CN114886144A - Composition and preparation method and application thereof - Google Patents
Composition and preparation method and application thereof Download PDFInfo
- Publication number
- CN114886144A CN114886144A CN202210533126.XA CN202210533126A CN114886144A CN 114886144 A CN114886144 A CN 114886144A CN 202210533126 A CN202210533126 A CN 202210533126A CN 114886144 A CN114886144 A CN 114886144A
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- acid
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- propylene glycol
- ethanol
- electronic cigarette
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- 239000000203 mixture Substances 0.000 title claims abstract description 127
- 238000002360 preparation method Methods 0.000 title claims abstract description 23
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims abstract description 80
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims abstract description 80
- JOOXCMJARBKPKM-UHFFFAOYSA-N 4-oxopentanoic acid Chemical compound CC(=O)CCC(O)=O JOOXCMJARBKPKM-UHFFFAOYSA-N 0.000 claims abstract description 78
- 239000005711 Benzoic acid Substances 0.000 claims abstract description 40
- 235000010233 benzoic acid Nutrition 0.000 claims abstract description 40
- 239000004310 lactic acid Substances 0.000 claims abstract description 40
- 235000014655 lactic acid Nutrition 0.000 claims abstract description 40
- 239000003571 electronic cigarette Substances 0.000 claims abstract description 39
- 229940040102 levulinic acid Drugs 0.000 claims abstract description 39
- 239000003085 diluting agent Substances 0.000 claims abstract description 24
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 117
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 109
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 42
- 239000000443 aerosol Substances 0.000 claims description 31
- IGIDLTISMCAULB-UHFFFAOYSA-N 3-methylvaleric acid Chemical compound CCC(C)CC(O)=O IGIDLTISMCAULB-UHFFFAOYSA-N 0.000 claims description 28
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims description 28
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims description 28
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 claims description 28
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 23
- 102000003610 TRPM8 Human genes 0.000 claims description 15
- 101150111302 Trpm8 gene Proteins 0.000 claims description 15
- 238000002156 mixing Methods 0.000 claims description 15
- XYHKNCXZYYTLRG-UHFFFAOYSA-N 1h-imidazole-2-carbaldehyde Chemical compound O=CC1=NC=CN1 XYHKNCXZYYTLRG-UHFFFAOYSA-N 0.000 claims description 14
- WLAMNBDJUVNPJU-UHFFFAOYSA-N 2-methylbutyric acid Chemical compound CCC(C)C(O)=O WLAMNBDJUVNPJU-UHFFFAOYSA-N 0.000 claims description 14
- GWYFCOCPABKNJV-UHFFFAOYSA-M 3-Methylbutanoic acid Natural products CC(C)CC([O-])=O GWYFCOCPABKNJV-UHFFFAOYSA-M 0.000 claims description 14
- GWYFCOCPABKNJV-UHFFFAOYSA-N beta-methyl-butyric acid Natural products CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 claims description 14
- 235000019260 propionic acid Nutrition 0.000 claims description 14
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 claims description 14
- 239000000018 receptor agonist Substances 0.000 claims description 14
- 229940044601 receptor agonist Drugs 0.000 claims description 14
- 239000011973 solid acid Substances 0.000 claims description 14
- UAXOELSVPTZZQG-UHFFFAOYSA-N tiglic acid Natural products CC(C)=C(C)C(O)=O UAXOELSVPTZZQG-UHFFFAOYSA-N 0.000 claims description 14
- NFLGAXVYCFJBMK-UHFFFAOYSA-N isomenthone Natural products CC(C)C1CCC(C)CC1=O NFLGAXVYCFJBMK-UHFFFAOYSA-N 0.000 claims description 11
- 239000002994 raw material Substances 0.000 claims description 11
- XHXUANMFYXWVNG-ADEWGFFLSA-N (-)-Menthyl acetate Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(C)=O XHXUANMFYXWVNG-ADEWGFFLSA-N 0.000 claims description 10
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 claims description 10
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 7
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 7
- 229940041616 menthol Drugs 0.000 claims description 7
- 239000001525 mentha piperita l. herb oil Substances 0.000 claims description 6
- 235000019477 peppermint oil Nutrition 0.000 claims description 6
- NFLGAXVYCFJBMK-RKDXNWHRSA-N (+)-isomenthone Natural products CC(C)[C@H]1CC[C@@H](C)CC1=O NFLGAXVYCFJBMK-RKDXNWHRSA-N 0.000 claims description 5
- 239000001605 (5-methyl-2-propan-2-ylcyclohexyl) acetate Substances 0.000 claims description 5
- XHXUANMFYXWVNG-UHFFFAOYSA-N D-menthyl acetate Natural products CC(C)C1CCC(C)CC1OC(C)=O XHXUANMFYXWVNG-UHFFFAOYSA-N 0.000 claims description 5
- UJNOLBSYLSYIBM-WISYIIOYSA-N [(1r,2s,5r)-5-methyl-2-propan-2-ylcyclohexyl] (2r)-2-hydroxypropanoate Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)[C@@H](C)O UJNOLBSYLSYIBM-WISYIIOYSA-N 0.000 claims description 5
- 229930007503 menthone Natural products 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- RWAXQWRDVUOOGG-UHFFFAOYSA-N N,2,3-Trimethyl-2-(1-methylethyl)butanamide Chemical compound CNC(=O)C(C)(C(C)C)C(C)C RWAXQWRDVUOOGG-UHFFFAOYSA-N 0.000 claims description 4
- VUNOFAIHSALQQH-UHFFFAOYSA-N Ethyl menthane carboxamide Chemical compound CCNC(=O)C1CC(C)CCC1C(C)C VUNOFAIHSALQQH-UHFFFAOYSA-N 0.000 claims description 3
- 239000007788 liquid Substances 0.000 abstract description 24
- 210000000214 mouth Anatomy 0.000 abstract description 16
- 230000001953 sensory effect Effects 0.000 abstract description 14
- 230000000638 stimulation Effects 0.000 abstract description 8
- 150000007524 organic acids Chemical class 0.000 abstract description 6
- 235000005985 organic acids Nutrition 0.000 abstract description 4
- 229960002715 nicotine Drugs 0.000 description 20
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 20
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 19
- 239000011259 mixed solution Substances 0.000 description 19
- 239000000463 material Substances 0.000 description 18
- 238000011156 evaluation Methods 0.000 description 11
- 230000007794 irritation Effects 0.000 description 9
- 235000011187 glycerol Nutrition 0.000 description 7
- 230000000391 smoking effect Effects 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- 230000000694 effects Effects 0.000 description 6
- 239000000243 solution Substances 0.000 description 5
- 238000001816 cooling Methods 0.000 description 4
- 230000006872 improvement Effects 0.000 description 4
- 230000009965 odorless effect Effects 0.000 description 4
- 239000000796 flavoring agent Substances 0.000 description 3
- 235000019634 flavors Nutrition 0.000 description 3
- 206010011224 Cough Diseases 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 238000000889 atomisation Methods 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 235000019504 cigarettes Nutrition 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 210000003928 nasal cavity Anatomy 0.000 description 2
- 239000013558 reference substance Substances 0.000 description 2
- 230000035807 sensation Effects 0.000 description 2
- 235000019615 sensations Nutrition 0.000 description 2
- 235000013599 spices Nutrition 0.000 description 2
- 230000009967 tasteless effect Effects 0.000 description 2
- QRYKPMDEGMJHAT-UHFFFAOYSA-N 1-ethyl-5-methyl-2-propan-2-ylcyclohexane-1-carboxamide Chemical compound CCC1(C(N)=O)CC(C)CCC1C(C)C QRYKPMDEGMJHAT-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 244000061176 Nicotiana tabacum Species 0.000 description 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 1
- 108010037150 Transient Receptor Potential Channels Proteins 0.000 description 1
- 102000011753 Transient Receptor Potential Channels Human genes 0.000 description 1
- 238000001467 acupuncture Methods 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000010835 comparative analysis Methods 0.000 description 1
- 230000008094 contradictory effect Effects 0.000 description 1
- 239000002826 coolant Substances 0.000 description 1
- 238000000586 desensitisation Methods 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 230000008447 perception Effects 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 239000000779 smoke Substances 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/10—Chemical features of tobacco products or tobacco substitutes
- A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/10—Chemical features of tobacco products or tobacco substitutes
- A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
- A24B15/167—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
Abstract
The invention discloses a composition and a preparation method and application thereof, wherein the composition comprises 20-25% of benzoic acid, 3-6% of lactic acid, 18-25% of levulinic acid and the balance of diluent. When the composition provided by the invention is applied to the electronic cigarette atomized liquid, the combination of benzoic acid, lactic acid and levulinic acid which are organic acids can effectively reduce the stimulation to the oral cavity and the throat after the existing electronic cigarette atomized liquid is sucked, so that the sensory comfort and pleasure of consumers sucking electronic cigarettes are improved.
Description
Technical Field
The invention relates to the technical field of electronic atomizing agents, and particularly relates to a composition, and a preparation method and application thereof.
Background
Flavor components such as essence and spice and nicotine are added into the electronic cigarette atomized liquid, aerosol is generated in an electronic heating mode, and a user can feel pleasure and satisfaction similar to those of a traditional cigarette after smoking. Free nicotine is added into the traditional electronic cigarette aerosol formula, after the aerosol is sucked, the electronic cigarette aerosol has large irritation to the oral cavity and the throat, cough is easily caused, and sensory experience of a user is reduced, so that even low-concentration nicotine such as 17mg/ml and 20mg/ml electronic cigarette aerosol also has the problem, and improvement is needed urgently.
Disclosure of Invention
The invention mainly aims to provide a composition, a preparation method and application thereof, and aims to reduce the irritation of an electronic cigarette atomized liquid to the oral cavity and the throat of a human body after being smoked, so that the sensory comfort and pleasure of smoking electronic cigarettes by consumers are improved.
In order to achieve the purpose, the invention provides a composition which comprises 20-25% of benzoic acid, 3-6% of lactic acid, 18-25% of levulinic acid and the balance of a diluent in sequence by mass.
Optionally, the mass fractions of the benzoic acid, the lactic acid and the levulinic acid in the composition are 23-24%, 4-5% and 21-23% in sequence.
Optionally, the composition further comprises low carbonic acid, wherein the low carbonic acid comprises acetic acid, 2-methylbutyric acid, butyric acid, propionic acid, n-valeric acid, isovaleric acid and 3-methylvaleric acid, and the mass fractions of the acetic acid, the 2-methylbutyric acid, the butyric acid, the propionic acid, the n-valeric acid, the isovaleric acid and the 3-methylvaleric acid in the composition are 0.02-0.05%, 0.03-0.06%, 0.02-0.05%, 0.01-0.06% and 0.01-0.04% in sequence.
Optionally, the mass fractions of the acetic acid, 2-methylbutyric acid, butyric acid, propionic acid, n-valeric acid, isovaleric acid, and 3-methylvaleric acid in the composition are 0.02%, 0.06%, 0.03%, 0.05%, 0.06%, and 0.04%, respectively.
Optionally, the composition further comprises a TRPM8 receptor agonist, and the mass fraction of the TRPM8 receptor agonist in the composition is 0.1-6%.
Optionally, the TRPM8 receptor agonist comprises at least one of peppermint oil, menthol, WS-23, L-menthone, menthyl acetate, menthyl lactate, WS-3, menthone glycerol ketal.
Optionally, the diluent comprises propylene glycol and ethanol, and the mass ratio of the propylene glycol to the ethanol is 1: 1-1: 3.
In order to achieve the above object, the present invention further provides a method for preparing the composition as described above, comprising the steps of:
dissolving solid acid in the raw materials by using a diluent, adding the rest raw materials, and uniformly mixing to obtain the composition.
In order to achieve the purpose, the invention further provides electronic cigarette atomization liquid which comprises the composition, and the mass fraction of the composition in the electronic cigarette atomization liquid is 0.5-8%.
According to the technical scheme provided by the invention, the composition comprises benzoic acid, lactic acid, levulinic acid and a diluent, and when the composition is applied to the electronic cigarette atomized liquid, the benzoic acid, lactic acid and levulinic acid in the composition are combined with organic acids, so that the stimulation to the oral cavity and the throat after the existing electronic cigarette atomized liquid is sucked can be effectively reduced, and the sensory comfort and pleasure of consumers sucking electronic cigarettes are improved.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially. In addition, the meaning of "and/or" appearing throughout includes three juxtapositions, exemplified by "A and/or B" including either A or B or both A and B. In addition, technical solutions between various embodiments may be combined with each other, but must be realized by a person skilled in the art, and when the technical solutions are contradictory or cannot be realized, such a combination should not be considered to exist, and is not within the protection scope of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Flavor components such as essence and spice and nicotine are added into the electronic cigarette atomized liquid, aerosol is generated in an electronic heating mode, and a user can feel pleasure and satisfaction similar to those of a traditional cigarette after smoking. Free nicotine is added into the traditional electronic cigarette aerosol formula, after the aerosol is sucked, the electronic cigarette aerosol has large irritation to the oral cavity and the throat, cough is easily caused, and sensory experience of a user is reduced, so that even low-concentration nicotine such as 17mg/ml and 20mg/ml electronic cigarette aerosol also has the problem, and improvement is needed urgently.
In view of this, the present invention provides a composition, which achieves the effect of improving the smoking experience of the electronic cigarette aerosol by adding an organic acid. Specifically, in some embodiments of the composition provided by the present invention, the composition includes 20 to 25% by mass, 3 to 6% by mass and 18 to 25% by mass of benzoic acid, lactic acid, levulinic acid and a diluent, and the balance is the diluent. It is understood that the composition may further include components other than the benzoic acid, lactic acid, levulinic acid and diluent, and when the composition includes only benzoic acid, lactic acid, levulinic acid and diluent, the "balance of diluent" means that the remaining components of the composition are all diluents other than the benzoic acid, lactic acid and levulinic acid, that is, the mass fractions of the benzoic acid, lactic acid and levulinic acid are 20 to 25%, 3 to 6% and 18 to 25% in this order, and the mass fraction of the diluent is 44 to 59%.
In the technical scheme provided by the invention, the composition comprises benzoic acid, lactic acid, levulinic acid and a diluent, when the composition is applied to the electronic cigarette aerosol, the benzoic acid, the lactic acid and the levulinic acid are combined, the benzoic acid can effectively improve the transmission efficiency of nicotine, the lactic acid can improve the throat impact feeling of the electronic cigarette aerosol at the throat, the levulinic acid can improve the conglobation property of aerosol, and can be combined with free nicotine to convert the free nicotine into a proton state, and the volatility of the proton state nicotine is weaker than that of the free nicotine, so that the stimulation of nicotine to the oral cavity and the throat of a human body is reduced after inhalation, and the stimulation to the oral cavity and the throat of the human body is easier to pass through a cerebral blood barrier, so that the stimulation to the oral cavity and the throat of the human body is effectively reduced after the existing electronic cigarette aerosol is inhaled, thereby improving the sensory comfort and pleasure of the consumer for smoking the electronic cigarette.
Further, in some preferred embodiments provided herein, the content of each organic acid is more preferably: the mass fractions of the benzoic acid, the lactic acid and the levulinic acid in the composition are 23-24%, 4-5% and 21-23% in sequence, and correspondingly, the mass fraction of the diluent is 48-52%. Within the content range, the composition has better smoking experience improvement effect when being applied to the electronic cigarette atomized liquid.
In other embodiments of the composition provided by the present invention, the composition further comprises a low carbonic acid, and the low carbonic acid comprises acetic acid, 2-methylbutyric acid, butyric acid, propionic acid, n-valeric acid, isovaleric acid, and 3-methylvaleric acid, and the mass fractions of the acetic acid, 2-methylbutyric acid, butyric acid, propionic acid, n-valeric acid, isovaleric acid, and 3-methylvaleric acid in the composition are 0.02 to 0.05%, 0.03 to 0.06%, 0.02 to 0.05%, 0.01 to 0.06%, and 0.01 to 0.04%, respectively. The low carbonic acid is naturally present in tobacco leaves, and can further soften aerosol and improve the comfort of the aerosol in the oral cavity and throat after being sucked. It should be noted that, when the composition further includes a low carbonic acid, "the balance is a diluent" means that the remaining components in the composition are diluents except the benzoic acid, the lactic acid, the levulinic acid and the low carbon acid, and the calculation of the mass fraction corresponding to each component is referred to above and is not repeated herein.
Further, in some preferred embodiments provided by the present invention, the content of each low carbonic acid is more preferably: the mass fractions of the acetic acid, the 2-methylbutyric acid, the butyric acid, the propionic acid, the n-valeric acid, the isovaleric acid and the 3-methylvaleric acid in the composition are 0.02%, 0.06%, 0.03%, 0.05%, 0.06% and 0.04% in sequence.
In still other embodiments provided by the present invention, the composition further comprises a TRPM8 receptor agonist, and the mass fraction of the TRPM8 receptor agonist in the composition is 0.1-6%. TRPM8 refers to the M-type (Melastatin) transient receptor potential channel 8, a pathway involving chemical sensations (e.g., cooling to cold temperatures) and sensations of infusion of menthol and therefore of the known cooling agents, TRPM8 receptor agonists have a cooling effect that helps to increase cooling in the mouth and throat, resulting in desensitization of the nicotine receptors, thereby achieving stimulation-inhibiting effects.
The TRPM8 receptor agonist may be selected from substances with cooling function commonly known in the art, and in some embodiments provided herein, the TRPM8 receptor agonist includes at least one of peppermint oil, menthol, N,2, 3-trimethyl-2-isopropyl butanamide (WS-23), L-menthone, menthyl acetate, menthyl lactate, N, ethyl-2-isopropyl-5-methylcyclohexanecarboxamide (WS-3), menthone glycerol ketal, and may be any one of the above substances or a mixture of any two or more of the above substances, and the specific mixing ratio is not limited, and falls within the scope of the present invention. The substance selected as the TRPM8 receptor agonist in the composition has the advantages of definite effect and small side effect.
The diluent can be selected from substances which are commonly used in the field and can dissolve and disperse organic acids such as benzoic acid, lactic acid, levulinic acid and the like, in some embodiments provided by the invention, the diluent comprises propylene glycol and ethanol, and the mass ratio of the propylene glycol to the ethanol is 1: 1-1: 3. Therefore, the diluent has good dissolving and dispersing effects on organic acids, low carbonic acid, TRPM8 receptor agonists and other substances in the composition, and the product performance is stable.
Based on the composition provided by the invention, the invention further provides a preparation method of the composition, which comprises the following steps: dissolving solid acid in the raw materials by using a diluent, adding the rest raw materials, and uniformly mixing to obtain the composition.
Weighing the raw materials in proportion, fully dissolving solid acid (such as benzoic acid) in the raw materials by using a diluent to form a mixed solution, adding the rest raw material components (such as lactic acid, low-carbon acid, TRPM8 receptor agonist and the like) into the mixed solution, and fully and uniformly mixing to obtain the composition. The preparation method is simple and easy to implement, the prepared composition is stable in quality, and when the composition is applied to the electronic cigarette atomized liquid, the irritation to the oral cavity and the throat can be effectively reduced, and the smoking experience of the electronic cigarette is improved.
In addition, based on the composition provided by the invention, the invention also provides an electronic cigarette aerosol, which comprises the composition, wherein the electronic cigarette aerosol can be a nicotine-containing electronic cigarette aerosol available on the market, or a nicotine-containing electronic cigarette aerosol prepared according to the prior art, and the composition provided by the invention is added into the electronic cigarette aerosol, so that the protection range of the electronic cigarette aerosol is met, and the specific formula of the electronic cigarette aerosol is not described herein. Further, the mass fraction of the composition in the electronic cigarette atomized liquid is 0.5-8%, and may be, for example, 0.5%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, or the like. The stimulation of the existing electronic cigarette atomized liquid to the oral cavity and the throat can be effectively reduced by adding the composition into the electronic cigarette atomized liquid, and the smooth and powerful throat hitting feeling and physiological satisfaction can be provided for consumers while the nicotine content is reduced.
The technical solutions of the present invention are further described in detail with reference to the following specific examples, which should be understood as merely illustrative and not limitative.
Example 1
(1) The composition comprises the following components in percentage by mass: 20% of benzoic acid, 3% of lactic acid, 18% of levulinic acid, 33% of ethanol and 11% of propylene glycol.
(2) The preparation method of the composition comprises the following steps: the benzoic acid is fully dissolved by using a mixed solution of ethanol and propylene glycol, then the levulinic acid and the lactic acid are added and uniformly mixed to prepare the composition.
Example 2
(1) The composition comprises the following components in percentage by mass: 23% of benzoic acid, 4% of lactic acid, 21% of levulinic acid, 32% of ethanol and 16% of propylene glycol.
(2) The preparation method of the composition comprises the following steps: the benzoic acid is fully dissolved by using a mixed solution of ethanol and propylene glycol, and then the levulinic acid and the lactic acid are added and uniformly mixed to prepare the composition.
Example 3
(1) The composition comprises the following components in percentage by mass: 23.5% of benzoic acid, 4.5% of lactic acid, 22% of levulinic acid, 25% of ethanol and 25% of propylene glycol.
(2) The preparation method of the composition comprises the following steps: the benzoic acid is fully dissolved by using a mixed solution of ethanol and propylene glycol, and then the levulinic acid and the lactic acid are added and uniformly mixed to prepare the composition.
Example 4
(1) The composition comprises the following components in percentage by mass: 24% of benzoic acid, 5% of lactic acid, 23% of levulinic acid, 34% of ethanol and 18% of propylene glycol.
(2) The preparation method of the composition comprises the following steps: the benzoic acid is fully dissolved by using a mixed solution of ethanol and propylene glycol, and then the levulinic acid and the lactic acid are added and uniformly mixed to prepare the composition.
Example 5
(1) The composition comprises the following components in percentage by mass: 25% of benzoic acid, 6% of lactic acid, 25% of levulinic acid, 43% of ethanol and 16% of propylene glycol.
(2) The preparation method of the composition comprises the following steps: the benzoic acid is fully dissolved by using a mixed solution of ethanol and propylene glycol, and then the levulinic acid and the lactic acid are added and uniformly mixed to prepare the composition.
Example 6
(1) The composition comprises the following components in percentage by mass: benzoic acid 23%, lactic acid 5%, levulinic acid 20%, acetic acid 0.02%, 2-methylbutyric acid 0.06%, butyric acid 0.03%, propionic acid 0.05%, n-valeric acid 0.06%, isovaleric acid 0.06%, and 3-methylvaleric acid 0.04%, ethanol 26.68%, propylene glycol 25%.
(2) The preparation method of the composition comprises the following steps: dissolving the solid acid material in the composition with mixed solution of ethanol and propylene glycol, adding the rest materials, and mixing to obtain the composition.
Example 7
(1) The composition comprises the following components in percentage by mass: benzoic acid 21%, lactic acid 3.5%, levulinic acid 20%, acetic acid 0.03%, 2-methylbutyric acid 0.03%, butyric acid 0.06%, propionic acid 0.02%, n-valeric acid 0.01%, isovaleric acid 0.01%, and 3-methylvaleric acid 0.01%, ethanol 30.33%, propylene glycol 25%.
(2) The preparation method of the composition comprises the following steps: dissolving the solid acid material in the composition with mixed solution of ethanol and propylene glycol, adding the rest materials, and mixing to obtain the composition.
Example 8
(1) The composition comprises the following components in percentage by mass: 24.5% of benzoic acid, 5.5% of lactic acid, 24% of levulinic acid, 0.05% of acetic acid, 0.04% of 2-methylbutyric acid, 0.04% of butyric acid, 0.03% of propionic acid, 0.03% of n-valeric acid, 0.03% of isovaleric acid, 0.02% of 3-methylvaleric acid, 25.8% of ethanol and 20% of propylene glycol.
(2) The preparation method of the composition comprises the following steps: fully dissolving the mixed solution of the solid acid raw material ethanol and the propylene glycol in the composition, then adding the rest raw material components, and uniformly mixing to obtain the composition.
Example 9
(1) The composition comprises the following components in percentage by mass: benzoic acid 22%, lactic acid 4%, levulinic acid 22%, peppermint oil 0.1%, ethanol 26.9% and propylene glycol 25%.
(2) The preparation method of the composition comprises the following steps: dissolving the solid acid material in the composition with mixed solution of ethanol and propylene glycol, adding the rest materials, and mixing to obtain the composition.
Example 10
(1) The composition comprises the following components in percentage by mass: 23% of benzoic acid, 5% of lactic acid, 19% of levulinic acid, 0.2% of peppermint oil, WS-230.3%, 27.5% of ethanol and 25% of propylene glycol.
(2) The preparation method of the composition comprises the following steps: dissolving the solid acid material in the composition with mixed solution of ethanol and propylene glycol, adding the rest materials, and mixing to obtain the composition.
Example 11
(1) The composition comprises the following components in percentage by mass: 23% of benzoic acid, 4% of lactic acid, 20% of levulinic acid, 0.2% of menthol, 0.2% of L-menthone, 0.6% of menthyl lactate, 26% of ethanol and 26% of propylene glycol.
(2) The preparation method of the composition comprises the following steps: dissolving the solid acid material in the composition with mixed solution of ethanol and propylene glycol, adding the rest materials, and mixing to obtain the composition.
Example 12
(1) The composition comprises the following components in percentage by mass: 24% of benzoic acid, 5% of lactic acid, 22% of levulinic acid, 0.5% of menthol, WS-230.5%, 0.5% of menthyl acetate, 30.5% of WS-ethanol, 24% of ethanol and 23% of propylene glycol.
(2) The preparation method of the composition comprises the following steps: dissolving the solid acid material in the composition with mixed solution of ethanol and propylene glycol, adding the rest materials, and mixing to obtain the composition.
Example 13
(1) The composition comprises the following components in percentage by mass: benzoic acid 21%, lactic acid 5%, levulinic acid 20%, peppermint oil 1%, menthol 0.4%, L-menthone 0.3%, menthyl acetate 0.3%, menthyl lactate 0.5%, menthone glycerol ketal 0.5%, ethanol 26%, propylene glycol 25%.
(2) The preparation method of the composition comprises the following steps: dissolving the solid acid material in the composition with mixed solution of ethanol and propylene glycol, adding the rest materials, and mixing to obtain the composition.
Example 14
(1) The composition comprises the following components in percentage by mass: benzoic acid 23%, lactic acid 5%, levulinic acid 20%, acetic acid 0.02%, 2-methylbutyric acid 0.06%, butyric acid 0.03%, propionic acid 0.05%, n-valeric acid 0.06%, isovaleric acid 0.06% and 3-methylvaleric acid 0.04%, L-menthone 5%, ethanol 23.68%, propylene glycol 23%.
(2) The preparation method of the composition comprises the following steps: dissolving the solid acid material in the composition with mixed solution of ethanol and propylene glycol, adding the rest materials, and mixing to obtain the composition.
Example 15
(1) The composition comprises the following components in percentage by mass: benzoic acid 23%, lactic acid 5%, levulinic acid 20%, acetic acid 0.02%, 2-methylbutyric acid 0.06%, butyric acid 0.03%, propionic acid 0.05%, n-valeric acid 0.06%, isovaleric acid 0.06% and 3-methylvaleric acid 0.04%, WS-31%, menthone glycerol ketal 5%, ethanol 23.68%, propylene glycol 22%.
(2) The preparation method of the composition comprises the following steps: dissolving the solid acid material in the composition with mixed solution of ethanol and propylene glycol, adding the rest materials, and mixing to obtain the composition.
Sensory evaluation method: the method is characterized in that an evaluator adopts an integral circulation method uniformly to suck 10 mouths continuously, each mouth is spaced for 30s, aerosol is sucked to fill the oral cavity and stays for 1-2 s, and the aerosol is swallowed by the throat to reach the lung for exchange and then is slowly exhaled from the nasal cavity. And setting 10 evaluators subjected to sensory evaluation training to evaluate the samples, wherein each evaluator evaluates the samples by using an electronic atomized liquid sensory evaluation table and scores the samples in a dark evaluation mode.
Grading standard: evaluating three indexes of throat hitting feeling, irritation, satisfaction and the like of the odorless electronic atomized liquid after inhalation; the throat-hitting feeling refers to the physical sensory degree of strong and weak impact of aerosol on the throat; the irritation refers to the sensory feeling of the aerosol on the irritation of the oral cavity, the throat and the nasal cavity, such as granular feeling, acupuncture feeling and the like; satisfiability refers to the degree of perception of brain excitation shortly after ingestion of the aerosol; the evaluation adopts a linear scale method, each index evaluation is divided into 3 grades, and the grade is scored according to the index evaluation degree: 0-3 is weaker, 4-6 is medium, and 7-9 is very strong; the throat-hit, irritation and satisfaction of the reference were evaluated for scores of 4, 7 and 4. The smoke panel scores the indexes of each sample and records the result, and the minimum scoring unit of the score value is 0.5.
The flavor compositions of examples 1 to 15 were mixed with nicotine at a mass ratio of 2:1, respectively, and stirred for 30min, and then the mixture was diluted with a mixed solution of propylene glycol and glycerin at a mass ratio of 1:1 to give a flavor-free electronic atomized liquid, and subjected to sensory evaluation. Diluting nicotine with a mixed solution of propylene glycol and glycerol until the nicotine concentration is 20mg/g, wherein the mass ratio of propylene glycol to glycerol is 1:1, and obtaining the evaluation reference substance of the odorless electronic atomized liquid.
And (4) counting results: the arithmetic mean of all evaluators was obtained for each individual index of the odorless electronic atomized liquid, and the comparative evaluation results of the odorless electronic atomized liquids of examples 1 to 15 are shown in table 1.
TABLE 1 sensory evaluation results of the electronic atomized liquid
As can be seen from table 1, the tasteless electronic atomized liquids of examples 1 to 15 of the present invention both had better throat-hitting feeling and satisfaction than the tasteless electronic atomized liquid evaluation reference substance of pure nicotine, and the irritation was significantly reduced. The composition provided by the invention can effectively reduce the sensory stimulation of the electronic cigarette atomized liquid, and simultaneously improve the throat-hitting feeling and satisfaction.
The above is only a preferred embodiment of the present invention, and it is not intended to limit the scope of the invention, and various modifications and changes will occur to those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention shall be included in the scope of the present invention.
Claims (9)
1. The composition is characterized by comprising 20-25% of benzoic acid, 3-6% of lactic acid and 18-25% of levulinic acid in sequence, and the balance of diluent.
2. The composition according to claim 1, wherein the mass fractions of the benzoic acid, the lactic acid and the levulinic acid in the composition are 23-24%, 4-5% and 21-23% in sequence.
3. The composition of claim 1, wherein the composition further comprises a low carbonic acid, and the low carbonic acid comprises acetic acid, 2-methylbutyric acid, butyric acid, propionic acid, n-valeric acid, isovaleric acid, and 3-methylvaleric acid, and the mass fractions of the acetic acid, 2-methylbutyric acid, butyric acid, propionic acid, n-valeric acid, isovaleric acid, and 3-methylvaleric acid in the composition are 0.02 to 0.05%, 0.03 to 0.06%, 0.02 to 0.05%, 0.01 to 0.06%, and 0.01 to 0.04%, respectively.
4. The composition of claim 3, wherein the mass fractions of acetic acid, 2-methylbutyric acid, butyric acid, propionic acid, n-valeric acid, isovaleric acid, and 3-methylvaleric acid in the composition are 0.02%, 0.06%, 0.03%, 0.05%, 0.06%, and 0.04%, respectively.
5. The composition of claim 1, further comprising a TRPM8 receptor agonist, wherein the TRPM8 receptor agonist is present in the composition at a weight fraction of 0.1 to 6%.
6. The composition of claim 5, wherein said TRPM8 receptor agonist comprises at least one of peppermint oil, menthol, WS-23, L-menthone, menthyl acetate, menthyl lactate, WS-3, menthone glycerol ketal.
7. The composition according to claim 1, wherein the diluent comprises propylene glycol and ethanol, and the mass ratio of the propylene glycol to the ethanol is 1: 1-1: 3.
8. A process for the preparation of a composition according to any one of claims 1 to 7, comprising the steps of:
dissolving solid acid in the raw materials by using a diluent, adding the rest raw materials, and uniformly mixing to obtain the composition.
9. An electronic cigarette aerosol is characterized by comprising the composition as claimed in any one of claims 1 to 7, wherein the mass fraction of the composition in the electronic cigarette aerosol is 0.5-8%.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105263345A (en) * | 2013-05-06 | 2016-01-20 | 派克斯实验公司 | Nicotine salt formulations for aerosol devices and methods thereof |
| CN110150760A (en) * | 2019-05-31 | 2019-08-23 | 钟术光 | A kind of aerosol generation system |
| CN112956729A (en) * | 2021-03-10 | 2021-06-15 | 深圳市华加生物科技有限公司 | Nicotine salt and preparation method thereof |
| CN113912585A (en) * | 2021-11-09 | 2022-01-11 | 深圳萨特瓦生物科技有限公司 | Composite nicotine salt, preparation method and application thereof, electronic cigarette oil and electronic cigarette |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105263345A (en) * | 2013-05-06 | 2016-01-20 | 派克斯实验公司 | Nicotine salt formulations for aerosol devices and methods thereof |
| CN110150760A (en) * | 2019-05-31 | 2019-08-23 | 钟术光 | A kind of aerosol generation system |
| CN112956729A (en) * | 2021-03-10 | 2021-06-15 | 深圳市华加生物科技有限公司 | Nicotine salt and preparation method thereof |
| CN113912585A (en) * | 2021-11-09 | 2022-01-11 | 深圳萨特瓦生物科技有限公司 | Composite nicotine salt, preparation method and application thereof, electronic cigarette oil and electronic cigarette |
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