carbonate (volume ratio 1.5: 8.5), pH value: 5.4, (adding to) total amount: 100ml；

Aqueous slkali: pyridoxol, concentration: 2.5%, solvent: ethyl alcohol and propylene glycol (volume ratio 1:9), (adding to) total amount: 100ml。

Atomising device: device example 4-1 (i.e. device shown in attached drawing 1-1~6) in specification.

Embodiment 23

Nicotine salting liquid: angelic acid ((Z) -2- methyl-2-butenoic acid) nicotine salt, concentration: 3.5%, solvent: water and the third two Alcohol, propene carbonate (volume ratio 1.5:6.5:2), pH value: 6.5, (adding to) total amount: 100ml；

Aqueous slkali: meglumine, concentration: 1%, solvent: water and glycerol triacetate (volume ratio 1.5:8.5), (adding to) are total Amount: 100ml.

Atomising device: device example 4-1 (i.e. device shown in attached drawing 1-1~6) in specification.

Embodiment 24

Nicotine salting liquid: carboxyglutamic acid nicotine salt, concentration: 4.5%, solvent: water and propylene glycol (volume ratio 2:8), pH Value: 6.2, (adding to) total amount: 100ml；

Aqueous slkali: galactosamine, concentration: 2.5%, solvent: water and propylene glycol, glycerol (volume ratio 1.5:7.5:1) (add To) total amount: 100ml.

Atomising device: device example 4-1 (i.e. device shown in attached drawing 1-1~6) in specification.

Embodiment 25

Nicotine salting liquid: glycyrrhizic acid nicotine salt, concentration: 3.5%, solvent: water and propylene glycol, glycerol caprylate (volume ratio 1.5:7.5:1), pH value: 6.1, (adding to) total amount: 100ml；

Aqueous slkali: caffeine, concentration: 0.5%, solvent: ethyl alcohol and propylene glycol (volume ratio 0.5:9.5), (adding to) total amount: 100ml。

Atomising device: device example 4-2 (i.e. device shown in attached drawing 2-1~2) in specification.

Embodiment 26

Nicotine salting liquid: aspartic acid nicotine salt, concentration: 3.5%, solvent: water and propylene glycol, glycerol triacetate (body Product is than 1.5:6.5:2), pH value: 5.7, (adding to) total amount: 100ml；

Aqueous slkali: 2- desosamine, concentration: 4.5%, solvent: water and propylene glycol, glycerol (volume ratio 1.5:7.0:1.5), (adding to) total amount: 100ml.

Atomising device: device example 4-3 (i.e. device shown in attached drawing 3-1) in specification.

Embodiment 27

Nicotine salting liquid: inosinicacid nicotine salt, concentration: 2.5%, solvent: water and propylene glycol, glycerol caprylate (volume ratio 1.5:7.5:1), pH value: 6.2, (adding to) total amount: 100ml；

Aqueous slkali: three butanolamines, concentration: 0.8%, solvent: propylene glycol, (adding to) total amount: 100ml.

Atomising device: device example 4-3 (i.e. device shown in attached drawing 3-1) in specification.

Embodiment 28

Nicotine salting liquid: cinnamic acid nicotine salt, concentration: 2.5%, solvent: water and propylene glycol, propene carbonate (volume ratio 1.5:6.5:2), pH value: 5.2, (adding to) total amount: 100ml；

Aqueous slkali: amido glucose, concentration: 0.5%, solvent: water and poloxamer 124, (adding to) total amount: 100ml.

Atomising device: device example 4-3 (i.e. device shown in attached drawing 3-1) in specification.

Embodiment 29

Nicotine salting liquid: nicotine hydrochloride salt, concentration: 2.5%, solvent: water and propylene glycol, glycerin tripropionate (volume ratio 1.5:7.5:1), pH value: 4.8, (adding to) total amount: 100ml；

Aqueous slkali: urethane (urethanes), concentration: 1.0%, solvent: Ergol and ethyl alcohol (volume ratio 8.5:1.5), total amount: 100ml (is added to).

Atomising device: device example 4-3 (i.e. device shown in attached drawing 3-1) in specification.

Embodiment 30

Nicotine salting liquid: nicotine sulphate salt, concentration: 1.5%, solvent: water and propylene glycol (volume ratio 1.5:8.5), pH value: 4.2, (adding to) total amount: 100ml；Propylene glycol

Aqueous slkali: dipropanolamine, concentration: 0.5%, solvent: acetic acid laurylene base ester and ethyl alcohol (volume ratio 8.5:1.5), (adding to) total amount: 100ml.

Atomising device: device example 4-4 in specification, device example 4-4 setting, is pressed in upper and lower shell by specification The revealed power supply module of utility model patent CN201420045870.6, atomization subsystem, attachment etc., are being arranged inside Two sets it is identical but be independently not communicated with containing disclosed in above-mentioned patent power supply module, atomization subsystem, the composition such as attachment (with The patent is identical) device.

Embodiment 31

Nicotine salting liquid: phosphoric acid nicotine salt, content: 1.5%, diluent or aerosol generating agent: camphor, (adding to) are total Amount: 100g；

Aqueous slkali: ethanol amine, concentration: 0.5%, solvent: ethyl vanillate and ethyl alcohol (volume ratio 8.5:1.5), (adding to) Total amount: 100ml.

Atomising device: device example 4-2 (i.e. device shown in attached drawing 2-1~2) in specification.

Embodiment 32

Nicotine salting liquid: benzene sulfonic acid nicotine salt, concentration: 4.5%, solvent: water and propylene glycol, propene carbonate (volume ratio 1.5:6.5:2), pH value: 5.6, (adding to) total amount: 100ml；

Aqueous slkali: trometamol, concentration: 2.5%, solvent: water and propylene glycol (volume ratio 1.5:8.5), (adding to) total amount: 100ml。

Atomising device: device example 4-4 in specification, device example 4-4 setting, is pressed in upper and lower shell by specification The revealed power supply module of utility model patent CN201420045870.6, atomization subsystem, attachment etc., are being arranged inside Two sets it is identical but be independently not communicated with containing disclosed in above-mentioned patent power supply module, atomization subsystem, the composition such as attachment (with The patent is identical) device.

Embodiment 33

Nicotine salting liquid: pyrosulfurous acid nicotine salt, content: 2.5%, diluent or aerosol generating agent: vanillic acid (adds To) total amount: 100g；

Aqueous slkali: diethanol amine, concentration: 0.8%, solvent: triethyl citrate, (adding to) total amount: 100ml.

Atomising device: device example 4-4 in specification, device example 4-4 setting, is pressed in upper and lower shell by specification The revealed power supply module of patent of invention CN200910080147.5, atomization subsystem, attachment etc., are being arranged inside two sets It is identical but be independently not communicated with containing the power supply module, atomization subsystem, the composition such as attachment disclosed in above-mentioned patent (specially with this Benefit it is identical) device.

Embodiment 34

Nicotine salting liquid: malic acid nicotine salt, concentration: 2.5%, solvent: water and propylene glycol, poly- dipropylene glycol (volume ratio 1.5:7.5:1), pH value: 5.0, (adding to) total amount: 100ml；

Aqueous slkali: sodium glutamate, concentration: 1.5%, solvent: water and propylene glycol (volume ratio 1.5:8.5), (adding to) total amount: 100ml。

Atomising device: what the both ends that two identical independent electronic smoking sets are independently not communicated with two respectively differed in size Conduit (such as rubber tube, silicone tube) is connected, and sucks after combination for oral cavity, and biggish one end of above-mentioned conduit is connected to smoking set fog Outlet, lesser one end are sucked for oral cavity, and small end outer diameter is 3mm-4mm.The electronic smoking set is patent of invention The smoking set or commercially available electronic smoking set disclosed in CN201410371441.2.

Embodiment 35

Nicotine salting liquid: Radix Glycyrrhizae diacid nicotine salt, concentration: 2.5%, solvent: water and propylene glycol, poly- dipropylene glycol (volume Than 1.5:7.5:1), pH value: 5.0, (adding to) total amount: 100ml；

Aqueous slkali: mycosamine, concentration: 1.5%, solvent: water and propylene glycol (volume ratio 1.5:8.5), (adding to) total amount: 100ml。

Atomising device: with embodiment 34.

Embodiment 36

Nicotine salting liquid: tartaric acid nicotine salt, concentration: 2.5%, solvent: water and propylene glycol, poly- dipropylene glycol (volume ratio 1.5:7.5:1), pH value: 5.0, (adding to) total amount: 100ml；

Aqueous slkali: dihydrochalcone sodium, concentration: 1.5%, solvent: water and propylene glycol (volume ratio 1.5:8.5), (adding to) Total amount: 100ml.

Atomising device: with embodiment 34.

Embodiment 37

Nicotine salting liquid: gluconic acid nicotine salt, concentration: 2.5%, solvent: water and propylene glycol, poly- dipropylene glycol (volume Than 1.5:7.5:1), pH value: 5.0, (adding to) total amount: 100ml；

Aqueous slkali: trisodium glycyrrhetinate, concentration: 1.5%, solvent: water and propylene glycol (volume ratio 1.5:8.5), (adding to) are total Amount: 100ml.

Atomising device: with embodiment 34.

Embodiment 38

Nicotine salting liquid: oxalic acid nicotine salt, concentration: 2.5%, solvent: water and propylene glycol, poly- dipropylene glycol (volume ratio 1.5:7.5:1), pH value: 5.0, (adding to) total amount: 100ml；

Aqueous slkali: meglumine, concentration: 1.5%, solvent: water and propylene glycol (volume ratio 1.5:8.5), (adding to) total amount: 100ml。

Atomising device: with embodiment 34.

Embodiment 39

Nicotine salting liquid: galactosaccharic acid nicotine salt, concentration: 2.5%, solvent: water and propylene glycol, poly- dipropylene glycol (body Product is than 1.5:7.5:

1), pH value: 5.0, (adding to) total amount: 100ml；

Aqueous slkali: saccharin sodium, concentration: 1.5%, solvent: water and propylene glycol (volume ratio 1.5:8.5), (adding to) total amount: 100ml。

Atomising device: with embodiment 34.

Embodiment 40

Nicotine salting liquid: glucosaccharic acid nicotine salt, concentration: 2.5%, solvent: water and propylene glycol, poly- dipropylene glycol (volume Than 1.5:7.5:1), pH value: 5.0, (adding to) total amount: 100ml；

Aqueous slkali: pyridoxol, concentration: 1.5%, solvent: water and propylene glycol (volume ratio 1.5:8.5), (adding to) total amount: 100ml。

Atomising device: with embodiment 34.

Embodiment 41

Nicotine salting liquid: glutamic acid nicotine salt, concentration: 2.5%, solvent: water and propylene glycol, poly- dipropylene glycol (volume ratio 1.5:7.5:1), pH value: 5.0, (adding to) total amount: 100ml；

Aqueous slkali: thiamines, concentration: 1.5%, solvent: water and propylene glycol (volume ratio 1.5:8.5), (adding to) total amount: 100ml。

Atomising device: with embodiment 34.

Embodiment 42

Nicotine salting liquid: aspartic acid nicotine salt, concentration: 2.5%, solvent: water and propylene glycol, poly- dipropylene glycol (volume Than 1.5:7.5:1), pH value: 5.0, (adding to) total amount: 100ml；

Aqueous slkali: pyridoxamine, concentration: 1.5%, solvent: water and propylene glycol (volume ratio 1.5:8.5), (adding to) total amount: 100ml。

Atomising device: with embodiment 34.

Embodiment 43

Nicotine salting liquid: benzoic acid nicotine salt, concentration: 2.5%, solvent: water and propylene glycol, poly- dipropylene glycol (volume ratio 1.5:7.5:1), pH value: 5.0, (adding to) total amount: 100ml；

Aqueous slkali: spermine acid, concentration: 1.5%, solvent: water and propylene glycol (volume ratio 1.5:8.5), (adding to) total amount: 100ml。

Atomising device: with embodiment 34.

Embodiment 44

Nicotine salting liquid: ascorbic acid nicotine salt, concentration: 2.5%, solvent: water and propylene glycol, poly- dipropylene glycol (volume Than 1.5:7.5:1), pH value: 5.0, (adding to) total amount: 100ml；

Aqueous slkali: lysine, concentration: 1.5%, solvent: water and propylene glycol (volume ratio 1.5:8.5), (adding to) total amount: 100ml。

Atomising device: with embodiment 34.

Embodiment 45

Nicotine salting liquid: dehydroascorbic acid nicotine salt, concentration: 2.5%, solvent: water and propylene glycol, poly- dipropylene glycol (volume ratio 1.5:7.5:

1), pH value: 5.0, (adding to) total amount: 100ml；

Aqueous slkali: methionine sodium, concentration: 1.5%, solvent: water and propylene glycol (volume ratio 1.5:8.5), (adding to) are total Amount: 100ml.

Atomising device: with embodiment 34.

Embodiment 46

Nicotine salting liquid: arabo-ascorbic acid nicotine salt, concentration: 2.5%, solvent: water and propylene glycol, poly- dipropylene glycol (body Product is than 1.5:7.5:

1), pH value: 5.0, (adding to) total amount: 100ml；

Aqueous slkali: Sodium Glycinate, concentration: 1.5%, solvent: water and propylene glycol (volume ratio 1.5:8.5), (adding to) total amount: 100ml。

Atomising device: with embodiment 34.

Embodiment 47 (reference examples 34)

Nicotine salting liquid: nicotine hydrochloride salt, concentration: 2.5%, solvent: water and propylene glycol, poly- dipropylene glycol (volume ratio 1.5:7.5:1), pH value: 5.0, (adding to) total amount: 100ml；

Aqueous slkali: ethanol amine, concentration: 1.5%, solvent: water and propylene glycol (volume ratio 1.5:8.5), (adding to) total amount: 100ml。

Atomising device: with embodiment 34.

Embodiment 48 (reference examples 35)

Nicotine salting liquid: citric acid nicotine salt, concentration: 2.5%, solvent: water and propylene glycol, poly- dipropylene glycol (volume ratio 1.5:7.5:1), pH value: 5.0, (adding to) total amount: 100ml；

Aqueous slkali: dibastic sodium phosphate, concentration: 1.5%, solvent: water and propylene glycol (volume ratio 1.5:8.5), (adding to) total amount: 100ml。

Atomising device: with embodiment 34.

Embodiment 49

Nicotine salt mixture: isovaleric acid nicotine salt, content: 1.5%, diluent or aerosol generating agent: D-sorbite, (adding to) total amount: 100g；

Aqueous slkali: triethanolamine, concentration: 1.5%, solvent: propylene glycol, (adding to) total amount: 100ml.

Atomising device: what the both ends that two identical independent electronic smoking sets are independently not communicated with two respectively differed in size Conduit (such as rubber tube, silicone tube) is connected, and sucks after combination for oral cavity, and biggish one end of above-mentioned conduit is connected to smoking set fog Outlet, lesser one end are sucked for oral cavity, and small end outer diameter is 3mm-4mm.The electronic smoking set is utility model patent The smoking set or commercially available electronic smoking set disclosed in CN201390000294.7.

Embodiment 50

Nicotine salt mixture: 2-Methyl Butyric Acid nicotine salt, content: 3.5%, diluent or aerosol generating agent: 1,3- bis- Hydroxypropanone-, (adding to) total amount: 100g；

Alkali mixture: urea, content: 1.5%, diluent or aerosol generating agent: D-sorbite, (adding to) total amount: 100g。

Atomising device: what the both ends that two identical independent electronic smoking sets are independently not communicated with two respectively differed in size Conduit (such as rubber tube, silicone tube) is connected, and sucks after combination for oral cavity, and biggish one end of above-mentioned conduit is connected to smoking set fog Outlet, lesser one end are sucked for oral cavity, and small end outer diameter is 3mm-4mm.The electronic smoking set is utility model patent The smoking set or commercially available electronic smoking set disclosed in CN201390000291.3.

Embodiment 51

Nicotine salt mixture: benzoic acid nicotine salt, content: 2.5%, diluent or aerosol generating agent: erythrose (adds To) total amount: 100g；

Alkali mixture: Portugal's ethamine, content: 1.0%, diluent or aerosol generating agent: xylitol, (adding to) total amount: 100g。

Atomising device: what the both ends that two identical independent electronic smoking sets are independently not communicated with two respectively differed in size Conduit (such as rubber tube, silicone tube) is connected, and sucks after combination for oral cavity, and biggish one end of above-mentioned conduit is connected to smoking set fog Outlet, lesser one end are sucked for oral cavity, and small end outer diameter is 3mm-4mm.The electronic smoking set is patent of invention The smoking set or commercially available electronic smoking set disclosed in CN201410371441.2.

Embodiment 52

Nicotine salting liquid: phenylacetic acid nicotine salt, concentration: 0.5%, solvent: water and propylene glycol (volume ratio 1.5:8.5), pH Value: 6.4, (adding to) total amount: 100ml；

Alkali mixture: thiamines, content: 2.0%, diluent or aerosol generating agent: antierythrite, (adding to) total amount: 100g。

Atomising device: what the both ends that two identical independent electronic smoking sets are independently not communicated with two respectively differed in size Conduit (such as rubber tube, silicone tube) is connected, and sucks after combination for oral cavity, and biggish one end of above-mentioned conduit is connected to smoking set fog Outlet, lesser one end are sucked for oral cavity, and small end outer diameter is 3mm-4mm.The electronic smoking set is patent of invention The smoking set or commercially available electronic smoking set disclosed in CN200710121524.6.

Embodiment 53

Nicotine salt mixture: isocaproic acid nicotine salt, content: 2.0%, diluent or aerosol generating agent: fructose, (adding to) Total amount: 100g；

Alkali mixture: urethane, content: 1.0%, diluent or aerosol generating agent: menthol, (adding to) total amount: 100g。

Atomising device: what the both ends that two identical independent electronic smoking sets are independently not communicated with two respectively differed in size Conduit (such as rubber tube, silicone tube) is connected, and sucks after combination for oral cavity, and biggish one end of above-mentioned conduit is connected to smoking set fog Outlet, lesser one end are sucked for oral cavity, and small end outer diameter is 3mm-4mm.The electronic smoking set is utility model patent The smoking set or commercially available electronic smoking set disclosed in CN201621239037.0.

Embodiment 54

Nicotine salt mixture: butyric acid nicotine salt, content: 4.5%, diluent or aerosol generating agent: lactic acid, (adding to) are total Amount: 100g；

Alkali mixture: arginine, content: 85%, diluent or aerosol generating agent: menthol, (adding to) total amount: 100g。

Atomising device: what the both ends that two identical independent electronic smoking sets are independently not communicated with two respectively differed in size Conduit (such as rubber tube, silicone tube) is connected, and sucks after combination for oral cavity, and biggish one end of above-mentioned conduit is connected to smoking set fog Outlet, lesser one end are sucked for oral cavity, and small end outer diameter is 3mm-4mm.The electronic smoking set is utility model patent The smoking set or commercially available electronic smoking set disclosed in CN201720429415.X.

Embodiment 55

Nicotine salt mixture: propionic acid nicotine salt, content: 2.0%, diluent or aerosol generating agent: lauric acid, (adding to) Total amount: 100g；

Aqueous slkali: mycosamine, concentration: 2.5%, solvent: water and propylene glycol, glycerol (volume ratio 1.5:6.5:2) (add To) total amount: 100ml.

Atomising device: device example 4-1 (i.e. device shown in attached drawing 1-1~6) in specification.

Embodiment 56

Nicotine salt mixture: acetic acid nicotine salt, content: 2.5%, diluent or aerosol generating agent: xylose, (adding to) are total Amount: 100g；

Alkali mixture: glycine, content: 75%, diluent or aerosol generating agent: Rou Dou guan alcohol, (adding to) total amount: 100g。

Atomising device: what the both ends that two identical independent electronic smoking sets are independently not communicated with two respectively differed in size Conduit (such as rubber tube, silicone tube) is connected, and sucks after combination for oral cavity, and biggish one end of above-mentioned conduit is connected to smoking set fog Outlet, lesser one end are sucked for oral cavity, and small end outer diameter is 3mm-4mm.The electronic smoking set is utility model patent The smoking set or commercially available electronic smoking set disclosed in CN201720429415.X.

Embodiment 57

Nicotine salting liquid: benzoic acid nicotine salt, concentration: 3.5%, solvent: water and triethylene glycol, propene carbonate (volume ratio 1.5:6.5:2), pH value: 6.5, (adding to) total amount: 100ml；

Aqueous slkali: meglumine, concentration: 1%, solvent: water and tetraethylene glycol (volume ratio 3:7), (adding to) total amount: 100ml.

Atomising device: what the both ends that two identical independent electronic smoking sets are independently not communicated with two respectively differed in size Conduit (such as rubber tube, silicone tube) is connected, and sucks after combination for oral cavity, and biggish one end of above-mentioned conduit is connected to smoking set fog Outlet, lesser one end are sucked for oral cavity, and small end outer diameter is 3mm-4mm.The electronic smoking set is utility model patent The smoking set or commercially available electronic smoking set disclosed in CN201621239037.0.

Embodiment 58

Nicotine salting liquid: carboxyglutamic acid nicotine salt, concentration: 1.5%, solvent: water and ethyl lactate (volume ratio 2:8), PH value: 6.2, (adding to) total amount: 100ml；

Aqueous slkali: lysine, concentration: 2.5%, solvent: water and propylene glycol, glycerol (volume ratio 1.5:7.5:1), (adding to) Total amount: 100ml.

Atomising device: device example 4-2 (i.e. device shown in attached drawing 2-1~2) in specification.

Embodiment 59

Nicotine salting liquid: glycyrrhizic acid nicotine salt, concentration: 0.5%, solvent: water and propylene glycol, glycerol triacetate (volume Than 1.5:6.5:2), pH value: 6.1, (adding to) total amount: 100ml；

Aqueous slkali: tromethamine, concentration: 0.5%, solvent: ethyl alcohol and ethyl myristate (volume ratio 0.5:9.5) (add To) total amount: 100ml.

Atomising device: what the both ends that two identical independent electronic smoking sets are independently not communicated with two respectively differed in size Conduit (such as rubber tube, silicone tube) is connected, and sucks after combination for oral cavity, and biggish one end of above-mentioned conduit is connected to smoking set fog Outlet, lesser one end are sucked for oral cavity, and small end outer diameter is 3mm-4mm.The electronic smoking set is patent of invention The smoking set or commercially available electronic smoking set disclosed in CN200710121524.6.

Embodiment 60

Nicotine salting liquid: glycyrrhizic acid nicotine salt, content: 1.0%, diluent or aerosol generating agent: ethyl vanillin, (adding to) total amount: 100g；

Aqueous slkali: diethanol amine, concentration: 0.5%, solvent: ethyl alcohol and dodecanedioic acid dimethyl ester (volume ratio 0.5: 9.5) total amount: 100ml, (is added to).

Atomising device: what the both ends that two identical independent electronic smoking sets are independently not communicated with two respectively differed in size Conduit (such as rubber tube, silicone tube) is connected, and sucks after combination for oral cavity, and biggish one end of above-mentioned conduit is connected to smoking set fog Outlet, lesser one end are sucked for oral cavity, and small end outer diameter is 3mm-4mm.The electronic smoking set is utility model patent The smoking set or commercially available electronic smoking set disclosed in CN201621239037.0.

Embodiment 61

Nicotine salt mixture: 2-Methyl Butyric Acid nicotine salt, content: 75%, diluent or aerosol generating agent: phenylacetic acid, (adding to) total amount: 100g；

Alkali mixture: urea, content: 1.0%, diluent or aerosol generating agent: arabinose, (adding to) total amount: 100g。

Atomising device: what the both ends that two identical independent electronic smoking sets are independently not communicated with two respectively differed in size Conduit (such as rubber tube, silicone tube) is connected, and sucks after combination for oral cavity, and biggish one end of above-mentioned conduit is connected to smoking set fog Outlet, lesser one end are sucked for oral cavity, and small end outer diameter is 3mm-4mm.The electronic smoking set is utility model patent The smoking set or commercially available electronic smoking set disclosed in CN201390000291.3.

Illustrate: 1), the above various embodiments pH adjusting agent be respectively (0.1mol/l's) respectively and nicotine at salt acid or salt Acid or sodium hydroxide solution；

2), the above solution and mixture are mixed uniformly；

3), above-mentioned nicotine salt solutions/mixtures and aqueous slkali/mixture are individually positioned in the isolation in above-mentioned atomising device In two fluid reservoirs (portion)/being not communicated with or accommodating chamber (or cavity) or above-mentioned composition (I) and (II) are first preset at respectively In the containers such as glass, ceramics, metal, then together with said vesse be placed on two fluid reservoirs/that above-mentioned isolation is not communicated with or In accommodating chamber (or cavity).

Reference examples 1~33-1,49~61-1

Reference substance is prepared as follows:

Respectively to the nicotine salting liquid 10ml (or nicotine salt mixture 10g) and its aqueous slkali in each corresponding embodiment The reference substance that 10ml (or alkali mixture 10g) uniformly mixes up to each corresponding reference examples, replaces pair in each corresponding embodiment The nicotine salting liquid 1 answered) and the aqueous slkali/or alkali mixture 2 that have neutralized).

Atomising device: corresponding embodiment is identical.

Reference examples 1~33-2,49~61-1

Reference substance:

1), the nicotine salting liquid or nicotine salt mixture in each corresponding embodiment, (constant as corresponding embodiment)； And

2) aqueous slkali, neutralized, or the alkali mixture neutralized, prepare as follows:

The corresponding alkali of the equivalent in each corresponding embodiment is taken, the corresponding solvent of about 85% full dose is added, is mixed, PH value is adjusted to 6.9~7.1 with (0.1mol/l) hydrochloric acid or sodium hydroxide solution, and the corresponding solvent of surplus is added to complete It measures (i.e. 100ml)；Or

The hydrochloride (i.e. its oneself be neutralized with hydrochloric acid) for taking the corresponding alkali in each corresponding embodiment, be added in right amount and its The corresponding diluent or aerosol generating agent of corresponding embodiment make the equivalent of the alkali in its equivalent content and corresponding embodiment Content is identical (in terms of free state alkali, content is identical as corresponding embodiment), mixes.

Above-mentioned nicotine salting liquid 1) and the aqueous slkali/or alkali mixture 2 that have neutralized) be not mixed, replacement is each respectively Corresponding nicotine salting liquid 1 in each corresponding embodiment) and the aqueous slkali/or alkali mixture 2 that have neutralized).

Atomising device: corresponding embodiment is identical.

Method of administration:

Examples 1 to 33,49~61

The nicotine salt that two fluid reservoir/accommodating chambers in the corresponding device of each embodiment are injected separately into the embodiment is molten Liquid (or nicotine salt mixture) and aqueous slkali (or alkali mixture), the nicotine salting liquid (or nicotine salt mixture) containing nicotine (with Free nicotine meter) 2-20mg (i.e. nicotine single dose be 2-20mg (in terms of free nicotine)), the aqueous slkali (or alkali mixture) and The volume number (or weight) of the nicotine salting liquid (or nicotine salt mixture) is identical.Then make the nicotine salting liquid (or nicotine salt Mixture) and aqueous slkali (or alkali mixture) atomization, every 6 seconds sucking aerosols of user are primary, and two kinds of aerosol sucking lungs are deep Locate (meeting) to breathe out or spue afterwards, until above-mentioned solution (or mixture) atomization finishes.

Embodiment 34~48

Two fluid reservoirs/liquid containing chamber in the corresponding device of each embodiment is injected separately into the nicotine in the embodiment The volume number of salting liquid and aqueous slkali, the nicotine salting liquid and the nicotine salting liquid is 0.50ml.Then make the nicotine salt molten Liquid and aqueous slkali atomization, every 6 seconds of user is primary by oral cavity (or/and nasal cavity) sucking aerosol, swallows through throat to lung, and two It is breathed out after kind aerosol sucking deep lung (meeting) by nasal cavity, until above-mentioned solution atomization finishes.

Reference examples 1~33-1,49~61-1

Each reference examples correspond to two fluid reservoirs in the device (corresponding embodiment device is identical) in embodiment/ Accommodating chamber injects the reference substance in the reference examples, and the volume number (or weight) of reference substance is identical in two fluid reservoir/accommodating chambers And it is identical as solution body product (or the mixture weight) for answering it embodiment to inject.Then make solution (or mixture) mist Change, user every 6 seconds primary by oral cavity (or/and nasal cavity) sucking aerosol, swallows through throat to lung, two kinds of aerosols sucking lungs It is breathed out behind portion depths (meeting) by nasal cavity, until above-mentioned solution (or mixture) atomization finishes.The corresponding reality of atomization speed It is identical to apply example.

Reference examples 1~33-2,49~61-2

Each reference examples correspond to two fluid reservoirs in the device (corresponding embodiment device is identical) in embodiment/ Accommodating chamber is injected separately into the nicotine salting liquid in the reference examples corresponding embodiment (or nicotine salt mixture) and the reference examples With aqueous slkali (or the alkali mixture neutralized), this nicotine salting liquid (or nicotine salt mixture) and the aqueous slkali that has neutralized Volume number (or the alkali mixture weight neutralized) it is identical and with solution body product (or the mixture of answering it embodiment to inject Weight) it is identical.Then making the aqueous slkali of the nicotine salting liquid (or nicotine salt mixture) and the neutralization, (or the alkali that has neutralized is mixed Close object) atomization, user every 6 seconds are primary by oral cavity (or/and nasal cavity) sucking aerosol, swallow through throat to lung, two kinds of gas It is breathed out after mist sucking deep lung (meeting) by nasal cavity, until above-mentioned solution (or mixture) atomization finishes.Atomization speed and its Corresponding embodiment is identical.

The test of 1 nicotine analysis of test case

Nicotine uptake assay see above state each embodiment, the method for administration of reference examples.The analysis of nicotine effect can basis Standard method as known in the art is completed, such as uses the bioanalysis for measuring receptor's plasma nicotine: user's sucking Aerosol, atomization finish process after, in 10min, 20min, 30min, 1hr, 1.5hr, 2hr, 3hr, 4hr, 6hr, 8hr, 12hr measures nicotine (in terms of free nicotine) blood concentration of user, and calculates AUC_0→∞(plasma concentration curve wraps the time The area enclosed reflects bioavailability/degree of nicotine).

It the results are shown in Table 4.The results show that the behavior in vivo such as embodiment bioavailability/degree is better than reference examples.

2 electronic cigarette aesthetic quality of test case detection

It is carried out referring to aesthetic quality's detection method of the patent CN201410788599.X tobacco juice for electronic smoke disclosed, it is specific to walk It is rapid as follows:

1) be arranged 4 aesthetic quality's Testing index, selected 4 aesthetic quality's Testing index be respectively as follows: hit the sense of (or choking) larynx, Irritation, satisfaction, comfort level, it is described to hit (or choking) larynx sense and refer to: the flue gas middle reaches that sucking tobacco juice for electronic smoke is generated through atomization From nicotine Qiang Ji throat to causing to cough, allow throat have the discomfort of constriction etc. " cigarette is allowed to choke " by；The irritation is Refer to: the flue gas that sucking tobacco juice for electronic smoke is generated through atomization to sense organ include oral cavity, throat and nasal cavity generate hot and cold, pain, Itch, be sour, pungent, peppery, bitter, salty, numb etc. various discomfort by；The satisfaction refers to: the cigarette that tobacco juice for electronic smoke is generated through atomization The comprehensive impression to being generated on sense organ such as gas strength, concentration；The comfort level refers to: tobacco juice for electronic smoke is generated through atomization Influence of the flue gas behind sucking oral cavity and exhalation to oral cavity level of comfort；

2) smoked panel test method using whole circulation, tobacco juice for electronic smoke is aspirated by member of smoking (method see above state it is each Embodiment, the method for administration of reference examples), the whole circulation method of smokeing panel test refers to: tobacco juice for electronic smoke is generated through atomization when smokeing panel test The sucking of flue gas direct oral cavity, throat, which are swallowed to lung, nasal cavity, to breathe out, and experiences, captures the overall process of smoke transportation, the member of smoking It is set as 51 people；

3) member of smoking carries out comprehensive marking to the aesthetic quality of tobacco juice for electronic smoke using scoring, reflects every aesthetic quality Influence degree of the Testing index to electronics tobacco quality.The scoring refers to: 4 aesthetic quality's Testing index respectively by 0,5 point, 10 points, 15,20,25 points of systems given a mark (as shown in table 3), 4 aesthetic quality's Testing index can be evaluated individually, can also be by beating Score value summation (one percentage of highest) overall evaluation.Aesthetic quality's marking value is higher, and the quality of the tobacco juice for electronic smoke is better.

The meaning table of the marking value of 3 aesthetic quality's Testing index of table

The minimum score unit of the marking value is 0.5.

4) aesthetic quality's testing result of member of smoking is counted, aesthetic quality's testing result to member of smoking into The method of row statistics, comprising the following steps: by the marking value of every aesthetic quality's Testing index of all members of smoking, remove respectively One minimum point and a high score calculate the average value of effective marking value of each aesthetic quality's Testing index.

It the results are shown in Table 5.The results show that embodiment aesthetic quality especially hits/choke larynx sense or satisfaction, comfort level aspect are excellent In reference examples.

Table 4-1 nicotine analysis: 10min blood concentration C_10min(ng/ml) and AUC_0→∞(nghr/ml) test result

	C10min	AUC0→∞		C10min	AUC0→∞
						Embodiment 1	5.2	11.3	Embodiment 2	22.6	39.7
Reference examples 1-1	3.1	7.4	Reference examples 2-1	13.5	24.4
						Reference examples 1-2	14	27	Reference examples 2-2	38	83

Table 4-2 nicotine analysis: 10min blood concentration C_10min(ng/ml) and AUC_0→∞(nghr/ml) test result

	C10min	AUC0→∞		C10min	AUC0→∞
						Embodiment 3	13.5	28.8	Embodiment 4	15.8	34.9
Reference examples 3-1	7.9	17.9	Reference examples 4-1	10.2	22.8
						Reference examples 3-2	41	97	Reference examples 4-2	77	167

Table 4-3 nicotine analysis: 10min blood concentration C_10min(ng/ml) and AUC_0→∞(nghr/ml) test result

	C10min	AUC0→∞		C10min	AUC0→∞
						Embodiment 5	17.7	38.6	Embodiment 6	20.6	51.8
Reference examples 5-1	10.8	23.5	Reference examples 6-1	12.7	28.9
						Reference examples 5-2	5.2	9.8	Reference examples 6-2	4.7	10.4

Table 4-4 nicotine analysis: 10min blood concentration C_10min(ng/ml) and AUC_0→∞(nghr/ml) test result

	C10min	AUC0→∞		C10min	AUC0→∞
						Embodiment 7	14.7	35.5	Embodiment 8	20.3	54.6
Reference examples 7-1	8.9	20.3	Reference examples 8-1	13.7	30.3
						Reference examples 7-2	3.4	8.1	Reference examples 8-2	8.8	20.4

Table 4-5 nicotine analysis: 10min blood concentration C_10min(ng/ml) and AUC_0→∞(nghr/ml) test result

	C10min	AUC0→∞		C10min	AUC0→∞
						Embodiment 9	22.7	51.3	Embodiment 10	8.8	21.7
Reference examples 9-1	14.6	33.8	Reference examples 10-1	5.5	12.9
						Reference examples 9-2	5.1	13.8	Reference examples 10-2	2.4	6.2

Table 4-6 nicotine analysis: 10min blood concentration C_10min(ng/ml) and AUC_0→∞(nghr/ml) test result

	C10min	AUC0→∞		C10min	AUC0→∞
						Embodiment 11	21.6	50.4	Embodiment 12	14.6	35.6
Reference examples 11-1	13.8	30.7	Reference examples 12-1	8.5	22.4
						Reference examples 11-2	4.8	11.6	Reference examples 12-2	6.3	15.8

Table 4-7 nicotine analysis: 10min blood concentration C_10min(ng/ml) and AUC_0→∞(nghr/ml) test result

	C10min	AUC0→∞		C10min	AUC0→∞
						Embodiment 13	23.8	55.8	Embodiment 14	9.3	25.8
Reference examples 13-1	15.4	35.9	Reference examples 14-1	6.2	15.7
						Reference examples 13-2	5.8	14.6	Reference examples 14-2	2.7	6.5

Table 4-8 nicotine analysis: 10min blood concentration C_10min(ng/ml) and AUC_0→∞(nghr/ml) test result

	C10min	AUC0→∞		C10min	AUC0→∞
						Embodiment 15	21.6	53.8	Embodiment 16	32.7	76.8
Reference examples 15-1	14.5	36.3	Reference examples 16-1	21.6	48.7
						Reference examples 15-2	5.8	13.8	Reference examples 16-2	7.6	21.4

Table 4-9 nicotine analysis: 10min blood concentration C_10min(ng/ml) and AUC_0→∞(nghr/ml) test result

	C10min	AUC0→∞		C10min	AUC0→∞
						Embodiment 17	23.6	57.4	Embodiment 18	9.5	27.5
Reference examples 17-1	16.5	37.2	Reference examples 18-1	6.1	15.8
						Reference examples 17-2	5.8	14.7	Reference examples 18-2	4.3	10.2

Table 4-10 nicotine analysis: 10min blood concentration C_10min(ng/ml) and AUC_0→∞(nghr/ml) test result

	C10min	AUC0→∞		C10min	AUC0→∞
						Embodiment 19	26.6	61.5	Embodiment 20	33.5	78.8
Reference examples 19-1	17.3	42.9	Reference examples 20-1	19.8	46.8
						Reference examples 19-2	6.8	17.8	Reference examples 20-2	8.8	21.9

Table 4-11 nicotine analysis: 10min blood concentration C_10min(ng/ml) and AUC_0→∞(nghr/ml) test result

	C10min	AUC0→∞		C10min	AUC0→∞
						Embodiment 21	36.7	82.5	Embodiment 22	34.2	76.4
Reference examples 21-1	20.6	57.9	Reference examples 22-1	18.7	51.2
						Reference examples 21-2	6.2	16.4	Reference examples 22-2	5.8	15.2

Table 4-12 nicotine analysis: 10min blood concentration C_10min(ng/ml) and AUC_0→∞(nghr/ml) test result

	C10min	AUC0→∞		C10min	AUC0→∞
						Embodiment 23	25.6	62.7	Embodiment 24	37.7	85.4
Reference examples 23-1	18.4	43.9	Reference examples 24-1	23.5	53.6
						Reference examples 23-2	8.9	21.5	Reference examples 24-2	9.4	27.3

Table 4-13 nicotine analysis: 10min blood concentration C_10min(ng/ml) and AUC_0→∞(nghr/ml) test result

	C10min	AUC0→∞		C10min	AUC0→∞
						Embodiment 25	18.7	46.1	Embodiment 26	37.3	87.6
Reference examples 25-1	11.6	25.3	Reference examples 26-1	20.4	48.9
						Reference examples 25-2	7.2	17.8	Reference examples 26-2	7.6	19.4

Table 4-14 nicotine analysis: 10min blood concentration C_10min(ng/ml) and AUC_0→∞(nghr/ml) test result

	C10min	AUC0→∞		C10min	AUC0→∞
						Embodiment 27	17.9	44.9	Embodiment 28	15.6	38.9
Reference examples 27-1	10.5	25.7	Reference examples 28-1	10.2	24.5
						Reference examples 27-2	6.4	15.3	Reference examples 28-2	4.7	11.5

Table 4-15 nicotine analysis: 10min blood concentration C_10min(ng/ml) and AUC_0→∞(nghr/ml) test result

	C10min	AUC0→∞		C10min	AUC0→∞
						Embodiment 29	24.2	61.3	Embodiment 30	17.3	43.6
Reference examples 29-1	13.7	34.3	Reference examples 30-1	10.6	26.2
						Reference examples 29-2	4.5	12.6	Reference examples 30-2	3.8	9.2

Table 4-16 nicotine analysis: 10min blood concentration C_10min(ng/ml) and AUC_0→∞(nghr/ml) test result

	C10min	AUC0→∞		C10min	AUC0→∞
						Embodiment 31	15.7	41.3	Embodiment 32	38.3	89.5
Reference examples 31-1	10.2	25.8	Reference examples 32-1	21.6	57.3
						Reference examples 31-2	4.1	10.6	Reference examples 32-2	7.8	20.4

Table 4-17 nicotine analysis: 10min blood concentration C_10min(ng/ml) and AUC_0→∞(nghr/ml) test result

Table 4-18 nicotine analysis: 10min blood concentration C_10min(ng/ml) and AUC_0→∞(nghr/ml) test result

	C10min	AUC0→∞		C10min	AUC0→∞
						Embodiment 50	26.8	83.7	Embodiment 51	20.4	74.6
Reference examples 50-1	17.8	48.8	Reference examples 51-1	13.1	42.7
						Reference examples 50-2	9.6	30.5	Reference examples 51-2	7.2	24.8

Table 4-19 nicotine analysis: 10min blood concentration C_10min(ng/ml) and AUC_0→∞(nghr/ml) test result

	C10min	AUC0→∞		C10min	AUC0→∞
						Embodiment 52	10.8	30.7	Embodiment 53	17.8	60.8
Reference examples 52-1	6.2	19.4	Reference examples 53-1	11.9	38.6
						Reference examples 52-2	3.6	12.2	Reference examples 53-2	5.6	19.4

Table 4-20 nicotine analysis: 10min blood concentration C_10min(ng/ml) and AUC_0→∞(nghr/ml) test result

	C10min	AUC0→∞		C10min	AUC0→∞
						Embodiment 54	42.7	134.6	Embodiment 55	21.6	69.4
Reference examples 54-1	27.2	83.7	Reference examples 55-1	12.8	40.3
						Reference examples 54-2	14.8	46.2	Reference examples 55-2	7.7	25.2

Table 4-21 nicotine analysis: 10min blood concentration C_10min(ng/ml) and AUC_0→∞(nghr/ml) test result

	C10min	AUC0→∞		C10min	AUC0→∞
						Embodiment 56	24.7	81.3	Embodiment 57	20.6	72.4
Reference examples 56-1	15.3	51.4	Reference examples 57-1	13.7	46.3
						Reference examples 56-2	8.4	31.2	Reference examples 57-2	7.1	25.4

Table 4-22 nicotine analysis: 10min blood concentration C_10min(ng/ml) and AUC_0→∞(nghr/ml) test result

	C10min	AUC0→∞		C10min
					Embodiment 58	18.3	64.7	Embodiment 59	12.8
Reference examples 58-1	11.5	38.6	Reference examples 59-1	7.2
					Reference examples 58-2	5.9	19.6	Reference examples 59-2	4.5

Table 4-23 nicotine analysis: 10min blood concentration C_10min(ng/ml) and AUC_0→∞(nghr/ml) test result

	C10min	AUC0→∞		C10min	AUC0→∞
						Embodiment 60	15.7	53.8	Embodiment 61	20.5	71.6
Reference examples 60-1	8.6	29.6	Reference examples 61-1	13.1	43.2
						Reference examples 60-2	4.9	18.7	Reference examples 61-2	6.8	23.5

Illustrate: C in above tables_10minUnit is ng/ml；AUC_0→∞Unit is nghr/ml.

Table 5-1 electronic cigarette aesthetic quality's testing result

	Hit/choke larynx sense	Irritation	Satisfaction	Comfort level
					Embodiment 1	20.3	15.9	16.3	17.6
Reference examples 1-1	5.7	16.0	10.2	7.4
					Reference examples 1-2	19.7	16.1	4.6	15.6

Table 5-2 electronic cigarette aesthetic quality's testing result

	Hit/choke larynx sense	Irritation	Satisfaction	Comfort level
					Embodiment 2	18.5	15.9	21.4	20.6
Reference examples 2-1	5.8	15.1	15.4	8.2
					Reference examples 2-2	19.7	16.4	4.2	21.5

Table 5-3 electronic cigarette aesthetic quality's testing result

	Hit/choke larynx sense	Irritation	Satisfaction	Comfort level
					Embodiment 3	21.6	17.4	18.4	20.2
Reference examples 3-1	6.9	16.7	12.3	9.2
					Reference examples 3-2	22.7	17.1	4.8	21.3

Table 5-4 electronic cigarette aesthetic quality's testing result

	Hit/choke larynx sense	Irritation	Satisfaction	Comfort level
					Embodiment 4	20.8	17.1	19.3	19.7
Reference examples 4-1	7.7	16.8	12.2	8.9
					Reference examples 4-2	21.6	16.3	8.3	17.9

Table 5-5 electronic cigarette aesthetic quality's testing result

Table 5-6 electronic cigarette aesthetic quality's testing result

	Hit/choke larynx sense	Irritation	Satisfaction	Comfort level
					Embodiment 6	20.1	18.8	23.2	19.4
Reference examples 6-1	3.6	17.3	16.2	12.8
					Reference examples 6-2	21.7	18.2	5.8	20.6

Table 5-7 electronic cigarette aesthetic quality's testing result

	Hit/choke larynx sense	Irritation	Satisfaction	Comfort level
					Embodiment 7	21.7	20.3	22.8	21.4
Reference examples 7-1	6.3	18.7	15.3	13.8
					Reference examples 7-2	22.1	21.6	4.9	20.8

Table 5-8 electronic cigarette aesthetic quality's testing result

	Hit/choke larynx sense	Irritation	Satisfaction	Comfort level
					Embodiment 8	19.6	21.6	22.4	20.7
Reference examples 8-1	5.5	17.6	15.2	13.8
					Reference examples 8-2	12.9	20.7	11.6	18.6

Table 5-9 electronic cigarette aesthetic quality's testing result

	Hit/choke larynx sense	Irritation	Satisfaction	Comfort level
					Embodiment 9	19.5	21.7	22.6	21.8
Reference examples 9-1	4.6	16.8	16.7	12.4
					Reference examples 9-2	18.8	20.5	5.7	22.3

Table 5-10 electronic cigarette aesthetic quality's testing result

	Hit/choke larynx sense	Irritation	Satisfaction	Comfort level
					Embodiment 10	22.8	21.8	18.7	23.6
Reference examples 10-1	6.8	16.6	12.6	14.5
					Reference examples 10-2	21.9	20.8	3.8	21.7

Table 5-11 electronic cigarette aesthetic quality's testing result

	Hit/choke larynx sense	Irritation	Satisfaction	Comfort level
					Embodiment 11	18.9	20.5	22.7	20.8
Reference examples 11-1	5.8	6.8	16.5	14.8
					Reference examples 11-2	20.3	21.9	3.2	21.7

Table 5-12 electronic cigarette aesthetic quality's testing result

	Hit/choke larynx sense	Irritation	Satisfaction	Comfort level
					Embodiment 12	19.3	18.5	21.6	20.5
Reference examples 12-1	5.8	14.5	15.7	15.3
					Reference examples 12-2	9.3	17.7	8.9	20.8

Table 5-13 electronic cigarette aesthetic quality's testing result

	Hit/choke larynx sense	Irritation	Satisfaction	Comfort level
					Embodiment 13	18.6	21.6	21.8	20.6
Reference examples 13-1	4.5	15.8	16.3	14.7
					Reference examples 13-2	15.7	19.9	5.4	19.3

Table 5-14 electronic cigarette aesthetic quality's testing result

	Hit/choke larynx sense	Irritation	Satisfaction	Comfort level
					Embodiment 14	21.4	18.9	18.4	20.7
Reference examples 14-1	7.8	13.6	12.6	13.6
					Reference examples 14-2	22.6	17.6	2.9	19.5

Table 5-15 electronic cigarette aesthetic quality's testing result

	Hit/choke larynx sense	Irritation	Satisfaction	Comfort level
					Embodiment 15	19.4	15.6	20.5	16.7
Reference examples 15-1	6.2	12.7	15.3	10.3
					Reference examples 15-2	20.3	12.8	5.2	12.9

Table 5-16 electronic cigarette aesthetic quality's testing result

	Hit/choke larynx sense	Irritation	Satisfaction	Comfort level
					Embodiment 16	18.8	20.7	23.5	19.9
Reference examples 16-1	4.2	19.9	16.8	12.5
					Reference examples 16-2	9.5	21.5	7.3	17.7

Table 5-17 electronic cigarette aesthetic quality's testing result

	Hit/choke larynx sense	Irritation	Satisfaction	Comfort level
					Embodiment 17	20.5	22.5	21.7	20.5
Reference examples 17-1	5.7	20.4	15.8	14.6
					Reference examples 17-2	21.3	21.8	6.3	20.4

Table 5-18 electronic cigarette aesthetic quality's testing result

	Hit/choke larynx sense	Irritation	Satisfaction	Comfort level
					Embodiment 18	21.6	23.9	17.8	22.8
Reference examples 18-1	7.9	19.9	12.3	15.4
					Reference examples 18-2	11.8	22.6	6.8	21.9

Table 5-19 electronic cigarette aesthetic quality's testing result

	Hit/choke larynx sense	Irritation	Satisfaction	Comfort level
					Embodiment 19	18.7	20.8	23.5	21.7
Reference examples 19-1	3.6	16.4	16.5	15.5
					Reference examples 1-2	17.6	19.7	5.3	22.1

Table 5-20 electronic cigarette aesthetic quality's testing result

	Hit/choke larynx sense	Irritation	Satisfaction	Comfort level
					Embodiment 20	17.5	19.8	23.8	18.9
Reference examples 20-1	2.8	14.6	16.2	12.6
					Reference examples 20-2	19.4	18.8	5.2	17.8

Table 5-21 electronic cigarette aesthetic quality's testing result

	Hit/choke larynx sense	Irritation	Satisfaction	Comfort level
					Embodiment 21	18.6	17.5	23.6	18.9
Reference examples 21-1	3.7	13.8	15.7	11.7
					Reference examples 21-2	15.6	16.8	4.5	17.8

Table 5-22 electronic cigarette aesthetic quality's testing result

	Hit/choke larynx sense	Irritation	Satisfaction	Comfort level
					Embodiment 22	17.4	20.5	23.2	20.6
Reference examples 22-1	2.2	16.5	16.4	13.8
					Reference examples 22-2	16.8	19.6	6.7	21.2

Table 5-23 electronic cigarette aesthetic quality's testing result

	Hit/choke larynx sense	Irritation	Satisfaction	Comfort level
					Embodiment 23	18.8	21.6	20.5	21.9
Reference examples 23-1	4.3	18.5	15.3	14.9
					Reference examples 23-2	18.3	20.6	7.8	18.5

Table 5-24 electronic cigarette aesthetic quality's testing result

	Hit/choke larynx sense	Irritation	Satisfaction	Comfort level
					Embodiment 24	17.8	20.6	22.7	20.3
Reference examples 24-1	3.2	16.2	15.6	14.7
					Reference examples 24-2	9.6	19.8	8.3	19.8

Table 5-25 electronic cigarette aesthetic quality's testing result

	Hit/choke larynx sense	Irritation	Satisfaction	Comfort level
					Embodiment 25	18.5	18.5	20.3	19.5
Reference examples 25-1	7.2	15.2	14.7	12.3
					Reference examples 25-2	9.3	17.4	8.8	18.8

Table 5-26 electronic cigarette aesthetic quality's testing result

	Hit/choke larynx sense	Irritation	Satisfaction	Comfort level
					Embodiment 26	18.2	20.3	23.3	20.6
Reference examples 26-1	3.2	15.3	15.9	13.2
					Reference examples 26-2	9.9	20.1	6.8	19.8

Table 5-27 electronic cigarette aesthetic quality's testing result

	Hit/choke larynx sense	Irritation	Satisfaction	Comfort level
					Embodiment 27	21.4	15.4	20.4	17.4
Reference examples 27-1	5.8	13.6	14.1	11.6
					Reference examples 27-2	9.7	13.3	8.2	13.9

Table 5-28 electronic cigarette aesthetic quality's testing result

Table 5-29 electronic cigarette aesthetic quality's testing result

	Hit/choke larynx sense	Irritation	Satisfaction	Comfort level
					Embodiment 29	19.6	21.8	21.6	20.6
Reference examples 29-1	4.8	15.7	16.4	14.3
					Reference examples 29-2	20.8	20.6	4.7	19.2

Table 5-30 electronic cigarette aesthetic quality's testing result

	Hit/choke larynx sense	Irritation	Satisfaction	Comfort level
					Embodiment 30	21.3	16.5	18.6	17.7
Reference examples 30-1	6.5	14.4	12.8	11.7
					Reference examples 30-2	20.1	14.9	4.1	15.6

Table 5-31 electronic cigarette aesthetic quality's testing result

	Hit/choke larynx sense	Irritation	Satisfaction	Comfort level
					Embodiment 31	21.5	16.8	19.3	16.6
Reference examples 31-1	7.8	14.6	13.7	10.4
					Reference examples 31-2	20.9	15.1	5.0	15.2

Table 5-32 electronic cigarette aesthetic quality's testing result

	Hit/choke larynx sense	Irritation	Satisfaction	Comfort level
					Embodiment 32	20.8	14.5	21.7	13.4
Reference examples 32-1	7.2	13.1	15.4	8.3
					Reference examples 32-2	19.8	12.0	6.6	11.7

Table 5-33 electronic cigarette aesthetic quality's testing result

	Hit/choke larynx sense	Irritation	Satisfaction	Comfort level
					Embodiment 33	20.4	16.1	19.6	15.6
Reference examples 33-1	5.8	14.6	14.7	9.5
					Reference examples 33-2	19.7	14.8	7.1	14.6

Table 5-34 electronic cigarette aesthetic quality's testing result

Table 5-35 electronic cigarette aesthetic quality's testing result

	Hit/choke larynx sense	Irritation	Satisfaction	Comfort level
					Embodiment 49	21.2	15.3	21.3	16.7
Reference examples 49-1	5.4	14.3	16.3	6.8
					Reference examples 49-2	19.2	14.6	7.4	15.3

Table 5-36 electronic cigarette aesthetic quality's testing result

	Hit/choke larynx sense	Irritation	Satisfaction	Comfort level
					Embodiment 50	20.8	16.3	22.3	16.4
Reference examples 50-1	12.7	14.8	16.3	9.3
					Reference examples 50-2	19.2	15.4	7.8	15.6

Table 5-37 electronic cigarette aesthetic quality's testing result

	Hit/choke larynx sense	Irritation	Satisfaction	Comfort level
					Embodiment 51	20.4	19.2	21.2	20.6
Reference examples 51-1	12.3	17.7	14.8	9.9
					Reference examples 51-2	19.2	18.3	7.3	18.6

Table 5-38 electronic cigarette aesthetic quality's testing result

	Hit/choke larynx sense	Irritation	Satisfaction	Comfort level
					Embodiment 52	21.2	20.8	19.6	19.3
Reference examples 52-1	7.2	18.7	14.7	7.5
					Reference examples 52-2	20.3	17.9	5.7	17.9

Table 5-39 electronic cigarette aesthetic quality's testing result

	Hit/choke larynx sense	Irritation	Satisfaction	Comfort level
					Embodiment 53	20.8	16.7	20.5	19.6
Reference examples 53-1	11.8	14.9	13.4	12.5
					Reference examples 53-2	19.4	15.6	6.7	15.6

Table 5-40 electronic cigarette aesthetic quality's testing result

	Hit/choke larynx sense	Irritation	Satisfaction	Comfort level
					Embodiment 54	20.4	16.2	19.6	18.6
Reference examples 54-1	9.8	14.8	12.2	12.5
					Reference examples 54-2	19.7	15.9	6.3	16.9

Table 5-41 electronic cigarette aesthetic quality's testing result

	Hit/choke larynx sense	Irritation	Satisfaction	Comfort level
					Embodiment 55	20.7	15.4	19.8	17.9
Reference examples 55-1	5.5	14.8	11.8	10.3
					Reference examples 55-2	19.8	15.2	6.8	14.3

Table 5-42 electronic cigarette aesthetic quality's testing result

	Hit/choke larynx sense	Irritation	Satisfaction	Comfort level
					Embodiment 56	20.8	15.1	20.7	16.4
Reference examples 56-1	9.3	14.3	12.2	9.5
					Reference examples 56-2	19.4	14.6	7.4	14.3

Table 5-43 electronic cigarette aesthetic quality's testing result

	Hit/choke larynx sense	Irritation	Satisfaction	Comfort level
					Embodiment 57	21.4	18.7	20.8	19.7
Reference examples 57-1	5.2	17.6	12.7	11.8
					Reference examples 57-2	21.7	18.2	7.7	15.6

Table 5-44 electronic cigarette aesthetic quality's testing result

	Hit/choke larynx sense	Irritation	Satisfaction	Comfort level
					Embodiment 58	20.8	19.9	18.6	18.6
Reference examples 58-1	6.8	17.9	10.2	10.5
					Reference examples 58-2	19.9	18.8	6.2	14.9

Table 5-45 electronic cigarette aesthetic quality's testing result

	Hit/choke larynx sense	Irritation	Satisfaction	Comfort level
					Embodiment 59	21.5	18.3	16.8	15.9
Reference examples 59-1	7.8	17.2	8.8	7.6
					Reference examples 59-2	20.7	17.8	4.7	10.4

Table 5-46 electronic cigarette aesthetic quality's testing result

	Hit/choke larynx sense	Irritation	Satisfaction	Comfort level
					Embodiment 60	20.8	16.3	18.2	16.4
Reference examples 60-1	7.9	14.8	11.2	11.3
					Reference examples 60-2	19.9	15.8	5.8	14.8

Table 5-47 electronic cigarette aesthetic quality's testing result

	Hit/choke larynx sense	Irritation	Satisfaction	Comfort level
					Embodiment 61	20.5	17.1	19.9	18.6
Reference examples 61-1	10.8	15.8	12.7	12.3
					Reference examples 61-2	19.5	16.8	6.7	14.5

Claims (10)

1. (strength foot, physiology satisfaction is good, and larynx sense of choking is low or nothing, and irritation is low or nothing, and it is good to cross larynx, nicotine biology benefit 1. a kind of High with rate (bioavilability), consumer's use feeling is good) electronic cigarette (or aerosol generates system/material), feature It is that the electronic cigarette (or aerosol generates system/material) includes containing pharmaceutically acceptable nicotine (nicotine) salt and pharmacy It goes up the composition (I) of acceptable aerosol or smoke creating agent and contains pharmaceutically acceptable alkalinity alkali more stronger than the nicotine (pKa value that its pKa value is greater than the nicotine) and pharmaceutically acceptable aerosol or the composition of smoke creating agent (II), (on State composition (I) and (II) be mutually isolated non-be blended together), above-mentioned composition (I) and (II) are (through aerosolization or vaporization Aerosolization or it is aerosolized after) used with aerosolization state or vaporization state or aerosol state or aerosol (aerosol) (/ disappear Take) person's sucking (in vivo (especially in lung's (alveolar))), (in use (/ consumption) person's body (especially in lung's (alveolar)) It meets and (generates free state nicotine)).
2. 2. electronic cigarette (or aerosol generates system/material) according to claim 1, it is characterised in that in the composition (I) The content of nicotine salt is 0.001%~25% (wt/wt)；

   Or the content of (alkalinity is more stronger than the nicotine) alkali described in the composition (II) is 0.001%~25% (wt/ wt)。
3. 3. electronic cigarette according to claim 1 (or aerosol generates system/material), it is characterised in that the composition (I) is Solution, pH value are usually 3~6.9；

   Or the composition (II) is solution, pH value is 7.2~12.
4. 4. electronic cigarette (or aerosol generates system/material) according to claim 1, it is characterised in that the nicotine salt is pharmacy Upper acceptable inorganic acid salt or acylate, the pKa value of above-mentioned acid are lower than nicotine pKa value, and the organic acid is selected from pharmaceutically Acceptable following acid: atomicity is the alkane or cycloalkane polybasic carboxylic acid, atomicity C2 of C2~C7 (preferably C2~C6) Hydrogen on the alkane or cycloalkane monocarboxylic acid of~C14 (preferably C2~C6), benzene compound molecular structure ring is by one or more carboxyls Carbon atom number is C1~C7 (more preferable C1~C6) linear chain or branched chain (preferably straight chain is dominant) alkane or cycloalkyl group, one or more The one or more hydroxyl carbon atom numbers of carboxyl are C2~C7 (preferably C2~C6) linear chain or branched chain alkane (preferably straight chain is dominant) hydrocarbon or ring It is that alkyl replaces and in molecular structure alkane chain highest carbon atom number not higher than the carboxylic acid of C7 (preferably C6), furan compound, Hydrogen on pyrylium compound and pyranone compounds molecular structure ring is C1~C7 (more preferable C1 by one or more carboxyl carbon atom numbers ~C6) linear chain or branched chain (preferably straight chain is dominant) alkane or the one or more hydroxyl carbon atom numbers of cycloalkyl group, one or more carboxyls are C2~C7 (more preferable C1~C6) linear chain or branched chain (preferably straight chain is dominant) alkane or cycloalkyl group replace and molecular structure Middle alkane chain highest carbon atom number is not higher than carboxylic acid, ascorbic acid, dehydroascorbic acid, (6-) deoxidation-L- of C7 (preferably C6) Ascorbic acid, glucoascorbic acid, arabo-ascorbic acid, alkane chain highest carbon atom number is not higher than C7 in other molecular structures The organic acid of (preferably C6, what more preferable straight chain was dominant) and the acid salt or ackd salt of above-mentioned multicomponent organic acid；

   Or the inorganic acid is selected from hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, pyrosulfuric acid, sulfurous acid, pyrosulfurous acid, thiosulfuric acid, sulfuric acid Hydrogen salt, dihydric phosphate, bisulfites, benzene sulfonic acid, sulfosalicylic acid and above-mentioned multi-element, inorganic acid acid salt or acidity Salt.
5. 5. electronic cigarette according to claim 1 (or aerosol generates system/material), it is characterised in that the alkali be selected from urea, Deanol, trometamol, ethanol amine, diethyl ethylene diamine, diethanol amine, triethanolamine, diethanol monoisopropanolamine, dihydroxy second Base tert-butyl alcohol amine, ethambutol (two butanol of ethylenediamine), isobutyl hydramine, dipropanolamine, tripropanol amine, triisopropanolamine, two is different Propanolamine, two butanolamines, three butanolamines, two isobutyl hydramine, three isobutyl hydramine, diamyl hydramine, three amylalcohol amine, diisoamyl hydramine, Three isoamyl hydramine, two hydramine, triethanol amine, tromethamine, urethane, amido monosaccharide or disaccharide, first or ethylization amido list Sugar or disaccharide, caffeine, pyridoxol/pungent, pyridoxamine, pyridoxal, thiamines, amino acid, the soluble basic salt of amino acid can Saccharin salt, glycyrrhizic acid normal salt and its basic salt or basic salt of dissolubility, dihydrochalcone normal salt and its basic salt or basic salt, flesh Hydrochlorate, soluble carbonic acid (just) salt, basic carbonate (just) salt, bicarbonate, percarbonate, soluble sulfurous acid (just) Salt, thiosulfuric acid (just) salt, phosphoric acid (just) salt, hydrophosphate, pyrophosphoric acid (just) salt and its basic salt or basic salt, alkali metal or Alkaline-earth metal soluble alkali salt and their mixture.
6. 6. electronic cigarette (or aerosol generates system/material) according to claim 1, it is characterised in that the aerosol or smog Generating agent is selected from pharmaceutically acceptable following additive: low boiling point or sublimation point sugar；Low boiling point or sublimation point polyalcohol；It is low Boiling point or sublimation point glycol；Low boiling point or sublimation point monohydric alcohol；Low boiling point or sublimation point acid；Low boiling point or sublimation point ether, aldehyde or Ketone；Low boiling point or sublimation point ester；And their mixture；Above-mentioned low boiling point or sublimation point are lower than 450 DEG C of temperature, but are not less than 70 ℃。
7. 7. electronic cigarette (or aerosol generates system/material) according to claim 1, it is characterised in that the aerosol or smog Generating agent is selected from C3H6O3, C3H6O3 dimer, 2- deoxidation-L-ribose, 2-deoxy-D-ribose 2- Deoxy-D-ribose, arabinose, erythrose, erythrulose, D- xylulose, fructose, ribose, xylose, glucose, sorb Sugar；Glycerol, xylitol, D-sorbite, antierythrite；Propylene glycol, butanediol, 1,2- pentanediol, 1,2- hexylene glycol, 1,2- heptan two Alcohol, 1,2- ethohexadiol；Atomicity is the monohydric alcohol of C2~C14, menthol, borneol, borneol, isoborneol；Lactic acid, benzoic acid, benzene Acetic acid, vanillic acid, salicylic acid, aspirin, atomicity are the fatty acid of C8-C14；Poloxamer, poly- two~six glycerol, poly- two ~six propylene glycol, poly- two~six ethylene glycol, vanillic aldehyde, ethyl vanillin, camphor；Glycerol atomicity is the fatty acid of C1~C8 Ester, triethylene glycol diacetate esters, lactic acid atomicity are the aliphatic alcohol ester of C1~C6, and atomicity is the fatty acid atom of C1~C18 Number is aliphatic alcohol ester, suberic acid diethylester, the dodecanedioic acid dimethyl ester, tetradecanedioic acid dimethyl ester of C1~C6, and atomicity is Aliphatic alcohol ester of C2~C6 polyacid atomicity for C1~C6, acetic acid laurylene base ester, Ergol, phenylethyl phenylacetate, Ethyl vanillate, propene carbonate；Water；Or their mixture.
8. 8. one kind is for electronic cigarette according to claim 1 (or aerosol generates system/material) aerosolization or vaporization or aerosol Change or aerosolized device (kits, device, equipment, unit), it is characterised in that the device include 2 independences not The atomization subsystem communicated, difference aerosolization or vaporization or aerosolization or the aerosolized composition (I) and (II).
9. 9. device according to claim 8, it is characterised in that the atomization subsystem respectively includes a fluid reservoir/or accommodating chamber It (and its constituting parts), a spray chamber (and its constituting parts), a mist or smoke path (and its constituting parts) or guiding piece 1 and hazes The component of change effect, above-mentioned fluid reservoir/or accommodating chamber are directly communicated with above-mentioned spray chamber or are connected to by guiding piece 2, above-mentioned mist Vapour or smoke path or 1 one end of guiding piece are communicated with above-mentioned spray chamber, and the other end inhales (mouth) Kong Xiangtong or above-mentioned with one respectively 2 mists or smoke path or 1 other end of guiding piece one inhale (mouth) hole nearby (" near " definition be from suction (mouth) hole Distance is no less than the 70% of the channel overall length, and preferably 90%, more preferably 95%.Most preferably 99%, in the range of) convergence after The connection of (mouth) hole or above-mentioned 2 mists or smoke path or 1 other end of guiding piece are inhaled with one jointly and inhales convergence at (mouth) hole one And communicate therewith, it to be isolated between above-mentioned two fluid reservoir/or accommodating chamber and is not communicated with, above-mentioned two atomizations interventricular septum is from being not communicated with, and above-mentioned two Between mist or smoke path or guiding piece 1 isolation be not communicated with (but above-mentioned suction (mouth) hole or it is defined above " near " except), on It states to be isolated between two guiding pieces 2 and be not communicated with.
10. 10. device according to claim 9, it is characterised in that the device further includes shell, power supply module, necessary attachment；It should It further include device Jin mono- Walk smoke grenade, control assembly, (pneumatic) switch block.